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Book ; Online ; E-Book: Nitrite and nitrate in human health and disease

Bryan, Nathan S. / Loscalzo, Joseph

(Nutrition and health)

2017

Author's details	Nathan S. Bryan, Joseph Loscalzo, editors
Series title	Nutrition and health
Language	English
Size	1 Online-Ressource (xxx, 349 Seiten), Illustrationen
Edition	Second edition
Publisher	Humana Press
Publishing place	Cham
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019365452
ISBN	978-3-319-46189-2 ; 9783319461878 ; 3-319-46189-3 ; 3319461877
DOI	10.1007/978-3-319-46189-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Nitric oxide deficiency is a primary driver of hypertension.

Bryan, Nathan S

Biochemical pharmacology

2022 Volume 206, Page(s) 115325

Abstract: Hypertension remains a global health crisis. High blood pressure is the number one modifiable risk factor in the onset and progression of cardiovascular disease. Despite many different classes of drug therapies approved for hypertension, the use of ... ...

Abstract	Hypertension remains a global health crisis. High blood pressure is the number one modifiable risk factor in the onset and progression of cardiovascular disease. Despite many different classes of drug therapies approved for hypertension, the use of polypharmacy and recommendations on lifestyle modification, many patients still suffer from uncontrolled or unmanaged hypertension. Nitric oxide is a naturally produced vasodilator that controls and regulates vascular tone and therefore controls and regulates blood pressure. Research over the past 40 years reveals that loss of nitric oxide production, termed endothelial dysfunction, is the earliest event in the development of hypertension. Strategies aimed at preventing the loss of nitric oxide production and/or therapeutic strategies designed to restore nitric oxide production will likely have a positive effect on patients' health and lead to better management of blood pressure. This review article will focus on the loss of nitric oxide production as the primary contributor to hypertension and also discuss safe and clinically proven strategies to restore nitric oxide production and recapitulate nitric oxide based signaling in humans.
MeSH term(s)	Humans ; Nitric Oxide/physiology ; Hypertension/drug therapy ; Blood Pressure ; Vasodilator Agents/pharmacology ; Cardiovascular Diseases/prevention & control ; Endothelium, Vascular
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Vasodilator Agents
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2022.115325
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Book: Nitrates and nitrites in human health and disease

Bryan, Nathan S. / Loscalzo, Joseph

(Nutrition and health)

2011

Author's details	Nathan S. Bryan ; Joseph Loscalzo, ed
Series title	Nutrition and health
Language	English
Size	XXII, 306 S. : Ill., graph. Darst., 26 cm
Publisher	Humana Press
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT016826607
ISBN	978-1-60761-615-3 ; 1-60761-615-7 ; 9781607616160 ; 1607616165
Database	Catalogue ZB MED Medicine, Health

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2011 A 1941	order for loan	Magazin

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Article ; Online: The Efficacy of Nitric Oxide-Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patients of African American and Hispanic Origin.

Bryan, Nathan S / Molnar, Janos / Somberg, John

The American journal of medicine

2023 Volume 136, Issue 10, Page(s) 1035–1040.e11

Abstract: Background: The study was initiated in 2020 to test the efficacy of a nitric oxide-generating lozenge (NOL) in outpatients with newly diagnosed COVID-19 to mitigate disease severity. The study enrolled high-risk patients, African American and Latino.: ...

Abstract	Background: The study was initiated in 2020 to test the efficacy of a nitric oxide-generating lozenge (NOL) in outpatients with newly diagnosed COVID-19 to mitigate disease severity. The study enrolled high-risk patients, African American and Latino. Methods: This was a randomized, double-blinded, prospective, placebo-controlled trial. The primary endpoint was hospitalization, intensive care unit admission, intubation, dialysis, and death. The secondary endpoints were time to symptom resolution and the effect on oxygen saturation. Patients ages 50-85 years with recent COVID-19 diagnosis with at least one risk factor were recruited. Patients were randomized to either active treatment or placebo using block randomization. Blood pressure and oxygen saturation (SpO Results: A total of 840 patients was planned, half in each of the lozenge and placebo groups. An interim review of data was prespecified. Of 524 patients, the composite endpoint occurred in 6 patients, 3 (1.1%) in each group. The time to symptom resolution was 1 day shorter on active treatment (8.7 ± 6.6 vs 9.8 ± 6.8 days) (P = .3). There was no change in SpO Conclusions: This study did not find a benefit of NOL therapy in COVID-19 patients and was terminated for futility. NOL treatment did not reduce mortality, hospitalization, intubation, or a reduction in symptoms duration. The study did find the NO lozenges were well tolerated in high-risk patients, without reported side effects.
MeSH term(s)	Humans ; Black or African American ; COVID-19/therapy ; Hispanic or Latino ; Nitric Oxide/therapeutic use ; Prospective Studies ; SARS-CoV-2 ; Treatment Outcome ; Middle Aged ; Aged ; Aged, 80 and over
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.05.021
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Article ; Online: Intentional benzodiazepine poisoning in older adults reported to United States Poison Centers.

Choi, Namkee G / Choi, Bryan Y / Marti, C Nathan / Baker, S David

Clinical toxicology (Philadelphia, Pa.)

2024 Volume 62, Issue 3, Page(s) 174–182

Abstract: Introduction: Despite known contraindications, benzodiazepines are frequently prescribed for older adults. This study utilizes poison control center data on benzodiazepine-involved cases aged 50 and above to compare the characteristics of suspected ... ...

Abstract	Introduction: Despite known contraindications, benzodiazepines are frequently prescribed for older adults. This study utilizes poison control center data on benzodiazepine-involved cases aged 50 and above to compare the characteristics of suspected suicide attempt with other intentional misuse cases. We also examined associations of major medical outcomes (major effect/death) with demographic characteristics and other co-used substances in each group. Methods: The study employed data from the America's Poison Center National Poison Data System from 2015-2022. Descriptive statistics and binary logistic regression models were used. Results: Of the benzodiazepine-poisoning cases of intentional misuse ( Discussion: Healthcare providers need to screen for suicidal ideation among benzodiazepine users, with special attention to an increased risk of suicide attempt among those who co-use antidepressants and opioids and to decreasing adverse outcomes in all misuse cases. Assessments of underlying mental health and substance use problems and medication regimens to minimize polypharmacy and drug interactions are needed to reduce adverse outcomes. Conclusions: Though the numbers of benzodiazepine-involved suicide attempt and other intentional misuse cases reported to United States poison centers decreased in recent years, the likelihood of major medical effect/death among these cases have increased.
MeSH term(s)	Humans ; Benzodiazepines/poisoning ; Poison Control Centers/statistics & numerical data ; Male ; Female ; United States/epidemiology ; Aged ; Middle Aged ; Suicide, Attempted/statistics & numerical data ; Aged, 80 and over ; Drug Overdose/epidemiology ; Poisoning/epidemiology
Chemical Substances	Benzodiazepines (12794-10-4)
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2024.2334828
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Article ; Online: The oral microbiome, nitric oxide and exercise performance.

Bryan, Nathan S / Burleigh, Mia C / Easton, Chris

Nitric oxide : biology and chemistry

2022 Volume 125-126, Page(s) 23–30

Abstract: The human microbiome comprises ∼ ... ...

Abstract	The human microbiome comprises ∼10
MeSH term(s)	Bacteria/metabolism ; Exercise ; Humans ; Microbiota ; Nitrates/metabolism ; Nitric Oxide/metabolism ; Nitrites/metabolism ; Nitrogen Oxides/metabolism
Chemical Substances	Nitrates ; Nitrites ; Nitrogen Oxides ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2022-05-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2022.05.004
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Article ; Online: Comparison of Screening Scores for Heparin- Induced Thrombocytopenia After Cardiopulmonary Bypass.

Cutler, Nathan S / Marchant, Bryan E

Journal of cardiothoracic and vascular anesthesia

2022 Volume 36, Issue 9, Page(s) 3570–3575

Abstract: Objectives: To compare screening scores for heparin-induced thrombocytopenia (HIT) after cardiopulmonary bypass (CPB).: Design: Retrospective cohort study.: Setting: Cardiothoracic surgery units within a large tertiary healthcare facility from ... ...

Abstract	Objectives: To compare screening scores for heparin-induced thrombocytopenia (HIT) after cardiopulmonary bypass (CPB). Design: Retrospective cohort study. Setting: Cardiothoracic surgery units within a large tertiary healthcare facility from September 2010 to January 2020. Participants: All adult patients tested for heparin-induced platelet antibody (HIPA) within 2 weeks after surgery requiring CPB. Interventions: Using data available to providers at the time HIPA were checked, the 4T's Score, a modified 4T's Score, and a score proposed by Lillo-Le Louet (LLL) et al. were calculated. A retrospective chart review was performed for each patient to determine actual presence of HIT, and screening scores were compared for accuracy. Measurements and main results: Criteria for inclusion were met in 266 patients. Of these, 34 (12.8%) were high likelihood of HIT, 16 (6.0%), additional patients were clinically ambiguous, and 216 (81.2%) were high likelihood of alternative cause for thrombocytopenia. HIPA tests done before postoperative day 5 were not associated with any high-likelihood cases of HIT regardless of preoperative heparin exposure. Although traditional 4T's ≥4, modified 4T's ≥3, and LLL ≥2 had statistically similar sensitivity for predicting HIT, the modified 4T's and LLL had superior specificity (p < 0.001). Conclusions: Appropriate screening for HIT curbed inappropriate HIPA testing, and reduced the need for empirical treatment while awaiting confirmatory test results. Traditional 4T's was statistically inferior to both the LLL score and a modified version of the 4T's to screen for HIT within 2 weeks of CPB.
MeSH term(s)	Adult ; Anticoagulants/adverse effects ; Blood Platelets ; Cardiopulmonary Bypass/adverse effects ; Heparin/adverse effects ; Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis
Chemical Substances	Anticoagulants ; Heparin (9005-49-6)
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.04.007
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Article ; Online: Functional Nitric Oxide Nutrition to Combat Cardiovascular Disease.

Bryan, Nathan S

Current atherosclerosis reports

2018 Volume 20, Issue 5, Page(s) 21

Abstract: Purpose of review: To reveal the mechanisms of nitric oxide (NO) production in humans and how lifestyle, drug therapy, and hygienic practices can decrease NO production. Furthermore, to show how functional nitric oxide nutrition can overcome these ... ...

Abstract	Purpose of review: To reveal the mechanisms of nitric oxide (NO) production in humans and how lifestyle, drug therapy, and hygienic practices can decrease NO production. Furthermore, to show how functional nitric oxide nutrition can overcome these limitations to restore endogenous NO production and combat cardiovascular disease. Recent findings: Research over the past decade has revealed that inorganic nitrate and nitrite found naturally in green leafy vegetables and other vegetables such as beets can provide the human body with a source of bioactive nitric oxide. NO is one of the most important molecules produced within the cardiovascular system that maintains normal blood pressure and prevents inflammation, immune dysfunction, and oxidative stress, hallmarks of cardiovascular disease. This pathway is dependent upon the amount of inorganic nitrate and nitrite in the foods we eat, the presence of oral nitrate-reducing bacteria, and sufficient stomach acid production. The concept of food being medicine and medicine being food has lost its place in the practice and implementation of modern medicine over the past century. Certain dietary patterns and specific foods are known to confer very significant protective effects for many human diseases, including cardiovascular disease, the number one killer of men and women in the developed world. However, identification of single or multiple bioactive molecules that are responsible for these effects has escaped scientists and nutritionists for many years. This review will highlight the biochemical, physiological, and epidemiological basis for functional nitric oxide nutrition that can be safely and effectively utilized in patients.
MeSH term(s)	Blood Pressure ; Cardiovascular Diseases/prevention & control ; Female ; Humans ; Male ; Microbiota ; Nitrates ; Nitric Oxide/metabolism ; Nitrites ; Nutritional Status ; Vegetables/chemistry
Chemical Substances	Nitrates ; Nitrites ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2018-03-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057369-8
ISSN	1534-6242 ; 1523-3804
ISSN (online)	1534-6242
ISSN	1523-3804
DOI	10.1007/s11883-018-0723-0
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Article ; Online: Dietary nitrate biochemistry and physiology. An update on clinical benefits and mechanisms of action.

Bryan, Nathan S / Ahmed, Sophia / Lefer, David J / Hord, Norman / von Schwarz, Ernst R

Nitric oxide : biology and chemistry

2023 Volume 132, Page(s) 1–7

Abstract: It is now more than 35 years since endothelium derived relaxing factor was identified as nitric oxide (NO). The last few decades have seen an explosion around nitric oxide biochemistry, physiology and clinical translation. The science reveals that all ... ...

Abstract	It is now more than 35 years since endothelium derived relaxing factor was identified as nitric oxide (NO). The last few decades have seen an explosion around nitric oxide biochemistry, physiology and clinical translation. The science reveals that all chronic disease is associated with decreased blood flow to the affected organ which results in increased inflammation, oxidative stress and immune dysfunction. This is true for cardiovascular disease, neurological disease, kidney, lung, liver disorders and every other major disorder. Since nitric oxide controls and regulates blood flow, oxygen and nutrient delivery to every cell, tissue and organ in the body and also mitigates inflammation, oxidative stress and immune dysfunction, a focus on restoring nitric oxide production is an obvious therapeutic strategy for a number of poorly managed chronic diseases. Since dietary nitrate is a major contributor to endogenous nitric oxide production, it should be considered as a means of therapy and restoration of nitric oxide. This review will update on the current state of the science and effects of inorganic nitrate administered through the diet on several chronic conditions and reveal how much is needed. It is clear now that antiseptic mouthwash and use of antacids disrupt nitrate metabolism to nitric oxide leading to clinical symptoms of nitric oxide deficiency. Based on the science, nitrate should be considered an indispensable nutrient that should be accounted for in dietary guidelines.
MeSH term(s)	Humans ; Nitrates ; Nitrites/metabolism ; Nitric Oxide/metabolism ; Cardiovascular Diseases/metabolism ; Inflammation/drug therapy
Chemical Substances	Nitrates ; Nitrites ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2023.01.003
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Article ; Online: The potential use of salivary nitrite as a marker of NO status in humans.

Bryan, Nathan S

Nitric oxide : biology and chemistry

2015 Volume 45, Page(s) 4–6

MeSH term(s)	Biomarkers/analysis ; Cardiovascular Diseases ; Humans ; Metabolic Networks and Pathways ; Nitric Oxide/physiology ; Nitrites/analysis ; Saliva/chemistry
Chemical Substances	Biomarkers ; Nitrites ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2015-02-15
Publishing country	United States
Document type	Letter
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2014.12.011
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