LIVIVO - Search results -

Search results

Result 1 - 10 of total 77

Search options

Article ; Online: Methylprednisolone for Coronavirus Disease 2019 (COVID-19): Was Benjamin Rush Prescient?

Lennox, Jeffrey L

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 72, Issue 9, Page(s) e382–e383

MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19 ; Double-Blind Method ; Humans ; Methylprednisolone ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	English
Publishing date	2020-08-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa1262
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Methylprednisolone for COVID-19: Was Benjamin Rush prescient?

Lennox, Jeffrey L

Clin. infect. dis

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #732026
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Methylprednisolone for Coronavirus Disease 2019 (COVID-19)

Lennox, Jeffrey L

Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

Was Benjamin Rush Prescient?

2020

Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/cid/ciaa1262
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The use of HIV-1 integrase inhibitors in antiretroviral naive patients.

Lennox, Jeffrey L

Current opinion in HIV and AIDS

2012 Volume 7, Issue 5, Page(s) 409–414

Abstract: Purpose of review: In this review we will discuss recent findings on the use of inhibitors of the HIV-1 integrase enzyme for the treatment of antiretroviral naive patients. We will also discuss differences between integrase inhibitors, and comment on ... ...

Abstract	Purpose of review: In this review we will discuss recent findings on the use of inhibitors of the HIV-1 integrase enzyme for the treatment of antiretroviral naive patients. We will also discuss differences between integrase inhibitors, and comment on the use of this class of drugs in the future. Recent findings: Raltegravir when taken twice daily is as effective and well tolerated as efavirenz. Once daily dosing of raltegravir is virologically inferior to raltegravir taken twice daily. A novel nucleoside-free regimen of raltegravir in combination with a once daily ritonavir-boosted protease inhibitor did not produce adequate viral suppression, although raltegravir with a twice daily protease inhibitor yielded better results. Subset analyses have demonstrated a favorable impact of raltegravir on lipid levels and body fat composition. Two once daily integrase inhibitors not yet Food and Drug Administration-approved, elvitegravir and dolutegravir, have completed phase-2 testing and are also virologically noninferior to efavirenz. Summary: Integrase inhibitors provide potent antiretroviral activity, little short-term toxicity and excellent tolerability. For patients with preexisting atherosclerosis or cardiac risk factors this class of therapy is a logical preferred treatment choice. Raltegravir is a preferred option for those in whom therapy for hepatitis C virus infection is anticipated.
MeSH term(s)	Antiretroviral Therapy, Highly Active/methods ; Clinical Trials as Topic ; Coinfection/drug therapy ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/therapeutic use ; Hepatitis C/drug therapy ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Oxazines ; Piperazines ; Pyridones ; Pyrrolidinones/therapeutic use ; Quinolones/therapeutic use ; Raltegravir Potassium ; Treatment Outcome
Chemical Substances	HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; Pyrrolidinones ; Quinolones ; Raltegravir Potassium (43Y000U234) ; elvitegravir (4GDQ854U53) ; dolutegravir (DKO1W9H7M1)
Language	English
Publishing date	2012-05-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502511-9
ISSN	1746-6318 ; 1746-630X
ISSN (online)	1746-6318
ISSN	1746-630X
DOI	10.1097/COH.0b013e3283562a27
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6812: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lymphocyte Count Derived Polygenic Score and Interindividual Variability in CD4 T-cell Recovery in Response to Antiretroviral Therapy.

Cardone, Kathleen M / Dudek, Scott / Keat, Karl / Bradford, Yuki / Cindi, Zinhle / Daar, Eric S / Gulick, Roy / Riddler, Sharon A / Lennox, Jeffrey L / Sinxadi, Phumla / Haas, David W / Ritchie, Marylyn D

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

2023 Volume 29, Page(s) 594–610

Abstract: Access to safe and effective antiretroviral therapy (ART) is a cornerstone in the global response to the HIV pandemic. Among people living with HIV, there is considerable interindividual variability in absolute CD4 T-cell recovery following initiation of ...

Abstract	Access to safe and effective antiretroviral therapy (ART) is a cornerstone in the global response to the HIV pandemic. Among people living with HIV, there is considerable interindividual variability in absolute CD4 T-cell recovery following initiation of virally suppressive ART. The contribution of host genetics to this variability is not well understood. We explored the contribution of a polygenic score which was derived from large, publicly available summary statistics for absolute lymphocyte count from individuals in the general population (PGSlymph) due to a lack of publicly available summary statistics for CD4 T-cell count. We explored associations with baseline CD4 T-cell count prior to ART initiation (n=4959) and change from baseline to week 48 on ART (n=3274) among treatment-naïve participants in prospective, randomized ART studies of the AIDS Clinical Trials Group. We separately examined an African-ancestry-derived and a European-ancestry-derived PGSlymph, and evaluated their performance across all participants, and also in the African and European ancestral groups separately. Multivariate models that included PGSlymph, baseline plasma HIV-1 RNA, age, sex, and 15 principal components (PCs) of genetic similarity explained ∼26-27% of variability in baseline CD4 T-cell count, but PGSlymph accounted for <1% of this variability. Models that also included baseline CD4 T-cell count explained ∼7-9% of variability in CD4 T-cell count increase on ART, but PGSlymph accounted for <1% of this variability. In univariate analyses, PGSlymph was not significantly associated with baseline or change in CD4 T-cell count. Among individuals of African ancestry, the African PGSlymph term in the multivariate model was significantly associated with change in CD4 T-cell count while not significant in the univariate model. When applied to lymphocyte count in a general medical biobank population (Penn Medicine BioBank), PGSlymph explained ∼6-10% of variability in multivariate models (including age, sex, and PCs) but only ∼1% in univariate models. In summary, a lymphocyte count PGS derived from the general population was not consistently associated with CD4 T-cell recovery on ART. Nonetheless, adjusting for clinical covariates is quite important when estimating such polygenic effects.
MeSH term(s)	Humans ; CD4-Positive T-Lymphocytes ; Prospective Studies ; Anti-HIV Agents/therapeutic use ; Computational Biology ; HIV Infections/drug therapy ; HIV Infections/genetics ; CD4 Lymphocyte Count ; Viral Load
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ISSN	2335-6936
ISSN (online)	2335-6936
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Three nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1.

Lennox, Jeffrey L / Landovitz, Raphael J / Ribaudo, Heather J

Annals of internal medicine

2015 Volume 162, Issue 6, Page(s) 461–462

MeSH term(s)	Female ; HIV Infections/drug therapy ; HIV Protease Inhibitors/therapeutic use ; HIV-1 ; Humans ; Male
Chemical Substances	HIV Protease Inhibitors
Language	English
Publishing date	2015-03-17
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L15-5066-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.178/2: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.

Li, Binglan / Veturi, Yogasudha / Verma, Anurag / Bradford, Yuki / Daar, Eric S / Gulick, Roy M / Riddler, Sharon A / Robbins, Gregory K / Lennox, Jeffrey L / Haas, David W / Ritchie, Marylyn D

PLoS genetics

2021 Volume 17, Issue 4, Page(s) e1009464

Abstract: As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing. However, the development of TWAS has outpaced statistical evaluation of TWAS gene ... ...

Abstract	As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing. However, the development of TWAS has outpaced statistical evaluation of TWAS gene prioritization performance. Current TWAS methods vary in underlying biological assumptions about tissue specificity of transcriptional regulatory mechanisms. In a previous study from our group, this may have affected whether TWAS methods better identified associations in single tissues versus multiple tissues. We therefore designed simulation analyses to examine how the interplay between particular TWAS methods and tissue specificity of gene expression affects power and type I error rates for gene prioritization. We found that cross-tissue identification of expression quantitative trait loci (eQTLs) improved TWAS power. Single-tissue TWAS (i.e., PrediXcan) had robust power to identify genes expressed in single tissues, but, often found significant associations in the wrong tissues as well (therefore had high false positive rates). Cross-tissue TWAS (i.e., UTMOST) had overall equal or greater power and controlled type I error rates for genes expressed in multiple tissues. Based on these simulation results, we applied a tissue specificity-aware TWAS (TSA-TWAS) analytic framework to look for gene-based associations with pre-treatment laboratory values from AIDS Clinical Trial Group (ACTG) studies. We replicated several proof-of-concept transcriptionally regulated gene-trait associations, including UGT1A1 (encoding bilirubin uridine diphosphate glucuronosyltransferase enzyme) and total bilirubin levels (p = 3.59×10-12), and CETP (cholesteryl ester transfer protein) with high-density lipoprotein cholesterol (p = 4.49×10-12). We also identified several novel genes associated with metabolic and virologic traits, as well as pleiotropic genes that linked plasma viral load, absolute basophil count, and/or triglyceride levels. By highlighting the advantages of different TWAS methods, our simulation study promotes a tissue specificity-aware TWAS analytic framework that revealed novel aspects of HIV-related traits.
MeSH term(s)	Computer Simulation ; Gene Expression Regulation/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Organ Specificity/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Transcriptome/genetics
Language	English
Publishing date	2021-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1009464
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance.

Anderson, Albert M / Tyor, William R / Mulligan, Mark J / Waldrop-Valverde, Drenna / Lennox, Jeffrey L / Letendre, Scott L

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2018 Volume 67, Issue 1, Page(s) 137–140

Abstract: New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 ... ...

Abstract	New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 concentration and worse neuropsychological performance.
MeSH term(s)	Adult ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV Core Protein p24/cerebrospinal fluid ; HIV Infections/cerebrospinal fluid ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Neurocognitive Disorders/diagnosis ; Neurocognitive Disorders/etiology ; Neuropsychological Tests ; RNA, Viral/blood ; RNA, Viral/cerebrospinal fluid
Chemical Substances	HIV Core Protein p24 ; RNA, Viral
Language	English
Publishing date	2018-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciy056
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy.

Amundson, Beret / Lai, Lillin / Mulligan, Mark J / Xu, Yong / Zheng, Zidou / Kundu, Suprateek / Lennox, Jeffrey L / Waldrop-Valverde, Drenna / Franklin, Donald / Swaims-Kohlmeier, Alison / Letendre, Scott L / Anderson, Albert M

Journal of neuroimmunology

2020 Volume 344, Page(s) 577246

Abstract: We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was ... ...

Abstract	We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
MeSH term(s)	Adult ; Antiretroviral Therapy, Highly Active/methods ; Cognition/drug effects ; Cognition/physiology ; Female ; Follow-Up Studies ; HIV Infections/cerebrospinal fluid ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Immunity, Cellular/drug effects ; Immunity, Cellular/immunology ; Male ; Middle Aged ; Retrospective Studies ; Viral Load/drug effects ; Viral Load/immunology
Language	English
Publishing date	2020-04-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2020.577246
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1646: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Antiretroviral therapy: when to start and which drugs to use.

Anderson, Albert M / Lennox, Jeffrey L

Current infectious disease reports

2008 Volume 10, Issue 4, Page(s) 332–339

Abstract: US guidelines for treating HIV infection now advocate antiretroviral therapy (ART) for all HIV-infected patients who have CD4(+) T-cell counts less than 350 cells/muL. Treatment is recommended for all pregnant women and patients with AIDS-defining ... ...

Abstract	US guidelines for treating HIV infection now advocate antiretroviral therapy (ART) for all HIV-infected patients who have CD4(+) T-cell counts less than 350 cells/muL. Treatment is recommended for all pregnant women and patients with AIDS-defining illnesses. At least one major guideline recommends ART for all patients with HIV--associated symptoms. Current first-line treatment for ART-naïve individuals consists of a combination of three agents: two nucleoside reverse transcriptase inhibitors plus either one ritonavir-boosted protease inhibitor or one nonnucleoside reverse transcriptase inhibitor (NNRTI). Although first-line therapies for HIV-infection provide excellent rates of virologic control, ART toxicities remain a challenge.
Language	English
Publishing date	2008-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-008-0053-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5519: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito