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Article: Rheumatoid arthritis - medication dosage in chronic kidney disease.

Tyczyńska, Kinga Maria / Augustyniak-Bartosik, Hanna / Świerkot, Jerzy

2024 Volume 61, Issue 6, Page(s) 481–491

Abstract: Renal failure in the course of rheumatoid arthritis (RA) is a consequence of many factors, including drug-induced nephrotoxicity, comorbidities and chronic inflammation. Contemporary treatment strategies have reduced the incidence of renal failure in the ...

Abstract	Renal failure in the course of rheumatoid arthritis (RA) is a consequence of many factors, including drug-induced nephrotoxicity, comorbidities and chronic inflammation. Contemporary treatment strategies have reduced the incidence of renal failure in the population of RA patients. However, it remains a problem for approximately 25% of patients. Therefore, special attention should be paid to the potential need for dosage modifications of administered medications. Many drugs used in the therapy of rheumatic diseases have not been thoroughly studied for their safety in patients with reduced glomerular filtration, resulting in limited data in this area. The establishment of precise, transparent, and consistent dosage recommendations for antirheumatic drugs in chronic kidney disease would significantly facilitate the care of patients with RA. The following review provides a general summary of the available knowledge regarding the dosage of rheumatic medications in renal insufficiency and aims to highlight the need for further research in this area.
Language	English
Publishing date	2024-01-18
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum/177005
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Article: Association of MICA and NKG2D genetic variants with disease susceptibility and outcome of anti-TNF therapy in patients with axial spondyloarthritis.

Wielińska, Joanna / Bugaj, Bartosz / Świerkot, Jerzy / Kolossa, Katarzyna / Iwaszko, Milena / Jeka, Sławomir / Bogunia-Kubik, Katarzyna

Clinical and experimental rheumatology

2024

Abstract: Objectives: The disruption of the NKG2D-MICA axis can induce an enhanced immune response and promote autoimmune processes during axial spondyloarthritis (axSpA) pathogenesis. We aimed to investigate potential relationships between selected single ... ...

Abstract	Objectives: The disruption of the NKG2D-MICA axis can induce an enhanced immune response and promote autoimmune processes during axial spondyloarthritis (axSpA) pathogenesis. We aimed to investigate potential relationships between selected single nucleotide polymorphisms within the MICA and NKG2D genes and disease susceptibility and clinical parameters in axSpA patients treated with TNF inhibitors. Methods: Genotyping of MICA rs1051792 and NKG2D rs1154831, rs1049174, and rs2255336 was performed in 163 axSpA patients and 234 healthy controls using a real-time PCR method. Results: MICA rs1051792 A allele was more common in patients than in controls (p<0.0001). Patients with the AA genotype showed greater disease activity score (BASDAI) after three (p=4×10-4) and six (p=0.032) months of treatment compared to G carriers. After three months of therapy with anti-TNFs, the MICA AA homozygosity occurred more often in non-responsive or moderately responsive patients than good responders with the same genotype (p=1×10-4). Additionally, patients bearing the NKG2D rs1154831 CC genotype demonstrated lower BASDAI scores (p=0.035) and were significantly more common among subjects with a good outcome (p=0.004) after six months of treatment. Conclusions: These results suggest that MICA and NKG2D gene polymorphisms may be biomarkers associated with disease susceptibility and clinical outcomes after anti-TNF therapy in axSpA patients and imply a rather less favourable effect of the MICA A and NKG2D G genetic variants.
Language	English
Publishing date	2024-02-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/l5346i
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Article: COVID-19 prophylaxis, diagnostics, and treatment in patients with rheumatic diseases. The Polish experts panel opinion.

Kwiatkowska, Brygida / Krajewska-Włodarczyk, Magdalena / Batko, Bogdan / Maślińska, Maria / Stajszczyk, Marcin / Świerkot, Jerzy / Wiland, Piotr / Żuber, Zbigniew / Tomasiewicz, Krzysztof

Reumatologia

2024 Volume 62, Issue 1, Page(s) 4–17

Abstract: As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, infection management in vulnerable populations requires formalized guidance. Although low-virulence variants of SARS-CoV-2 remain predominant, they pose an increased risk of severe ... ...

Abstract	As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, infection management in vulnerable populations requires formalized guidance. Although low-virulence variants of SARS-CoV-2 remain predominant, they pose an increased risk of severe illness in adults with rheumatic and musculoskeletal diseases (RMDs). Several disease-specific (chronic long-grade inflammation, concomitant immunosuppression) and individual (advanced age, multimorbidity, pregnancy, vaccination status) factors contribute to excess risk in RMD populations. Various post-COVID-19 manifestations are also increasingly reported and appear more commonly than in the general population. At a pathogenetic level, complex interplay involving innate and acquired immune dysregulation, viral persistence, and genetic predisposition shapes a unique susceptibility profile. Moreover, incident cases of SARS-CoV-2 infection as a trigger factor for the development of autoimmune conditions have been reported. Vaccination remains a key preventive strategy, and encouraging active education and awareness will be crucial for rheumatologists in the upcoming years. In patients with RMDs, COVID-19 vaccines' benefits outweigh the risks. Derivation of specialized diagnostic and therapeutic protocols within a comprehensive COVID-19 care plan represents an ideal scenario for healthcare system organization. Vigilance for symptoms of infection and rapid diagnosis are key for introducing antiviral treatment in patients with RMDs in a timely manner. This review provides updated guidance on optimal immunization, diagnosis, and antiviral treatment strategies.
Language	English
Publishing date	2024-03-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum/183469
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Article: Searching for New Genetic Biomarkers of Axial Spondyloarthritis.

Bugaj, Bartosz / Wielińska, Joanna / Bogunia-Kubik, Katarzyna / Świerkot, Jerzy

Journal of clinical medicine

2022 Volume 11, Issue 10

Abstract: Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the spine. In addition to musculoskeletal symptoms, there are also extra-articular manifestations. The aim of this study was to search for new biomarkers associated with ... ...

Abstract	Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the spine. In addition to musculoskeletal symptoms, there are also extra-articular manifestations. The aim of this study was to search for new biomarkers associated with the clinical presentation and treatment response in axSpA patients. Methods: In this study, 106 axSpA patients and 110 healthy controls were enrolled. Six single-nucleotide polymorphisms (SNPs) were selected for genotyping: ERAP1 rs2287987, ERAP2 rs2549782, TNF rs1800629, TNFRSF1A rs767455, TNFRSF1B rs1061622, and FCGR2A rs1801274. Participants were examined at baseline and after 12 and 24 weeks of anti-TNF therapy. Results: SNPs associated with high axSpA initial activity were TNFRSF1A rs767455 and TNFRSF1B rs1061622 (p < 0.008). The ERAP1 rs2287987 AA genotype was more frequently observed in patients with enthesitis (AA vs. G+, p = 0.049), while the TNFRSF1B rs1061622 GG genotype was more common in participants with uveitis (GG vs. TT, p = 0.042). Potential in predicting anti-TNF treatment response was demonstrated by ERAP1 rs2287987, ERAP2 rs2549782, TNFRSF1B rs1061622, and FCGR2A rs1801274. Conclusions: SNPs can be used to identify patients at risk of severe disease to initiate treatment earlier. Genetic testing will allow clinicians to choose the right drug for the patient.
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11102912
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Article: The role of diet in rheumatoid arthritis.

Skoczyńska, Marta / Świerkot, Jerzy

Reumatologia

2018 Volume 56, Issue 4, Page(s) 259–267

Abstract: Rheumatoid arthritis (RA) is a systemic connective tissue disease which develops in the course of an autoimmune inflammatory process triggered by environmental factors in a genetically predisposed person. One of the environmental factors is the diet. RA ... ...

Abstract	Rheumatoid arthritis (RA) is a systemic connective tissue disease which develops in the course of an autoimmune inflammatory process triggered by environmental factors in a genetically predisposed person. One of the environmental factors is the diet. RA patients' adherence to a healthy diet remains low, despite plentiful data confirming positive effects of some foods, e.g. fish rich in n-3 polyunsaturated fatty acids (PUFAs), as well as the negative influence of unhealthy eating patterns, such as high consumption of fats and sugars, on RA incidence, activity and treatment response. In this review, we present current knowledge on the role of diet in rheumatoid arthritis, including dietary factors' preventive/promoting influence on RA development, as well as their impact on RA activity. We hope this article will aid and encourage clinicians to recommend a relevant dietary intervention to their RA patients.
Language	English
Publishing date	2018-08-31
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum.2018.77979
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Article ; Online: VDR Polymorphic Variants Are Related to Improvements in CRP and Disease Activity in Patients with Axial Spondyloarthritis That Undergo Anti-TNF Treatment.

Bugaj, Bartosz / Wielińska, Joanna / Świerkot, Jerzy / Bogunia-Kubik, Katarzyna / Górna, Katarzyna

Genes

2022 Volume 13, Issue 10

Abstract: Vitamin D deficiency is related with susceptibility or progression of various autoimmune diseases. The aim of the study was to assess potential relations between single nucleotide polymorphisms (SNPs) in the vitamin D receptor-coding gene ( ...

Abstract	Vitamin D deficiency is related with susceptibility or progression of various autoimmune diseases. The aim of the study was to assess potential relations between single nucleotide polymorphisms (SNPs) in the vitamin D receptor-coding gene (
MeSH term(s)	Humans ; Female ; Receptors, Calcitriol/genetics ; Genetic Predisposition to Disease ; Tumor Necrosis Factor Inhibitors ; Axial Spondyloarthritis ; Polymorphism, Single Nucleotide
Chemical Substances	Receptors, Calcitriol ; Tumor Necrosis Factor Inhibitors ; VDR protein, human
Language	English
Publishing date	2022-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13101873
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Article ; Online: Searching for New Genetic Biomarkers of Axial Spondyloarthritis

Bartosz Bugaj / Joanna Wielińska / Katarzyna Bogunia-Kubik / Jerzy Świerkot

Journal of Clinical Medicine, Vol 11, Iss 2912, p

2022 Volume 2912

Abstract	Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the spine. In addition to musculoskeletal symptoms, there are also extra-articular manifestations. The aim of this study was to search for new biomarkers associated with the clinical presentation and treatment response in axSpA patients. Methods: In this study, 106 axSpA patients and 110 healthy controls were enrolled. Six single-nucleotide polymorphisms (SNPs) were selected for genotyping: ERAP1 rs2287987, ERAP2 rs2549782, TNF rs1800629, TNFRSF1A rs767455, TNFRSF1B rs1061622, and FCGR2A rs1801274. Participants were examined at baseline and after 12 and 24 weeks of anti-TNF therapy. Results: SNPs associated with high axSpA initial activity were TNFRSF1A rs767455 and TNFRSF1B rs1061622 ( p < 0.008). The ERAP1 rs2287987 AA genotype was more frequently observed in patients with enthesitis ( AA vs. G+ , p = 0.049), while the TNFRSF1B rs1061622 GG genotype was more common in participants with uveitis ( GG vs. TT , p = 0.042). Potential in predicting anti-TNF treatment response was demonstrated by ERAP1 rs2287987, ERAP2 rs2549782, TNFRSF1B rs1061622, and FCGR2A rs1801274. Conclusions: SNPs can be used to identify patients at risk of severe disease to initiate treatment earlier. Genetic testing will allow clinicians to choose the right drug for the patient.
Keywords	spondyloarthritis ; ankylosing spondylitis ; SNP ; genetic biomarker ; extra-articular manifestations ; uveitis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Primary Immunodeficiencies: Diseases of Children and Adults - A Review.

Lewandowicz-Uszyńska, Aleksandra / Pasternak, Gerard / Świerkot, Jerzy / Bogunia-Kubik, Katarzyna

Advances in experimental medicine and biology

2020 Volume 1289, Page(s) 37–54

Abstract: Primary immunodeficiencies (PIDs) belong to a group of rare congenital diseases occurring all over the world that may be seen in both children and adults. In most cases, genetic predispositions are already known. As shown in this review, genetic ... ...

Abstract	Primary immunodeficiencies (PIDs) belong to a group of rare congenital diseases occurring all over the world that may be seen in both children and adults. In most cases, genetic predispositions are already known. As shown in this review, genetic abnormalities may be related to dysfunction of the immune system, which manifests itself as recurrent infections, increased risk of cancer, and autoimmune diseases. This article reviews the various forms of PIDs, including their characterization, management strategies, and complications. Novel aspects of the diagnostics and monitoring of PIDs are presented.
MeSH term(s)	Adult ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/genetics ; Child ; Genetic Predisposition to Disease ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/epidemiology ; Immunologic Deficiency Syndromes/genetics ; Neoplasms ; Primary Immunodeficiency Diseases
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/5584_2020_556
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Article: Leki biopodobne--szansa czy zagrozenie?

Swierkot, Jerzy

Wiadomosci lekarskie (Warsaw, Poland : 1960)

2013 Volume 66, Issue 2 Pt 2, Page(s) 200–205

Abstract: Strong interest in biosimilars dates back several years. In the coming years the patent protection ends for subsequent biological drugs, including monoclonal antibodies. This paper organizes the most important facts related to the issue of biosimilars. A ...

Title translation	Biosimilars--opportunity or threat?.
Abstract	Strong interest in biosimilars dates back several years. In the coming years the patent protection ends for subsequent biological drugs, including monoclonal antibodies. This paper organizes the most important facts related to the issue of biosimilars. A biosimilar is a biotherapeutic product which is similar in terms of quality, efficacy and safety to an already licensed reference biotherapeutic product'. It should be noted that biosimilars approved underthe current regulations of the European Medicines Agency (EMA) meet the stringent standards of safety, efficacy and immunogenicity. It is also important to realize that the biosimilar has the right to that name, if it is registered by regulatory authorities like EMA or FDA. One should not confuse biosimilar drugs with those which counterfeit or imitate. Clinical trials on the convertibility of innovative and biosimilar drugs are ongoing. Nevertheless,there is no regulatory framework and clear guidelines of conduct in this regard. In the near future, thanks to the registration of the first biosimilar monoclonal antibodies in rheumatology and gastroenterology the availability of biological treatment for patients should increase.
MeSH term(s)	Biological Products/standards ; Biological Products/therapeutic use ; Biosimilar Pharmaceuticals/standards ; Biosimilar Pharmaceuticals/therapeutic use ; Chronic Disease/drug therapy ; Drug and Narcotic Control ; Europe ; Guidelines as Topic ; Humans ; Pharmaceutical Preparations/standards ; Poland
Chemical Substances	Biological Products ; Biosimilar Pharmaceuticals ; Pharmaceutical Preparations
Language	Polish
Publishing date	2013
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	414731-5
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
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Article ; Online: Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis.

Frankowski, Marek / Świerkot, Jerzy / Gomułkiewicz, Marek / Korman, Lucyna / Skoczyńska, Marta / Starba, Aleksandra

Rheumatology international

2021 Volume 42, Issue 4, Page(s) 631–638

Abstract: Methotrexate (MTX) is recommended as a first-line treatment for rheumatoid arthritis (RA). There are no strict guidelines regarding monitoring for liver damage in RA patients. This study aimed to evaluate noninvasive diagnostic procedures in assessing ... ...

Abstract	Methotrexate (MTX) is recommended as a first-line treatment for rheumatoid arthritis (RA). There are no strict guidelines regarding monitoring for liver damage in RA patients. This study aimed to evaluate noninvasive diagnostic procedures in assessing liver fibrosis in RA patients. Ninety-six RA patients were recruited for this study. The procollagen III N-terminal peptide (PIIINP) serum level was measured in all patients. The Enhanced Liver Fibrosis score (ELF-1) was calculated for 82 patients. Transient elastography (TE) was performed in 91 patients, those examined were divided into two groups: a study and control group, comprising patients with and without risk factors for liver fibrosis, respectively. The TE result correlated only with the body mass index-BMI (p < 0.05); there was no correlation with the cumulative MTX dose (p = 0.33). The TE result was significantly higher in those with risk factors for liver fibrosis than in those without risk factors (TE result > = 7.1 kPa 28/42 vs 13/41, HR = 2.103, Mann-Whitney U test, approximately 0.02). There was a positive correlation between the PIIINP level and body weight (p = 0.028), cumulative MTX dose (p = 0.007), RA activity (p = 0.028) and diabetes mellitus (DM) (p = 0.001). There was a positive correlation between the ELF-1 score and age (p < 0.001), cumulative MTX dose (p = 0.007) and RA activity (p < 0.001). The PIIINP level and ELF-1 score are not organ specific, and readings may vary depending on RA activity. TE is organ specific and can be performed by a skilled ultrasonographer might be useful to assess actual liver condition.
MeSH term(s)	Arthritis, Rheumatoid/chemically induced ; Arthritis, Rheumatoid/drug therapy ; Chemical and Drug Induced Liver Injury/diagnostic imaging ; Chemical and Drug Induced Liver Injury/etiology ; Elasticity Imaging Techniques ; Humans ; Liver Cirrhosis/chemically induced ; Liver Diseases ; Methotrexate/adverse effects
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2021-12-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-05059-z
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