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Article ; Online: Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.

Mattmann, Margrith E / Yu, Haibo / Lin, Zhihong / Xu, Kaiping / Huang, Xiaofang / Long, Shunyou / Wu, Meng / McManus, Owen B / Engers, Darren W / Le, Uyen M / Li, Min / Lindsley, Craig W / Hopkins, Corey R

Bioorganic & medicinal chemistry letters

2012 Volume 22, Issue 18, Page(s) 5936–5941

Abstract: A high-throughput screen utilizing a depolarization-triggered thallium influx through KCNQ1 channels was developed and used to screen the MLSMR collection of over 300,000 compounds. An iterative medicinal chemistry approach was initiated and from this ... ...

Abstract	A high-throughput screen utilizing a depolarization-triggered thallium influx through KCNQ1 channels was developed and used to screen the MLSMR collection of over 300,000 compounds. An iterative medicinal chemistry approach was initiated and from this effort, ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM). ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.
MeSH term(s)	Animals ; Dose-Response Relationship, Drug ; Humans ; KCNQ1 Potassium Channel/agonists ; KCNQ1 Potassium Channel/metabolism ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Piperidines/pharmacology ; Rats ; Structure-Activity Relationship ; Substrate Specificity ; Thiazoles/chemical synthesis ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Tosyl Compounds/chemical synthesis ; Tosyl Compounds/chemistry ; Tosyl Compounds/pharmacology
Chemical Substances	(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide ; KCNQ1 Potassium Channel ; Piperidines ; Thiazoles ; Tosyl Compounds
Language	English
Publishing date	2012-08-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.07.060
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Zs.A 3203: Show issues

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Article ; Online: Local Stress Measurements in Polycrystalline Metallic Tensile Specimens Using High Resolution EBSD.

Ruggles, T / Gilliland, W / Noell, P / Craig, R / Fitzgerald, K / Carroll, J

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue Supplement_1, Page(s) 96–97

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.041
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Article: Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury.

Green, Tabitha R F / Carey, Sean D / Mannino, Grant / Craig, John A / Rowe, Rachel K / Zielinski, Mark R

Frontiers in neuroscience

2024 Volume 18, Page(s) 1361014

Abstract: Traumatic brain injury (TBI) can induce dysregulation of sleep. Sleep disturbances include hypersomnia and hyposomnia, sleep fragmentation, difficulty falling asleep, and altered electroencephalograms. TBI results in inflammation and altered hemodynamics, ...

Abstract	Traumatic brain injury (TBI) can induce dysregulation of sleep. Sleep disturbances include hypersomnia and hyposomnia, sleep fragmentation, difficulty falling asleep, and altered electroencephalograms. TBI results in inflammation and altered hemodynamics, such as changes in blood brain barrier permeability and cerebral blood flow. Both inflammation and altered hemodynamics, which are known sleep regulators, contribute to sleep impairments post-TBI. TBIs are heterogenous in cause and biomechanics, which leads to different molecular and symptomatic outcomes. Animal models of TBI have been developed to model the heterogeneity of TBIs observed in the clinic. This review discusses the intricate relationship between sleep, inflammation, and hemodynamics in pre-clinical rodent models of TBI.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2024.1361014
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Article ; Online: Variations in Risk of Cancer and Death From Cancer According to Kidney Allograft Function, Graft Loss, and Return to Dialysis.

Au, Eric H K / Chapman, Jeremy R / Teixeira-Pinto, Armando / Craig, Jonathan C / Wong, Germaine

Transplantation

2023 Volume 107, Issue 6, Page(s) 1359–1364

Abstract: Background: Cancer incidence and mortality may change with varying kidney allograft function and after graft loss. We aimed to quantify cancer incidence and mortality during periods with a functioning graft and after graft loss.: Methods: We included ...

Abstract	Background: Cancer incidence and mortality may change with varying kidney allograft function and after graft loss. We aimed to quantify cancer incidence and mortality during periods with a functioning graft and after graft loss. Methods: We included all adult Australians aged 20 and above who commenced kidney replacement therapy between 1982 and 2014 using data from Australia and New Zealand Dialysis and Transplant Registry. We calculated the standardized incidence ratios and standardized mortality ratios (standardized against the Australian general population) for dialysis patients and transplant recipients during periods with a functioning graft and after graft loss. Results: A total of 44 765 dialysis patients without transplants, 13 443 with first kidney transplants, 2951 after first graft loss, 1010 with second transplants, and 279 after second graft loss were followed for 274 660 patient-years. Cancer incidence and mortality (per 100 000 patient-years) were 1564 and 760 in dialysis patients, 1564 and 689 in recipients of first transplants, 1188 and 390 after first graft loss, 1525 and 693 after second transplants, and 1645 and 779 after second graft loss. Cancer standardized incidence ratios and standardized mortality ratios (95% confidence intervals) were 1.15 (1.11-1.20) and 1.29 (1.21-1.36) for dialysis patients, 2.03 (1.94-2.13) and 2.50 (2.33-2.69) for recipients following their first transplant, 1.55 (1.29-1.85) and 1.40 (1.00-1.90) after first graft loss, 2.18 (1.79-2.63) and 3.00 (2.23-3.96) for second transplants, 2.59 (1.56-4.04) and 3.82 (1.75-7.25) after second graft loss. Conclusions: In kidney transplant recipients, cancer incidence and mortality are highest during periods with a functioning graft and remained higher than in the general population even after graft loss.
MeSH term(s)	Adult ; Humans ; Renal Dialysis ; Australia/epidemiology ; Neoplasms ; Allografts ; Kidney ; Graft Survival ; Registries ; Graft Rejection/etiology
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004493
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article: The role of coronary computed tomography angiography in pregnancy-associated myocardial infarction.

Chokhachi, Reihaneh / Reiss, Craig K

Oxford medical case reports

2023 Volume 2023, Issue 4, Page(s) omad041

Abstract: Background: Pregnancy-associated coronary artery dissection is one of the critical causes of myocardial infarction in young females. The challenges in the diagnosis and follow-up of pregnancy-associated myocardial infarction prompted us to highlight the ...

Abstract	Background: Pregnancy-associated coronary artery dissection is one of the critical causes of myocardial infarction in young females. The challenges in the diagnosis and follow-up of pregnancy-associated myocardial infarction prompted us to highlight the potential role of coronary computed angiography in managing this life-threatening medical condition. Case summary: We describe a case of a 29-year-old female with sudden onset chest discomfort one-week postpartum. She presented to the hospital with an ST-elevation myocardial infarction and was urgently taken to the cath lab for PCI and stent placement. Thirteen months later, with intermittent chest discomfort, an coronary computed tomography was done, demonstrating evidence of SCAD and aneurysm formation in the left main coronary artery and left circumflex coronary artery. Repeat cardiac catheterization confirmed the same diagnosis. Given her refractory chest discomfort and the chance of aneurysm rupture decision was made to proceed with a three-vessel CABG. At 3-month and 1-year followup visits, the patient is doing well and remains pain-free. Conclusion: In this case presentation, we aim to highlight the potential role of Coronary Computed tomography angiography in the diagnosis and follow-up of pregnancy-associated spontaneous coronary artery dissection, given the high accuracy and non invasiveness of this diagnostic modality in the context of the high prevalence of spontaneous coronary artery dissection in symptomatic or asymptomatic pregnancy-associated myocardial infarction.
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omad041
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Article ; Online: Hibernating female big brown bats (Eptesicus fuscus) adjust huddling and drinking behaviour, but not arousal frequency, in response to low humidity.

Muise, Kristina A / Dzal, Yvonne A / Fletcher, Quinn E / Willis, Craig K R

The Journal of experimental biology

2024 Volume 227, Issue 5

Abstract: Many mammals hibernate during winter, reducing energy expenditure via bouts of torpor. The majority of a hibernator's energy reserves are used to fuel brief, but costly, arousals from torpor. Although arousals likely serve multiple functions, an ... ...

Abstract	Many mammals hibernate during winter, reducing energy expenditure via bouts of torpor. The majority of a hibernator's energy reserves are used to fuel brief, but costly, arousals from torpor. Although arousals likely serve multiple functions, an important one is to restore water stores depleted during torpor. Many hibernating bat species require high humidity, presumably to reduce torpid water loss, but big brown bats (Eptesicus fuscus) appear tolerant of a wide humidity range. We tested the hypothesis that hibernating female E. fuscus use behavioural flexibility during torpor and arousals to maintain water balance and reduce energy expenditure. We predicted: (1) E. fuscus hibernating in dry conditions would exhibit more compact huddles during torpor and drink more frequently than bats in high humidity conditions; and (2) the frequency and duration of torpor bouts and arousals, and thus total loss of body mass would not differ between bats in the two environments. We housed hibernating E. fuscus in temperature- and humidity-controlled incubators at 50% or 98% relative humidity (8°C, 110 days). Bats in the dry environment maintained a more compact huddle during torpor and drank more frequently during arousals. Bats in the two environments had a similar number of arousals, but arousal duration was shorter in the dry environment. However, total loss of body mass over hibernation did not differ between treatments, indicating that the two groups used similar amounts of energy. Our results suggest that behavioural flexibility allows hibernating E. fuscus to maintain water balance and reduce energy costs across a wide range of hibernation humidities.
MeSH term(s)	Animals ; Female ; Humidity ; Chiroptera/physiology ; Hibernation/physiology ; Arousal/physiology ; Drinking Behavior ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.246699
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Zs.A 2629: Show issues

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Article ; Online: Pharmacogenetics of P2Y

Thomas, Cameron D / Williams, Alexis K / Lee, Craig R / Cavallari, Larisa H

Pharmacotherapy

2023 Volume 43, Issue 2, Page(s) 158–175

Abstract: ... Oral ... ...

Abstract	Oral P2Y
MeSH term(s)	Humans ; Clopidogrel/therapeutic use ; Platelet Aggregation Inhibitors/adverse effects ; Ticagrelor/therapeutic use ; Prasugrel Hydrochloride ; Pharmacogenetics ; Percutaneous Coronary Intervention/adverse effects ; Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/genetics ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C19/therapeutic use ; Purinergic P2Y Receptor Antagonists/adverse effects ; Treatment Outcome
Chemical Substances	Clopidogrel (A74586SNO7) ; Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC) ; Prasugrel Hydrochloride (G89JQ59I13) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Purinergic P2Y Receptor Antagonists
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.2758
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article ; Online: Towards a global sustainable development agenda built on social-ecological resilience.

Scown, Murray W / Craig, Robin K / Allen, Craig R / Gunderson, Lance / Angeler, David G / Garcia, Jorge H / Garmestani, Ahjond

Global sustainability

2023 Volume 6, Issue e8, Page(s) 1–14

Abstract: Non-technical summary: The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex ... ...

Abstract	Non-technical summary: The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of social-ecological resilience, which emphasises the ability of systems to absorb, adapt, and transform in the face of change. We determine the strengths of the current SDGs, which should form a basis for the next agenda, and identify key gaps that should be filled. Technical summary: The United Nations' sustainable development goals (SDGs) are past their halfway point and the next global development agenda will soon need to be developed. While laudable, the SDGs have received strong criticism from many, and scholars have proposed that adopting complex adaptive or social-ecological system approaches would increase the effectiveness of the agenda. Here we dive deeper into these discussions to explore how the theory of social-ecological resilience could serve as a strong foundation for the next global sustainable development agenda. We identify the strengths and weaknesses of the current SDGs by determining which of the 169 targets address each of 43 factors affecting social-ecological resilience that we have compiled from the literature. The SDGs with the strongest connections to social-ecological resilience are the environment-focus goals (SDGs 2, 6, 13, 14, 15), which are also the goals consistently under-prioritised in the implementation of the current agenda. In terms of the 43 factors affecting social-ecological resilience, the SDG strengths lie in their communication, inclusive decision making, financial support, regulatory incentives, economic diversity, and transparency in governance and law. On the contrary, ecological factors of resilience are seriously lacking in the SDGs, particularly with regards to scale, cross-scale interactions, and non-stationarity. Social media summary: The post-2030 agenda should build on strengths of SDGs 2, 6, 13, 14, 15, and fill gaps in scale, variability, and feedbacks.
Language	English
Publishing date	2023-09-10
Publishing country	England
Document type	Journal Article
ISSN	2059-4798
ISSN (online)	2059-4798
DOI	10.1017/sus.2023.8
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Article ; Online: Kinetics of the reaction of ferrous ions with hydroxyl radicals in the temperature range 25-300 °C.

Barr, Logan / Conrad, Jacy K / McGregor, Christine / Perron, Randy / Yakabuskie, Pamela A / Stuart, Craig R

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 5, Page(s) 4278–4283

Abstract: The kinetics and mechanism of the reaction between OH radicals and ferrous ions in the temperature range 25-300 °C were studied using pulse radiolysis. At temperatures <150 °C the rate of reaction is essentially independent of temperature, while at ... ...

Abstract	The kinetics and mechanism of the reaction between OH radicals and ferrous ions in the temperature range 25-300 °C were studied using pulse radiolysis. At temperatures <150 °C the rate of reaction is essentially independent of temperature, while at temperatures >150 °C the activation energy is 45.8 ± 3.0 kJ mol
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp03819j
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Article ; Online: The Associations of Basic Psychological Need Satisfaction and Need Frustration with Cannabis-Related Outcomes in a Multi-Site Sample of College Students.

Richards, Dylan K / Schwebel, Frank J / Field, Craig A / Pearson, Matthew R

Journal of psychoactive drugs

2023 , Page(s) 1–10

Abstract: Psychological need satisfaction and need frustration, proposed by self-determination theory, may serve as conditions that foster health-promoting and health-impairing behaviors related to cannabis use. In the present study, we examined the measurement ... ...

Abstract	Psychological need satisfaction and need frustration, proposed by self-determination theory, may serve as conditions that foster health-promoting and health-impairing behaviors related to cannabis use. In the present study, we examined the measurement model of psychological need satisfaction and need frustration and their associations with cannabis protective behavioral strategies use, negative cannabis-related consequences, and cannabis use severity. Data were from 1394 college students from 10 universities across the U.S. who reported past-month cannabis use. A higher-order factor model representing general psychological need satisfaction and need frustration provided a good fit to the data. Regressing the three observed cannabis outcome variables onto these higher-order latent factors, we found that greater need satisfaction was associated with more frequent cannabis protective behavioral strategies use and fewer negative cannabis-related consequences. Greater need frustration was associated with greater negative cannabis-related consequences and cannabis use severity. Further, an interaction effect between need satisfaction and need frustration emerged for each cannabis outcome such that greater need satisfaction attenuated the associations between need frustration and cannabis outcomes and greater need frustration strengthened the associations between need satisfaction and cannabis outcomes. Implications for the roles of need satisfaction and need frustration in cannabis use and future intervention development are discussed.
Language	English
Publishing date	2023-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	392405-1
ISSN	2159-9777 ; 0279-1072
ISSN (online)	2159-9777
ISSN	0279-1072
DOI	10.1080/02791072.2023.2191605
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