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  1. Article ; Online: Thromboelastometry-guided treatment algorithm in postpartum haemorrhage. Comment on Br J Anaesth 2023; 130: 165-74.

    Di Mascio, Nicholas / Walsh, Don / Higgins, Nikki

    British journal of anaesthesia

    2023  Volume 130, Issue 6, Page(s) e456–e458

    MeSH term(s) Female ; Humans ; Postpartum Hemorrhage/therapy ; Thrombelastography ; Blood Loss, Surgical ; Algorithms
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.02.012
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  2. Article ; Online: Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease

    Ryan S. O'Dell / Albert Higgins-Chen / Dhruva Gupta / Ming-Kai Chen / Mika Naganawa / Takuya Toyonaga / Yihuan Lu / Gessica Ni / Anna Chupak / Wenzhen Zhao / Elaheh Salardini / Nabeel B. Nabulsi / Yiyun Huang / Amy F.T. Arnsten / Richard E. Carson / Christopher H. van Dyck / Adam P. Mecca

    NeuroImage: Clinical, Vol 39, Iss , Pp 103457- (2023)

    2023  

    Abstract: ... regional patterns of covariance in synaptic density using [11C]UCB-J PET and assessed the association ... between principal components (PC) subject scores with cognitive performance. Methods: [11C]UCB-J binding ...

    Abstract Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [11C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance. Methods: [11C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid– cognitively normal participants aged 55–85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (ROI). Results: Parallel analysis determined three significant PCs explaining 70.2% of the total variance. PC1 was characterized by positive loadings with similar contributions across the majority of ROIs. PC2 was characterized by positive and negative loadings with strongest contributions from subcortical and parietooccipital cortical regions, respectively, while PC3 was characterized by positive and negative loadings with strongest contributions from rostral and caudal cortical regions, respectively. Within the AD group, PC1 subject scores were positively correlated with performance across all cognitive domains (Pearson r = 0.24–0.40, P = 0.06–0.006), PC2 subject scores were inversely correlated with age (Pearson r = -0.45, P = 0.002) and PC3 subject scores were significantly correlated with CDR-sb (Pearson r = 0.46, P = 0.04). No significant correlations were observed between cognitive performance and PC subject scores in CN participants. Conclusions: This data-driven approach defined specific spatial patterns of synaptic density correlated with unique participant characteristics within the AD group. Our findings reinforce synaptic density as a robust biomarker of disease presence and severity in the early stages of AD.
    Keywords Alzheimer’s disease ; Synaptic density ; SV2A ; [11C]UCB-J ; Positron emission tomography ; Principal component analysis ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 571
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Erratum to: 'United in earnest: first pilot sites for increased surgical capacity for rheumatic heart disease announced by cardiac surgery intersociety alliance' [Eur J Cardiothorac Surg 2021;59:1139-43].

    Enumah, Zachary Obinna / Bolman, Ralph Morton / Zilla, Peter / Boateng, Percy / Wilson, Barry / Kumar, A Sampath / Chotivatanapong, Taweesak / Beyersdorf, Friedhelm / Pomar, Jose / Sliwa, Karen / Eiselé, Jean-Luc / Dearani, Joseph / Higgins, Robert

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Volume 60, Issue 6, Page(s) 1480

    Language English
    Publishing date 2021-10-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab414
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    Zs.A 2303: Show issues Location:
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  4. Book: THE CHEMISTRY AND MICROBIOLOGY OF POLLUTION. BY I.J. HIGGINS AND R.G. BURNS

    Higgins, Irving J.

    1975  

    Title variant CHEMISTRY AND MICROBIOLOGY OF POLLUTION
    Keywords Umweltverschmutzung ; Umweltchemikalie
    Subject Umweltverunreinigung ; Pollution ; Umweltkontamination ; Umweltchemikalien
    Size VIII,248 S.
    Publisher ACADEMIC PRESS
    Publishing place LONDON (U.A.)
    Document type Book
    HBZ-ID HT000176657
    ISBN 0-12-347950-9 ; 978-0-12-347950-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1978 A 522 order for loan Magazin

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  5. Article: Brain gamma-aminobutyric acid measurement by proton double-quantum filtering with selective J rewinding.

    Choi, Changho / Coupland, Nicholas J / Hanstock, Christopher C / Ogilvie, Catherine J / Higgins, Andrea C M / Gheorghiu, Dan / Allen, Peter S

    Magnetic resonance in medicine

    2005  Volume 54, Issue 2, Page(s) 272–279

    Abstract: An optimized single-shot proton double-quantum (DQ) filter for the quantification of gamma-aminobutyric acid (GABA) levels in human brain is reported. It is demonstrated that creation of DQ coherences following dual-resonance-selective refocusing gives a ...

    Abstract An optimized single-shot proton double-quantum (DQ) filter for the quantification of gamma-aminobutyric acid (GABA) levels in human brain is reported. It is demonstrated that creation of DQ coherences following dual-resonance-selective refocusing gives a theoretical editing efficiency of 50% for the detection of the GABA resonance at 3.01 ppm. The sequence times are optimized with both numerical and experimental analyses of the editing performance, giving an experimental editing efficiency of 42%. It is acknowledged that homocarnosine is partially coedited, leading to a 20% contribution to the edited signal; however, macromolecule contamination is negligible in vivo under these experimental conditions. The GABA concentration in human prefrontal cortex is estimated to be 0.8 +/- 0.1 micromol/g (mean +/- SD, n = 6), with reference to the internal standard creatine at 9 micromol/g.
    MeSH term(s) Adult ; Brain Chemistry ; Humans ; Macromolecular Substances/metabolism ; Magnetic Resonance Spectroscopy/methods ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Macromolecular Substances ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.20563
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    Zs.A 1959: Show issues Location:
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  6. Article: Correspondence.

    Higgins, J M

    Buffalo medical journal

    2023  Volume 67, Issue 11, Page(s) 661

    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426473-3
    ISSN 1040-3817
    ISSN 1040-3817
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  7. Article: Correspondence.

    Higgins, J M

    Buffalo medical journal

    2023  Volume 67, Issue 9, Page(s) 512

    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426473-3
    ISSN 1040-3817
    ISSN 1040-3817
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  8. Article: Relation of Foul Air to Consumption.

    Higgins, P J

    Buffalo medical and surgical journal

    2023  Volume 21, Issue 1, Page(s) 32–33

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426472-1
    ISSN 1040-3825
    ISSN 1040-3825
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  9. Article ; Online: Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.

    Kassie, Fekadu / Anderson, Lorraine B / Higgins, Leeann / Pan, Yunqian / Matise, Ilze / Negia, Mesfin / Upadhyaya, Pramod / Wang, Mingyao / Hecht, Stephen S

    Carcinogenesis

    2008  Volume 29, Issue 3, Page(s) 610–619

    Abstract: ... of proteins in lung tumors from A/J mice treated with a mixture of 4-(methylnitrosamino)-1-(3-pyridyl)-1 ...

    Abstract We used isobaric tag labeling coupled with mass spectrometry to compare the relative abundance of proteins in lung tumors from A/J mice treated with a mixture of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene versus normal mouse lung tissues. Levels of 59 proteins changed-30 increased and 29 decreased-in tumor tissues versus normal tissues. Among proteins that showed increased levels in tumor tissues versus normal tissues were glycolytic enzymes, ribosomal proteins, fatty acid synthase, cathepsins D and H and carbonic anhydrase 2. On the other hand, the levels of cytochrome P450 enzymes 2B10 and 2F2, glutathione S-transferases mu-1, procollagen VI, Clara cell 10 kDA (CC10) protein, histones, receptor advanced glycation end product, and lung carbonyl reductase were lower in tumor tissues versus normal lung tissues. Upon dietary administration of a combination of N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine plus myo-inositol or indole-3-carbinol to carcinogen-treated mice, the relative abundance of 60S ribosomal protein L4 and carbonic anhydrase in tumor tissues decreased whereas that of histones, glutathione S-transferases mu, receptor advanced glycation end product, transglutaminase, and procollagen VI increased. Western assays with lung tissue homogenates not only verified the proteomics results for selected proteins but also showed differential expression of hypoxia inducible factor-1alpha, a transcription factor for most of the proteins that showed changes in relative abundance. This is the first report on the application of quantitative proteomics to study the relative abundance of proteins in a mouse model of lung carcinogenesis. These proteins may have utility for development of candidate lung cancer biomarkers and as targets of chemopreventive/chemotherapeutic agents.
    MeSH term(s) Amino Acid Sequence ; Animals ; Benzo(a)pyrene/toxicity ; Blotting, Western ; Carcinogens/toxicity ; Chromatography, Liquid ; Lung Neoplasms/chemically induced ; Lung Neoplasms/metabolism ; Lung Neoplasms/prevention & control ; Mice ; Molecular Sequence Data ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/metabolism ; Nitrosamines/toxicity ; Tandem Mass Spectrometry
    Chemical Substances Carcinogens ; Neoplasm Proteins ; Nitrosamines ; Benzo(a)pyrene (3417WMA06D) ; 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (7S395EDO61)
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgn014
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    Zs.A 1558: Show issues Location:
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  10. Article ; Online: Addiction psychiatry and psychiatry trainees: a still complicated relationship.

    Torales, Julio / O'Higgins, Marcelo / Barrios, Iván

    International review of psychiatry (Abingdon, England)

    2024  Volume 35, Issue 5-6, Page(s) 503–505

    MeSH term(s) Humans ; Addiction Medicine ; Psychiatry/education ; Internship and Residency
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018090-4
    ISSN 1369-1627 ; 0954-0261
    ISSN (online) 1369-1627
    ISSN 0954-0261
    DOI 10.1080/09540261.2023.2275699
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