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  1. Article: Successful treatment of pulmonary invasive fungal infection by

    Ramírez, Isabel / Hidrón, Alicia / Cardona, Ricardo

    Clinical case reports

    2018  Volume 6, Issue 6, Page(s) 1153–1157

    Abstract: ... ...

    Abstract Penicillium
    Language English
    Publishing date 2018-05-02
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.1527
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  2. Article ; Online: Correction to: Concomitant onset of systemic lupus erythematosus and disseminated histoplasmosis: a case-based review.

    Peinado-Acevedo, Juan Sebastián / Varela, Diana-Cristina / Hidrón, Alicia

    Rheumatology international

    2020  Volume 41, Issue 9, Page(s) 1681

    Language English
    Publishing date 2020-12-17
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04758-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1639: Show issues Location:
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  3. Article ; Online: Concomitant onset of systemic lupus erythematosus and disseminated histoplasmosis: a case-based review.

    Peinado-Acevedo, Juan Sebastián / Varela, Diana-Cristina / Hidrón, Alicia

    Rheumatology international

    2020  Volume 41, Issue 9, Page(s) 1673–1680

    Abstract: Introduction: Concomitant infections during the debut or relapse of systemic lupus erythematosus are a common scenario, due to multiple mechanisms including the use of immunosuppressive drugs and autoimmunity per se. Invasive fungal infections are rare ... ...

    Abstract Introduction: Concomitant infections during the debut or relapse of systemic lupus erythematosus are a common scenario, due to multiple mechanisms including the use of immunosuppressive drugs and autoimmunity per se. Invasive fungal infections are rare in systemic lupus erythematosus and are associated with profound immunosuppressed states. Disseminated histoplasmosis in patients with lupus has rarely been reported and the concomitant presentation of both entities is exceptional.
    Methods: We describe a case and performed a literature review in order to identify all case reports. A literature search was carried out using in PubMed/MEDLINE, EMBASE and Google Scholar (the first 200 relevant references) bibliographic databases. All available inclusion studies from January 1968 through July 2020. All data were tabulated, and outcomes were cumulatively analyzed.
    Results: Thirty-one additional cases were identified. Disseminated histoplasmosis was the most common clinical presentation and most cases have been reported in patients with a prior diagnosis of lupus in the setting of moderate to high steroid dose use, usually in combination with some other immunosuppressant. Description at systemic lupus disease onset was only reported in 3 cases with a high associated mortality. In our patient, severe disease activity, significant immunosuppression, malnutrition and multi-organ compromise conditioned the patient's fatal outcome.
    Conclusion: Histoplasmosis can closely mimic activity of lupus. Thus, early clinical recognition is important since a delay in diagnosis and treatment can lead to fatal outcomes.
    MeSH term(s) Adult ; Female ; Histoplasmosis/diagnosis ; Histoplasmosis/etiology ; Histoplasmosis/physiopathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2020-11-04
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04739-6
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  4. Article ; Online: Bone involvement in non-congenital syphilis

    Trujillo, Daniela / Agudelo, Carlos Andrés / Chavarriaga, Andrés / Villa, Pablo / Vélez, Alejandro / Cardona, Ricardo / Hidrón, Alicia

    Biomedica : revista del Instituto Nacional de Salud

    2023  Volume 43, Issue 2, Page(s) 157–163

    Abstract: We documented two stages of bone involvement due to syphilis in two adult patients infected with human immunodeficiency virus. Bony lesions of secondary versus tertiary syphilis cannot be differentiated on clinical or radiologic grounds alone. Given the ... ...

    Title translation Compromiso óseo por sífilis no congénita
    Abstract We documented two stages of bone involvement due to syphilis in two adult patients infected with human immunodeficiency virus. Bony lesions of secondary versus tertiary syphilis cannot be differentiated on clinical or radiologic grounds alone. Given the rarity of this clinical presentation, there is no consensus on treatment duration and related outcomes.
    MeSH term(s) Adult ; Humans ; Syphilis/complications ; Syphilis/diagnosis ; Bone Diseases ; Consensus
    Language Spanish
    Publishing date 2023-06-30
    Publishing country Colombia
    Document type Journal Article
    ZDB-ID 2059952-3
    ISSN 2590-7379 ; 2590-7379
    ISSN (online) 2590-7379
    ISSN 2590-7379
    DOI 10.7705/biomedica.6603
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  5. Article: A man with weight loss and cardiac tamponade: Pericardial tuberculosis.

    Uribe Pulido, Natalí / Osorio Sandoval, Germán / Hidrón Botero, Alicia / Ribero Vargas, Marcel

    IDCases

    2021  Volume 26, Page(s) e01248

    Abstract: We herein described a case of pericardial tuberculosis presenting as a cardiac tamponade in a HIV-negative man with restrictive pericarditis initially, but during treatment with antituberculous drugs and without the addition of corticosteroids, he ... ...

    Abstract We herein described a case of pericardial tuberculosis presenting as a cardiac tamponade in a HIV-negative man with restrictive pericarditis initially, but during treatment with antituberculous drugs and without the addition of corticosteroids, he developed constrictive pericarditis that required surgery. We raise the discussion of the indication of corticosteroids in these cases.
    Language English
    Publishing date 2021-08-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01248
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  6. Article ; Online: HIV/AIDS infection in critical care: epidemiological profile and risk factors for mortality in a Colombian cohort.

    Penagos Gaviria, Sara / Zapata, Natalia / Villa, Pablo / Agudelo, Carlos A / Molina, Francisco J / González, Marco A / Durango, Laura V / Zapata, Silvana / Galeano, Carlos / Cardona, Jonathan / Rivera, Sebastián / Hidron, Alicia I

    Journal of infection in developing countries

    2023  Volume 17, Issue 1, Page(s) 102–110

    Abstract: Introduction: Outcomes of human immunodeficiency virus (HIV) infected patients admitted to intensive care units (ICU) have improved with antiretroviral therapy (ART). However, whether the outcomes have improved in low- and middle-income countries, ... ...

    Abstract Introduction: Outcomes of human immunodeficiency virus (HIV) infected patients admitted to intensive care units (ICU) have improved with antiretroviral therapy (ART). However, whether the outcomes have improved in low- and middle-income countries, paralleling those of high-income countries is unknown. The objective of this study was to describe a cohort of HIV-infected patients admitted to ICU in a middle-income country and identify the risk factors associated with mortality.
    Methodology: A cohort study of HIV-infected patients admitted to five ICUs in Medellín, Colombia, between 2009 and 2014 was done. The association of demographic, clinical and laboratory variables with mortality was analyzed using a Poisson regression model with random effects.
    Results: During this time period, 472 admissions of 453 HIV-infected patients were included. Indications for ICU admission were: respiratory failure (57%), sepsis/septic shock (30%) and central nervous system (CNS) compromise (27%). Opportunistic infections (OI) explained 80% of ICU admissions. Mortality rate was 49%. Factors associated with mortality included hematological malignancies, CNS compromise, respiratory failure, and APACHE II score ≥ 20.
    Conclusions: Despite advances in HIV care in the ART era, half of HIV-infected patients admitted to the ICU died. This elevated mortality was associated to underlying disease severity (respiratory failure and APACHE II score ≥ 20), and host conditions (hematological malignancies, admission for CNS compromise). Despite the high prevalence of OIs in this cohort, mortality was not directly associated to OIs.
    MeSH term(s) Humans ; Colombia/epidemiology ; Cohort Studies ; Acquired Immunodeficiency Syndrome ; Hospital Mortality ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Critical Care ; Risk Factors ; Intensive Care Units ; Shock, Septic ; Respiratory Insufficiency ; Hematologic Neoplasms
    Language English
    Publishing date 2023-01-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.15859
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  7. Article ; Online: Rhinosporidiosis in Colombia: case series and literature review.

    Vélez, Alejandro / Jiménez, Guillermo / Hidrón, Alicia / Talero, Sandra / Agudelo, Carlos Andrés

    Tropical doctor

    2018  Volume 48, Issue 4, Page(s) 289–293

    Abstract: Rhinosporidiosis is a chronic granulomatous disease that affects mucosal surfaces. Its epidemiology and clinical presentation in Colombia are not well-known. We therefore reviewed all 58 reported cases between 1964 and 2015 to raise awareness among ... ...

    Abstract Rhinosporidiosis is a chronic granulomatous disease that affects mucosal surfaces. Its epidemiology and clinical presentation in Colombia are not well-known. We therefore reviewed all 58 reported cases between 1964 and 2015 to raise awareness among clinicians in a non-endemic area. Of the patients, 64% were male (median age = 15 years) and 57% had ocular and 43% nasal manifestations; there were no disseminated cases of the disease. All lesions were surgically removed.
    MeSH term(s) Adolescent ; Animals ; Child ; Colombia/epidemiology ; Female ; Humans ; Male ; Retrospective Studies ; Rhinosporidiosis/epidemiology ; Rhinosporidium/isolation & purification
    Language English
    Publishing date 2018-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/0049475518787123
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1056: Show issues Location:
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  8. Article ; Online: Risk factors for vitamin D deficiency among veterans with and without HIV infection.

    Hidron, Alicia I / Hill, Brittany / Guest, Jodie L / Rimland, David

    PloS one

    2015  Volume 10, Issue 4, Page(s) e0124168

    Abstract: Objectives: We aimed to describe and compare the prevalence of vitamin D deficiency between HIV-negative and HIV-infected veterans in the southern United States, and to determine risk factors for vitamin D deficiency for HIV infected patients.: ... ...

    Abstract Objectives: We aimed to describe and compare the prevalence of vitamin D deficiency between HIV-negative and HIV-infected veterans in the southern United States, and to determine risk factors for vitamin D deficiency for HIV infected patients.
    Methods: Cross-sectional, retrospective study including all patients followed at the Atlanta VA Medical Center with the first 25-hydroxyvitamin D [25(OH)D] level determined between January 2007 and August 2010. Multivariate logistic regression analysis was used to determine risk factors associated with vitamin D deficiency (< 20 ng/ml).
    Results: There was higher prevalence of 25(OH)D deficiency among HIV-positive compared to HIV-negative patients (53.2 vs. 38.5%, p <0.001). Independent risk factors for vitamin D deficiency in HIV + patients included black race (OR 3.24, 95% CI 2.28-4.60), winter season (OR 1.39, 95% CI 1.05-1.84) and higher GFR (OR 1.01, CI 1.00-1.01); increasing age (OR 0.98, 95% CI 0.95-0.98), and tenofovir use (OR 0.72, 95% CI 0.54-0.96) were associated with less vitamin D deficiency.
    Conclusions: Vitamin D deficiency is a prevalent problem that varies inversely with age and affects HIV-infected patients more than other veterans in care. In addition to age, tenofovir and kidney disease seem to confer a protective effect from vitamin D deficiency in HIV-positive patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Comorbidity ; Cross-Sectional Studies ; Female ; HIV Infections/blood ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Obesity ; Retrospective Studies ; Risk Factors ; Veterans ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Young Adult
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0124168
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  9. Article: Post-COVID-19 Necrotizing Pneumonia in Patients on Invasive Mechanical Ventilation.

    Hidron, Alicia / Quiceno, William / Cardeño, John J / Roncancio, Gustavo / García, Cristian

    Infectious disease reports

    2021  Volume 13, Issue 3, Page(s) 835–842

    Abstract: 1) Background: Few reports of necrotizing pneumonia in patients with COVID-19 have been published. We have observed an elevated incidence at two hospitals in our city, suggesting this complication is not uncommon, and may have been overlooked. (2) ... ...

    Abstract (1) Background: Few reports of necrotizing pneumonia in patients with COVID-19 have been published. We have observed an elevated incidence at two hospitals in our city, suggesting this complication is not uncommon, and may have been overlooked. (2) Methods: This article presents a retrospective, descriptive cohort study that was undertaken from 22 March 2020 to 15 June 2021 in two tertiary care hospitals in Medellín, Colombia. All adult patients admitted to the intensive care unit (ICU) for respiratory failure related to confirmed COVID-19, on invasive mechanical ventilation (IMV), with imaging or surgical findings documenting necrotizing pneumonia (NP) were included. (3) Results: Of 936 patients with COVID-19 that required IMV, 42 (4.5%) developed NP. Overall mortality was 57% and in-hospital mortality was 71%, occurring 15-79 days after COVID-19 diagnosis. NP was diagnosed at a median of 27 days after COVID-19 symptom onset and 15.5 days after initiation of IMV. Infections were polymicrobial in 52.4% of patients.
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13030075
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  10. Article ; Online: Rhinosporidiosis in the Americas: A Systematic Review of Native Cases.

    Penagos, Sara / Zapata, Natalia / Castro, Juan José / Hidron, Alicia / Agudelo, Carlos Andrés

    The American journal of tropical medicine and hygiene

    2021  Volume 105, Issue 1, Page(s) 171–175

    Abstract: Rhinosporidiosis is a chronic mucosal infection caused by Rhinosporidium seeberi, an aquatic protistan parasite. It presents as nasal or ocular polypoidal or vascularized masses. It is endemic in tropical and subtropical areas, especially in South Asia; ... ...

    Abstract Rhinosporidiosis is a chronic mucosal infection caused by Rhinosporidium seeberi, an aquatic protistan parasite. It presents as nasal or ocular polypoidal or vascularized masses. It is endemic in tropical and subtropical areas, especially in South Asia; R. seeberi´s endemicity in the Americas is often overlooked. The objective of this study was to describe the demographic and clinical characteristics of patients with rhinosporidiosis in the Americas, its management, and patient outcomes. This study is a systematic review of cases of human rhinosporidiosis in the Americas reported in the literature from 1896 to February 28, 2019. This review screened 1,994 reports, of which 115 were eligible for further analysis. The selected reports described 286 cases of human rhinosporidiosis between 1896 and 2019. Cases were diagnosed in Brazil (32.2%), Colombia (24.4%), Paraguay (12.6%), and the United States (11.9%). The majority of the cases (91%) occurred in geographic areas with altitudes < 1,000 m above sea level and in areas with median temperatures ≥ 25°C (67.3%). Most of the patients presented nasal (65%) and ocular involvement (35%). Surgical treatment was provided for 99.6% of patients, but 19.8% of them recurred. This review describes the under-recognized geographic distribution and clinical presentation of rhinosporidiosis in the Americas and highlights clinical differences to cases in Asia, specifically in reference to a higher prevalence of ocular disease and higher relapse rates.
    MeSH term(s) Americas/epidemiology ; Humans ; Rhinosporidiosis/diagnosis ; Rhinosporidiosis/epidemiology ; Rhinosporidiosis/therapy ; Symptom Assessment
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Systematic Review
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1411
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