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  1. Article ; Online: The cell cycle loops UTP around CAD.

    Sahu, Umakant / Ben-Sahra, Issam

    Nature metabolism

    2023  Volume 5, Issue 2, Page(s) 199–200

    MeSH term(s) Uridine Triphosphate/metabolism ; Cell Cycle ; Cell Division
    Chemical Substances Uridine Triphosphate (UT0S826Z60)
    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00737-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: GATOR2 rings GATOR1 to speak to mTORC1.

    Sahu, Umakant / Ben-Sahra, Issam

    Molecular cell

    2022  Volume 83, Issue 1, Page(s) 6–8

    Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and ... ...

    Abstract The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.
    MeSH term(s) Mechanistic Target of Rapamycin Complex 1/genetics ; TOR Serine-Threonine Kinases/genetics ; Multiprotein Complexes/genetics ; Leucine ; Lysosomes
    Chemical Substances Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Multiprotein Complexes ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Regulation of nucleotide metabolism in cancers and immune disorders.

    Ali, Eunus S / Ben-Sahra, Issam

    Trends in cell biology

    2023  Volume 33, Issue 11, Page(s) 950–966

    Abstract: Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for energy production and the synthesis of macromolecules, including proteins, lipids, and nucleic acids. Nucleotides are continuously replenished through the ... ...

    Abstract Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for energy production and the synthesis of macromolecules, including proteins, lipids, and nucleic acids. Nucleotides are continuously replenished through the activation of the nucleotide synthesis pathways. Despite the importance of nucleotides in cell physiology, there is still much to learn about how the purine and pyrimidine synthesis pathways are regulated in response to intracellular and exogenous signals. Over the past decade, evidence has emerged that several signaling pathways [Akt, mechanistic target of rapamycin complex I (mTORC1), RAS, TP53, and Hippo-Yes-associated protein (YAP) signaling] alter nucleotide synthesis activity and influence cell function. Here, we examine the mechanisms by which these signaling networks affect de novo nucleotide synthesis in mammalian cells. We also discuss how these molecular links can be targeted in diseases such as cancers and immune disorders.
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
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    Zs.A 3410: Show issues Location:
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  4. Article ; Online: GATOR2 rings GATOR1 to speak to mTORC1

    Sahu, Umakant / Ben-Sahra, Issam

    Molecular Cell. 2023 Jan., v. 83, no. 1 p.6-8

    2023  

    Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and ... ...

    Abstract The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.
    Keywords leucine ; rapamycin ; ubiquitination
    Language English
    Dates of publication 2023-01
    Size p. 6-8.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.12.011
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/501: Show issues

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  5. Article ; Online: ASS1igning purine dependency to cancer.

    Villa, Elodie / Ben-Sahra, Issam

    Nature cancer

    2020  Volume 1, Issue 9, Page(s) 862–863

    MeSH term(s) Humans ; Neoplasms/therapy ; Purines
    Chemical Substances Purines ; purine (W60KTZ3IZY)
    Language English
    Publishing date 2020-08-03
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-020-00117-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: A spoonful of DHAP keeps mTORC1 running on sugars.

    Hoxhaj, Gerta / Locasale, Jason W / Ben-Sahra, Issam

    Nature metabolism

    2020  Volume 2, Issue 9, Page(s) 801–802

    Language English
    Publishing date 2020-07-27
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-0246-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SGLT2 Inhibition on Cardiac Mitochondrial Function: Searching for a Sweet Spot.

    Sawicki, Konrad Teodor / Ben-Sahra, Issam / McNally, Elizabeth M

    Journal of the American Heart Association

    2021  Volume 10, Issue 13, Page(s) e021949

    MeSH term(s) Diabetic Cardiomyopathies ; Humans ; Mitochondria ; Sodium-Glucose Transporter 2
    Chemical Substances Sodium-Glucose Transporter 2
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.021949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth.

    Ben-Sahra, Issam / Puissant, Alexandre

    Cell metabolism

    2018  Volume 28, Issue 6, Page(s) 805–807

    Abstract: Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 ... ...

    Abstract Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth.
    MeSH term(s) Breast Neoplasms ; Creatine ; Creatine Kinase, Mitochondrial Form ; Humans ; Phosphorylation ; Receptor, ErbB-2 ; Tyrosine
    Chemical Substances Tyrosine (42HK56048U) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Creatine Kinase, Mitochondrial Form (EC 2.7.3.2) ; Creatine (MU72812GK0)
    Language English
    Publishing date 2018-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2018.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
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  9. Article ; Online: Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.

    Sahu, Umakant / Villa, Elodie / Reczek, Colleen R / Zhao, Zibo / O'Hara, Brendan P / Torno, Michael D / Mishra, Rohan / Shannon, William D / Asara, John M / Gao, Peng / Shilatifard, Ali / Chandel, Navdeep S / Ben-Sahra, Issam

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6690, Page(s) 1484–1492

    Abstract: Cellular purines, particularly adenosine 5'-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, but not purines, maintain pyruvate oxidation and ... ...

    Abstract Cellular purines, particularly adenosine 5'-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, but not purines, maintain pyruvate oxidation and the tricarboxylic citric acid (TCA) cycle by regulating pyruvate dehydrogenase (PDH) activity. PDH activity requires sufficient substrates and cofactors, including thiamine pyrophosphate (TPP). Depletion of cellular pyrimidines decreased TPP synthesis, a reaction carried out by TPP kinase 1 (TPK1), which reportedly uses ATP to phosphorylate thiamine (vitamin B1). We found that uridine 5'-triphosphate (UTP) acts as the preferred substrate for TPK1, enabling cellular TPP synthesis, PDH activity, TCA-cycle activity, lipogenesis, and adipocyte differentiation. Thus, UTP is required for vitamin B1 utilization to maintain pyruvate oxidation and lipogenesis.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Lipogenesis ; Pyrimidines/metabolism ; Pyruvates/metabolism ; Thiamine/metabolism ; Thiamine Pyrophosphate/metabolism ; Uridine Triphosphate/metabolism ; Oxidation-Reduction ; Citric Acid Cycle ; Protein Kinases/metabolism ; Humans ; HeLa Cells ; Pyruvate Dehydrogenase Complex/metabolism
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Pyrimidines ; Pyruvates ; Thiamine (X66NSO3N35) ; Thiamine Pyrophosphate (Q57971654Y) ; Uridine Triphosphate (UT0S826Z60) ; Protein Kinases (EC 2.7.-) ; Pyruvate Dehydrogenase Complex
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adh2771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  10. Article: Mechano-dependent sorbitol accumulation supports biomolecular condensate.

    Torrino, Stephanie / Oldham, William M / Tejedor, Andrés R / Burgos, Ignacio S / Rachedi, Nesrine / Fraissard, Kéren / Chauvet, Caroline / Sbai, Chaima / O'Hara, Brendan P / Abélanet, Sophie / Brau, Frederic / Clavel, Stephan / Collepardo-Guevara, Rosana / Espinosa, Jorge R / Ben-Sahra, Issam / Bertero, Thomas

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA ... ...

    Abstract Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA metabolism
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.24.550444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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