LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 70

Search options

  1. Book ; Online ; E-Book: Concepts in Biology

    Gilbert, Marc / Pirkmajer, Sergej

    A Historical Perspective

    2023  

    Language English
    Size 1 online resource (340 pages)
    Edition 1st ed.
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-394-23632-8 ; 1-394-23630-1 ; 9781786309402 ; 978-1-394-23632-9 ; 978-1-394-23630-5 ; 1786309408
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: AMPK and glucose deprivation exert an isoform-specific effect on the expression of Na

    Vidović, Anja / Dolinar, Klemen / Chibalin, Alexander V / Pirkmajer, Sergej

    Journal of muscle research and cell motility

    2024  

    Abstract: In skeletal muscle, ... ...

    Abstract In skeletal muscle, Na
    Language English
    Publishing date 2024-05-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 283053-x
    ISSN 1573-2657 ; 0142-4319
    ISSN (online) 1573-2657
    ISSN 0142-4319
    DOI 10.1007/s10974-024-09673-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2376: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 298: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Therapeutic hyperthermia for the treatment of infection-a narrative review.

    Markota, Andrej / Kalamar, Žiga / Fluher, Jure / Pirkmajer, Sergej

    Frontiers in physiology

    2023  Volume 14, Page(s) 1215686

    Abstract: Modulating body temperature, mostly through the use of antipyretics, is a commonly employed therapeutic intervention in medical practice. However, emerging evidence suggests that hyperthermia could serve as an adjuvant therapy for patients with infection. ...

    Abstract Modulating body temperature, mostly through the use of antipyretics, is a commonly employed therapeutic intervention in medical practice. However, emerging evidence suggests that hyperthermia could serve as an adjuvant therapy for patients with infection. We performed a narrative review to explore the application of therapeutic hyperthermia in the treatment of infection. A number of studies have been performed in the pre-antibiotic era, enrolling patients with neurosyphilis and gonococcal infections, with reported cure rates at around 60%-80%. We have outlined the potential molecular and immunological mechanisms explaining the possible beneficial effects of therapeutic hyperthermia. For some pathogens increased temperature exerts a direct negative effect on virulence; however, it is presumed that temperature driven activation of the immune system is probably the most important factor affecting microbial viability. Lastly, we performed a review of modern-era studies where modulation of body temperature has been used as a treatment strategy. In trials of therapeutic hypothermia in patients with infection worse outcomes have been observed in the hypothermia group. Use of antipyretics has not been associated with any improvement in clinical outcomes. In modern-era therapeutic hyperthermia achieved by physical warming has been studied in one pilot trial, and better survival was observed in the hyperthermia group. To conclude, currently there is not enough data to support the use of therapeutic hyperthermia outside clinical trials; however, available studies are in favor of at least a temperature tolerance strategy for non-neurocritical patients.
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1215686
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Hormonal regulation of Na

    Pirkmajer, Sergej / Chibalin, Alexander V

    Current topics in membranes

    2019  Volume 83, Page(s) 315–351

    Abstract: ... ...

    Abstract Na
    MeSH term(s) Animals ; Biological Evolution ; Hormones/metabolism ; Humans ; Sodium-Potassium-Exchanging ATPase/chemistry ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Hormones ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/bs.ctm.2019.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Insulin, dibutyryl-cAMP, and glucose modulate expression of patatin-like domain containing protein 7 in cultured human myotubes.

    Miš, Katarina / Lulić, Ana-Marija / Marš, Tomaž / Pirkmajer, Sergej / Katalinić, Maja

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1139303

    Abstract: Expression of patatin-like phospholipase domain containing protein 7 (PNPLA7), also known as neuropathy target esterase-related esterase (NRE), a lysophospholipase, increases with fasting and decreases with feeding in mouse skeletal muscle, indicating it ...

    Abstract Expression of patatin-like phospholipase domain containing protein 7 (PNPLA7), also known as neuropathy target esterase-related esterase (NRE), a lysophospholipase, increases with fasting and decreases with feeding in mouse skeletal muscle, indicating it is regulated by insulin, counterregulatory hormones, such as glucocorticoids and catecholamines, and/or nutrients. In cultured mouse adipocytes insulin reduces
    MeSH term(s) Humans ; Mice ; Animals ; Insulin/pharmacology ; Insulin/metabolism ; Glucose/metabolism ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Glucocorticoids/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2) ; Glucocorticoids ; RNA, Messenger
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1139303
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The role of AMPK in regulation of Na

    Pirkmajer, Sergej / Petrič, Metka / Chibalin, Alexander V

    Journal of muscle research and cell motility

    2021  Volume 42, Issue 1, Page(s) 77–97

    Abstract: AMP-activated protein kinase (AMPK) is a cellular energy gauge and a major regulator of cellular energy homeostasis. Once activated, AMPK stimulates nutrient uptake and the ATP-producing catabolic pathways, while it suppresses the ATP-consuming anabolic ... ...

    Abstract AMP-activated protein kinase (AMPK) is a cellular energy gauge and a major regulator of cellular energy homeostasis. Once activated, AMPK stimulates nutrient uptake and the ATP-producing catabolic pathways, while it suppresses the ATP-consuming anabolic pathways, thus helping to maintain the cellular energy balance under energy-deprived conditions. As much as ~ 20-25% of the whole-body ATP consumption occurs due to a reaction catalysed by Na
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Adenosine Triphosphatases/metabolism ; Humans ; Ions/metabolism ; Muscle, Skeletal/metabolism
    Chemical Substances Ions ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2021-01-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283053-x
    ISSN 1573-2657 ; 0142-4319
    ISSN (online) 1573-2657
    ISSN 0142-4319
    DOI 10.1007/s10974-020-09594-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2376: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 298: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells.

    Zandona, Antonio / Zorbaz, Tamara / Miš, Katarina / Pirkmajer, Sergej / Katalinić, Maja

    Arhiv za higijenu rada i toksikologiju

    2022  Volume 73, Issue 4, Page(s) 277–284

    Abstract: Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death. To investigate this further, we analysed interactions between these oximes and acetylcholine ... ...

    Abstract Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death. To investigate this further, we analysed interactions between these oximes and acetylcholine receptors (AChRs) and how they affect several signalling pathways to find a relation between the observed toxicities and their effects on these specific targets. Chlorinated bispyridinium oximes caused time-dependent cytotoxicity by inhibiting the phosphorylation of STAT3 and AMPK without decreasing ATP and activated ERK1/2 and p38 MAPK signal cascades. Imidazolium oximes induced a time-independent and significant decrease in ATP and inhibition of the ERK1/2 signalling pathway along with phosphorylation of p38 MAPK, AMPK, and ACC. These pathways are usually triggered by a change in cellular energy status or by external signals, which suggests that oximes interact with some membrane receptors. Interestingly,
    MeSH term(s) Humans ; Oximes/pharmacology ; Antidotes/pharmacology ; AMP-Activated Protein Kinases ; Pyridinium Compounds/toxicity ; Neuroblastoma ; p38 Mitogen-Activated Protein Kinases ; Adenosine Triphosphate ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/pharmacology ; Acetylcholinesterase/metabolism
    Chemical Substances Oximes ; Antidotes ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Pyridinium Compounds ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Adenosine Triphosphate (8L70Q75FXE) ; Cholinesterase Inhibitors ; Cholinesterase Reactivators ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2022-12-30
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 127289-5
    ISSN 1848-6312 ; 0004-1254
    ISSN (online) 1848-6312
    ISSN 0004-1254
    DOI 10.2478/aiht-2022-73-3688
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.550: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Stefin B Inhibits NLRP3 Inflammasome Activation via AMPK/mTOR Signalling.

    Trstenjak-Prebanda, Mojca / Biasizzo, Monika / Dolinar, Klemen / Pirkmajer, Sergej / Turk, Boris / Brault, Veronique / Herault, Yann / Kopitar-Jerala, Nataša

    Cells

    2023  Volume 12, Issue 23

    Abstract: Stefin B (cystatin B) is an inhibitor of lysosomal and nuclear cysteine cathepsins. The gene for stefin B is located on human chromosome 21 and its expression is upregulated in the brains of individuals with Down syndrome. Biallelic loss-of-function ... ...

    Abstract Stefin B (cystatin B) is an inhibitor of lysosomal and nuclear cysteine cathepsins. The gene for stefin B is located on human chromosome 21 and its expression is upregulated in the brains of individuals with Down syndrome. Biallelic loss-of-function mutations in the stefin B gene lead to Unverricht-Lundborg disease-progressive myoclonus epilepsy type 1 (EPM1) in humans. In our past study, we demonstrated that mice lacking stefin B were significantly more sensitive to sepsis induced by lipopolysaccharide (LPS) and secreted higher levels of interleukin 1-β (IL-1β) due to increased inflammasome activation in bone marrow-derived macrophages. Here, we report lower interleukin 1-β processing and caspase-11 expression in bone marrow-derived macrophages prepared from mice that have an additional copy of the stefin B gene. Increased expression of stefin B downregulated mitochondrial reactive oxygen species (ROS) generation and lowered the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in macrophages. We determined higher AMP-activated kinase phosphorylation and downregulation of mTOR activity in stefin B trisomic macrophages-macrophages with increased stefin B expression. Our study showed that increased stefin B expression downregulated mitochondrial ROS generation and increased autophagy. The present work contributes to a better understanding of the role of stefin B in regulation of autophagy and inflammasome activation in macrophages and could help to develop new treatments.
    MeSH term(s) Animals ; Humans ; Mice ; AMP-Activated Protein Kinases ; Cystatin B/physiology ; Inflammasomes/metabolism ; Interleukin-1 ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism ; TOR Serine-Threonine Kinases ; Transcription Factors
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Cystatin B (88844-95-5) ; Inflammasomes ; Interleukin-1 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Transcription Factors
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12232731
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Phosphorylation of Na

    Petrič, Metka / Vidović, Anja / Dolinar, Klemen / Miš, Katarina / Chibalin, Alexander V / Pirkmajer, Sergej

    The Journal of membrane biology

    2021  Volume 254, Issue 5-6, Page(s) 531–548

    Abstract: ... ...

    Abstract Na
    MeSH term(s) AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Adenosine Triphosphate/metabolism ; Cells, Cultured ; Epidermal Growth Factor/metabolism ; ErbB Receptors/metabolism ; Humans ; Ions/metabolism ; Kidney/metabolism ; Ouabain/pharmacology ; Phosphorylation/drug effects ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Ions ; Ouabain (5ACL011P69) ; Epidermal Growth Factor (62229-50-9) ; Adenosine Triphosphate (8L70Q75FXE) ; Sodium (9NEZ333N27) ; ErbB Receptors (EC 2.7.10.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3082-x
    ISSN 1432-1424 ; 0022-2631
    ISSN (online) 1432-1424
    ISSN 0022-2631
    DOI 10.1007/s00232-021-00209-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations.

    Bizjak, Maruša / Malavašič, Petra / Pirkmajer, Sergej / Pavlin, Mojca

    Biochemical and biophysical research communications

    2019  Volume 515, Issue 2, Page(s) 296–302

    Abstract: Metabolic pathways of cancer cells depend on the concentrations of nutrients in their micro-environment as well as on the cell-to-cell interactions. Here we examined the effects of glucose, pyruvate and glutamine on the sensitivity of MDA-MB-231 cells to ...

    Abstract Metabolic pathways of cancer cells depend on the concentrations of nutrients in their micro-environment as well as on the cell-to-cell interactions. Here we examined the effects of glucose, pyruvate and glutamine on the sensitivity of MDA-MB-231 cells to metabolic drug metformin using standard 2D culture, in which cells are grown in a monolayer, and 3D tumor spheroids, in which three-dimensional growth of cells better mimics a tumor. To examine effects of nutrients on metformin action, MDA-MB-231 cells were grown in commonly used media (DMEM, MEM and RPMI-1640) that differ mainly in the concentrations of amino acids. We used MTS assay and Hoechst and propidium iodide staining to determine cell number, viability and survival, respectively. We also determined the size of tumor spheroids and assessed effects of nutrients on metformin-stimulated AMP-activated protein kinase activation. Non-essential amino acids suppressed the effects of metformin on MDA-MB-231 cells in a 2D culture and in 3D tumor spheroids. Glutamine and pyruvate weakly diminished the effects of metformin in 2D culture. Furthermore, glucose protected tumor spheroids against metformin-induced disintegration. Our results show that nutrient availability must be considered when we evaluate the effects of metformin in 2D culture and in biologically more relevant 3D tumor spheroids.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Cell Culture Techniques/methods ; Cell Survival/drug effects ; Enzyme Activation/drug effects ; Female ; Glucose/metabolism ; Glucose/pharmacology ; Glutamine/metabolism ; Glutamine/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Metformin/pharmacology ; Nutrients/metabolism ; Pyruvic Acid/metabolism ; Pyruvic Acid/pharmacology ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Tumor Microenvironment/drug effects
    Chemical Substances Hypoglycemic Agents ; Glutamine (0RH81L854J) ; Pyruvic Acid (8558G7RUTR) ; Metformin (9100L32L2N) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2019.05.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top