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Book ; Online: Age-Related Macular Degeneration and Diabetic Retinopathy

Westenskow, Peter D. / Ebneter, Andreas

2022

Keywords	Research & information: general ; Biology, life sciences ; subthreshold micropulse laser ; 577-nm laser ; laser fixed parameters ; diabetic retinopathy ; diabetic macular edema ; optical coherence tomography ; autofluorescence ; real-life ; diabetic macular oedema ; visual prognosis ; indicators ; personalized medicine ; age-related macular degeneration ; choroidal neovascularization ; classification ; machine learning ; type 2 diabetes ; retinopathy ; ethnicity ; general practice ; risk factors ; progression ; glycemic gap ; glucose variability ; ETDRS classification ; biomarkers ; phenotypes ; anti-vascular endothelial growth factor ; diabetic retinopathy severity scale ; panretinal leakage index ; neovascular age-related macular degeneration ; anti-VEGF therapy ; retinal thickness ; visual acuity ; variability ; leakage index ; microaneurysms ; intravitreal aflibercept ; neovascularization ; ultra-widefield fluorescein angiography ; retinal imaging ; quantitative biomarkers ; precision medicine ; autoantibodies ; AT1-receptor ; PAR1 ; VEGF-A ; VEGF-B ; VEGF-receptor 2 ; AMD ; complement system ; semi-quantitative multiplex profilin ; mass spectrometry ; C4 ; vitronectin ; factor I ; genetic variants ; metabolites ; HDL ; central area thickness ; biomarker ; microRNA ; anti-VEGF ; retina ; edema ; OCT ; tomography ; microphysiological systems ; blood-neural barriers ; neurovascular unit ; disease modeling ; 3D models ; organ-on-a-chip ; inner blood-retinal barrier ; n/a
Language	0\|e
Size	1 electronic resource (228 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021610371
ISBN	9783036542096 ; 3036542094
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Age-Related Macular Degeneration and Diabetic Retinopathy.

Ebneter, Andreas / Westenskow, Peter D

Journal of personalized medicine

2022 Volume 12, Issue 4

Abstract: More than 15 years ago, the results of the pivotal trials supporting the intravitreal use of ranibizumab were published [ ... ]. ...

Abstract	More than 15 years ago, the results of the pivotal trials supporting the intravitreal use of ranibizumab were published [...].
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12040581
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Age-Related Macular Degeneration and Diabetic Retinopathy

Andreas Ebneter / Peter D. Westenskow

Journal of Personalized Medicine, Vol 12, Iss 581, p

2022 Volume 581

Abstract: More than 15 years ago, the results of the pivotal trials supporting the intravitreal use of ranibizumab were published [.] ...

Abstract	More than 15 years ago, the results of the pivotal trials supporting the intravitreal use of ranibizumab were published [.]
Keywords	n/a ; Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Basic Training in Palliative Medicine for Internal Medicine Residents: Pilot Testing of a Canadian Model in Switzerland.

Ebneter, Andreas Samuel / Kaya, Ebru / Mair, Petra / Affollter, Barbara / Eychmueller, Steffen

Palliative medicine reports

2024 Volume 5, Issue 1, Page(s) 171–176

Abstract: Background: In Switzerland, palliative care (PC) clinical training is well established at undergraduate and specialist postgraduate levels. However, postgraduate nonspecialist training curricula are less documented.: Local problem: A structured ... ...

Abstract	Background: In Switzerland, palliative care (PC) clinical training is well established at undergraduate and specialist postgraduate levels. However, postgraduate nonspecialist training curricula are less documented. Local problem: A structured curriculum for nonspecialist rotation within internal medicine (IM) in specialized PC wards is lacking. Objective: To pilot two versions of a PC nonspecialist curriculum for IM residents in Swiss PC units. Methods: In the pilot phase, two curricula-short immersion (3-10 weeks, based on the University of Toronto's Internal-Medicine PC Rotation) and standard nonspecialist (11-18 weeks, based on the Canadian Society of Palliative Care Physician Competencies)-were assessed using a mixed-method online survey. One university and two nonuniversity sites participated. The analysis was descriptive. Results: Five residents and eight supervisors of five training rotations (July-October 2023) responded. Overall, curriculum quality and feasibility (content and time) received positive ratings across all groups, with high satisfaction concerning organization, educational design, learning support, climate, experience, and facilities. Nonuniversity sites were generally rated more positively than university sites. Qualitative feedback paralleled these findings, highlighting the curriculum's relevance and fit with learners' needs and suggesting potential simplifications and more personalized planning. Conclusions: Establishing short and standard duration curricula for a PC program is viable and well received by nonspecialist trainees. Future implementation should concentrate on personalized learning objectives and streamlining the content and structure of the competencies. Cooperation within various training settings (university and regional hospitals) as well as on an international level (e.g., Canada-Switzerland) may further improve the quality of the proposed training formats.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ISSN	2689-2820
ISSN (online)	2689-2820
DOI	10.1089/pmr.2024.0004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perceptions and needs of an outpatient palliative care team regarding digital care conferences in palliative care: a mixed-method online survey.

Ebneter, Andreas Samuel / Maessen, Maud / Sauter, Thomas C / Jenelten, Georgette / Eychmueller, Steffen

Swiss medical weekly

2024 Volume 154, Page(s) 3487

Abstract: Background: Telemedicine in palliative care (PC) is increasingly being used, especially in outpatient settings with large geographic distances. Its proven benefits include improved communication, coordination quality and time savings. However, the ... ...

Abstract	Background: Telemedicine in palliative care (PC) is increasingly being used, especially in outpatient settings with large geographic distances. Its proven benefits include improved communication, coordination quality and time savings. However, the effect on symptom control is less evident. Whether these benefits apply to the Swiss setting and the needs of healthcare professionals (HCPs) is unknown. Objectives: To identify the perceptions and needs of healthcare professionals (nurses and physicians) regarding telemedicine (generally and specifically for care conferences) in a Swiss outpatient palliative care network. Methods: We conducted a cross-sectional, mixed-method online survey with purposefully sampled healthcare professionals from an outpatient palliative care team as baseline data during the planning phase of a quality improvement project (digital care conferences). Findings/results: Of the 251 HCPs approached, 66 responded, including nurses (n = 37) and physicians (n = 29), with an overall response rate of 26.6%. These were distributed into two groups: general palliative care HCPs (n = 48, return rate 21.3%) and specialised palliative care HCPs (n = 18, return rate 69.2%). Generally, telemedicine was perceived as useful. Potential easy access to other HCPs and hence improved communication and coordination were perceived as advantages. Barriers included a lack of acceptance and physical contact, unsolved questions about potential data breaches and technical obstacles. Regarding digital care conferences, the perceived acceptance and feasibility were good; preferred participants were the specialised palliative care HCPs (nurses and physicians), primary physicians and home care nurses, as well as the leadership of a nurse. The needs of the HCPs were as follows: (a) clear and efficient planning, (b) usability and security and (c) visual contact with the patient. Conclusion: Digital care conferences are perceived as a feasible and useful tool by healthcare professionals in a local palliative care network in Switzerland. A pilot phase will be the next step towards systematic integration of this telemedicine modality into outpatient palliative care.
MeSH term(s)	Humans ; Palliative Care ; Outpatients ; Cross-Sectional Studies ; Health Personnel ; Physicians
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/s.3487
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Palliative care and COVID-19: a bibliometric analysis.

Bernardis, Alessandra / Gonzalez-Jaramillo, Valentina / Ebneter, Andreas S / Eychmüller, Steffen

BMJ supportive & palliative care

2023

Abstract: Objective: To assess the impact of COVID-19 on the palliative care (PC) publication trend in the last 10 years and the collaboration between countries and main topics that were discussed in the papers.: Methods: We used Scopus to identify ... ...

Abstract	Objective: To assess the impact of COVID-19 on the palliative care (PC) publication trend in the last 10 years and the collaboration between countries and main topics that were discussed in the papers. Methods: We used Scopus to identify publications on PC between 2012 and 2021 and publications about PC and COVID-19 between 2020 and 2021. We used VOSviewer to assess the main topics using the keywords from the papers and to assess country collaboration. Results: 1937 publications resulted. An increase in publications about PC was observed during the pandemic, only partially explained by OVID-19-related publications. Cancer-related PC publications were the ones with the most marked increase. We identified six clusters in the distribution of the keywords: bioethics, cancer, nursing home/telemedicine, public health, caring and PC following the WHO definition. The countries with higher number of publications were the United States and England. Conclusion: We showed an increase in the number of PC publications in the last 2 years that was only partially explained by COVID-19-related publications. Most of the publications increase was due to cancer-related publications, since, during the time of the pandemic, publications on cancer and PC increased markedly, while those on heart failure, lung disease and dementia, remained constant.
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2022-004108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Quality of care as an individual concept: Proposition of a three-level concept for clinical practice.

Ebneter, Andreas Samuel / Vonlanthen, Ronald / Eychmueller, Steffen

Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

2022 Volume 173, Page(s) 17–21

Abstract: Background: Quality in health care is a complex framework with many components. The word "quality" is used in different official settings and different contexts (public health, certification, patient safety). On individual and team levels, the ... ...

Abstract	Background: Quality in health care is a complex framework with many components. The word "quality" is used in different official settings and different contexts (public health, certification, patient safety). On individual and team levels, the perception of quality is heterogenous, and the term is often used beyond the theoretical framework. Therefore, it remains a challenge to describe the perceived quality of care in the clinical setting. The aim of this paper is to present a simple concept that can be used to visually define the perceived quality of care for the individual health care professional. Methods/concept: An experience-based concept that uses different levels of "quality of care" individually to guide the supervision of health care professionals (residents) and quality goal setting in teams is presented, with the assumption that the ambition of any health care professional is to provide excellence in care. Three perceived levels of quality of care are defined, described, and visualized, namely, a) security, b) comfort, and c) perfection. The "comfort level" defines a sustainable level of care where the optimal balance between good patient care and resource use is achieved. Excellence of care is located between the comfort and the perfection level. The practical application of this proposed concept is described in three settings, namely, 1) the threshold for asking advice from the supervisor (resident physicians), 2) in supervision/coaching discussions between residents and supervisors, and 3) in the analysis of perceived quality of care and goals setting within the team. Conclusion: A simplified, purpose-built but well-defined concept to visually depict the perception of quality of care by clinicians can be useful in clinical practice, for the supervision of residents and for team dynamics.
MeSH term(s)	Germany ; Health Personnel ; Humans ; Patient Safety
Language	English
Publishing date	2022-05-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2412512-X
ISSN	2212-0289 ; 1865-9217
ISSN (online)	2212-0289
ISSN	1865-9217
DOI	10.1016/j.zefq.2022.05.003
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Article ; Online: Perceptions and needs of an outpatient palliative care team regarding digital care conferences in palliative care

Andreas Samuel Ebneter / Maud Maessen / Thomas C. Sauter / Georgette Jenelten / Steffen Eychmueller

Swiss Medical Weekly, Vol 154, Iss

a mixed-method online survey

2024 Volume 1

Abstract: BACKGROUND: Telemedicine in palliative care (PC) is increasingly being used, especially in outpatient settings with large geographic distances. Its proven benefits include improved communication, coordination quality and time savings. However, the effect ...

Abstract	BACKGROUND: Telemedicine in palliative care (PC) is increasingly being used, especially in outpatient settings with large geographic distances. Its proven benefits include improved communication, coordination quality and time savings. However, the effect on symptom control is less evident. Whether these benefits apply to the Swiss setting and the needs of healthcare professionals (HCPs) is unknown. OBJECTIVES: To identify the perceptions and needs of healthcare professionals (nurses and physicians) regarding telemedicine (generally and specifically for care conferences) in a Swiss outpatient palliative care network. METHODS: We conducted a cross-sectional, mixed-method online survey with purposefully sampled healthcare professionals from an outpatient palliative care team as baseline data during the planning phase of a quality improvement project (digital care conferences). FINDINGS/RESULTS: Of the 251 HCPs approached, 66 responded, including nurses (n = 37) and physicians (n = 29), with an overall response rate of 26.6%. These were distributed into two groups: general palliative care HCPs (n = 48, return rate 21.3%) and specialised palliative care HCPs (n = 18, return rate 69.2%). Generally, telemedicine was perceived as useful. Potential easy access to other HCPs and hence improved communication and coordination were perceived as advantages. Barriers included a lack of acceptance and physical contact, unsolved questions about potential data breaches and technical obstacles. Regarding digital care conferences, the perceived acceptance and feasibility were good; preferred participants were the specialised palliative care HCPs (nurses and physicians), primary physicians and home care nurses, as well as the leadership of a nurse. The needs of the HCPs were as follows: (a) clear and efficient planning, (b) usability and security and (c) visual contact with the patient. CONCLUSION: Digital care conferences are perceived as a feasible and useful tool by healthcare professionals in a local palliative care network in ...
Keywords	Medicine ; R
Subject code	650
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Feasibility, acceptability and needs in telemedicine for palliative care.

Ebneter, Andreas S / Sauter, Thomas C / Christen, Andri / Eychmueller, Steffen

Swiss medical weekly

2022 Volume 152, Issue 9-10

Abstract: Background: Telemedicine in palliative care was initially developed in countries where geography or resources limit access to care services. Recently, largely owing to the COVID-19 pandemic, this technology is being increasingly used in highly urbanised ...

Abstract	Background: Telemedicine in palliative care was initially developed in countries where geography or resources limit access to care services. Recently, largely owing to the COVID-19 pandemic, this technology is being increasingly used in highly urbanised countries such as Switzerland. However, there is still scepticism regarding whether these tools can be used effectively in palliative care, a relationship-based speciality that is generally highly dependent on compassion, communication and direct human interaction. The objective of this review was to analyse the needs, elements of feasibility, and reasons for acceptance or possible barriers before the implementation of a telemedicine intervention in Switzerland. Methods: The method used was a scoping review, following the PRISMA-ScR reporting guidelines. We searched the PubMed, Ovid SP, Medline, Cochrane and Scopus databases for relevant reports. Charting and analyses of the data were done by a single researcher. A total of 520 records were screened and assessed for eligibility. Finally, 27 studies and 4 registry entries were included. Main reasons for exclusion were wrong population and intervention. Results: The prevailing study type was the single-arm intervention study. Most studies originated from countries with geographic barriers to access. Feasibility was good in 69% of all studies. Good acceptability (84.1-100%) was confirmed in the majority of the studies. The needs of the patients or the healthcare professionals were directly addressed in only five (16%) studies. Three needs were consistently reported: communication, coordination and technical reliability. Conclusion: Despite a broad range of studies on telemedicine in palliative care, patients' needs are rarely addressed. Therefore, especially in countries such as Switzerland, a needs assessment is recommended before the implementation of a new telemedicine intervention, to guarantee high feasibility and acceptability.
MeSH term(s)	COVID-19/therapy ; Feasibility Studies ; Humans ; Palliative Care/methods ; Pandemics ; Reproducibility of Results ; Telemedicine
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2022.w30148
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Article ; Online: Retrospective validation of the postnatal Growth and Retinopathy of Prematurity (G-ROP) criteria in a Swiss cohort.

Vinayahalingam, Nithursa / McDougall, Jane / Ahrens, Olaf / Ebneter, Andreas

BMC ophthalmology

2022 Volume 22, Issue 1, Page(s) 19

Abstract: Background: Currently used screening criteria for retinopathy of prematurity (ROP) show high sensitivity for predicting treatment-requiring ROP but low specificity; over 90% of examined infants do not develop ROP that requires treatment (type 1 ROP). A ... ...

Abstract	Background: Currently used screening criteria for retinopathy of prematurity (ROP) show high sensitivity for predicting treatment-requiring ROP but low specificity; over 90% of examined infants do not develop ROP that requires treatment (type 1 ROP). A novel weight gain-based prediction model was developed by the G-ROP study group to increase the specificity of the screening criteria and keep the number of ophthalmic examinations as low as possible. This retrospective cohort study aimed to externally validate the G-ROP screening criteria in a Swiss cohort. Methods: Data from 645 preterm infants in ROP screening at Inselspital Bern between January 2015 and December 2019 were retrospectively retrieved from the screening log and analysed. The G-ROP screening criteria, consisting of 6 trigger parameters, were applied in infants with complete data. To determine the performance of the G-ROP prediction model for treatment-requiring ROP, sensitivity and specificity were calculated. Results: Complete data were available for 322 infants who were included in the analysis. None of the excluded infants had developed type 1 ROP. By applying the 6 criteria in the G-ROP model, 214 infants were flagged to undergo screening: among these, 14 developed type 1 ROP, 9 developed type 2 ROP, and 43 developed milder stages of ROP. The sensitivity for predicting treatment-requiring ROP was 100% (CI, 0.79-1.00), and the specificity was 41% (CI, 0.35 -0.47). Implementing the novel G-ROP screening criteria would reduce the number of infants entering ROP screening by approximately one third. Conclusions: The overall prevalence of treatment-requiring ROP was low (2.15%). Previously published performance parameters for the G-ROP algorithm were reproducible in this Swiss cohort. Importantly, all treatment-requiring infants were correctly identified. By using these novel criteria, the burden of screening examinations could be significantly reduced.
MeSH term(s)	Birth Weight ; Cohort Studies ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Neonatal Screening ; Retinopathy of Prematurity ; Retrospective Studies ; Risk Factors ; Switzerland
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-021-02227-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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