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Article ; Online: Defective autophagic flux aggravates cadmium-induced Sertoli cell apoptosis.

Chen, Na / Wan, Xiaoyan / Cheng, Shun / Tang, Guiju / Xia, Dan / Xu, Yanling / Shen, Yi

2024 Volume 273, Page(s) 116095

Abstract: The male reproductive dysfunction accounts for 50% of infertile couples in the world. Cadmium (Cd) is one of the most harmful heavy metals to both the environment and inhabitants. Accumulating data suggest that Cd could cause male infertility. Sertoli ... ...

Abstract	The male reproductive dysfunction accounts for 50% of infertile couples in the world. Cadmium (Cd) is one of the most harmful heavy metals to both the environment and inhabitants. Accumulating data suggest that Cd could cause male infertility. Sertoli cell (SC) is a somatic cell of testis and a key regulator of spermatogenesis by providing physical and nutritional support for developing sperm. Many studies showed that Cd induced dysfunction of SCs was directly related to male reproductive damage. However, the mechanism of SCs injury caused by Cd remains to be clarified. We found that Cd treatment caused a significant increase of apoptosis in SCs cells, accompanied by a marked increase in the production of ROS. These results were associated with the formation of mitochondria-containing autophagosomes and increased expression of LC3-II in vitro. Interestingly, our results showed that Cd did not promote but inhibited the fusion of mitochondria-containing autophagosomes with lysosomes by reducing the function of lysosomes. Together, this study provides insight into the negative effects of Cd, which interferes with autophagic flux and induces the apoptosis of SCs.
MeSH term(s)	Male ; Humans ; Cadmium/metabolism ; Sertoli Cells/metabolism ; Semen ; Autophagy ; Apoptosis
Chemical Substances	Cadmium (00BH33GNGH)
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116095
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Article: Pharmacokinetics and Excretion Study of

Xia, Hui / Yang, Chao / Zhou, Beijia / Tang, Huali / Yang, Ligang / Liao, Wang / Sun, Guiju

Foods (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis ... ...

Abstract	A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis of
Language	English
Publishing date	2021-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10112851
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Article ; Online: MiR-144-3p inhibits the proliferation and metastasis of lung cancer A549 cells via targeting HGF.

Fang, Guiju / Zhang, Canhui / Liu, Zhixin / Peng, Zhiwen / Tang, Meiyan / Xue, Qing

Journal of cardiothoracic surgery

2022 Volume 17, Issue 1, Page(s) 117

Abstract: Aim: MicroRNAs have been confirmed as vital regulators in gene expression, which could affect multiple cancer cell biological behaviors. This study aims to elucidate the molecular mechanism of miR-144-3p in lung cancer cellular proliferation and ... ...

Abstract	Aim: MicroRNAs have been confirmed as vital regulators in gene expression, which could affect multiple cancer cell biological behaviors. This study aims to elucidate the molecular mechanism of miR-144-3p in lung cancer cellular proliferation and metastasis. Methods: MiR-144-3p expression in lung cancer tissues and cell lines was detected by qRT-PCR. HGF was predicted as the target gene of miR-144-3p using TargetScan and dual luciferase reporter assay. Immunohistochemistry and qRT-PCR were used to explore the impacts of HCF on lung cancer tissues and cell lines. Impacts of miR-144-3p and HGF on cancer cellular proliferation, migration and invasion were elucidated by CCK-8, Flow cytometry, Transwell invasion and Wound-healing assay. Moreover, nude mouse xenograft model was established to evaluate the effects of miR-144-3p on lung cancer cells. Results: MiR-144-3p exhibited a reduction in both lung cancer tissues and cell lines. HGF was a direct target of miR-144-3p. In contrast to the miR-144-3p expression level, HGF showed a higher level in lung cancer tissues and cell lines. Overexpression miR-144-3p suppressed A549 and NCI-H1299 cell proliferation and metastasis, whereas this was reversed by HGF. MiR-144-3p exhibited an inhibitory effect on A549 cell-induced tumor growth of nude mice. Conclusions: This study reveals miR-144-3p/HGF axis may be involved in the suppression of lung cancer cellular proliferation and development, and miR-144-3p may function as a potential therapeutic target in lung cancer treatment in the future.
MeSH term(s)	A549 Cells ; Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Hepatocyte Growth Factor/genetics ; Hepatocyte Growth Factor/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	HGF protein, human ; MIRN144 microRNA, human ; MicroRNAs ; Hepatocyte Growth Factor (67256-21-7)
Language	English
Publishing date	2022-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01861-3
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Article: Tissue distribution of Lycium barbarum polysaccharides in rat tissue by fluorescein isothiocyanate labeling

Yang, Chao / Xia, Hui / Tang, Huali / Yang, Ligang / Sun, Guiju

Food science and human wellness. 2022 July, v. 11, no. 4

2022

Abstract: To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides (LBPs) based ... ...

Abstract	To date, in vivo investigations of polysaccharide’s pharmacokinetics are significantly restricted by the difficulty in their detection. This study was conducted to establish the quantitative determination of Lycium barbarum polysaccharides (LBPs) based on fluorescein isothiocyanate (FITC) pre-labeling and to investigate their tissue distribution in rat. We obtained the calibration curves linear over the range of 0–25µg/mL in rat tissue samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions (RSD, %) were within 15%, and the relative recovery ranged 95.2%–102.4%, with RSD range 1.48%–9.58%, indicating that this experiment was suitable for the determination of LBPs. The fluorescence intensity was measured after 24h storage at room temperature, 3 times of freeze-cycle and cryopreservation at –20 °C for 15 day, these results indicated that the stability of the samples was good. LBP-FITC was mainly absorbed by the small intestine and stomach, and mainly excreted in the urine through the kidney; this distinct difference in the tissue distribution of LBPs could be attributed to the size of these LBPs in relation to the pore sizes of the vascular beds in the kidney and liver. Results showed in this study enable us to comprehensively understand the biological effects of LBPs following its oral ingestion.
Keywords	Lycium barbarum ; ambient temperature ; cryopreservation ; fluorescein ; fluorescence ; food science ; humans ; isothiocyanates ; kidneys ; liver ; pharmacokinetics ; polysaccharides ; quantitative analysis ; rats ; small intestine ; stomach ; tissue distribution ; urine
Language	English
Dates of publication	2022-07
Size	p. 837-844.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2712869-6
ISSN	2213-4530
ISSN	2213-4530
DOI	10.1016/j.fshw.2022.03.004
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Article ; Online: Purification, structural identification, antioxidant activity, and inhibitory effects on digestive enzymes of α-glucan from Chuanminshen violaceum

Gao, Tao / Liu, Shuang / Luo, Huang-yang / Wu, Ren / Yan, Rui / He, Ling-zhi / Nie, Qing-yu / Tang, Hua-li / Sun, Guiju

Journal of Functional Foods. 2023 May, v. 104 p.105536-

2023

Abstract: Chuanminshen violaceum, as a food and folk medicine, is cultivated and grown only in China. Its polysaccharides play an important role in medicinal benefits. Herein, crude C. violaceum polysaccharides (CVPs) were purified to yield two polysaccharide ... ...

Abstract	Chuanminshen violaceum, as a food and folk medicine, is cultivated and grown only in China. Its polysaccharides play an important role in medicinal benefits. Herein, crude C. violaceum polysaccharides (CVPs) were purified to yield two polysaccharide fractions (CVPs-1-G and CVPs-2-G) using DEAE Cellulose-52 and Sephadex G-100 column chromatography. Structural analyses indicated that both CVPs-1-G and CVPs-2-G were glucans with average molecular weights of 8.1 kDa and 187.5 kDa, respectively. The main chain of the major component (CVPs-1-G) might be composed of (1 → 4)-linked α-Glcp, and the branched-chain might be an α-Glcp → 4)-α-D-Glcp-(1 → 6)-α-D-Glcp-(1 → 4)-α-D-Glcp, which connected to the main chain through the O-6 position of → 3,6)-α-D-Glcp-(1 →. In addition, CVPs-1-G displayed ABTS, DPPH, and hydroxyl radical scavenging activity, as well as competitive inhibitory activities of α-amylase and non-competitive inhibitory activities of lipase and pepsin. According to molecular docking, its inhibitory activity on digestive enzyme might be caused by hydrogen bond and hydrophobic interaction between them. Thus, CVPs exhibit strong potential for use in functional foods and pharmaceuticals.
Keywords	alpha-amylase ; antioxidant activity ; carboxylic ester hydrolases ; chromatography ; drugs ; glucans ; hydrogen bonding ; hydrophobic bonding ; hydroxyl radicals ; pepsin ; traditional medicine ; China ; Chuanminshen violaceum ; α-glucan ; Structural identification ; Digestive enzyme activity ; Kinetics of digestive enzyme
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105536
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of combined administration of calcium, iron, zinc, chrysanthemum flavonoids, and DMSA on the treatment of lead intoxication in mice.

Huali, Tang / Honglei, Peng / Feng, Wang / Shaokang, Wang / Ligang, Yang / Jianghong, Liu / Guiju, Sun

Journal of biochemical and molecular toxicology

2019 Volume 34, Issue 2, Page(s) e22425

Abstract: The effect of combined administration of calcium (Ca), iron (Fe), zinc (Zn), chrysanthemum flavonoids, and meso-2,3-dimercaptosuccinic acid (DMSA) on the treatment of lead (Pb) intoxication in mice was studied. One hundred ninety female mice (SPF level, ... ...

Abstract	The effect of combined administration of calcium (Ca), iron (Fe), zinc (Zn), chrysanthemum flavonoids, and meso-2,3-dimercaptosuccinic acid (DMSA) on the treatment of lead (Pb) intoxication in mice was studied. One hundred ninety female mice (SPF level, aged 18-22 days) were randomly divided into two groups as experimental animals. Mice in group I (10 mice) served as normal control animals, and were administered deionized water containing 12.5 μL/L acetate acid for 6 weeks, whereas mice in group II (180 mice) were exposed to 0.1% (wt/vol) of lead acetate in deionized water for 6 weeks and served as experimental animals. After 6 weeks of successful modeling, 180 mice from group II (lead-exposed) were divided into 18 groups of 10 mice each, 16 of which were treated by the combined administration of Ca, Fe, Zn, chrysanthemum flavonoids, and DMSA by L
MeSH term(s)	Animals ; Calcium/administration & dosage ; Calcium/pharmacology ; Chrysanthemum/chemistry ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Flavonoids/administration & dosage ; Flavonoids/pharmacology ; Glutathione/blood ; Glutathione Peroxidase/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Iron/administration & dosage ; Iron/pharmacology ; Lead/adverse effects ; Lead/blood ; Lead Poisoning/drug therapy ; Liver/drug effects ; Liver/metabolism ; Malondialdehyde/metabolism ; Mice ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Oxidative Stress/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Porphobilinogen Synthase/blood ; Succimer/administration & dosage ; Succimer/pharmacology ; Superoxide Dismutase/blood ; Treatment Outcome ; Zinc/administration & dosage ; Zinc/pharmacology
Chemical Substances	Flavonoids ; Plant Extracts ; Lead (2P299V784P) ; Nitric Oxide (31C4KY9ESH) ; Malondialdehyde (4Y8F71G49Q) ; Succimer (DX1U2629QE) ; Iron (E1UOL152H7) ; Glutathione Peroxidase (EC 1.11.1.9) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Superoxide Dismutase (EC 1.15.1.1) ; Porphobilinogen Synthase (EC 4.2.1.24) ; Glutathione (GAN16C9B8O) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.22425
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Article: Clinical outcomes and influencing factors of PD-1/PD-L1 in hepatocellular carcinoma.

Wang, Jiting / Li, Jun / Tang, Guiju / Tian, Yuan / Su, Song / Li, Yaling

Oncology letters

2021 Volume 21, Issue 4, Page(s) 279

Abstract: Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and the global 5-year survival rate ranges from 5-30%. In China, HCC seriously threatens the nation's health; the incidence of HCC ranks fourth among all theriomas, and the mortality ... ...

Abstract	Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and the global 5-year survival rate ranges from 5-30%. In China, HCC seriously threatens the nation's health; the incidence of HCC ranks fourth among all theriomas, and the mortality rate is the third highest worldwide. The main therapies for HCC are surgical treatment or liver transplantation; however, most patients with HCC will experience postoperative recurrence or metastasis, eventually resulting in mortality. As for advanced or unresectable HCC, the current appropriate treatment strategy is transarterial chemoembolization; however, limited therapeutic effect and natural or acquired drug resistance affect the efficacy of this approach. Previous studies have demonstrated that PD-L1 expression on host cells and myeloid cells plays an important role in PD-L1 blocked-mediated tumor regression. Thus, further research on programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) is required. Countries including the United States, France, Britain and China have developed PD-1/PD-L1 blockers, including nivolumab, pembrolizumab, cemiplimab, atezolizumab, avelumab, durvalumab, toripalimab, sintilimab and camrelizumab. Notably, all of these blockers have therapeutic effect and influencing factors in HCC. Factors that influence the clinical outcome of PD-1 have also been discovered, such as inflammatory genes, specific receptors and signaling pathways. The discovery of these factors will help to identify novel methods, such as combination treatment, to decrease the influence of other factors on the efficacy of PD-1/PD-L1. Sorafenib and lenvatinib have been approved for first-line treatment for patients with advanced HCC. When first-line treatment frequently fails, pembrolizumab and ipilimumab plus nivolumab are used following sorafenib (but not lenvatinib) treatment in advanced HCC. Thus, tumor immunotherapy using PD-1/PD-L1 blockers exhibits promising outcomes for the treatment of HCC, and more novel PD-1/PD-L1 inhibitors are being developed to fight against this disease. The present review discusses the clinical results and influencing factors of PD-1/PD-L1 inhibitors in HCC to provide insight into the development and optimization of PD-1/PD-L1 inhibitors in the treatment of HCC.
Language	English
Publishing date	2021-02-10
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2021.12540
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Article ; Online: Reversal effect of Jagged1 signaling inhibition on CCl4-induced hepatic fibrosis in rats.

Tang, Guiju / Weng, Zhihong / Song, Jun / Chen, Yixiong

Oncotarget

2017 Volume 8, Issue 37, Page(s) 60778–60788

Abstract: The role of the Notch ligand Jagged1 in hepatic fibrosis remains to be elucidated. In the current study, we investigated the role of Jagged1 in the activation of hepatic stellate cells (HSCs) and development of hepatic fibrosis in rats. ...

Abstract	The role of the Notch ligand Jagged1 in hepatic fibrosis remains to be elucidated. In the current study, we investigated the role of Jagged1 in the activation of hepatic stellate cells (HSCs) and development of hepatic fibrosis in rats.
Language	English
Publishing date	2017-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.18484
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Article: Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling

Xia, Hui / Yang, Chao / Zhou, Beijia / Tang, Huali / Yang, Ligang / Liao, Wang / Sun, Guiju

Foods. 2021 Nov. 18, v. 10, no. 11

2021

Abstract	A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis of L. barbarum polysaccharides (LBP). The calibration curves linear over the range of 0.2–20 µg/mL in rat plasma, and 0.25–500 μg/mL in urine and feces samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions (RSD, %) of the method were under 15% with the relative recovery ranging from 84.6% to 104.0% and the RSD ranging from 0.47% to 7.28%. The concentration–time curve of LBP-FITC in plasma following intragastric administration at 100, 50 and 25 mg/kg well fitted to a nonlinear model. LBP-FITC slowly eliminated from plasma according to the long half-lives (t₁/₂ = 31.39, 38.09, and 45.76 h, respectively) and mean retention times (MRT₀–ₜ = 18.38, 19.15 and 20.07 h, respectively; AUC₀–∞ = 230.49, 236.18 and 242.57 h, respectively) after administration of LBP-FITC at doses of 100, 50, and 25 mg/kg, respectively. After intragastric administration at 50 mg/kg for 72 h, the concentration of LBP-FITC in urine and feces was 0.09 ± 0.04% and 92.18 ± 3.61% respectively; the excretion rate of urine was the highest in 0–4 h period and decreased continuously in 4–24 h period. The excretion rate of feces was the highest in 4–10 h, 48.28 ± 9.349% in feces within 4–10 h, and decreased rapidly in 10–24 h. The present study showed that LBP was absorbed as its prototype and most proportion of LBP was excreted from feces, indicating a long time remaining in intestine.
Keywords	Lycium barbarum ; excretion ; feces ; fluorescein ; fluorescence ; gel chromatography ; half life ; intestines ; intragastric administration ; isothiocyanates ; nonlinear models ; pharmacokinetics ; polysaccharides ; prototypes ; rats ; urine
Language	English
Dates of publication	2021-1118
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10112851
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China.

Xue, Kathy S / Tang, Lili / Sun, Guiju / Wang, Shaokang / Hu, Xu / Wang, Jia-Sheng

BMC cancer

2019 Volume 19, Issue 1, Page(s) 1218

Abstract: Background: Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ... ...

Abstract	Background: Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ESCC are largely unknown. Methods: A mycotoxin biomarker-incorporated, population-based case-control study was performed in Huaian area, Jiangsu Province, one of the two high-risk areas in China. Exposure biomarkers of aflatoxins (AF) and fumonisins (FN) were quantitatively analyzed using HPLC-fluorescence techniques. Results: Among the cases (n = 190), the median levels of AF biomarker, serum AFB Conclusions: Mycotoxin exposure, especially to AFB
MeSH term(s)	Aflatoxins/blood ; Aflatoxins/toxicity ; Aged ; Biomarkers/blood ; Biomarkers/urine ; China ; Chromatography, High Pressure Liquid ; Dietary Exposure ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/epidemiology ; Esophageal Squamous Cell Carcinoma/chemically induced ; Esophageal Squamous Cell Carcinoma/epidemiology ; Female ; Food Contamination ; Fumonisins/toxicity ; Fumonisins/urine ; Humans ; Male ; Middle Aged ; Risk Factors
Chemical Substances	Aflatoxins ; Biomarkers ; Fumonisins
Language	English
Publishing date	2019-12-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-019-6439-x
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