Article ; Online: Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections.
2020 Volume 144, Page(s) 110128
Abstract: It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been ... ...
| Abstract | It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been subjected to in the months/years preceding the infection could be immunocompromising. Statins are among the most widely prescribed cholesterol-lowering drugs. As competitive inhibitors of HMG-CoA-reductase, the key enzyme of the "mevalonate pathway" through which essential compounds, not only cholesterol, are synthesized, statins decrease the levels of cholesterol, and thus LDLs, as an innate defense mechanism, with controversial results in decreasing mortality from cardiovascular disease. Moreover, statins have pleiotropic, mostly deleterious effects on many cell types, including immune cells. In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. |
|---|---|
| MeSH term(s) | COVID-19/immunology ; Cholesterol/metabolism ; Cholesterol, LDL/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Immune System ; Immunity, Innate ; Inflammation ; Lipoproteins, LDL/metabolism ; Mevalonic Acid/chemistry ; Models, Theoretical ; Oxidation-Reduction ; Oxidative Stress ; Selenoproteins/chemistry ; COVID-19 Drug Treatment |
| Chemical Substances | Cholesterol, LDL ; Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoproteins, LDL ; Selenoproteins ; Cholesterol (97C5T2UQ7J) ; Mevalonic Acid (S5UOB36OCZ) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 193145-3 |
| ISSN | 1532-2777 ; 0306-9877 |
| ISSN (online) | 1532-2777 |
| ISSN | 0306-9877 |
| DOI | 10.1016/j.mehy.2020.110128 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1132: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.