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Book ; Online: Advances in Underground Energy Storage for Renewable Energy Sources

Loredo, Jorge / Menéndez, Javier / Menéndez, Javier

2021

Keywords	Research & information: general ; Technology: general issues ; energy storage ; underground pumped storage ; economic feasibility ; ancillary services ; day-ahead market ; underground space ; mining structures ; underground reservoir ; empirical analysis ; numerical modelling ; hydropower plants ; hydrogen ; underground storage ; leakage ; monitoring ; protocol ; helium ; aquifer ; renewable energy ; hydropower ; mine ; groundwater ; environmental impacts ; efficiency ; wind energy ; photovoltaics ; wind curtailment ; mesoscale atmospheric model ; hydro-pumped storage ; abandoned mines ; underground reservoirs ; CAES ; analytical modelling ; sealing layer ; environmental impact ; hydrogen storage ; sealing liners ; Liner Rock Caverns ; epoxy resin ; hydrogen permeability ; exergy ; salt caverns ; pumped storage hydropower ; energy storage system ; quarry ; open pit ; hydrochemistry ; n/a
Size	1 electronic resource (183 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021290248
ISBN	9783036518794 ; 3036518797
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19.

Menendez, Javier A

Aging

2020 Volume 12, Issue 10, Page(s) 8760–8765

Abstract: Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease caused by infection with the novel coronavirus SARS-CoV-2. Metformin is capable of suppressing one ...

Abstract	Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease caused by infection with the novel coronavirus SARS-CoV-2. Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca
MeSH term(s)	Aged ; Betacoronavirus/physiology ; COVID-19 ; Calcium Release Activated Calcium Channels/metabolism ; Coronavirus Infections/blood ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Drug Repositioning/methods ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism ; Interleukin-6/immunology ; Metformin/pharmacokinetics ; Metformin/therapeutic use ; Pandemics ; Particulate Matter/immunology ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Reactive Oxygen Species/immunology ; SARS-CoV-2 ; Signal Transduction/drug effects ; Thrombosis/drug therapy ; Thrombosis/metabolism
Chemical Substances	Calcium Release Activated Calcium Channels ; Hypoglycemic Agents ; Interleukin-6 ; Particulate Matter ; Reactive Oxygen Species ; Metformin (9100L32L2N)
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.103347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metformin: Sentinel of the Epigenetic Landscapes That Underlie Cell Fate and Identity.

Menendez, Javier A

Biomolecules

2020 Volume 10, Issue 5

Abstract: The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin). The current consensus is that metformin exerts indirect pleiotropy on core metabolic hallmarks of aging, such as the ... ...

Abstract	The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin). The current consensus is that metformin exerts indirect pleiotropy on core metabolic hallmarks of aging, such as the insulin/insulin-like growth factor 1 and AMP-activated protein kinase/mammalian Target Of Rapamycin signaling pathways, downstream of its primary inhibitory effect on mitochondrial respiratory complex I. Alternatively, but not mutually exclusive, metformin can exert regulatory effects on components of the biologic machinery of aging itself such as chromatin-modifying enzymes. An integrative metabolo-epigenetic outlook supports a new model whereby metformin operates as a guardian of cell identity, capable of retarding cellular aging by preventing the loss of the information-theoretic nature of the epigenome. The ultimate anti-aging mechanism of metformin might involve the global preservation of the epigenome architecture, thereby ensuring cell fate commitment and phenotypic outcomes despite the challenging effects of aging noise. Metformin might therefore inspire the development of new gerotherapeutics capable of preserving the epigenome architecture for cell identity. Such gerotherapeutics should replicate the ability of metformin to halt the erosion of the epigenetic landscape, mitigate the loss of cell fate commitment, delay stochastic/environmental DNA methylation drifts, and alleviate cellular senescence. Yet, it remains a challenge to confirm if regulatory changes in higher-order genomic organizers can connect the capacity of metformin to dynamically regulate the three-dimensional nature of epigenetic landscapes with the 4
MeSH term(s)	Animals ; Cell Differentiation ; Cellular Senescence ; Epigenesis, Genetic/drug effects ; Humans ; Hypoglycemic Agents/pharmacology ; Metformin/pharmacology
Chemical Substances	Hypoglycemic Agents ; Metformin (9100L32L2N)
Keywords	covid19
Language	English
Publishing date	2020-05-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10050780
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fatty acid synthase: a druggable driver of breast cancer brain metastasis.

Menendez, Javier A / Lupu, Ruth

Expert opinion on therapeutic targets

2022 Volume 26, Issue 5, Page(s) 427–444

Abstract: Introduction: Brain metastasis (BrM) is a key contributor to morbidity and mortality in breast cancer patients, especially among high-risk epidermal growth factor receptor 2-positive (HER2+) and triple-negative/basal-like molecular subtypes. Optimal ... ...

Abstract	Introduction: Brain metastasis (BrM) is a key contributor to morbidity and mortality in breast cancer patients, especially among high-risk epidermal growth factor receptor 2-positive (HER2+) and triple-negative/basal-like molecular subtypes. Optimal management of BrM is focused on characterizing a 'BrM dependency map' to prioritize targetable therapeutic vulnerabilities. Areas covered: We review recent studies addressing the targeting of BrM in the lipid-deprived brain environment, which selects for brain-tropic breast cancer cells capable of cell-autonomously generating fatty acids by upregulating Expert opinion: Targeting FASN represents a new therapeutic opportunity for patients with breast cancer and BrM. Delivery of brain-permeable FASN inhibitors and identifying strategies to target metabolic plasticity that might compensate for impaired brain FASN activity are two potential roadblocks that may hinder FASN-centered strategies against BrM.
MeSH term(s)	Brain Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Fatty Acid Synthases/metabolism ; Female ; Humans ; Lipogenesis ; Tumor Microenvironment
Chemical Substances	Fatty Acid Synthases (EC 2.3.1.85)
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2022.2077189
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Article ; Online: Oral roflumilast as a therapeutic option for psoriasis, what role does it have? Case report and literature review.

Gimeno Castillo, Javier / De la Torre Gomar, Francisco Javier / Menéndez Parrón, Aida / Martínez de Lagrán Álvarez de Arcaya, Zuriñe

The Journal of dermatological treatment

2023 Volume 34, Issue 1, Page(s) 2240456

MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Phosphodiesterase 4 Inhibitors/therapeutic use ; Aminopyridines/therapeutic use ; Psoriasis/drug therapy ; Administration, Oral
Chemical Substances	Roflumilast (0P6C6ZOP5U) ; Phosphodiesterase 4 Inhibitors ; Aminopyridines
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Review ; Case Reports
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2023.2240456
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Article ; Online: Análisis del dengue autóctono en un hospital de enfermedades infecciosas en la ciudad de Buenos Aires, Argentina.

Sánchez Doncell, Javier / Sotelo, Carina A / Menéndez, Sandra E / Braga, Ignacio / Giamperetti, Sergio / Francos, José L

Medicina

2024 Volume 84, Issue 1, Page(s) 81–86

Abstract: Introduction: Dengue is a disease transmitted by mosquitoes of the Aedes genus; this has presented a historical increase in cases in South America, which represents a public health problem. From the Febrile Emergency Unit (UFU) of Hospital Muñiz, the ... ...

Title translation	Analysis of indigenous dengue in an infectious diseases Hospital in Buenos Aires, Argentina.
Abstract	Introduction: Dengue is a disease transmitted by mosquitoes of the Aedes genus; this has presented a historical increase in cases in South America, which represents a public health problem. From the Febrile Emergency Unit (UFU) of Hospital Muñiz, the laboratory results were analyzed and the circulating serotype was identified at the level of the Autonomous City of Buenos Aires (CABA), confirming the proportion of indigenous cases, recording symptoms and epidemiology. The objective of this analysis is to highlight the increase in indigenous cases of dengue in CABA. Methods: An observational and retrospective study was carried out, from January 1 to May 8, 2023, of the positive PCR results for dengue. Results: 1159 patients with febrile symptoms were assisted, of which 554 (47.7%) were probable cases while the remaining 542 (46.7%) were febrile syndromes of another etiology. Of the probable cases, 162 with positive PCR results (29%) were evaluated, of which 18 (11%) were imported and 144 (89%) native. DENV-2 predominated (86% of confirmed cases). The clinical manifestations were fever (100%), myalgia (100%), headache (98%), arthralgia (87%), nausea (46%), and retroocular pain (39%). Discussion: For 10 years, there has been an increase in the number of indigenous dengue cases in CABA. In the analysis of this article, autochthonous dengue appears as an outbreak at the city level. Notification of the clinic and epidemiology is important to consider public health strategies in the fight against dengue and possible new studies related to outbreaks and epidemics.
MeSH term(s)	Animals ; Humans ; Dengue/diagnosis ; Dengue/epidemiology ; Argentina/epidemiology ; Retrospective Studies ; Communicable Diseases/epidemiology ; Disease Outbreaks
Language	Spanish
Publishing date	2024-01-15
Publishing country	Argentina
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article: Clinical Outcomes and Tendon Healing After Arthroscopic Isolated Subscapularis Tendon Repair: Results at Midterm Follow-up.

Kilic, Ali Ihsan / Zuk, Nicholas A / Ardebol, Javier / Pak, Theresa / Menendez, Mariano E / Denard, Patrick J

Orthopaedic journal of sports medicine

2024 Volume 12, Issue 2, Page(s) 23259671241229429

Abstract: Background: Few studies have reported clinical outcomes and tendon healing rates after arthroscopic isolated subscapularis (SSC) repair (AISR).: Purpose/hypothesis: The primary purpose of this study was to evaluate clinical outcomes and tendon ... ...

Abstract	Background: Few studies have reported clinical outcomes and tendon healing rates after arthroscopic isolated subscapularis (SSC) repair (AISR). Purpose/hypothesis: The primary purpose of this study was to evaluate clinical outcomes and tendon healing after AISR. It was hypothesized that AISR would result in satisfactory clinical outcomes along with a high rate of tendon healing at the midterm follow-up. The secondary purpose was to assess the influence of tear size and muscle atrophy on SSC tendon healing and patient-reported outcomes. It was hypothesized that both would be negatively correlated with healing but would have no effect on clinical outcomes . Study design: Case series; Level of evidence, 4. Methods: A retrospective analysis was conducted on prospectively collected data for 77 patients who underwent primary AISR between 2011 and 2021 at a single institution, with a minimum 2-year postoperative follow-up for all patients. Functional outcomes were assessed using the American Shoulder and Elbow Surgeons (ASES) score, the Subjective Shoulder Value (SSV), and the visual analog scale for pain. Repair techniques and concomitant procedures were also collected. SSC tendon healing was evaluated via ultrasound at the final follow-up. Linear regression analysis was performed to determine factors affecting SSC healing. Results: The mean follow-up was 58.1 ± 3.3 months. ASES scores significantly improved from 41.5 to 81.6, and the SSV improved from 38.2 to 80.5 ( Conclusion: Improved clinical outcomes and an overall high rate of tendon healing were seen at the midterm follow-up after AISR. Smaller tear sizes with less muscle atrophy were correlated with improved tendon healing. However, even when the tendon incompletely healed, the procedure improved functional outcomes.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671241229429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A garment that measures brain activity: proof of concept of an EEG sensor layer fully implemented with smart textiles.

López-Larraz, Eduardo / Escolano, Carlos / Robledo-Menéndez, Almudena / Morlas, Leyre / Alda, Alexandra / Minguez, Javier

Frontiers in human neuroscience

2023 Volume 17, Page(s) 1135153

Abstract: This paper presents the first garment capable of measuring brain activity with accuracy comparable to that of state-of-the art dry electroencephalogram (EEG) systems. The main innovation is an EEG sensor layer (i.e., the electrodes, the signal ... ...

Abstract	This paper presents the first garment capable of measuring brain activity with accuracy comparable to that of state-of-the art dry electroencephalogram (EEG) systems. The main innovation is an EEG sensor layer (i.e., the electrodes, the signal transmission, and the cap support) made entirely of threads, fabrics, and smart textiles, eliminating the need for metal or plastic materials. The garment is connected to a mobile EEG amplifier to complete the measurement system. As a first proof of concept, the new EEG system (Garment-EEG) was characterized with respect to a state-of-the-art Ag/AgCl dry-EEG system (Dry-EEG) over the forehead area of healthy participants in terms of: (1) skin-electrode impedance; (2) EEG activity; (3) artifacts; and (4) user ergonomics and comfort. The results show that the Garment-EEG system provides comparable recordings to Dry-EEG, but it is more susceptible to artifacts under adverse recording conditions due to poorer contact impedances. The textile-based sensor layer offers superior ergonomics and comfort compared to its metal-based counterpart. We provide the datasets recorded with Garment-EEG and Dry-EEG systems, making available the first open-access dataset of an EEG sensor layer built exclusively with textile materials. Achieving user acceptance is an obstacle in the field of neurotechnology. The introduction of EEG systems encapsulated in wearables has the potential to democratize neurotechnology and non-invasive brain-computer interfaces, as they are naturally accepted by people in their daily lives. Furthermore, supporting the EEG implementation in the textile industry may result in lower cost and less-polluting manufacturing processes compared to metal and plastic industries.
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2023.1135153
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Article ; Online: Reliability of magnetic resonance for temporomandibular joint disc perforation: A 12 years retrospective study.

Millón Cruz, Alejandrina / Martin-Granizo, Rafael / Barone, Simona / Pérez Rodríguez, Luis Miguel / Menéndez, Salomé Merino / Falahat Noushzady, Farzin / Arias Díaz, Javier

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2024

Abstract: The aim of this study was to evaluate the reliability of magnetic resonance imaging (MRI) in detecting disc perforations in the temporomandibular joint (TMJ), and to establish diagnostic criteria for this purpose. The retrospective analysis included ... ...

Abstract	The aim of this study was to evaluate the reliability of magnetic resonance imaging (MRI) in detecting disc perforations in the temporomandibular joint (TMJ), and to establish diagnostic criteria for this purpose. The retrospective analysis included patients who had undergone preoperative MRI and TMJ arthroscopy at the same hospital. Direct and indirect signs of disc abnormalities on MRI were compared with arthroscopic findings of disc perforation. Out of 355 joints evaluated in 185 patients, arthroscopy confirmed disc perforations in 14.7% of cases. Several MRI findings were significantly associated with disc perforation, including anterior disc displacement without reduction (ADDwoR), signal alterations in the mid-disc area, disc deformity (SAMD), retrocondylar disc fragments, osteophytes, condylar bone marrow degeneration (CBMD), and joint effusion in both joint spaces (ESJS-EIJS). Regression analysis revealed that SAMD, osteophytes, and CBDM were strongly associated with disc perforation. The ROC curve showed that MRI had an AUC = 0.791, with a sensitivity of 88.5% and a specificity of 61.5%. Two diagnostic methods, one based on three findings (osteophytes, ADDwoR, and SAMD) and one based on two direct signs (ADDwoR and SAMD), yielded high sensitivity and specificity values of 80.4% and 69.8%, and 84.3% and 62.5%, respectively. In conclusion, MRI demonstrated acceptable accuracy in the detection of TMJ disc perforations, with specific diagnostic criteria offering high sensitivity and specificity. Significant MRI indicators of disc perforation included SAMD, osteophytes, and CBDM. This study provides valuable information on the use of MRI as a diagnostic tool for TMJ disc perforations.
Language	English
Publishing date	2024-04-10
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2024.04.005
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Article ; Online: BOOK REVIEW

Javier Menéndez-Blázquez

Polar Research, Vol 42, Pp 1-

2023 Volume 2

Keywords	Environmental sciences ; GE1-350 ; Oceanography ; GC1-1581
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Norwegian Polar Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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