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  1. Article ; Online: Methamphetamine psychosis: epidemiology and management.

    Glasner-Edwards, Suzette / Mooney, Larissa J

    CNS drugs

    2014  Volume 28, Issue 12, Page(s) 1115–1126

    Abstract: Psychotic symptoms and syndromes are frequently experienced among individuals who use methamphetamine, with recent estimates of up to approximately 40 % of users affected. Although transient in a large proportion of users, acute symptoms can include ... ...

    Abstract Psychotic symptoms and syndromes are frequently experienced among individuals who use methamphetamine, with recent estimates of up to approximately 40 % of users affected. Although transient in a large proportion of users, acute symptoms can include agitation, violence, and delusions, and may require management in an inpatient psychiatric or other crisis intervention setting. In a subset of individuals, psychosis can recur and persist and may be difficult to distinguish from a primary psychotic disorder such as schizophrenia. Differential diagnosis of primary vs. substance-induced psychotic disorders among methamphetamine users is challenging; nevertheless, with careful assessment of the temporal relationship of symptoms to methamphetamine use, aided by state-of-the art psychodiagnostic assessment instruments and use of objective indicators of recent substance use (i.e., urine toxicology assays), coupled with collateral clinical data gathered from the family or others close to the individual, diagnostic accuracy can be optimized and the individual can be appropriately matched to a plan of treatment. The pharmacological treatment of acute methamphetamine-induced psychosis may include the use of antipsychotic medications as well as benzodiazepines, although symptoms may resolve without pharmacological treatment if the user is able to achieve a period of abstinence from methamphetamine. Importantly, psychosocial treatment for methamphetamine dependence has a strong evidence base and is the optimal first-line treatment approach to reducing rates of psychosis among individuals who use methamphetamines. Prevention of methamphetamine relapse is the most direct means of preventing recurrence of psychotic symptoms and syndromes. Long-term management of individuals presenting with recurrent and persistent psychosis, even in the absence of methamphetamine use, may include both behavioral treatment to prevent resumption of methamphetamine use and pharmacological treatment targeting psychotic symptoms. In addition, treatment of co-occurring psychiatric disorders including depression and anxiety is important as a means of preventing relapse to methamphetamine use, which is often triggered by associated symptoms.
    MeSH term(s) Central Nervous System Stimulants/adverse effects ; Humans ; Methamphetamine/adverse effects ; Psychoses, Substance-Induced/diagnosis ; Psychoses, Substance-Induced/epidemiology ; Psychoses, Substance-Induced/physiopathology ; Psychoses, Substance-Induced/therapy
    Chemical Substances Central Nervous System Stimulants ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2014-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-014-0209-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evidence-based practices in addiction treatment: review and recommendations for public policy.

    Glasner-Edwards, Suzette / Rawson, Richard

    Health policy (Amsterdam, Netherlands)

    2010  Volume 97, Issue 2-3, Page(s) 93–104

    Abstract: The movement in recent years towards evidence-based practice (EBP) in health care systems and policy has permeated the substance abuse treatment system, leading to a growing number of federal and statewide initiatives to mandate EBP implementation. ... ...

    Abstract The movement in recent years towards evidence-based practice (EBP) in health care systems and policy has permeated the substance abuse treatment system, leading to a growing number of federal and statewide initiatives to mandate EBP implementation. Nevertheless, due to a lack of consensus in the addiction field regarding procedures or criteria to identify EBPs, the optimal processes for disseminating empirically based interventions into real-world clinical settings have not been identified. Although working lists of interventions considered to be evidence-based have been developed by a number of constituencies advocating EBP dissemination in addiction treatment settings, the use of EBP lists to form policy-driven mandates has been controversial. This article examines the concept of EBP, critically reviews criteria used to evaluate the evidence basis of interventions, and highlights the manner in which such criteria have been applied in the addictions field. Controversies regarding EBP implementation policies and practices in addiction treatment are described, and suggestions are made to shift the focus of dissemination efforts from manualized psychosocial interventions to specific skill sets that are broadly applicable and easily learned by clinicians. Organizational and workforce barriers to EBP implementation are delineated, with corresponding recommendations to facilitate successful dissemination of evidence-based skills.
    MeSH term(s) Diffusion of Innovation ; Evidence-Based Practice ; Health Policy ; Humans ; Information Dissemination ; Practice Guidelines as Topic ; Substance-Related Disorders/rehabilitation ; United States
    Language English
    Publishing date 2010-06-16
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605805-x
    ISSN 1872-6054 ; 0168-8510
    ISSN (online) 1872-6054
    ISSN 0168-8510
    DOI 10.1016/j.healthpol.2010.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Association of Alcohol Severity and Sleep Quality in Problem Drinkers.

    Hartwell, Emily E / Bujarski, Spencer / Glasner-Edwards, Suzette / Ray, Lara A

    Alcohol and alcoholism (Oxford, Oxfordshire)

    2015  Volume 50, Issue 5, Page(s) 536–541

    Abstract: Aims: The association between alcohol use and sleep problems is well established and clinically meaningful, particularly as predictors of relapse. This study aims to elucidate the relationship between sleep disturbances and alcohol problems in a non- ... ...

    Abstract Aims: The association between alcohol use and sleep problems is well established and clinically meaningful, particularly as predictors of relapse. This study aims to elucidate the relationship between sleep disturbances and alcohol problems in a non-treatment-seeking community sample using an alcoholism problem severity factor.
    Methods: Participants were problem drinkers (N = 295) from the Los Angeles community who had a breath alcohol content (BrAC) of 0.00 g/dl when they completed an in-person assessment battery comprised of measures of sleep quality, anxiety and depression, cigarette smoking, as well as multiple assessments of alcohol use and alcohol use problems.
    Results: A series of hierarchical regressions showed that alcohol problem severity explained a significant amount of variance in sleep disturbance beyond demographic, mood and smoking variables. Alcohol problem severity was predictive of the PSQI global score (B = 1.11, P < 0.001), perceived sleep quality factor (B = 0.18, P < 0.001) and daily disturbance factor (B = 0.28, P < 0.001). However, contrary to study hypothesis, alcohol problem severity was predictive of improved sleep efficiency (B = -0.14, P < 0.05).
    Conclusions: In sum, alcohol problem severity may be predictive of sleep disturbances. Given the complex nature of these relationships, further work is needed to develop adequate treatment for sleep disturbance during alcohol recovery. Nonetheless, this study suggests that as alcohol problem severity increases so do sleep problems. Thus, attending to sleep problems at early stages of alcohol problems may be warranted.
    MeSH term(s) Adult ; Alcohol Drinking/epidemiology ; Alcohol Drinking/trends ; Alcoholism/diagnosis ; Alcoholism/epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Male ; Severity of Illness Index ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Young Adult
    Language English
    Publishing date 2015-05-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604956-4
    ISSN 1464-3502 ; 0309-1635 ; 0735-0414
    ISSN (online) 1464-3502
    ISSN 0309-1635 ; 0735-0414
    DOI 10.1093/alcalc/agv046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sex Differences in the Association Between Internalizing Symptoms and Craving in Methamphetamine Users.

    Hartwell, Emily E / Moallem, Nathasha R / Courtney, Kelly E / Glasner-Edwards, Suzette / Ray, Lara A

    Journal of addiction medicine

    2016  Volume 10, Issue 6, Page(s) 395–401

    Abstract: Objectives: Methamphetamine (MA) users often have substantial psychiatric comorbidities, with nearly a third reporting lifetime mood disorders and over a quarter reporting lifetime anxiety disorders. Female MA users are more likely to endorse depression ...

    Abstract Objectives: Methamphetamine (MA) users often have substantial psychiatric comorbidities, with nearly a third reporting lifetime mood disorders and over a quarter reporting lifetime anxiety disorders. Female MA users are more likely to endorse depression and anxiety symptoms compared with men. Craving has been related to mood/anxiety symptoms in MA users. To extend the literature on sex differences in MA use disorder, the present study examines the role of sex as a moderator of the relationship between mood/anxiety symptoms and MA craving.
    Methods: Participants (N = 203) were nontreatment-seeking, current MA users, recruited from the Los Angeles community for enrollment in a larger pharmacotherapy trial. At the assessment visit, participants completed multiple measures including the Methamphetamine Urge Questionnaire, the Beck Depression Inventory, and the Beck Anxiety Inventory.
    Results: The relationship between depression symptomatology and MA craving was moderated by sex (F = 6.18, P = 0.01), such that the relationship was positive and significant for men (P < 0.001), but was not significant for women. Similarly, sex significantly moderated the relationship between anxiety and MA craving (F = 5.99, P = 0.02), such that the relationship was also positive and significant in men, but not in women (P < 0.001).
    Conclusions: These results suggest that men may be more sensitive to the effects of internalizing symptoms on MA craving than women. Given craving's propensity to predict relapse, these initial findings indicate the necessity of treating comorbid psychiatric problems in male MA users, which may in turn assist in the attenuation of craving.
    MeSH term(s) Adult ; Amphetamine-Related Disorders/epidemiology ; Central Nervous System Stimulants/adverse effects ; Comorbidity ; Craving ; Depression/epidemiology ; Female ; Humans ; Los Angeles/epidemiology ; Male ; Methamphetamine/adverse effects ; Sex Factors
    Chemical Substances Central Nervous System Stimulants ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2016-07-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000000250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Daily factors driving daily substance use and chronic pain among older adults with HIV: An exploratory study using ecological momentary assessment.

    Kuerbis, Alexis / Reid, M Carrington / Lake, Jordan E / Glasner-Edwards, Suzette / Jenkins, Jessica / Liao, Diana / Candelario, Jury / Moore, Alison A

    Alcohol (Fayetteville, N.Y.)

    2018  Volume 77, Page(s) 31–39

    Abstract: Background: Adults 50 and older make up approximately 50% of persons living with HIV. Multiple co-morbidities are common among this group, including chronic pain and substance abuse, yet little is known about the daily factors that either enhance or ... ...

    Abstract Background: Adults 50 and older make up approximately 50% of persons living with HIV. Multiple co-morbidities are common among this group, including chronic pain and substance abuse, yet little is known about the daily factors that either enhance or inhibit these experiences or behaviors. This study explored daily drivers of substance use, pain, and relief from pain among older adults living with HIV utilizing ecological momentary assessment (EMA).
    Method: Participants (N = 55), ages 49-71, completed seven consecutive days of daily EMA online surveys prior to treatment initiation within a randomized controlled trial. Multilevel modeling tested predictors of pain, substance use, and relief from pain by examining within- and between-person relationships.
    Results: Results revealed an associational, reciprocal relationship between daily worst pain and daily drinking, where greater worst pain ratings predicted heavier drinking and heavier drinking predicted greater daily and overall pain. Greater happiness and poorer quality of sleep predicted greater daily worst pain. Exercising and overall confidence to cope with pain without medication were associated with lower levels of daily worst pain. Finally, spending less time with a loved one over time and reporting any coping behavior were associated with relief from pain.
    Conclusion: Investigation of daily factors that drive pain and substance use behaviors among this unique population help inform which daily factors are most risky to their health and well-being. Alcohol use emerged as the only substance associated with both driving pain and responding to pain. Findings suggest key points for prevention and intervention.
    MeSH term(s) Aged ; Chronic Pain/diagnosis ; Chronic Pain/epidemiology ; Chronic Pain/psychology ; Ecological Momentary Assessment ; Female ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/psychology ; Humans ; Male ; Middle Aged ; Pain Measurement/methods ; Pain Measurement/psychology ; Pilot Projects ; Risk Factors ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology
    Language English
    Publishing date 2018-10-09
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 605912-0
    ISSN 1873-6823 ; 0741-8329
    ISSN (online) 1873-6823
    ISSN 0741-8329
    DOI 10.1016/j.alcohol.2018.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Response: innovations and implementation.

    Gavriel, Mardell / Glasner-Edwards, Suzette / Sackler, Helen

    Addiction science & clinical practice

    2008  Volume 4, Issue 2, Page(s) 47–49

    MeSH term(s) Behavior Therapy/methods ; Combined Modality Therapy ; Comorbidity ; Cooperative Behavior ; Diffusion of Innovation ; Goals ; Mental Disorders/psychology ; Mental Disorders/rehabilitation ; Motivation ; Patient Care Team ; Problem Solving ; Randomized Controlled Trials as Topic ; Secondary Prevention ; Substance Withdrawal Syndrome/psychology ; Substance Withdrawal Syndrome/rehabilitation ; Substance-Related Disorders/psychology ; Substance-Related Disorders/rehabilitation
    Language English
    Publishing date 2008-08-13
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2492632-2
    ISSN 1940-0640 ; 1940-0640
    ISSN (online) 1940-0640
    ISSN 1940-0640
    DOI 10.1151/ascp084247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Cognitive Behavioral Therapy-Based Text Messaging Intervention Versus Medical Management for HIV-Infected Substance Users: Study Protocol for a Pilot Randomized Trial.

    Glasner-Edwards, Suzette / Patrick, Kevin / Ybarra, Michele L / Reback, Cathy J / Rawson, Richard A / Chokron Garneau, Helene / Chavez, Kathryn / Venegas, Alexandra

    JMIR research protocols

    2016  Volume 5, Issue 2, Page(s) e131

    Abstract: Background: Evidence-based psychosocial interventions for addictions and related conditions such as cognitive behavioral therapy (CBT) are underutilized. Obstacles to implementation of CBT in clinical settings include limited availability of quality ... ...

    Abstract Background: Evidence-based psychosocial interventions for addictions and related conditions such as cognitive behavioral therapy (CBT) are underutilized. Obstacles to implementation of CBT in clinical settings include limited availability of quality training, supervision, and certification in CBT for clinicians; high rates of clinician turnover and high caseloads; and limited qualifications of the workforce to facilitate CBT expertise.
    Objective: Mobile phone-based delivery of CBT, if demonstrated to be feasible and effective, could be transformative in broadening its application and improving the quality of addiction treatment. No experimental interventions that deliver CBT targeting both drug use and medication adherence using text messaging have been previously reported; as such, the objective of this study is to develop and test an SMS-based treatment program for HIV-positive adults with comorbid substance use disorders.
    Methods: With user input, we developed a 12-week CBT-based text messaging intervention (TXT-CBT) targeting antiretroviral (ART) adherence, risk behaviors, and drug use in a population of HIV-infected substance users.
    Results: The intervention has been developed and is presently being tested in a pilot randomized clinical trial. Results will be reported later this year.
    Conclusions: This investigation will yield valuable knowledge about the utility of a cost-effective, readily deployable text messaging behavioral intervention for HIV-infected drug users.
    Language English
    Publishing date 2016-06-24
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/resprot.5407
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  8. Article: Mindfulness Based Relapse Prevention for Stimulant Dependent Adults: A Pilot Randomized Clinical Trial.

    Glasner-Edwards, Suzette / Mooney, Larissa J / Ang, Alfonso / Garneau, Hélène Chokron / Hartwell, Emily / Brecht, Mary-Lynn / Rawson, Richard A

    Mindfulness

    2016  Volume 8, Issue 1, Page(s) 126–135

    Abstract: In light of the known associations between stress, negative affect, and relapse, mindfulness strategies hold promise as a means of reducing relapse susceptibility. In a pilot randomized clinical trial, we evaluated the effects of Mindfulness Based ... ...

    Abstract In light of the known associations between stress, negative affect, and relapse, mindfulness strategies hold promise as a means of reducing relapse susceptibility. In a pilot randomized clinical trial, we evaluated the effects of Mindfulness Based Relapse Prevention (MBRP), relative to a health education control condition (HE) among stimulant dependent adults receiving contingency management. All participants received a 12-week contingency management (CM) intervention. Following a 4-week CM-only lead in phase, participants were randomly assigned to concurrently receive MBRP (n=31) or HE (n=32). Stimulant dependent adults age 18 and over. A university based clinical research center. The primary outcomes were stimulant use, measured by urine drug screens weekly during the intervention and at 1-month post-treatment, negative affect, measured by the Beck Depression Inventory and Beck Anxiety Inventory, and psychiatric severity, measured by the Addiction Severity Index. Medium effect sizes favoring MBRP were observed for negative affect and overall psychiatric severity outcomes. Depression severity changed differentially over time as a function of group, with MBRP participants reporting greater reductions through follow-up (p=0.03; Effect Size=0.58). Likewise, the MBRP group evidenced greater declines in psychiatric severity, (p=0.01; Effect Size=0.61 at follow-up). Among those with depressive and anxiety disorders, MBRP was associated with lower odds of stimulant use relative to the control condition (Odds Ratio= 0.78, p=0.03 and OR=0.68, p=0.04). MBRP effectively reduces negative affect and psychiatric impairment, and is particularly effective in reducing stimulant use among stimulant dependent adults with mood and anxiety disorders.
    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2543424-X
    ISSN 1868-8535 ; 1868-8527
    ISSN (online) 1868-8535
    ISSN 1868-8527
    DOI 10.1007/s12671-016-0586-9
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  9. Article ; Online: Does Posttraumatic Stress Disorder (PTSD) Affect Post-Treatment Methamphetamine Use?

    Glasner-Edwards, Suzette / Mooney, Larissa J / Ang, Alfonso / Hillhouse, Maureen / Rawson, Richard

    Journal of dual diagnosis

    2013  Volume 9, Issue 2, Page(s) 123–128

    Abstract: Objective: Although trauma is a well-established risk factor for substance use disorders, little is known about the association between posttraumatic stress disorder (PTSD) and treatment outcomes among methamphetamine users. In the present study, we ... ...

    Abstract Objective: Although trauma is a well-established risk factor for substance use disorders, little is known about the association between posttraumatic stress disorder (PTSD) and treatment outcomes among methamphetamine users. In the present study, we examine the relationship between PTSD and post-treatment methamphetamine use outcomes, hospitalizations, and overall psychiatric impairment.
    Methods: Using data from 526 adults in the largest psychosocial clinical trial of methamphetamine users conducted to date, this study examined: (1) treatment outcomes of methamphetamine users with concomitant PTSD three years after psychosocial treatment for methamphetamine dependence; and (2) PTSD symptom clusters as risk factors for post-treatment relapse to methamphetamine use.
    Results: PTSD was associated with poorer methamphetamine use outcomes; methamphetamine use frequency throughout the 3-year follow-up was significantly greater among individuals with a PTSD diagnosis, and those with PTSD had more than five times the odds of reporting methamphetamine use in the 30 days prior to the follow-up interview,
    Conclusions: Addressing these high risk PTSD symptoms and syndromes in methamphetamine users may be helpful as a means of improving treatment outcomes in this population.
    Language English
    Publishing date 2013-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2179549-6
    ISSN 1550-4271 ; 1550-4263
    ISSN (online) 1550-4271
    ISSN 1550-4263
    DOI 10.1080/15504263.2013.779157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bulimia nervosa among methamphetamine dependent adults: association with outcomes three years after treatment.

    Glasner-Edwards, Suzette / Mooney, Larissa J / Marinelli-Casey, Patricia / Hillhouse, Maureen / Ang, Alfonso / Rawson, Richard

    Eating disorders

    2011  Volume 19, Issue 3, Page(s) 259–269

    Abstract: Although weight loss is among the most commonly cited reasons for using methamphetamine (MA), little is known about the association between eating disorders and treatment outcomes in this population. This study examined psychiatric, substance use, and ... ...

    Abstract Although weight loss is among the most commonly cited reasons for using methamphetamine (MA), little is known about the association between eating disorders and treatment outcomes in this population. This study examined psychiatric, substance use, and functional outcomes of MA users (N = 526) with bulimia nervosa 3 years after treatment for MA dependence. Bulimia nervosa was observed among 2.4% (N = 13) of the participants and was associated with poorer MA use outcomes, increased health service utilization, and higher levels of functional impairment. Addressing MA use among adults with eating disorders may be helpful as a means of improving treatment outcomes.
    MeSH term(s) Adult ; Amphetamine-Related Disorders/epidemiology ; Amphetamine-Related Disorders/psychology ; Amphetamine-Related Disorders/therapy ; Bulimia Nervosa/epidemiology ; Bulimia Nervosa/psychology ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Male ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2011-05-24
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1209799-8
    ISSN 1532-530X ; 1064-0266 ; 1067-1633
    ISSN (online) 1532-530X
    ISSN 1064-0266 ; 1067-1633
    DOI 10.1080/10640266.2011.566149
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