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  1. Article ; Online: Recurrent

    Tsigrelis, Constantine

    Cleveland Clinic journal of medicine

    2020  Volume 87, Issue 6, Page(s) 347–359

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Antimicrobial Stewardship/methods ; Clostridioides difficile/isolation & purification ; Clostridium Infections/etiology ; Clostridium Infections/physiopathology ; Clostridium Infections/therapy ; Humans ; Microbiota/drug effects ; Patient Care Management/methods ; Secondary Prevention/methods
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.87gr.20001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of institutional guideline adherence for carbapenem use at a large academic medical center.

    Michalski, Derek / Ghamrawi, Riane J / Tsigrelis, Constantine

    Infectious diseases (London, England)

    2017  , Page(s) 1–3

    Language English
    Publishing date 2017-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2017.1381986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antimicrobial resistance in the intensive care unit: mechanisms, epidemiology, and management of specific resistant pathogens.

    Fraimow, Henry S / Tsigrelis, Constantine

    Critical care clinics

    2011  Volume 27, Issue 1, Page(s) 163–205

    Abstract: Infections caused by drug-resistant and multidrug-resistant microbial pathogens pose tremendous challenges to health care systems, including challenges related to the diagnosis, treatment, and containment of these infections. These challenges are ... ...

    Abstract Infections caused by drug-resistant and multidrug-resistant microbial pathogens pose tremendous challenges to health care systems, including challenges related to the diagnosis, treatment, and containment of these infections. These challenges are amplified in the intensive care unit (ICU), where pressures for selection and emergence of resistance and risks of transmission of resistant pathogens are highest, and where the threat of resistance drives selection of empiric antimicrobial regimens. This article reviews basic concepts of resistance to antibacterial agents including mechanisms and modes of transmission, and discusses management issues for the important drug-resistant pathogens found in the ICU.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Drug Resistance, Multiple, Bacterial ; Humans ; Intensive Care Units
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2010.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Skeletal muscle abscess caused by Blastomyces dermatitidis.

    Tsigrelis, Constantine / Baddour, Larry M

    The American journal of the medical sciences

    2008  Volume 337, Issue 4, Page(s) 293–294

    Abstract: Muscle involvement is an extremely rare manifestation of blastomycosis. We, therefore, report a case of a large gluteal muscle abscess caused by Blastomyces dermatitidis in a young, immunocompetent male. In addition, we review the literature to further ... ...

    Abstract Muscle involvement is an extremely rare manifestation of blastomycosis. We, therefore, report a case of a large gluteal muscle abscess caused by Blastomyces dermatitidis in a young, immunocompetent male. In addition, we review the literature to further characterize the syndrome of skeletal muscle blastomycosis.
    MeSH term(s) Abscess/etiology ; Abscess/microbiology ; Abscess/pathology ; Antifungal Agents/therapeutic use ; Blastomyces/pathogenicity ; Blastomycosis/complications ; Blastomycosis/drug therapy ; Blastomycosis/physiopathology ; Humans ; Male ; Muscle, Skeletal/microbiology ; Muscle, Skeletal/pathology ; Young Adult
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2008-08-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1097/maj.0b013e3181863264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of endocarditis due to Proteus species: a literature review.

    Kalra, Ankur / Cooley, Christine / Tsigrelis, Constantine

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2011  Volume 15, Issue 4, Page(s) e222–5

    Abstract: Endocarditis due to Proteus species is very rare. We report a case of endocarditis due to Proteus mirabilis that was successfully treated with ampicillin and gentamicin, and review the treatment regimens of previously published cases of Proteus ... ...

    Abstract Endocarditis due to Proteus species is very rare. We report a case of endocarditis due to Proteus mirabilis that was successfully treated with ampicillin and gentamicin, and review the treatment regimens of previously published cases of Proteus endocarditis.
    MeSH term(s) Ampicillin/administration & dosage ; Ampicillin/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Female ; Gentamicins/administration & dosage ; Gentamicins/therapeutic use ; Humans ; Middle Aged ; Proteus/classification ; Proteus/drug effects ; Proteus/isolation & purification ; Proteus Infections/drug therapy ; Proteus Infections/microbiology ; Proteus mirabilis/drug effects ; Proteus mirabilis/isolation & purification ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Gentamicins ; Ampicillin (7C782967RD)
    Language English
    Publishing date 2011-04
    Publishing country Canada
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2010.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Incidence and mortality of sepsis, severe sepsis, and septic shock in intensive care unit patients with candidemia.

    Ng, Kevin / Schorr, Christa / Reboli, Annette C / Zanotti, Sergio / Tsigrelis, Constantine

    Infectious diseases (London, England)

    2015  Volume 47, Issue 8, Page(s) 584–587

    Abstract: In this incidence study, of 16 074 patients admitted to the intensive care unit (ICU) from 1/1/2003 to 7/31/2011, 161 cases of candidemia were identified. The incidence of sepsis (27%), severe sepsis (31%), and septic shock (40%) was remarkably high in ... ...

    Abstract In this incidence study, of 16 074 patients admitted to the intensive care unit (ICU) from 1/1/2003 to 7/31/2011, 161 cases of candidemia were identified. The incidence of sepsis (27%), severe sepsis (31%), and septic shock (40%) was remarkably high in these cases of candidemia, as was the all-cause in-hospital mortality for sepsis (30%), severe sepsis (44%), and septic shock (65%).
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Candida/isolation & purification ; Candidemia/epidemiology ; Candidemia/mortality ; Female ; Hospital Mortality ; Humans ; Incidence ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Prospective Studies ; Sepsis/epidemiology ; Sepsis/microbiology ; Sepsis/mortality ; Shock, Septic/epidemiology ; Shock, Septic/microbiology ; Shock, Septic/mortality ; Time Factors ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.3109/23744235.2015.1028100
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  7. Article: Methemoglobinemia revisited: an important complication after transesophageal echocardiography.

    Tsigrelis, Constantine / Weiner, Leonard

    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

    2006  Volume 7, Issue 6, Page(s) 470–472

    Abstract: Methemoglobinemia induced by the use of benzocaine-containing topical anesthetics is a rare, but potentially lethal complication after transesophageal echocardiography (TEE). We report a patient who developed methemoglobinemia after TEE. A review of the ... ...

    Abstract Methemoglobinemia induced by the use of benzocaine-containing topical anesthetics is a rare, but potentially lethal complication after transesophageal echocardiography (TEE). We report a patient who developed methemoglobinemia after TEE. A review of the literature was performed and the majority of cases of benzocaine-induced methemoglobinemia reported thus far have occurred in patients undergoing TEE, endotracheal intubation, esophagogastroduodenoscopy, and bronchoscopy. All of these procedures have become more frequent than before, and there is a need to reemphasize the potential problem and to reconsider the need for further use of topical anesthetics.
    MeSH term(s) Aged, 80 and over ; Anesthetics, Local/adverse effects ; Benzocaine/adverse effects ; Echocardiography, Transesophageal/adverse effects ; Female ; Humans ; Methemoglobinemia/chemically induced ; Methemoglobinemia/etiology ; Methemoglobinemia/therapy ; Risk Factors
    Chemical Substances Anesthetics, Local ; Benzocaine (U3RSY48JW5)
    Language English
    Publishing date 2006-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2021408-X
    ISSN 1532-2114 ; 1525-2167
    ISSN (online) 1532-2114
    ISSN 1525-2167
    DOI 10.1016/j.euje.2005.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Salmonella aortitis treated with endovascular aortic repair.

    Pulimamidi, Shipali / Caputo, Francis J / Fraimow, Henry S / Nahra, Raquel / Tsigrelis, Constantine

    Annals of vascular surgery

    2014  Volume 28, Issue 5, Page(s) 1314.e5–10

    Abstract: Salmonella aortitis is a known complication of Salmonella infection that usually requires surgical therapy. It is unknown whether endovascular aortic repair (EVAR) is an acceptable alternative to conventional aortic surgery for patients with Salmonella ... ...

    Abstract Salmonella aortitis is a known complication of Salmonella infection that usually requires surgical therapy. It is unknown whether endovascular aortic repair (EVAR) is an acceptable alternative to conventional aortic surgery for patients with Salmonella aortitis who are at high risk for perioperative complications. We therefore report 2 cases of Salmonella aortitis treated with EVAR and review the literature to further characterize previously published cases.
    MeSH term(s) Aged, 80 and over ; Aortitis/diagnostic imaging ; Aortitis/microbiology ; Aortitis/surgery ; Blood Vessel Prosthesis ; Endovascular Procedures/methods ; Fatal Outcome ; Female ; Humans ; Salmonella Infections/diagnostic imaging ; Salmonella Infections/microbiology ; Salmonella Infections/surgery ; Salmonella enteritidis/isolation & purification ; Stents ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-07
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2013.09.015
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  9. Article: Pravastatin: a potential cause for acute pancreatitis.

    Tsigrelis, Constantine / Pitchumoni, C S

    World journal of gastroenterology

    2005  Volume 12, Issue 43, Page(s) 7055–7057

    Abstract: Acute pancreatitis (AP) secondary to drugs is un-common, with an incidence ranging from 0.3% to 2.0% of AP cases. Drug-induced AP due to statins is rare, and only 12 cases have thus far been reported. In this case report, we report a case of a 50-year- ... ...

    Abstract Acute pancreatitis (AP) secondary to drugs is un-common, with an incidence ranging from 0.3% to 2.0% of AP cases. Drug-induced AP due to statins is rare, and only 12 cases have thus far been reported. In this case report, we report a case of a 50-year-old female on pravastatin therapy for 3 d prior to developing symptoms of AP. The common etiological factors for AP were all excluded. The patient was admitted to the intensive care unit secondary to respiratory distress, though she subsequently improved and was discharged 14 d after admission. Although the incidence of drug-induced AP is low, clinicians should have a high index of suspicion for it in patients with AP due to an unknown etiology. Clinicians should be aware of the association of statins with AP. If a patient taking a statin develops abdominal pain, clinicians should consider the diagnosis of AP and conduct the appropriate laboratory and diagnostic evaluation if indicated.
    MeSH term(s) Acute Disease ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use ; Female ; Humans ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/physiopathology ; Middle Aged ; Pancreatitis/chemically induced ; Pancreatitis/diagnosis ; Pancreatitis/physiopathology ; Pravastatin/adverse effects ; Pravastatin/therapeutic use
    Chemical Substances Anticholesteremic Agents ; Pravastatin (KXO2KT9N0G)
    Language English
    Publishing date 2005-07-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v12.i43.7055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  10. Article ; Online: 65-year-old man with persistent fever.

    Haider, Zehra / Tsigrelis, Constantine / Baddour, Larry M

    Mayo Clinic proceedings

    2009  Volume 84, Issue 11, Page(s) 1017–1020

    MeSH term(s) Academic Medical Centers ; Aged ; Animals ; Cattle ; Dose-Response Relationship, Drug ; Doxycycline/administration & dosage ; Drug Administration Schedule ; Fever of Unknown Origin/drug therapy ; Fever of Unknown Origin/etiology ; Follow-Up Studies ; Humans ; Male ; Minnesota ; Patient Satisfaction ; Q Fever/complications ; Q Fever/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Doxycycline (N12000U13O)
    Language English
    Publishing date 2009-10-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/S0025-6196(11)60672-1
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