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Article: Delayed sleep-wake rhythm is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with major depressive disorder.

Takaesu, Yoshikazu / Kanda, Yuta / Nagahama, Yu / Shiroma, Ayano / Ishii, Miho / Hashimoto, Tasuku / Watanabe, Koichiro

2022 Volume 13, Page(s) 1022144

Abstract: Background: The delayed sleep-wake phase is commonly observed in major depressive disorder (MDD) and thought to be associated with functional impairments. This study aimed to evaluate the relationship between the delayed sleep-wake phase, cognitive ... ...

Abstract	Background: The delayed sleep-wake phase is commonly observed in major depressive disorder (MDD) and thought to be associated with functional impairments. This study aimed to evaluate the relationship between the delayed sleep-wake phase, cognitive dysfunction, social dysfunction, and quality of life in patients with MDD. Methods: This cross-sectional design included 33 outpatients with MDD. Objective sleep-wake rhythm was assessed by actigraphy. Functional impairments were evaluated by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J), World Health Organization Disability Assessment Schedule (WHO-DAS), and Euro QOL 5 dimensions (EQ5D). Results: Actigraphic assessment of the delayed sleep-wake phase (midpoint of sleep) was significantly correlated with the composite score of the BACS-J ( Conclusion: Our study's results suggested that the delayed sleep-wake phase is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with MDD. Clinicians should pay attention to the sleep-wake rhythm in patients with MDD in clinical settings.
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.1022144
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Substituent Effect on Two-Photon Absorption of Diphenylacetylene Derivatives with an Electron-Donating/Withdrawing Group.

Ishii, Tetsuro / Isozaki, Tasuku / Kinoshita, Sho / Takeuchi, Ryo / Kashihara, Wataru / Suzuki, Tadashi

The journal of physical chemistry. A

2021 Volume 125, Issue 8, Page(s) 1688–1695

Abstract: Two-photon absorption for diphenylacetylene derivatives with an electron-donating (ED) or electron-withdrawing (EW) group (DPA-Rs) was investigated by high-sensitivity optical-probing photoacoustic spectroscopy. Two-photon absorption spectra and two- ... ...

Abstract	Two-photon absorption for diphenylacetylene derivatives with an electron-donating (ED) or electron-withdrawing (EW) group (DPA-Rs) was investigated by high-sensitivity optical-probing photoacoustic spectroscopy. Two-photon absorption spectra and two-photon absorption cross sections σ
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.0c10545
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Article: A Manually Curated Gene Model Set for an Ascidian,

Satou, Yutaka / Tokuoka, Miki / Oda-Ishii, Izumi / Tokuhiro, Sinichi / Ishida, Tasuku / Liu, Boqi / Iwamura, Yuri

Zoological science

2022 Volume 39, Issue 3, Page(s) 253–260

Abstract: Gene/transcript model sets predicted from decoded genome sequences are an important resource for a wide range of biological studies. Accuracy of gene models is therefore critical for deducing accurate conclusions. Computationally predicted models are ... ...

Abstract	Gene/transcript model sets predicted from decoded genome sequences are an important resource for a wide range of biological studies. Accuracy of gene models is therefore critical for deducing accurate conclusions. Computationally predicted models are sometimes inconsistent with experimental data from cDNA clones and RNA-sequencing. In an ascidian,
MeSH term(s)	Animals ; Base Sequence ; Biological Evolution ; Chromosomes ; Ciona intestinalis/genetics ; Genome
Language	English
Publishing date	2022-06-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038883-4
ISSN	2212-3830 ; 0289-0003
ISSN (online)	2212-3830
ISSN	0289-0003
DOI	10.2108/zs210102
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Article ; Online: Spin Ice-like Magnetic Relaxation of a Two-dimensional Network based on Manganese(III) Salen-type Single-Molecule Magnets.

Kachi-Terajima, Chihiro / Eiba, Tasuku / Ishii, Rikako / Miyasaka, Hitoshi / Kodama, Yuta / Saito, Toshiaki

Angewandte Chemie (International ed. in English)

2020 Volume 59, Issue 49, Page(s) 22048–22053

Abstract: Spin ice is an exotic type of magnetism displayed by bulk rare-earth pyrochlore oxides. We discovered a spin ice-like magnetic relaxation of [{Mn(saltmen)} ...

Abstract	Spin ice is an exotic type of magnetism displayed by bulk rare-earth pyrochlore oxides. We discovered a spin ice-like magnetic relaxation of [{Mn(saltmen)}
Language	English
Publishing date	2020-09-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202008914
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Article ; Online: Two-photon absorption property of Cl-substituted diphenylacetylenes by optical-probing photoacoustic spectroscopy.

Ishii, Tetsuro / Ando, Saki / Isozaki, Tasuku / Takeuchi, Ryo / Kashihara, Wataru / Suzuki, Tadashi

The Journal of chemical physics

2019 Volume 151, Issue 13, Page(s) 134304

Abstract: Two-photon absorption spectra and two-photon absorption cross sections of Cl-substituted diphenylacetylenes (ClDPAs) were investigated by optical-probing photoacoustic spectroscopy and quantum chemical calculations for the first time. The two-photon ... ...

Abstract	Two-photon absorption spectra and two-photon absorption cross sections of Cl-substituted diphenylacetylenes (ClDPAs) were investigated by optical-probing photoacoustic spectroscopy and quantum chemical calculations for the first time. The two-photon absorption spectra of ClDPAs exhibited intense two-photon absorption bands at around 480 nm, which are forbidden by one-photon absorption. The two-photon absorption cross sections σ
Language	English
Publishing date	2019-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5121505
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Article ; Online: RECiQ

Kazuaki Hisatsune / Tasuku Murata / Koretsugu Ogata / Minemasa Hida / Akira Ishii / Hitoshi Tsuchihashi / Yumi Hayashi / Kei Zaitsu

ACS Omega, Vol 5, Iss 36, Pp 23351-

A Rapid and Easy Method for Determining Cyanide Intoxication by Cyanide and 2‑Aminothiazoline-4-carboxylic Acid Quantification in the Human Blood Using Probe Electrospray Ionization Tandem Mass Spectrometry

2020 Volume 23357

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of psychological features and development of an assessment tool for event-related psychological distress after experiencing non-traumatic stressful events.

Ryota Seki / Tasuku Hashimoto / Mami Tanaka / Hiroki Ishii / Michi Ogawa / Aiko Sato / Atsushi Kimura / Akihiro Shiina / Michiko Nakazato / Masaomi Iyo

PLoS ONE, Vol 16, Iss 3, p e

2021 Volume 0249126

Abstract: Stressful events in daily life that are non-traumatic (e.g., family-, school-, work-, interpersonal-, and health-related problems) frequently cause various mood disturbances. For some people, being exposed to non-traumatic but stressful events could ... ...

Abstract	Stressful events in daily life that are non-traumatic (e.g., family-, school-, work-, interpersonal-, and health-related problems) frequently cause various mood disturbances. For some people, being exposed to non-traumatic but stressful events could trigger the onset and relapse of mood disorders. Furthermore, non-traumatic stressful events also cause event-related psychological distress (ERPD), similar to that of post-traumatic stress disorder (PTSD; i.e., intense intrusive imagery or memory recall, avoidance, and hyperarousal) in the general population and individuals with mood disorders. However, previous ERPD studies only showed that people with ERPD display PTSD-like symptoms after non-traumatic experiences; they failed to get to the crux of the matter by only utilizing trauma- or PTSD-related assessment tools. We thus aimed to identify the psychological phenomena and features of ERPD after individuals experienced non-traumatic stressful events, and to develop and validate an appropriate ERPD assessment tool. First, we conducted a qualitative study to obtain the psychological features through interviews with 22 individuals (mean age = 41.50 years old, SD = 12.24) with major depressive disorder or bipolar disorder. Second, in the quantitative component, we implemented a web-based survey with 747 participants of the general population (mean age = 41.96 years old, SD = 12.64) by using ERPD-related questionnaires created based on the qualitative study; then, we examined the reliability and validity of the ERPD assessment tool. Results yielded that the psychological features of ERPD comprised four factors: feelings of revenge, rumination, self-denial, and mental paralysis. These were utilized in the developed 24-item measure of ERPD-a novel self-report assessment tool. For various professionals involved in mental healthcare, this tool can be used to clarify and assess psychological phenomena in people with ERPD.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of psychological features and development of an assessment tool for event-related psychological distress after experiencing non-traumatic stressful events.

Seki, Ryota / Hashimoto, Tasuku / Tanaka, Mami / Ishii, Hiroki / Ogawa, Michi / Sato, Aiko / Kimura, Atsushi / Shiina, Akihiro / Nakazato, Michiko / Iyo, Masaomi

PloS one

2021 Volume 16, Issue 3, Page(s) e0249126

Abstract	Stressful events in daily life that are non-traumatic (e.g., family-, school-, work-, interpersonal-, and health-related problems) frequently cause various mood disturbances. For some people, being exposed to non-traumatic but stressful events could trigger the onset and relapse of mood disorders. Furthermore, non-traumatic stressful events also cause event-related psychological distress (ERPD), similar to that of post-traumatic stress disorder (PTSD; i.e., intense intrusive imagery or memory recall, avoidance, and hyperarousal) in the general population and individuals with mood disorders. However, previous ERPD studies only showed that people with ERPD display PTSD-like symptoms after non-traumatic experiences; they failed to get to the crux of the matter by only utilizing trauma- or PTSD-related assessment tools. We thus aimed to identify the psychological phenomena and features of ERPD after individuals experienced non-traumatic stressful events, and to develop and validate an appropriate ERPD assessment tool. First, we conducted a qualitative study to obtain the psychological features through interviews with 22 individuals (mean age = 41.50 years old, SD = 12.24) with major depressive disorder or bipolar disorder. Second, in the quantitative component, we implemented a web-based survey with 747 participants of the general population (mean age = 41.96 years old, SD = 12.64) by using ERPD-related questionnaires created based on the qualitative study; then, we examined the reliability and validity of the ERPD assessment tool. Results yielded that the psychological features of ERPD comprised four factors: feelings of revenge, rumination, self-denial, and mental paralysis. These were utilized in the developed 24-item measure of ERPD-a novel self-report assessment tool. For various professionals involved in mental healthcare, this tool can be used to clarify and assess psychological phenomena in people with ERPD.
MeSH term(s)	Adult ; Algorithms ; Bipolar Disorder/pathology ; Bipolar Disorder/psychology ; Case-Control Studies ; Cognition ; Depressive Disorder, Major/pathology ; Depressive Disorder, Major/psychology ; Female ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Psychological Distress ; Self Report ; Stress, Psychological ; Surveys and Questionnaires
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0249126
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Article ; Online: Prospective Analysis of Immunosuppressive Therapy in Cardiac Sarcoidosis With Fluorodeoxyglucose Myocardial Accumulation: The PRESTIGE Study.

Morimoto, Ryota / Unno, Kazumasa / Fujita, Naotoshi / Sakuragi, Yasuhiro / Nishimoto, Takuya / Yamashita, Masato / Kuwayama, Tasuku / Hiraiwa, Hiroaki / Kondo, Toru / Kuwatsuka, Yachiyo / Okumura, Takahiro / Ohshima, Satoru / Takahashi, Hiroshi / Ando, Masahiko / Ishii, Hideki / Kato, Katsuhiko / Murohara, Toyoaki

JACC. Cardiovascular imaging

2023 Volume 17, Issue 1, Page(s) 45–58

Abstract: Background: Fluorodeoxyglucose positron emission tomography (: Objectives: The goal of this study was to evaluate the efficacy of methotrexate (MTX) in patients refractory to PSL assessed by using cardiac metabolic activity (CMA) in : Methods: A ... ...

Abstract	Background: Fluorodeoxyglucose positron emission tomography ( Objectives: The goal of this study was to evaluate the efficacy of methotrexate (MTX) in patients refractory to PSL assessed by using cardiac metabolic activity (CMA) in Methods: A total of 59 patients with active CS were prospectively enrolled. CMA (standardized uptake value × accumulation area) was used as an indicator of active inflammation, and a 6-month regimen of PSL therapy was introduced, followed by a second FDG scan. Poor responders to PSL therapy (CMA reduction rate <70%) and patients with recurrent CS (CMA reduction rate ≥70% after initial PSL therapy but CMA recurred after an additional 6 months of therapy) were randomly assigned to the MTX or repeat PSL (re-PSL) therapy groups for another 6 months. Results: Fifty-six patients completed the initial 6-month PSL therapy regimen. Median CMA reduced from 203.3 to 1.0 (P < 0.001), and 47 patients were allocated to the response group, 9 to the poor response group, and 2 to the recurrent group. Accordingly, 11 patients were randomly assigned to the MTX (n = 5) or re-PSL (n = 6) groups. After 6 months, neither group showed a significant reduction in CMA values. MTX was comparable to re-PSL in reducing CMA. Conclusions: The 6-month regimen of PSL was a potent therapeutic tool for active CS. When MTX was added to low-dose PSL in patients refractory to the initial PSL therapy, there was no significant difference compared with re-PSL. Further studies are needed to evaluate the therapeutic potential of MTX for active CS, including how MTX works when it is administered in higher doses or for longer periods.
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/drug therapy ; Radiopharmaceuticals ; Predictive Value of Tests ; Myocardium/metabolism ; Sarcoidosis/diagnostic imaging ; Sarcoidosis/drug therapy ; Sarcoidosis/metabolism ; Positron-Emission Tomography/methods ; Myocarditis ; Immunosuppression Therapy
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2023.05.017
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Article: Antibody Clicking as a Strategy to Modify Antibody Functionalities on the Surface of Targeted Cells

Komatsu, Toru / Kyo, Etsu / Ishii, Haruki / Tsuchikama, Kyoji / Yamaguchi, Aiko / Ueno, Tasuku / Hanaoka, Kenjiro / Urano, Yasuteru

Journal of the American Chemical Society. 2020 Sept. 08, v. 142, no. 37

2020

Abstract: We established a methodology for initiating cross-linking of antibodies selectively on the cell surface through intermolecular copper-free click reactions facilitated by increased effective concentrations of antibodies binding to target antigens. Upon ... ...

Abstract	We established a methodology for initiating cross-linking of antibodies selectively on the cell surface through intermolecular copper-free click reactions facilitated by increased effective concentrations of antibodies binding to target antigens. Upon cross-linking of tetrazine- and bicyclononyne-modified trastuzumab on the surface of HER2-overexpressing cells, increased antibody uptake and activation of intracellular signaling were observed. Our findings demonstrate that the cross-linking reaction can significantly alter the biophysical properties of proteins, activating their unique functionalities on targeted cells to realize an increased cargo delivery and synthetic manipulation of cellular signaling.
Keywords	Americans ; antibodies ; antigens ; cell communication ; crosslinking ; journals ; proteins ; surfaces
Language	English
Dates of publication	2020-0908
Size	p. 15644-15648.
Publishing place	American Chemical Society
Document type	Article
Note	NALT-AP-4-rerunAP2-fuzzy
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.0c05331
Database	NAL-Catalogue (AGRICOLA)

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