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Article ; Online: Medication Management Skills in Older Skilled Nursing Facility Residents Transitioning Home.

Marcum, Zachary A / Hardy, Susan E

Journal of the American Geriatrics Society

2015 Volume 63, Issue 6, Page(s) 1266–1268

MeSH term(s)	Aged ; Aged, 80 and over ; Cognition ; Cross-Sectional Studies ; Female ; Humans ; Male ; Patient Discharge ; Pilot Projects ; Prospective Studies ; Self Care/psychology ; Skilled Nursing Facilities
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.13469
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Article ; Online: Everything old is new again.

Hardy, Susan E

The journals of gerontology. Series A, Biological sciences and medical sciences

2009 Volume 64, Issue 1, Page(s) 149

MeSH term(s)	Aged ; Aging/blood ; Endocrine System Diseases/blood ; Endocrine System Diseases/drug therapy ; Hormones/therapeutic use ; Humans ; Prognosis
Chemical Substances	Hormones
Language	English
Publishing date	2009-01-20
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/gln036
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Article: Easing the Nursing Shortage: Tools for Retaining Nurses through Mentorship.

Bélanger-Hardy, Élisabeth / Palmer, Karen S / Kokorelias, Kristina M / Chan, Christine / Law, Susan

Nursing leadership (Toronto, Ont.)

2023 Volume 36, Issue 2, Page(s) 17–26

Abstract: To increase retention of nurses and ease the nursing shortage, innovative mentorship strategies must be implemented. Our rapid review shows that mentorship programs in hospitals for early-, mid- and late-career nurses is an effective way to improve nurse ...

Abstract	To increase retention of nurses and ease the nursing shortage, innovative mentorship strategies must be implemented. Our rapid review shows that mentorship programs in hospitals for early-, mid- and late-career nurses is an effective way to improve nurse retention. The unique needs of internationally educated nurses must also be considered in these programs to bolster the Canadian nursing workforce supply. We highlight five tools that are critical to the successful implementation of nurse mentorship programs in hospitals: (1) establish reciprocal relationships between mentors, mentees, hospital administrators and leaders (2) facilitate administrative structures, resources and support for mentors and mentees (3) enable effective features of mentorship programs (4) ensure that mentorship promotes professional and personal development and (5) support internationally educated nurses through mentorship.
MeSH term(s)	Humans ; Canada ; Hospitals ; Mentors ; Nursing Staff
Language	English
Publishing date	2023-11-15
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2115337-1
ISSN	1910-622X ; 1481-9643
ISSN	1910-622X ; 1481-9643
DOI	10.12927/cjnl.2023.27206
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Article: Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults.

Hardy, Susan E

The American journal of geriatric pharmacotherapy

2009 Volume 7, Issue 1, Page(s) 34–59

Abstract: Background: Depressive symptoms, fatigue, and apathy are common symptoms among medically ill older adults and patients with advanced disease, and have been associated with morbidity and mortality. Methylphenidate has been used to treat these symptoms ... ...

Abstract	Background: Depressive symptoms, fatigue, and apathy are common symptoms among medically ill older adults and patients with advanced disease, and have been associated with morbidity and mortality. Methylphenidate has been used to treat these symptoms because of its rapid effect. Despite the long history of methylphenidate use for the treatment of depressive symptoms, fatigue, and apathy, there is little definitive evidence to support its use. Objective: The aim of this paper was to review the efficacy and tolerability of methylphenidate in the treatment of depressive symptoms, fatigue, and apathy in medically ill older adults and adults receiving palliative care. Methods: English-language articles presenting systematic reviews, clinical trials, or case series describing the use of methylphenidate for the treatment of depressive symptoms, fatigue, or apathy in medically ill older adults or adults receiving palliative care were identified. The key words methylphenidate and either depressive, depression, fatigue, or apathy were used to search the Cochrane Database, MEDLINE, PsycINFO, and International Pharmaceutical Abstracts. Included articles addressed depressive symptoms, fatigue, or apathy in (1) older adults (generally, age > or =65 years), particularly those with comorbid medical illness; (2) adults receiving palliative care; and (3) adults with other chronic illnesses. I excluded articles regarding treatment of depression in healthy young adults; bipolar disorder and attention-deficit/hyperactivity disorder; and narcolepsy, chronic fatigue syndrome, and related disorders. Results: A total of 19 controlled trials of methylphenidate in medically ill older adults or patients in palliative care were identified. Unfortunately, their conflicting results, small sample sizes, and poor methodologic quality limited the ability to draw inferences regarding the efficacy of methylphenidate, although evidence of tolerability was stronger. The available evidence suggests possible effectiveness of methylphenidate for depressive symptoms, fatigue, and apathy in various medically ill populations. Conclusion: In the absence of definitive evidence of effectiveness, trials of low-dose methylphenidate in medically ill adults with depression, fatigue, or apathy, with monitoring for response and adverse effects, are appropriate.
MeSH term(s)	Aged ; Aged, 80 and over ; Antidepressive Agents/therapeutic use ; Chronic Disease/drug therapy ; Clinical Trials as Topic ; Depression/drug therapy ; Depression/psychology ; Fatigue/drug therapy ; Humans ; Methylphenidate/therapeutic use ; Terminally Ill/psychology
Chemical Substances	Antidepressive Agents ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2009-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2189280-5
ISSN	1876-7761 ; 1543-5946
ISSN (online)	1876-7761
ISSN	1543-5946
DOI	10.1016/j.amjopharm.2009.02.006
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Article ; Online: Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors.

Kleckner, Amber S / Kleckner, Ian R / Culakova, Eva / Wojtovich, Andrew P / Klinedinst, N Jennifer / Kerns, Sarah L / Hardy, Sara J / Inglis, Julia E / Padula, Gilbert D A / Mustian, Karen M / Janelsins, Michelle C / Dorsey, Susan G / Saligan, Leorey N / Peppone, Luke J

Nursing research

2022 Volume 71, Issue 5, Page(s) 411–417

Abstract: Background: Cancer-related fatigue is a prevalent, debilitating, and persistent condition. Mitochondrial dysfunction is a putative contributor to cancer-related fatigue, but relationships between mitochondrial function and cancer-related fatigue are not ...

Abstract	Background: Cancer-related fatigue is a prevalent, debilitating, and persistent condition. Mitochondrial dysfunction is a putative contributor to cancer-related fatigue, but relationships between mitochondrial function and cancer-related fatigue are not well understood. Objectives: We investigated the relationships between mitochondrial DNA (mtDNA) gene expression and cancer-related fatigue, as well as the effects of fish and soybean oil supplementation on these relationships. Methods: A secondary analysis was performed on data from a randomized controlled trial of breast cancer survivors 4-36 months posttreatment with moderate-severe cancer-related fatigue. Participants were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g each daily for 6 weeks. At pre- and postintervention, participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire and provided whole blood for assessment of mtDNA gene expression. The expression of 12 protein-encoding genes was reduced to a single dimension using principal component analysis for use in regression analysis. Relationships between mtDNA expression and cancer-related fatigue were assessed using linear regression. Results: Among 68 participants, cancer-related fatigue improved and expression of all mtDNA genes decreased over 6 weeks with no effect of treatment group on either outcome. Participants with lower baseline mtDNA gene expression had greater improvements in cancer-related fatigue. No significant associations were observed between mtDNA gene expression and cancer-related fatigue at baseline or changes in mtDNA gene expression and changes in cancer-related fatigue. Discussion: Data from this exploratory study add to the growing literature that mitochondrial dysfunction may contribute to the etiology and pathophysiology of cancer-related fatigue.
MeSH term(s)	Breast Neoplasms/complications ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Cancer Survivors ; DNA, Mitochondrial/genetics ; Fatigue/genetics ; Fatigue/therapy ; Female ; Gene Expression ; Genes, Mitochondrial ; Humans ; Soybean Oil
Chemical Substances	DNA, Mitochondrial ; Soybean Oil (8001-22-7)
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	80332-7
ISSN	1538-9847 ; 0029-6562
ISSN (online)	1538-9847
ISSN	0029-6562
DOI	10.1097/NNR.0000000000000598
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qualities of fatigue and associated chronic conditions among older adults.

Hardy, Susan E / Studenski, Stephanie A

Journal of pain and symptom management

2010 Volume 39, Issue 6, Page(s) 1033–1042

Abstract: Context: Although fatigue is a common and distressing symptom, a well-specified definition of fatigue is lacking. One of the least well-defined aspects of fatigue is its quality, which might reflect the underlying pathophysiology.: Objective: To ... ...

Abstract	Context: Although fatigue is a common and distressing symptom, a well-specified definition of fatigue is lacking. One of the least well-defined aspects of fatigue is its quality, which might reflect the underlying pathophysiology. Objective: To identify the qualities of fatigue and assess whether they are associated with distinct chronic conditions. Methods: We identified five fatigue qualities in the literature, two mental and three physical, and selected representative items from those available in our data from a prospective cohort of 495 community-dwelling primary care patients aged 65 years or older. We then examined the prevalence of each quality, the correlations among qualities, and the association of fatigue qualities with health and functional status, including chronic conditions. Results: Fatigue was very common among older primary care patients, with 70% reporting one or more fatigue qualities and 43% reporting feeling tired most of the time, and was associated with worse health and functional status. Physical fatigue qualities were more common than mental qualities. Correlations among fatigue qualities were 0.09-0.27 and did not support the mental vs. physical classification. Different fatigue qualities were not well explained by older adults' underlying chronic conditions. Rather, the cumulative number of fatigue qualities was associated with worse health and function. Conclusion: These first steps in exploring fatigue qualities suggest that different fatigue qualities could represent disparate manifestations of a common underlying etiology, while not ruling out distinct underlying pathophysiologies.
MeSH term(s)	Aged ; Chronic Disease ; Cognition/physiology ; Fatigue/diagnosis ; Fatigue/physiopathology ; Female ; Health Status ; Humans ; Male ; Muscle Fatigue/physiology ; Neuropsychological Tests
Language	English
Publishing date	2010-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2009.09.026
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Article: Identity in young adulthood: Links with mental health and risky behavior.

Schwartz, Seth J / Hardy, Sam A / Zamboanga, Byron L / Meca, Alan / Waterman, Alan S / Picariello, Simona / Luyckx, Koen / Crocetti, Elisabetta / Kim, Su Yeong / Brittian, Aerika S / Roberts, Sharon E / Whitbourne, Susan Krauss / Ritchie, Rachel A / Brown, Elissa J / Forthun, Larry F

Journal of applied developmental psychology

2021 Volume 36, Page(s) 39–52

Abstract: The present study was conducted to contribute to our understanding of young adult identity development by deriving latent profiles from intrapersonal and interpersonal indices of identity synthesis and confusion. A sample of 9737 college-attending young ... ...

Abstract	The present study was conducted to contribute to our understanding of young adult identity development by deriving latent profiles from intrapersonal and interpersonal indices of identity synthesis and confusion. A sample of 9737 college-attending young adults completed measures of identity, mental health, and health risk behaviors. Four latent profiles emerged: Synthesized (high synthesis, low confusion), Diffused (moderate synthesis, high confusion), Elevated (high synthesis and confusion), and Moderate (moderate synthesis and confusion). The Synthesized profile was associated with the highest well-being and the lowest levels of internalizing, externalizing, and health risks. The Diffused and Elevated profiles were both associated with low well-being and with high internalizing, externalizing, and risky behaviors - with the Elevated profile highest on all of the negative outcomes. The Moderate profile scored intermediately on well-being, internalizing, externalizing, and health risks. These results are discussed in terms of the role of identity within a successful transition to adulthood.
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ISSN	0193-3973
ISSN	0193-3973
DOI	10.1016/j.appdev.2014.10.001
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Article: Care of the HIV-infected pregnant woman in the developed world.

Hardy, Erica / Cu-Uvin, Susan

Obstetric medicine

2015 Volume 8, Issue 1, Page(s) 13–17

Abstract: The reduction of human immunodeficiency virus (HIV) transmission from mother to child is one of the success stories of modern medicine and public health. In the developed world, with universal HIV counseling and testing, antiretroviral prophylaxis, ... ...

Abstract	The reduction of human immunodeficiency virus (HIV) transmission from mother to child is one of the success stories of modern medicine and public health. In the developed world, with universal HIV counseling and testing, antiretroviral prophylaxis, scheduled Caesarean delivery if indicated, and avoidance of breastfeeding, HIV transmission from mother to infant can be <2%. Despite this, transmissions continue to occur, often due to lack of knowledge of HIV status. Missed opportunities for prevention and prevention challenges include late prenatal care, lack of HIV testing in pregnancy, lack of preconception counseling, unintended pregnancy, and substance abuse. We review preconception counseling including options for serodiscordant couples, and antepartum, peripartum and postpartum care of the HIV-infected woman in the developed world, and advocate for a comprehensive, collaborative, multidisciplinary approach.
Language	English
Publishing date	2015-05-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612229-7
ISSN	1753-4968 ; 1753-495X
ISSN (online)	1753-4968
ISSN	1753-495X
DOI	10.1177/1753495X14531753
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Article: Fatigue and function over 3 years among older adults.

Hardy, Susan E / Studenski, Stephanie A

The journals of gerontology. Series A, Biological sciences and medical sciences

2008 Volume 63, Issue 12, Page(s) 1389–1392

Abstract: Background: Fatigue is a common complaint among older adults, but the association of fatigue with subsequent function is not well known.: Methods: This 3-year longitudinal study of older primary care patients evaluates the association of fatigue, ... ...

Abstract	Background: Fatigue is a common complaint among older adults, but the association of fatigue with subsequent function is not well known. Methods: This 3-year longitudinal study of older primary care patients evaluates the association of fatigue, operationalized as feeling tired most of the time, with functional status at baseline and over time. Results: After adjustment for multiple potential confounders, participants who were tired at baseline had worse Short Form-36 Physical Performance Index scores, activity of daily living scores, and gait speeds. These functional deficits persisted throughout the follow-up period. Conclusions: Fatigue in older adults is associated with functional deficits that persist for years. Further research is needed to understand the causes of fatigue and to develop specific treatments for this serious symptom.
MeSH term(s)	Activities of Daily Living ; Aged ; Comorbidity ; Fatigue/epidemiology ; Fatigue/physiopathology ; Female ; Health Status Indicators ; Humans ; Linear Models ; Male
Language	English
Publishing date	2008-12-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/63.12.1389
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Article ; Online: Assessing the impact of a national social marketing campaign for antimicrobial resistance on public awareness, attitudes, and behaviour, and as a supportive tool for healthcare professionals, England, 2017 to 2019.

Gilham, Ellie L / Casale, Ella / Hardy, Alison / Ayeni, Adeola H / Sunyer, Ella / Harris, Tori / Feechan, Rachel / Heltmann, Anna / Fawcett, Malcolm / Hopkins, Susan / Ashiru-Oredope, Diane

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 28, Issue 47

Abstract: BackgroundPrevious United Kingdom campaigns targeting antimicrobial resistance (AMR) recommended running multimedia campaigns over an increased timeframe. The 3-year-long Keep Antibiotics Working (KAW) campaign was a mass media campaign in England ... ...

Abstract	BackgroundPrevious United Kingdom campaigns targeting antimicrobial resistance (AMR) recommended running multimedia campaigns over an increased timeframe. The 3-year-long Keep Antibiotics Working (KAW) campaign was a mass media campaign in England targeting the public and general practitioners (GPs).MethodsEvery year, pre- and post-campaign questionnaire data were collected from the public, whereas post-campaign interview data were obtained from GPs. Data were weighted to allow pre- and post-campaign comparisons between independent samples. Significant changes in nominal and ordinal data were determined using Pearson's chi-squared (
MeSH term(s)	Child ; Humans ; Anti-Bacterial Agents/therapeutic use ; Social Marketing ; Drug Resistance, Bacterial ; England ; Health Personnel ; Health Knowledge, Attitudes, Practice
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-11-24
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2023.28.47.2300100
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