LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 259

Search options

  1. Article ; Online: What is the optimal approach to infiltration and extravasation of nonchemotherapy medications?

    Tarpey, Abby / Narechania, Shraddha / Malesker, Mark

    Cleveland Clinic journal of medicine

    2023  Volume 90, Issue 5, Page(s) 292–296

    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.90a.22029
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Genomic differentiation in Pacific cod using Pool-Seq.

    Spies, Ingrid / Tarpey, Carolyn / Kristiansen, Trond / Fisher, Mary / Rohan, Sean / Hauser, Lorenz

    Evolutionary applications

    2022  Volume 15, Issue 11, Page(s) 1907–1924

    Abstract: Patterns of genetic differentiation across the genome can provide insight into selective forces driving adaptation. We used pooled whole genome sequencing, gene annotation, and environmental covariates to evaluate patterns of genomic differentiation and ... ...

    Abstract Patterns of genetic differentiation across the genome can provide insight into selective forces driving adaptation. We used pooled whole genome sequencing, gene annotation, and environmental covariates to evaluate patterns of genomic differentiation and to investigate mechanisms responsible for divergence among proximate Pacific cod (
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2405496-3
    ISSN 1752-4563 ; 1752-4571
    ISSN (online) 1752-4563
    ISSN 1752-4571
    DOI 10.1111/eva.13488
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Top 10 research priorities for irritable bowel syndrome: results of a James Lind Alliance priority setting partnership.

    Black, Christopher J / McKenzie, Yvonne A / Scofield-Marlowe, Morgan / Setter, Peter / Tarpey, Maryrose / Ford, Alexander C

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 6, Page(s) 499–501

    MeSH term(s) Humans ; Irritable Bowel Syndrome/therapy ; Biomedical Research
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00072-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: The top 10 research priorities for pancreatitis: findings from a James Lind Alliance priority setting partnership.

    Mitra, Vikramjit / Munnelly, Stacey / Grammatikopoulos, Tassos / Mole, Damian / Hopper, Andrew / Ryan, Barbara / Phillips, Mary / Tarpey, Maryrose / Leeds, John

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 9, Page(s) 780–782

    MeSH term(s) Humans ; Biomedical Research ; Pancreatitis/therapy
    Language English
    Publishing date 2023-06-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00151-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Do no harm: physicians' duties toward suicidal patients.

    Koopersmith, Eve Green / Tarpey, Colleen M

    Medical economics

    2014  Volume 91, Issue 9, Page(s) 30–31

    MeSH term(s) Documentation ; Harm Reduction ; Humans ; Liability, Legal ; Physician-Patient Relations ; Professional Role ; Suicide/prevention & control ; United States
    Language English
    Publishing date 2014-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 411622-7
    ISSN 0025-7206
    ISSN 0025-7206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Complying with disability rules for hearing-impaired patients.

    Breitenbach, Roy W / Tarpey, Colleen M

    Medical economics

    2014  Volume 91, Issue 1, Page(s) 49–50

    MeSH term(s) Guideline Adherence ; Humans ; Persons With Hearing Impairments/legislation & jurisprudence ; Physician-Patient Relations ; Sign Language
    Language English
    Publishing date 2014-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 411622-7
    ISSN 0025-7206
    ISSN 0025-7206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis.

    Burnett, Heather / Fahrbach, Kyle / Cichewicz, Allie / Jindal, Ramandeep / Tarpey, Jialu / Durand, Adeline / Di Domenico, Maximiliano / Reichelt, Andreas / Viljoen, Adie

    Current medical research and opinion

    2022  Volume 38, Issue 5, Page(s) 777–784

    Abstract: Objective: Network meta-analysis was used to derive estimates of the relative efficacy of inclisiran, evolocumab, alirocumab, bempedoic acid, and ezetimibe in patients with hypercholesterolemia and/or at increased cardiovascular risk due to elevated low- ...

    Abstract Objective: Network meta-analysis was used to derive estimates of the relative efficacy of inclisiran, evolocumab, alirocumab, bempedoic acid, and ezetimibe in patients with hypercholesterolemia and/or at increased cardiovascular risk due to elevated low-density lipoprotein cholesterol taking maximum tolerated dose statins.
    Methods: Clinical trials published through February 2021 comparing percent change from baseline in low-density lipoprotein cholesterol were identified
    Results: Results from the base-case analyses demonstrated that inclisiran, evolocumab, and alirocumab provide superior efficacy over placebo, bempedoic acid, and ezetimibe in terms of reduction in low-density lipoprotein cholesterol. Inclisiran was also comparable to alirocumab (mean difference: 0.78% [95% CrI: -8.35, 9.88]) and evolocumab (8.16%, [95% CrI: -1.82, 18.49]). Findings of a scenario which also included trials conducted in patients with heterozygous familial hypercholesterolemia were consistent with the base case. There was evidence of statistical heterogeneity across the included trials, roughly equivalent to variation of 5-10% change in low-density lipoprotein cholesterol, suggesting that any differences between treatments that were greater than 5-10% are generalizable.
    Conclusions: This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally tolerated statins who are at increased cardiovascular risk.
    MeSH term(s) Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use ; Bayes Theorem ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Cholesterol ; Cholesterol, LDL ; Ezetimibe/therapeutic use ; Heart Disease Risk Factors ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hypercholesterolemia/complications ; Hypercholesterolemia/drug therapy ; Hyperlipidemias/drug therapy ; Network Meta-Analysis ; Risk Factors ; Treatment Outcome
    Chemical Substances Anticholesteremic Agents ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J) ; Ezetimibe (EOR26LQQ24)
    Language English
    Publishing date 2022-03-20
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2022.2049164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma.

    De Noon, Solange / Piggott, Robert / Trotman, Jamie / Tadross, John A / Fittall, Matthew / Hughes, Debbie / Ye, Hongtao / Munasinghe, Emani / Murray, Matthew / Tirabosco, Roberto / Amary, Fernanda / Coleman, Nicholas / Watkins, James / Hubank, Michael / Tarpey, Patrick / Behjati, Sam / Flanagan, Adrienne M

    The Journal of pathology

    2023  Volume 259, Issue 2, Page(s) 119–124

    Abstract: The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using ... ...

    Abstract The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using cytogenetic and molecular techniques did not identify an underlying somatic change involving the FOSL1 gene to explain this finding. Prompted by an unusual index case, we report the discovery of a novel FOSL1 rearrangement in desmoplastic fibroblastoma using whole-genome and targeted RNA sequencing. We investigated 15 desmoplastic fibroblastomas and 15 fibromas of tendon sheath using immunohistochemistry, in situ hybridisation and targeted RNA sequencing. Rearrangements in FOSL1 and FOS were identified in 10/15 and 2/15 desmoplastic fibroblastomas respectively, which mirrors the pattern of FOS rearrangements observed in benign bone and vascular tumours. Fibroma of tendon sheath, which shares histological features with desmoplastic fibroblastoma, harboured USP6 rearrangements in 9/15 cases and did not demonstrate rearrangements in any of the four FOS genes. The overall concordance between FOSL1 immunohistochemistry and RNA sequencing results was 90%. These findings illustrate that FOSL1 and FOS rearrangements are a recurrent event in desmoplastic fibroblastoma, establishing this finding as a useful diagnostic adjunct and expanding the spectrum of tumours driven by FOS gene family alterations. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
    MeSH term(s) Humans ; Fibroma, Desmoplastic/diagnosis ; Fibroma, Desmoplastic/genetics ; Fibroma, Desmoplastic/pathology ; Fibroma/genetics ; Gene Rearrangement ; In Situ Hybridization ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology ; Ubiquitin Thiolesterase/genetics
    Chemical Substances USP6 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.12: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Fatigue is a common symptom in myelin oligodendrocyte glycoprotein antibody disease.

    Ladakis, Dimitrios C / Gould, Jennifer / Khazen, Jenny M / Lefelar, Julia M / Tarpey, Scott / Bies, Charles J / Salky, Rebecca / Fitzgerald, Kathryn C / Bhargava, Pavan / Nourbakhsh, Bardia / Sotirchos, Elias S

    Multiple sclerosis journal - experimental, translational and clinical

    2022  Volume 8, Issue 4, Page(s) 20552173221131235

    Abstract: Background: Unlike multiple sclerosis and neuromyelitis optica, the burden of fatigue in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unclear.: Objective: To compare fatigue levels between people with MOGAD and household ...

    Abstract Background: Unlike multiple sclerosis and neuromyelitis optica, the burden of fatigue in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unclear.
    Objective: To compare fatigue levels between people with MOGAD and household controls (HC) and explore factors associated with fatigue severity.
    Methods: In a cross-sectional survey, data were collected from people with MOGAD and HC by utilizing an online questionnaire. Data elements included demographics, sleep quality measures, comorbidities, MOGAD characteristics, and fatigue severity measured by the Modified Fatigue Impact Scale (MFIS). We compared fatigue severity between MOGAD participants and HC and assessed the associations between demographic and disease characteristics and fatigue severity.
    Results: There were 180/283 MOGAD and 61/126 HC respondents. Compared to HC, people with MOGAD reported more severe fatigue, as measured by the MFIS total score (49.3 vs. 36.5;
    Conclusions: Fatigue is common in people with MOGAD, and a history of bilateral optic neuritis, comorbid conditions, and ongoing disease activity appear to contribute to fatigue severity.
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2841884-0
    ISSN 2055-2173 ; 2055-2173
    ISSN (online) 2055-2173
    ISSN 2055-2173
    DOI 10.1177/20552173221131235
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Prospective individual patient data meta-analysis: Evaluating convalescent plasma for COVID-19.

    Goldfeld, Keith S / Wu, Danni / Tarpey, Thaddeus / Liu, Mengling / Wu, Yinxiang / Troxel, Andrea B / Petkova, Eva

    Statistics in medicine

    2021  Volume 40, Issue 24, Page(s) 5131–5151

    Abstract: As the world faced the devastation of the COVID-19 pandemic in late 2019 and early 2020, numerous clinical trials were initiated in many locations in an effort to establish the efficacy (or lack thereof) of potential treatments. As the pandemic has been ... ...

    Abstract As the world faced the devastation of the COVID-19 pandemic in late 2019 and early 2020, numerous clinical trials were initiated in many locations in an effort to establish the efficacy (or lack thereof) of potential treatments. As the pandemic has been shifting locations rapidly, individual studies have been at risk of failing to meet recruitment targets because of declining numbers of eligible patients with COVID-19 encountered at participating sites. It has become clear that it might take several more COVID-19 surges at the same location to achieve full enrollment and to find answers about what treatments are effective for this disease. This paper proposes an innovative approach for pooling patient-level data from multiple ongoing randomized clinical trials (RCTs) that have not been configured as a network of sites. We present the statistical analysis plan of a prospective individual patient data (IPD) meta-analysis (MA) from ongoing RCTs of convalescent plasma (CP). We employ an adaptive Bayesian approach for continuously monitoring the accumulating pooled data via posterior probabilities for safety, efficacy, and harm. Although we focus on RCTs for CP and address specific challenges related to CP treatment for COVID-19, the proposed framework is generally applicable to pooling data from RCTs for other therapies and disease settings in order to find answers in weeks or months, rather than years.
    MeSH term(s) COVID-19/therapy ; Coronavirus Infections ; Humans ; Immunization, Passive ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top