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  1. Article ; Online: Enzalutamide in Biochemically Recurrent Prostate Cancer.

    Pollak, Michael

    The New England journal of medicine

    2024  Volume 390, Issue 1, Page(s) 90

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/drug therapy ; Nitriles ; Phenylthiohydantoin/therapeutic use ; Benzamides
    Chemical Substances enzalutamide (93T0T9GKNU) ; Nitriles ; Phenylthiohydantoin (2010-15-3) ; Benzamides
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2313228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Intrinsic Clocks

    Pollak, Daniela D. / Partonen, Timo

    2018  

    Abstract: ... of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young ...

    Abstract Intrinsic Clocks presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis.It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest.The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called "clock genes."
    Keywords Medicine (General) ; Neurology. Diseases of the nervous system
    Size 1 electronic resource (117 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099643
    ISBN 9782889454518 ; 2889454517
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Publisher Correction: Restructuring and serving web-accessible streamflow data from the NOAA National Water Model historic simulations.

    Johnson, J Michael / Blodgett, David L / Clarke, Keith C / Pollak, Jon

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 192

    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-03035-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diet boosts the effectiveness of a cancer drug.

    Pollak, Michael

    Nature

    2018  Volume 560, Issue 7719, Page(s) 439–440

    MeSH term(s) Antineoplastic Agents ; Diet ; Feedback ; Insulin ; Phosphatidylinositol 3-Kinases
    Chemical Substances Antineoplastic Agents ; Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2018-08-20
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-05871-x
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    Zs.A 26: Show issues Location:
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    Zs.MO 244: Show issues

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  5. Article ; Online: Behavioral Phenotypes and Comorbidity in 3q29 Deletion Syndrome: Results from the 3q29 Registry.

    Pollak, Rebecca M / Mortillo, Michael / Murphy, Melissa M / Mulle, Jennifer G

    Journal of autism and developmental disorders

    2024  

    Abstract: 3q29 deletion syndrome (3q29del) is associated with a significantly increased risk for neurodevelopmental and neuropsychiatric disorders. However, the full spectrum of behavioral phenotypes associated with 3q29del is still evolving. Individuals with ... ...

    Abstract 3q29 deletion syndrome (3q29del) is associated with a significantly increased risk for neurodevelopmental and neuropsychiatric disorders. However, the full spectrum of behavioral phenotypes associated with 3q29del is still evolving. Individuals with 3q29del (n = 96, 60.42% male) or their guardian completed the Achenbach Child or Adult Behavior Checklist (CBCL/ABCL) via the online 3q29 registry (3q29deletion.org). Typically developing controls (n = 57, 49.12% male) were ascertained as a comparison group. We analyzed mean performance on the CBCL/ABCL for individuals with 3q29del and controls across composite, DSM-keyed, and developmental scales; and the relationship between CBCL/ABCL performance and clinical and developmental phenotypes for individuals with 3q29del. Individuals with 3q29del showed significantly elevated behavioral and developmental impairment relative to controls across CBCL/ABCL domains. A substantial proportion of study participants with 3q29del scored in the Borderline or Clinical range for composite and DSM-keyed scales, indicating significant behavioral problems that may require clinical evaluation. We found that the preschool CBCL DSM-keyed autism spectrum problems scale is a potential screening tool for autism spectrum disorder (ASD) for individuals with 3q29del; CBCL/ABCL DSM-keyed scales were not accurate screeners for anxiety disorders or attention-deficit/hyperactivity disorder (ADHD) in our study sample. We identified a high degree of psychiatric comorbidity in individuals with 3q29del, with 60.42% (n = 58) of individuals with 3q29del scoring in the Borderline or Clinical range on two or more DSM-keyed CBCL/ABCL scales. Finally, we found that the degree of developmental delay in participants with 3q29del does not explain the increased behavioral problems observed on the CBCL/ABCL. The CBCL/ABCL can be used as screening tools in populations such as 3q29del, even in the presence of substantial psychiatric comorbidity. These results expand our understanding of the phenotypic spectrum of 3q29del and demonstrate an effective method for recruiting and phenotyping a large sample of individuals with a rare genetic disorder.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06218-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 765: Show issues Location:
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  6. Article ; Online: The effects of metformin on gut microbiota and the immune system as research frontiers.

    Pollak, Michael

    Diabetologia

    2017  Volume 60, Issue 9, Page(s) 1662–1667

    Abstract: Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has revealed complexity not previously appreciated, and opened new research directions. The extent ...

    Abstract Recent studies have revealed that metformin influences gut microbiota and the immune system although neither is a classic target of the drug. This research has revealed complexity not previously appreciated, and opened new research directions. The extent to which immunomodulatory effects and actions on the microbiota are related to each other and account for effects on host energy metabolism remains to be determined. These sites of action may be relevant not only to the efficacy of metformin for its established use in type 2 diabetes, but also to proposed novel indications in oncology and other diseases.
    MeSH term(s) Gastrointestinal Microbiome/drug effects ; Humans ; Metformin/therapeutic use ; Microbiota/drug effects
    Chemical Substances Metformin (9100L32L2N)
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-017-4352-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 279: Show issues Location:
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  7. Book ; Conference proceedings: First International Workshop on Growth Hormone, Insulin-like Growth Factors and Neoplasia

    Pollak, Michael

    proceedings of a workshop held in Boston, Massachusetts, [24 - 25] October 1999

    (Growth hormone & IGF research ; 10, Suppl. A)

    2000  

    Event/congress International Workshop on Growth Hormone, Insulin-Like Growth Factors and Neoplasia (1, 1999, BostonMass.)
    Author's details organizing committee: M. Pollak
    Series title Growth hormone & IGF research ; 10, Suppl. A
    Collection
    Language English
    Size 53 S.
    Publisher Churchill Livingstone
    Publishing place Edinburgh u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT012804856
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3319 -10,Suppl.A- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Introducing Cancer Center Director Perspectives on Prevention.

    DuBois, Raymond N / Pollak, Michael N

    Cancer prevention research (Philadelphia, Pa.)

    2022  Volume 15, Issue 11, Page(s) 713–714

    Language English
    Publishing date 2022-10-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-22-0425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6766: Show issues Location:
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  9. Article ; Online: Paul F. Lazarsfeld

    Michael Pollak

    Política & Sociedade, Vol 17, Iss 38, Pp 94-

    fundador de uma multinacional científica

    2018  Volume 134

    Abstract: Este artigo examina os condicionantes sociais da carreira de Paul F. Lazarsfeld, buscando determinar os fatores de ruptura e de continuidade que a caracterizam. Na primeira parte, analisa a juventude de Paul F. Lazarsfeld a partir de sua relação com os ... ...

    Abstract Este artigo examina os condicionantes sociais da carreira de Paul F. Lazarsfeld, buscando determinar os fatores de ruptura e de continuidade que a caracterizam. Na primeira parte, analisa a juventude de Paul F. Lazarsfeld a partir de sua relação com os meios socialistas e judeus de Viena. Na segunda parte, estuda as reações diferenciais à emigração, apoiando-se particularmente na comparação entre as atitudes opostas de Theodor Adorno e de Paul Lazarsfeld. Em seguida, analisa as capacidades específicas que permitiram a Lazarsfeld fundar uma nova forma de empreendimento intelectual, assentado sobre uma divisão racional do trabalho e uma organização quase industrial da produção intelectual, o que foi possível graças ao uso de uma metodologia positivista que segmentava e mecanizava as diferentes operações intelectuais. Por fim, o trabalho examina as estratégias por meio das quais, apoiando-se sobre a política das fundações privadas, Lazarsfeld contribuiu para exportar para a Europa do Leste e do Oeste a sociologia empirista americana e, ao mesmo tempo, o modelo de relações que associa a pesquisa social a agentes econômicos e políticos, tal como se constituiu nos Estados Unidos durante os anos 1920 e 1930. Uma estratégia de conquista de novos mercados intelectuais que coincidiu com as estratégias de modernização e de reconquista ideológica que ocorriam na Europa nesse mesmo período.
    Keywords Sociologia da sociologia ; Paul F. Lazarsfeld ; Internacionalização da sociologia norte-americana ; Ciência social e engajamento ; Fundações privadas ; Financiamento à pesquisa ; Political institutions and public administration (General) ; JF20-2112 ; Social sciences (General) ; H1-99
    Language Portuguese
    Publishing date 2018-06-01T00:00:00Z
    Publisher Universidade Federal de Santa Catarina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Uma sociologia em ato dos intelectuais

    Michael Pollak

    Política & Sociedade, Vol 17, Iss 39, Pp 22-

    os combates de Karl Kraus

    2018  Volume 62

    Abstract: A posição que Karl Kraus ocupou no campo intelectual austríaco é única na história dos intelectuais. Em vez de tentar reconstruir seu pensamento como uma teoria, é possível interpretá-lo como um revelador das regras do jogo que caracterizam o campo ... ...

    Abstract A posição que Karl Kraus ocupou no campo intelectual austríaco é única na história dos intelectuais. Em vez de tentar reconstruir seu pensamento como uma teoria, é possível interpretá-lo como um revelador das regras do jogo que caracterizam o campo intelectual. Os escritos de Kraus sugerem muito mais uma releitura no sentido de uma sociologia-ação, que lança mão de técnicas de provocação para tornar visíveis as sanções a que ficam expostos aqueles que atrapalham o jogo combinado de dissimulação das relações entre intelectuais e poder. A análise das intervenções de Kraus possibilita vincular suas lutas a fenômenos de crise do campo intelectual. O papel desempenhado por ele foi o de denunciar as implicações de um processo de racionalização das atividades intelectuais, definido, inicialmente, pela substituição de um mercado intelectual pelo mecenato e, depois, pela extensão e estruturação desse mercado em razão de demandas sociais cada vez mais precisas.
    Keywords Karl Kraus ; Intelectuais ; Poder ; Doxa ; Guerra Mundial ; Political institutions and public administration (General) ; JF20-2112 ; Social sciences (General) ; H1-99
    Language Portuguese
    Publishing date 2018-11-01T00:00:00Z
    Publisher Universidade Federal de Santa Catarina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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