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Article ; Online: Policies and practice of solid organ donation amongst people living with HIV in Canada: time for education and re-evaluation.

Vulesevic, Branka / Lauscher, Darren / Kumar, Deepali / Sapir-Pichhadze, Ruth / Tchervenkov, Jean / Angel, Jonathan B / Wolfe, Cameron / Costiniuk, Cecilia T

HIV research & clinical practice

2024 Volume 25, Issue 1, Page(s) 2323848

Abstract: The numbers of organ donors in Canada and the USA fall short of increasing demand, resulting in increased morbidity, poor health outcomes, higher medical costs and death of many individuals waitlisted for transplantation. In the US, since 2013 when the ... ...

Abstract	The numbers of organ donors in Canada and the USA fall short of increasing demand, resulting in increased morbidity, poor health outcomes, higher medical costs and death of many individuals waitlisted for transplantation. In the US, since 2013 when the US HIV Organ Policy Equity (HOPE) Act lifted the ban on organ donation between people living with HIV, the option of using organs from People with HIV became a reality. In Canada, HIV diagnosis was an exclusion criterion to organ donation until 2017, when permission was granted if requirements for 'exceptional distribution' could be met. Still, donation of organs from people with HIV poses challenges. Herein, we overview policies involving donors with HIV in Canada in order to inform healthcare providers, researchers and the community. We also advocate for the need to reassess these policies, highlight educational needs and engage interest in advancing research to inform policy reforms.
MeSH term(s)	Humans ; Tissue and Organ Procurement ; Organ Transplantation/methods ; Health Policy ; Canada ; HIV Infections/diagnosis
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article ; Review
ISSN	2578-7470
ISSN (online)	2578-7470
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Article ; Online: Neutrophils and Circulating Inflammatory Biomarkers in Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction.

Chaar, Diana / Dumont, Benjamin L / Vulesevic, Branka / Neagoe, Paul-Eduard / Räkel, Agnès / White, Michel / Sirois, Martin G

The American journal of cardiology

2022 Volume 178, Page(s) 80–88

Abstract: Heart failure with preserved ejection fraction (HFpEF) is characterized by low-grade chronic inflammation, which could be exacerbated by type 2 diabetes mellitus (DM). We hypothesized that neutrophils in patients with DM and patients with HFpEF with/ ... ...

Abstract	Heart failure with preserved ejection fraction (HFpEF) is characterized by low-grade chronic inflammation, which could be exacerbated by type 2 diabetes mellitus (DM). We hypothesized that neutrophils in patients with DM and patients with HFpEF with/without DM contribute to low-grade inflammation through the release of pro-inflammatory cytokines. Venous blood was withdrawn from patients with DM (n = 22), HFpEF (n = 15), HFpEF with DM (n = 13), and healthy controls (CTL) (n = 21). Levels of circulating cytokines and in vitro cytokines released by isolated neutrophils were assessed by enzyme-linked immunosorbent assay. Compared with CTL, there was a significant decrease in circulating nitric oxide in patients with DM (p ≤0.001), HFpEF (p ≤0.05), and HFpEF with DM (p ≤0.001) up to 44%. Circulating soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels increased (up to 2.5-fold and 1.9-fold, respectively; p ≤0.001) in patients with HFpEF and patients with HFpEF and DM, whereas soluble E-selectin only increased in patients with HFpEF and DM (1.4-fold, p ≤0.001). Circulating vascular endothelial growth factor levels were similar in CTL and patients with DM but were decreased in patients with HFpEF with/without DM (up to 94%; p ≤0.001). Circulating C-reactive protein, interleukin (IL)-8, IL-6, and IL-receptor antagonist increased in all patient groups with a maximum of 3.3-fold, 4.7-fold, 4.8-fold, and 1.6-fold, respectively, in patients with HFpEF and patients with DM. In vitro, lipopolysaccharide increased neutrophils IL-6 release from HFpEF with DM (3.7-fold; p ≤0.001), and IL-8 release from DM and HFpEF with DM versus CTL (2.8-fold and 10.1-fold, respectively; p ≤0.001). IL-1 receptor antagonist and vascular endothelial growth factor release from HFpEF neutrophils significantly decreased up to 87.0% and 92.2%, respectively, versus CTL. Neutrophils from patients with DM and HFpEF release more cytokines than CTL. This increase in pro-inflammatory status may explain the greater event rate in patients with HFpEF and DM.
MeSH term(s)	Biomarkers ; Cytokines ; Diabetes Mellitus, Type 2/complications ; Heart Failure ; Humans ; Inflammation ; Interleukin-6 ; Neutrophils/metabolism ; Stroke Volume ; Vascular Endothelial Growth Factor A
Chemical Substances	Biomarkers ; Cytokines ; Interleukin-6 ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.05.026
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Article ; Online: Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.

Fadzeyeva, Evgenia / Locatelli, Cassandra A A / Trzaskalski, Natasha A / Nguyen, My-Anh / Capozzi, Megan E / Vulesevic, Branka / Morrow, Nadya M / Ghorbani, Peyman / Hanson, Antonio A / Lorenzen-Schmidt, Ilka / Doyle, Mary-Anne / Seymour, Richard / Varin, Elodie M / Fullerton, Morgan D / Campbell, Jonathan E / Mulvihill, Erin E

iScience

2023 Volume 26, Issue 5, Page(s) 106748

Abstract: Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 ...

Abstract	Mice systemically lacking dipeptidyl peptidase-4 (DPP4) have improved islet health, glucoregulation, and reduced obesity with high-fat diet (HFD) feeding compared to wild-type mice. Some, but not all, of this improvement can be linked to the loss of DPP4 in endothelial cells (ECs), pointing to the contribution of non-EC types. The importance of intra-islet signaling mediated by α to β cell communication is becoming increasingly clear; thus, our objective was to determine if β cell DPP4 regulates insulin secretion and glucose tolerance in HFD-fed mice by regulating the local concentrations of insulinotropic peptides. Using β cell double incretin receptor knockout mice, β cell- and pancreas-specific
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106748
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Article ; Online: Preventative behaviours and COVID-19 infection in a Canadian cohort of people living with HIV.

Hammond, Keely / Lee, Terry / Vulesevic, Branka / Singer, Joel / Needham, Judy / Burchell, Ann N / Samji, Hasina / Walmsley, Sharon / Hull, Mark / Jenabian, Mohammad-Ali / Routy, Jean-Pierre / Margolese, Shari / Mandarino, Enrico / Anis, Aslam H / Cooper, Curtis L / Costiniuk, Cecilia T

AIDS research and therapy

2023 Volume 20, Issue 1, Page(s) 73

Abstract: Few studies have examined preventative behaviour practices with respect to COVID-19 among people living with HIV (human immunodeficiency virus). Using a cross-sectional survey from a Canadian Institutes of Health Research Canadian HIV Trials Network ... ...

Abstract	Few studies have examined preventative behaviour practices with respect to COVID-19 among people living with HIV (human immunodeficiency virus). Using a cross-sectional survey from a Canadian Institutes of Health Research Canadian HIV Trials Network study (CTN 328) of people living with HIV on vaccine immunogenicity, we examined the relationships between participant characteristics and behavioural practices intended to prevent COVID-19 infection. Participants living in four Canadian urban centers were enrolled between April 2021-January 2022, at which time they responded to a questionnaire on preventative behaviour practices. Questionnaire and clinical data were combined to explore relationships between preventive behaviours and (1) known COVID-19 infection pre-enrolment, (2) multimorbidity, (3) developing symptomatic COVID-19 infection, and (4) developing symptomatic COVID-19 infection during the Omicron wave. Among 375 participants, 49 had COVID-19 infection pre-enrolment and 88 post-enrolment. The proportion of participants reporting always engaging in preventative behaviours included 87% masking, 79% physical distancing, 70% limiting social gatherings, 65% limiting contact with at-risk individuals, 33% self-isolating due to symptoms, and 26% self-quarantining after possible exposure. Participants with known COVID-19 infection pre-enrolment were more likely to self-quarantine after possible exposure although asymptomatic (65.0% vs 23.4%, p < 0.001; Chi-square test). Participants with multiple comorbidities more likely endorsed physical distancing (85.7% vs 75.5%, p = 0.044; Chi-square test), although this was not significant in logistic regression analysis adjusted for age, sex, race, number of household members, number of bedrooms/bathrooms in the household per person, influenza immunization, and working in close physical proximity to others. Overall, participants reported frequent practice of preventative behaviours.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; HIV ; Cross-Sectional Studies ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Canada/epidemiology
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173450-1
ISSN	1742-6405 ; 1742-6405
ISSN (online)	1742-6405
ISSN	1742-6405
DOI	10.1186/s12981-023-00571-7
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Article ; Online: Neutrophils pro-inflammatory and anti-inflammatory cytokine release in patients with heart failure and reduced ejection fraction.

Chaar, Diana / Dumont, Benjamin / Vulesevic, Branka / Neagoe, Paul-Eduard / Rakel, Agnes / Sirois, Martin G / White, Michel

ESC heart failure

2021 Volume 8, Issue 5, Page(s) 3855–3864

Abstract: Aims: Heart failure with reduced ejection fraction (HFrEF) is characterized by sub-clinical inflammation. Changes in selected biomarkers of inflammation concomitant with the release of pro-inflammatory and anti-inflammatory cytokines by neutrophils have ...

Abstract	Aims: Heart failure with reduced ejection fraction (HFrEF) is characterized by sub-clinical inflammation. Changes in selected biomarkers of inflammation concomitant with the release of pro-inflammatory and anti-inflammatory cytokines by neutrophils have not been investigated in patients with HFrEF. Methods and results: Fifty-two patients, aged 68.8 ± 1.7 years, with HFrEF and left ventricular ejection fraction 28.7 ± 1.0%, and 21 healthy controls (CTL) were recruited. Twenty-five HF patients had type 2 diabetes. Venous blood samples from HF and CTL were collected once. Neutrophil-derived pro-inflammatory and anti-inflammatory cytokine levels were assessed in plasma by ELISA. Plasma biomarkers assessed included: C-reactive protein (CRP), vascular endothelial growth factor (VEGF), interleukins (IL)-6, -8, -1 receptor antagonist (-1RA), nitric oxide (NO), soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1) and E-Selectin (sE-Sel). Neutrophils were isolated and stimulated with various agonists to promote VEGF, IL-6, IL-8, and IL-1RA release. Compared with CTL, HFrEF patients showed a marked decrease in circulating VEGF [178.0 (interquartile range; IQR 99.6; 239.2) vs. 16.2 (IQR 9.3; 20.2) pg/mL, P ≤ 0.001] and NO [45.2 (IQR 42.1; 57.6) vs. 40.6 (IQR 30.4; 47.1) pg/mL, P = 0.0234]. All other circulating biomarkers were significantly elevated. Neutrophils isolated from patients with HFrEF exhibited a greater IL-8 release in response to LPS [1.2 ± 0.1 (CTL); 10.4 ± 1.6 ng/mL (HFrEF) and 12.4 ± 1.6 ng/mL (HFrEF and DM), P ≤ 0.001]. IL-6 release in response to LPS was not changed in HFrEF patients without diabetes, whereas it was significantly increased in patients with HFrEF and diabetes [46.7 ± 3.9 (CTL) vs. 165.8 ± 48.0 pg/mL (HFrEF), P = 0.1713 and vs. 397.7 ± 67.4 pg/mL (HFrEF and DM), P ≤ 0.001]. In contrast, the release of VEGF and IL-1RA was significantly reduced in HFrEF (VEGF; TNF-α: 38.6 ± 3.1 and LPS: 25.3 ± 2.6 pg/mL; IL1RA; TNF-α: 0.6 ± 0.04 and LPS: 0.3 ± 0.02 ng/mL) compared with CTL (VEGF; TNF-α: 60.0 ± 9.4 and LPS: 41.2 ± 5.9 pg/mL; IL1RA; TNF-α: 3.3 ± 0.2 and LPS: 2.3 ± 0.1 ng/mL). Conclusions: Patients with HFrEF exhibit a significant decrease in circulating VEGF. The release of VEGF and both pro-inflammatory and anti-inflammatory cytokines from the stimulated neutrophils is markedly altered in these patients. The clinical significance of these findings deserves further investigation.
MeSH term(s)	Anti-Inflammatory Agents ; Cytokines ; Diabetes Mellitus, Type 2 ; Heart Failure ; Humans ; Neutrophils ; Stroke Volume ; Vascular Endothelial Growth Factor A ; Ventricular Function, Left
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13539
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Article ; Online: Natural History of Mitral Annular Calcification and Calcific Mitral Valve Disease.

Willner, Nadav / Burwash, Ian G / Beauchesne, Luc / Chan, Vince / Vulesevic, Branka / Ascah, Kathy / Coutinho, Thais / Promislow, Steve / Stadnick, Ellamae / Chan, Kwan L / Mesana, Thierry / Messika-Zeitoun, David

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2022 Volume 35, Issue 9, Page(s) 925–932

Abstract: Background: The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) have been poorly defined. The aim of this study was to evaluate the progression rate of MAC and of the development of CMVD. ...

Abstract	Background: The natural history of mitral annular calcification (MAC) and risk for developing calcific mitral valve disease (CMVD) have been poorly defined. The aim of this study was to evaluate the progression rate of MAC and of the development of CMVD. Methods: Patients with MAC and paired echocardiograms ≥1 year apart between 2005 and 2019 were included. Progression rates from mild or moderate to severe MAC and to CMVD (defined as severe MAC and significant mitral stenosis and/or regurgitation) were assessed, along with potential association with sex. Results: A total of 11,605 patients (mean age, 73 ± 10 years; 51% men) with MAC (78% mild, 17% moderate, 5% severe) were included and underwent follow-up echocardiography at 4.2 ± 2.7 years. Among patients with mild or moderate MAC, 33% presented with severe MAC at 10 years. The rate of severe MAC was higher in women than in men (41% vs 24% [P < .001]; hazard ratio, 1.3; P < .001) and in patients with moderate versus mild MAC (71% vs 22% [P < .001]; hazard ratio, 6.1; P < .001). At 10 years, 10% presented with CMVD (4%, 23%, and 60% in patients with mild, moderate, and severe MAC, respectively), which was predicted by female sex (15% vs 5%; P < .0001), even after adjustment for MAC severity (hazard ratio, 1.9; P < .001). Conclusion: In this large cohort of patients with MAC, progression to severe MAC was common and frequently resulted in CMVD. Female sex was associated with higher progression rates. MAC and CMVD are expected to dramatically increase as the population ages, highlighting the importance of a better understanding of the pathophysiology of MAC to develop effective preventive medical therapies.
MeSH term(s)	Aged ; Aged, 80 and over ; Calcinosis/diagnosis ; Calcinosis/diagnostic imaging ; Echocardiography ; Female ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/epidemiology ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve Stenosis/diagnostic imaging
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2022.05.007
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Article ; Online: Subclinical Inflammation in Heart Failure: A Neutrophil Perspective.

Vulesevic, Branka / Sirois, Martin G / Allen, Bruce G / de Denus, Simon / White, Michel

The Canadian journal of cardiology

2018 Volume 34, Issue 6, Page(s) 717–725

Abstract: Although it is widely recognized that inflammation plays a critical role in the development and pathology of heart failure (HF), very little is known about the involvement of one of the most abundant immune cells in the blood, a primary immune response ... ...

Abstract	Although it is widely recognized that inflammation plays a critical role in the development and pathology of heart failure (HF), very little is known about the involvement of one of the most abundant immune cells in the blood, a primary immune response cell: the neutrophil. This review summarizes the current literature on the role of subclinical inflammation, with a focus on the neutrophil in the pathophysiology of the HF syndrome. Some emerging therapeutic strategies are also discussed.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Asymptomatic Diseases ; Heart Failure/immunology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Immunity, Cellular ; Inflammation/diagnosis ; Inflammation/immunology ; Inflammation/therapy ; Neutrophils/immunology
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2018-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2018.01.018
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Article ; Online: Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities.

Lavoie, Simon S / Dumas, Elizabeth / Vulesevic, Branka / Neagoe, Paul-Eduard / White, Michel / Sirois, Martin G

Journal of immunology (Baltimore, Md. : 1950)

2018 Volume 200, Issue 11, Page(s) 3801–3813

Abstract: Neutrophil extracellular traps (NETs) are composed of nuclear DNA in a web-like structure extruded from neutrophils in response to either bacterial infection or inflammation. We previously reported the expression of angiopoietin Tie2 receptor on human ... ...

Abstract	Neutrophil extracellular traps (NETs) are composed of nuclear DNA in a web-like structure extruded from neutrophils in response to either bacterial infection or inflammation. We previously reported the expression of angiopoietin Tie2 receptor on human neutrophils and the capacity of both angiopoietins (Ang1 and Ang2) to induce proinflammatory activities, such as synthesis and release of platelet-activating factor, upregulation of β
MeSH term(s)	Angiopoietin-1/metabolism ; Angiopoietin-2/metabolism ; CD18 Antigens/metabolism ; Cells, Cultured ; Endothelial Cells/metabolism ; Extracellular Matrix/metabolism ; Extracellular Traps/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation/metabolism ; Neutrophils/metabolism ; Platelet Activating Factor/metabolism ; Receptor, TIE-2/metabolism ; Signal Transduction/physiology ; Up-Regulation/physiology
Chemical Substances	Angiopoietin-1 ; Angiopoietin-2 ; CD18 Antigens ; Platelet Activating Factor ; Receptor, TIE-2 (EC 2.7.10.1)
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1701203
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Article ; Online: Clinical implications of left atrial size adjustment: Impact of obesity.

Mulloy, Andrew / Siouti, Leila / Beauchesne, Luc / Chan, Kwan L / Vulesevic, Branka / Ascah, Kathy / Countinho, Thais / Promislow, Steve / Burwash, Ian G / Messika-Zeitoun, David

Archives of cardiovascular diseases

2021 Volume 114, Issue 8-9, Page(s) 561–569

Abstract: Background: American and European societies recommend using left atrial (LA) volume adjusted to body surface area (BSA) as the means of indexing LA volume to the patient's body size irrespective of morphometric characteristics.: Aim: To evaluate the ... ...

Abstract	Background: American and European societies recommend using left atrial (LA) volume adjusted to body surface area (BSA) as the means of indexing LA volume to the patient's body size irrespective of morphometric characteristics. Aim: To evaluate the impact of obesity on LA volume indexation to BSA on the presence and degree of LA enlargement. Methods: From our echocardiography database, we extracted all consecutive adults referred for a transthoracic echocardiography in 2019 (n=28,725; 64±17 years; 55% male; 31% obese [body mass index≥30kg/m Results: LA Conclusions: Indexing LA volume to measured BSA versus ideal BSA markedly underestimates the presence and severity of LA enlargement, especially in obese patients, with potential important clinical implications.
MeSH term(s)	Adult ; Diastole ; Female ; Heart Atria/diagnostic imaging ; Humans ; Male ; Obesity/complications ; Obesity/diagnosis ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2021-04-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2021.01.007
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Article ; Online: Understanding COVID-19 Vaccine Confidence in People Living with HIV: A pan-Canadian Survey.

Costiniuk, Cecilia T / Singer, Joel / Needham, Judy / Yang, Yanbo / Qian, Hong / Chambers, Catharine / Burchell, Ann N / Samji, Hasina / Colmegna, Ines / Del Canto, Sugandhi / Godin, Guy-Henri / Habanyama, Muluba / Hui, Christian / Kroch, Abigail / Mandarino, Enrico / Margolese, Shari / Martin, Carrie / Owino, Maureen / Mohammadi, Tima /

Zhang, Wei / Pelaez, Sandra / Kovacs, Colin / Benko, Erika / Vulesevic, Branka / Cooper, Curtis L / Anis, Aslam H

AIDS and behavior

2023 Volume 27, Issue 8, Page(s) 2669–2680

Abstract: Understanding the roots of Covid-19 vaccine hesitancy in at-risk groups, such as persons living with HIV (PLWH), is of utmost importance. We developed a modified Vaccine Hesitancy Scale (VHS) questionnaire using items from the National Advisory Committee ...

Abstract	Understanding the roots of Covid-19 vaccine hesitancy in at-risk groups, such as persons living with HIV (PLWH), is of utmost importance. We developed a modified Vaccine Hesitancy Scale (VHS) questionnaire using items from the National Advisory Committee on Immunization Acceptability Matrix. To examine factors associated with receiving COVID-19 vaccine and the link between vaccine attitudes and beliefs with vaccine behavior, PLWH were recruited via social media and community-based organizations (February-May 2022). Descriptive statistics were used to summarize results. Total VHS score was generated by adding Likert scale scores and linear regression models used to compare results between participants who received or did not receive COVID-19 vaccines. Logistic regression models were used to identify factors associated with vaccine uptake. A total of 246 PLWH indicated whether they received a COVID-19 vaccine. 89% received ≥ 1 dose. Mean total VHS(SD) for persons having received ≥ 1 COVID-19 vaccine was 17.8(6.2) vs. 35.4(9.4) for participants not having received any COVID-19 vaccine. Persons who received ≥ 1 dose were significantly older than those who had not received any (48.4 ± 13.8 vs. 34.0 ± 7.7 years, p < 0.0001). The majority of participants considered COVID-19 vaccination important for their health(81.3%) and the health of others(84.4%). Multivariate logistic regression revealed the odds of taking ≥ 1dose were increased 2.4-fold [95% CI 1.6, 3.5] with each increase in age of 10 years (p < 0.0001). Sex and ethnicity were not different between groups. In conclusion, PLWH accept COVID-19 vaccines for both altruistic and individual reasons. With evolving recommendations and increasing numbers of booster vaccines, we must re-examine the needs of PLWH regularly.
MeSH term(s)	Humans ; Child ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19/prevention & control ; Canada/epidemiology ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Ethnicity ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-023-03991-8
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