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Article: Formation of Zinc Thiolates by Reductive Cleavage of Disulfides with the Zn/AlCl3 System in Aqueous Media, and their Use for Michael Addition

Movassagh, Barahman / Yousef Zakinezhad

Zeitschrift für Naturforschung. 2014 June 2, v. 61, no. 1

2014

Abstract: ... Michael addition to α,β -unsaturated carbonyl compounds mediated by the Zn/AlCl₃ system in aqueous media ...

Abstract	A simple, convenient, and efficient one-pot protocol for the reductive cleavage of disulfides and Michael addition to α,β -unsaturated carbonyl compounds mediated by the Zn/AlCl₃ system in aqueous media is reported.
Keywords	carbonyl compounds ; sulfides ; zinc
Language	English
Dates of publication	2014-0602
Size	p. 47-49.
Publishing place	Verlag der Zeitschrift für Naturforschung
Document type	Article
ZDB-ID	124635-5
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
ISSN	0340-5087 ; 0044-3174 ; 0932-0776 ; 0341-0447 ; 0341-0420
DOI	10.1515/znb-2006-0109
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Does offering small financial incentives to smokers at the time of being wait-listed for surgery increase smoking cessation by the day of surgery? A randomised feasibility trial.

Webb, Ashley / Coward, Lisa / Yousef, Michael / Karamesinis, Alexandra / Leong, Samuel

BMJ open

2023 Volume 13, Issue 12, Page(s) e080693

Abstract: Objective: This study aims to assess whether offering small financial incentives to smokers on elective surgery wait-lists is feasible and increases quitting before surgery.: Design: Randomised controlled trial, prospective, double-blinded.: ... ...

Abstract	Objective: This study aims to assess whether offering small financial incentives to smokers on elective surgery wait-lists is feasible and increases quitting before surgery. Design: Randomised controlled trial, prospective, double-blinded. Setting: Single-centre, Australian metropolitan public hospital. Participants: 620 adult smokers (≥10 cigarettes per day) were randomised on being wait-listed for elective surgery and 404 underwent operations (28 January 2021-31 July 2022) at the hospital (65.2%) by trial's end. Intervention: Intervention participants were offered at wait-listing an $A70 supermarket voucher for verified abstinence on the day of surgery, provided they registered an intention to quit before surgery. Registrants intending to quit were also referred to Quitline. Neither intervention was offered to control participants (usual care). Smokers wait-listed from 17 May 2021 were offered an increased incentive of $A140. Main outcome measures: Primary outcome, quitting at least 24 hours before surgery, verified by exhaled carbon monoxide testing. Feasibility outcomes were the proportion taking up offers, ease of patient contact and disputes about quit status. Results: Of 620 randomised participants (control 312, intervention 308), 404 had surgery at the hospital during the trial (control 214, intervention 190), which was lower than expected (for COVID-19 reasons). Offering $A70 resulted in 21.9% registering to quit, increasing to 32.6% with $A140. Telephone calls were the most effective means to gain registrations. The proportion of intervention group patients verified quit at least 24 hours before surgery was similar to controls (9.5% vs 8.9%, OR 1.1, 95% CI 0.5 to 2.2). Quitline contact was higher in the intervention group (13.2% vs 2.3%, OR 6.3, 95% CI 2.3 to 21.6). Disputes over test results did not occur, but 17.4% of intervention participants claiming quit failed verification. Conclusion: A single offer of financial rewards for perioperative cessation was feasible, without achieving clinically important quit differences. Trial registration number: ACTRN12620000130965.
MeSH term(s)	Adult ; Humans ; Smoking Cessation/methods ; Smokers ; Motivation ; Feasibility Studies ; Prospective Studies ; Australia
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-080693
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Profound Lingual Tonsil Hypertrophy Associated With Gonococcal Pharyngitis.

Liu, Amy / Tang, Michael E / Yousef, Andrew / Meller, Leo L T / Vahabzadeh-Hagh, Andrew M

Ear, nose, & throat journal

2023 , Page(s) 1455613231178116

Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613231178116
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Article: Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases.

Tizabi, Yousef / Getachew, Bruk / Aschner, Michael

Research square

2023

Abstract: Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases and are therefore of significant environmental and medical concerns. We have previously reported that damage to neuroblastoma-derived ... ...

Abstract	Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases and are therefore of significant environmental and medical concerns. We have previously reported that damage to neuroblastoma-derived dopaminergic cells (SH-SY5Y) by both Fe and Mn could be prevented by pre-treatment with nicotine. Moreover, butyrate, a short chain fatty acid (SCFA) provided protection against salsolinol, a selective dopaminergic toxin, in the same cell line. Here, we broadened the investigation to determine whether butyrate might also protect against Fe and/or Mn, and whether, if combined with nicotine, an additive or synergistic effect might be observed. Both butyrate and nicotine concentration-dependently blocked Fe and Mn toxicities. The ineffective concentrations of nicotine and butyrate, when combined, provided full protection against both Fe and Mn. Moreover, the effects of nicotine but not butyrate could be blocked by mecamylamine, a non-selective nicotinic antagonist. On the other hand, the effects of butyrate, but not nicotine, could be blocked by beta-hydroxy butyrate, a fatty acid-3 receptor antagonist. These results not only provide further support for neuroprotective effects of both nicotine and butyrate but indicate distinct mechanisms of action for each one. Furthermore, potential utility of the combination of butyrate and nicotine against heavy metal toxicities is suggested.
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3389904/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture.

Tizabi, Yousef / Getachew, Bruk / Aschner, Michael

Neurotoxicity research

2023 Volume 42, Issue 1, Page(s) 3

Abstract	Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases and are therefore of significant environmental and medical concerns. We have previously reported that damage to neuroblastoma-derived dopaminergic cells (SH-SY5Y) by both Fe and Mn could be prevented by pre-treatment with nicotine. Moreover, butyrate, a short chain fatty acid (SCFA) provided protection against salsolinol, a selective dopaminergic toxin, in the same cell line. Here, we broadened the investigation to determine whether butyrate might also protect against Fe and/or Mn, and whether, if combined with nicotine, an additive or synergistic effect might be observed. Both butyrate and nicotine concentration-dependently blocked Fe and Mn toxicities. Ineffective concentrations of nicotine and butyrate, when combined, provided full protection against both Fe and Mn. Moreover, the effects of nicotine but not butyrate could be blocked by mecamylamine, a non-selective nicotinic antagonist. On the other hand, the effects of butyrate, but not nicotine, could be blocked by beta-hydroxy butyrate, a fatty acid-3 receptor antagonist. These results not only provide further support for neuroprotective effects of both nicotine and butyrate but also indicate distinct mechanisms of action for each one. Furthermore, potential utility of butyrate and nicotine combination against heavy metal toxicities is suggested.
MeSH term(s)	Humans ; Nicotine/toxicity ; Manganese/toxicity ; Iron/toxicity ; Butyrates/pharmacology ; Cell Line, Tumor ; Neuroblastoma ; Cell Culture Techniques
Chemical Substances	Nicotine (6M3C89ZY6R) ; Manganese (42Z2K6ZL8P) ; Iron (E1UOL152H7) ; Butyrates
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00682-z
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Article ; Online: Does offering small financial incentives to smokers at the time of being wait-listed for surgery increase smoking cessation by the day of surgery? A randomised feasibility trial

Ashley Webb / Lisa Coward / Michael Yousef / Alexandra Karamesinis / Samuel Leong

BMJ Open, Vol 13, Iss

2023 Volume 12

Abstract: Objective This study aims to assess whether offering small financial incentives to smokers on elective surgery wait-lists is feasible and increases quitting before surgery.Design Randomised controlled trial, prospective, double-blinded.Setting Single- ... ...

Abstract	Objective This study aims to assess whether offering small financial incentives to smokers on elective surgery wait-lists is feasible and increases quitting before surgery.Design Randomised controlled trial, prospective, double-blinded.Setting Single-centre, Australian metropolitan public hospital.Participants 620 adult smokers (≥10 cigarettes per day) were randomised on being wait-listed for elective surgery and 404 underwent operations (28 January 2021–31 July 2022) at the hospital (65.2%) by trial’s end.Intervention Intervention participants were offered at wait-listing an $A70 supermarket voucher for verified abstinence on the day of surgery, provided they registered an intention to quit before surgery. Registrants intending to quit were also referred to Quitline. Neither intervention was offered to control participants (usual care). Smokers wait-listed from 17 May 2021 were offered an increased incentive of $A140.Main outcome measures Primary outcome, quitting at least 24 hours before surgery, verified by exhaled carbon monoxide testing. Feasibility outcomes were the proportion taking up offers, ease of patient contact and disputes about quit status.Results Of 620 randomised participants (control 312, intervention 308), 404 had surgery at the hospital during the trial (control 214, intervention 190), which was lower than expected (for COVID-19 reasons). Offering $A70 resulted in 21.9% registering to quit, increasing to 32.6% with $A140. Telephone calls were the most effective means to gain registrations. The proportion of intervention group patients verified quit at least 24 hours before surgery was similar to controls (9.5% vs 8.9%, OR 1.1, 95% CI 0.5 to 2.2). Quitline contact was higher in the intervention group (13.2% vs 2.3%, OR 6.3, 95% CI 2.3 to 21.6). Disputes over test results did not occur, but 17.4% of intervention participants claiming quit failed verification.Conclusion A single offer of financial rewards for perioperative cessation was feasible, without achieving clinically important quit ...
Keywords	Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Validation Performance of a Machine Learning Classifier in Interstitial Lung Disease Cases Without Definite or Probable Usual Interstitial Pneumonia Pattern on CT Using Clinical and Pathology-Supported Diagnostic Labels.

Chang, Marcello / Reicher, Joshua J / Kalra, Angad / Muelly, Michael / Ahmad, Yousef

Journal of imaging informatics in medicine

2024 Volume 37, Issue 1, Page(s) 297–307

Abstract: We previously validated Fibresolve, a machine learning classifier system that non-invasively predicts idiopathic pulmonary fibrosis (IPF) diagnosis. The system incorporates an automated deep learning algorithm that analyzes chest computed tomography (CT) ...

Abstract	We previously validated Fibresolve, a machine learning classifier system that non-invasively predicts idiopathic pulmonary fibrosis (IPF) diagnosis. The system incorporates an automated deep learning algorithm that analyzes chest computed tomography (CT) imaging to assess for features associated with idiopathic pulmonary fibrosis. Here, we assess performance in assessment of patterns beyond those that are characteristic features of usual interstitial pneumonia (UIP) pattern. The machine learning classifier was previously developed and validated using standard training, validation, and test sets, with clinical plus pathologically determined ground truth. The multi-site 295-patient validation dataset was used for focused subgroup analysis in this investigation to evaluate the classifier's performance range in cases with and without radiologic UIP and probable UIP designations. Radiologic assessment of specific features for UIP including the presence and distribution of reticulation, ground glass, bronchiectasis, and honeycombing was used for assignment of radiologic pattern. Output from the classifier was assessed within various UIP subgroups. The machine learning classifier was able to classify cases not meeting the criteria for UIP or probable UIP as IPF with estimated sensitivity of 56-65% and estimated specificity of 92-94%. Example cases demonstrated non-basilar-predominant as well as ground glass patterns that were indeterminate for UIP by subjective imaging criteria but for which the classifier system was able to correctly identify the case as IPF as confirmed by multidisciplinary discussion generally inclusive of histopathology. The machine learning classifier Fibresolve may be helpful in the diagnosis of IPF in cases without radiological UIP and probable UIP patterns.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-023-00914-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder.

Csoka, Antonei B / El Kouhen, Nacer / Bennani, Samia / Getachew, Bruk / Aschner, Michael / Tizabi, Yousef

Biomolecules

2024 Volume 14, Issue 4

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life of ...

Abstract	Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe deficits in social communication and interaction, repetitive movements, abnormal focusing on objects, or activity that can significantly affect the quality of life of the afflicted. Neuronal and glial cells have been implicated. It has a genetic component but can also be triggered by environmental factors or drugs. For example, prenatal exposure to valproic acid or acetaminophen, or ingestion of propionic acid, can increase the risk of ASD. Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of this disorder. Epigenetics refers to DNA modifications that alter gene expression without making any changes to the DNA sequence. Although an increasing number of pharmaceuticals and environmental chemicals are being implicated in the etiology of ASD, here, we specifically focus on the molecular influences of the abovementioned chemicals on epigenetic alterations in neuronal and glial cells and their potential connection to ASD. We conclude that a better understanding of these phenomena can lead to more effective interventions in ASD.
MeSH term(s)	Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/metabolism ; Autism Spectrum Disorder/chemically induced ; Humans ; Epigenesis, Genetic/drug effects ; Neuroglia/metabolism ; Neuroglia/drug effects ; Valproic Acid/pharmacology ; Valproic Acid/adverse effects ; Propionates/pharmacology ; Animals ; Acetaminophen/adverse effects ; Neurons/metabolism ; Neurons/drug effects ; Neurons/pathology ; DNA Methylation/drug effects
Chemical Substances	Valproic Acid (614OI1Z5WI) ; Propionates ; Acetaminophen (362O9ITL9D) ; propionic acid (JHU490RVYR)
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14040437
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization of recombinant phytase of Klebsiella sp. and the influence of novel 3-phytase on mineral solubility in broiler diets under an in vitro digestion assay.

Houshyar, Mohammad / Saki, Ali Asghar / Alikhani, Mohammad Yousef / Bedford, Michael Richard / Soleimani, Meysam / Kamarehei, Farideh

Protein expression and purification

2024 , Page(s) 106489

Abstract: Phytate (inositol hexaphosphate) is the major storage form of phosphorus (P) in nature, and phytases catalyze the hydrolysis of P from phytate and the formation of inositol phosphate isomers. In this study, a bacterium that produces phytase was isolated ... ...

Abstract	Phytate (inositol hexaphosphate) is the major storage form of phosphorus (P) in nature, and phytases catalyze the hydrolysis of P from phytate and the formation of inositol phosphate isomers. In this study, a bacterium that produces phytase was isolated in a phytase screening medium. The bacterium was identified as Klebsiella sp. using phenotypic and molecular techniques. The PhyK phytase gene was successfully amplified from the genome, inserted into the pET-21a (+) vector, and expressed as a recombinant protein in E. Coli BL21. The efficiency of a laboratory phytase (Lab-Ph, PhyK phytase) was determined and compared with a commercial phytase (Com-Ph, Quantum Blue 40P phytase, AB Vista) under an in vitro digestion assay. The native signal peptide effectively facilitated the translocation of the protein to the periplasmic space of E. Coli BL21, resulting in the proper folding of the protein and the manifestation of desirable enzyme activity. The Lab-Ph displayed the temperature and pH optima at 50°C and 5 respectively. Under an in vitro digestion assay condition, Lab-Ph improved the P solubility coefficient in broiler diets. In comparison, the Com-Ph significantly increased the P solubility coefficient even when compared with the Lab-Ph. This study has shown that Lab-Ph possesses the necessary biochemical properties to be used in various industrial applications. However, Lab-Ph is extremely sensitive to heat treatment. The Lab-Ph and Com-Ph under in vitro digestion assay improve the solubility coefficient of P in the broiler diet.
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1055455-5
ISSN	1096-0279 ; 1046-5928
ISSN (online)	1096-0279
ISSN	1046-5928
DOI	10.1016/j.pep.2024.106489
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Article: Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma.

NPJ precision oncology

2024 Volume 8, Issue 1, Page(s) 27

Abstract: The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Overall survival ...

Abstract	The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Overall survival (OS) analysis demonstrated that KRAS mutation status and subtypes were prognostic (p < 0.001). Relative to patients with KRAS wildtype tumors (median OS 38 months), patients with KRAS
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ISSN	2397-768X
ISSN	2397-768X
DOI	10.1038/s41698-024-00505-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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