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  1. Article: Methylene blue for refractory hypotension: a case report.

    Weissgerber, Alicia J

    AANA journal

    2008  Volume 76, Issue 4, Page(s) 271–274

    Abstract: Methylene blue has multiple indications for use, but recently it has been shown to be useful in treating refractory hypotension. Anaphylaxis results in widespread vasodilation and hypotension. Epinephrine has been described as the drug of choice in the ... ...

    Abstract Methylene blue has multiple indications for use, but recently it has been shown to be useful in treating refractory hypotension. Anaphylaxis results in widespread vasodilation and hypotension. Epinephrine has been described as the drug of choice in the treatment of hypotension for anaphylaxis, but the increased heart rate may be poorly tolerated by some patients. This case report describes a 79-year-old man with a history of diastolic dysfunction who was admitted for elective coronary artery bypass graft surgery. After induction of general anesthesia, symptoms of anaphylaxis developed with urticaria and decreased mean arterial pressure. The hypotension was refractory to vasoactive agents and volume repletion. Methylene blue was primed in the cardiopulmonary bypass pump and was effective in restoring hemodynamic stability. Furthermore, the patient required a decreased amount of vasoactive agents in the postoperative course. The suspected mechanism of action of methylene blue is inhibition of the enzyme nitric oxide synthase, which ultimately prevents the smooth muscle dilation that accompanies anaphylaxis. Methylene blue may be a valuable adjunct in the treatment of anaphylaxis and other causes of refractory hypotension.
    MeSH term(s) Aged ; Anaphylaxis/complications ; Anesthesia, General/adverse effects ; Anti-Bacterial Agents/adverse effects ; Antibiotic Prophylaxis/adverse effects ; Cardiopulmonary Bypass ; Cefazolin/adverse effects ; Coronary Artery Bypass ; Coronary Disease/surgery ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Guanylate Cyclase/antagonists & inhibitors ; Humans ; Hypotension/drug therapy ; Hypotension/etiology ; Male ; Methylene Blue/pharmacology ; Methylene Blue/therapeutic use ; Nitric Oxide Synthase/antagonists & inhibitors ; Patient Selection ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Enzyme Inhibitors ; Nitric Oxide Synthase (EC 1.14.13.39) ; Guanylate Cyclase (EC 4.6.1.2) ; Cefazolin (IHS69L0Y4T) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603605-3
    ISSN 0094-6354
    ISSN 0094-6354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1286: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Correlating an 11-point verbal numeric rating scale to a 4-point verbal rating scale in the measurement of pruritus.

    Jenkins, Herman H / Spencer, Eliot D / Weissgerber, Alicia J / Osborne, Lisa A / Pellegrini, Joseph E

    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

    2009  Volume 24, Issue 3, Page(s) 152–155

    Abstract: Pruritus, the subjective sensation of itch, can be a difficult symptom to assess and treat. Evaluating levels of patient discomfort across populations has proven to be challenging because of a lack of a standardized measurement tool to quantify levels of ...

    Abstract Pruritus, the subjective sensation of itch, can be a difficult symptom to assess and treat. Evaluating levels of patient discomfort across populations has proven to be challenging because of a lack of a standardized measurement tool to quantify levels of itch. The most widely used tool is the 4-point verbal rating scale (VRS-4), but others use an 11-point verbal numeric rating scale (VNRS-11). Therefore, the purpose of our study was to correlate a VNRS-11 to a VRS-4 for the assessment of pruritus. Fifty parturients were enrolled in this correlational study. Each subject's level of pruritus was measured at five specific intervals after administration of intrathecal opioids. The scales were administered one minute apart in random order. Data analysis demonstrated a strong correlation between these two scales, (r=.910 to .853) indicating that each verbal descriptor on the VRS-4 could readily be substituted with a quantifiable range on the VNRS-11.
    MeSH term(s) Humans ; Nursing Assessment ; Pruritus/diagnosis ; Pruritus/nursing ; Pruritus/physiopathology
    Language English
    Publishing date 2009-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329844-6
    ISSN 1532-8473 ; 0883-9433 ; 1089-9472
    ISSN (online) 1532-8473
    ISSN 0883-9433 ; 1089-9472
    DOI 10.1016/j.jopan.2009.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2458: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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