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  1. Book: Mei jie zhong yao ren chu chuan ran bing de yuohai sheng wu

    Pan, Mingzheng

    2008  

    Title variant Bu ru dong wu bing
    Author's details Pan Mingzheng, Lin Lianggong, Liu Zhenxuan bian zhu
    MeSH term(s) Zoonoses ; Disease Vectors ; Mammals
    Language Chinese
    Size 412 p. :, ill.
    Publisher Xing zheng yuan nong ye wei yuan hui dong zhi wu fang yi jian yi ju ; Zhong Tai ke ji da xue ; Guo li Taiwan da xue
    Publishing place Taibei Shi
    Document type Book
    ISBN 9789860130713 ; 986013071X
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article ; Online: The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application.

    Pan, Yao-Jie / Liu, Bo-Wen / Pei, Dong-Sheng

    DNA and cell biology

    2022  Volume 41, Issue 9, Page(s) 790–809

    Abstract: Formula: see text] Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play differential functions from the same pre-mRNA. Recently, increasing numbers of studies have emerged, unmasking the association between AS ... ...

    Abstract [Formula: see text] Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play differential functions from the same pre-mRNA. Recently, increasing numbers of studies have emerged, unmasking the association between AS and cancer. In this review, we arranged AS events that are closely related to cancer progression and presented promising treatments based on AS for cancer therapy. Obtaining proliferative capacity, acquiring invasive properties, gaining angiogenic features, shifting metabolic ability, and getting immune escape inclination are all splicing events involved in biological processes. Spliceosome-targeted and antisense oligonucleotide technologies are two novel strategies that are hopeful in tumor therapy. In addition, bioinformatics applications based on AS were summarized for better prediction and elucidation of regulatory routines mingled in. Together, we aimed to provide a better understanding of complicated AS events associated with cancer biology and reveal AS a promising target of cancer treatment in the future.
    MeSH term(s) Alternative Splicing/genetics ; Computational Biology ; Humans ; Neoplasms/drug therapy ; Neoplasms/therapy ; RNA Precursors/genetics ; RNA Precursors/therapeutic use ; Spliceosomes/genetics
    Chemical Substances RNA Precursors
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2022.0322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2061: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: PAK5 potentiates slug transactivation of N-cadherin to facilitate metastasis of renal cell carcinoma.

    Liu, Xu / Pan, Yao-Jie / Kang, Meng-Jie / Jiang, Xin / Guo, Zhong-Ying / Pei, Dong-Sheng

    Cellular signalling

    2023  Volume 110, Page(s) 110803

    Abstract: Renal cell carcinoma (RCC) is an aggravating cancer with a poor prognosis and a high rate of metastasis. PAK5, a p21-activated kinases, has shown to be overexpressed in a variety of cancers, including RCC. In previous studies, we discovered that PAK5 ... ...

    Abstract Renal cell carcinoma (RCC) is an aggravating cancer with a poor prognosis and a high rate of metastasis. PAK5, a p21-activated kinases, has shown to be overexpressed in a variety of cancers, including RCC. In previous studies, we discovered that PAK5 regulates cell migration and invasion in RCC cell lines. However, the underlying mechanisms remain obscure. In this study, we consolidated that PAK5 confers a pro-metastatic phenotype RCC cells in vitro and exacerbates metastasis in vivo. High PAK5 expression was associated with an advanced TNM stage and a lower overall survival. Furthermore, PAK5 increases the expression level of N-cadherin. In terms of mechanism, PAK5 bound to Slug and phosphorylated it at serine 87. As a result, phosphorylated Slug transactivated N-cadherin, accelerating the epithelial-mesenchymal transition. Collectively, Slug is a novel PAK5 substrate, and PAK5-mediated phosphorylation of Slug-S87 increases N-cadherin and the pro-metastatic phenotype of RCC, implying that phosphorylated Slug-S87 could be a therapeutic target in progressive RCC.
    MeSH term(s) Humans ; Cadherins/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Phosphorylation ; Snail Family Transcription Factors/metabolism ; Transcriptional Activation
    Chemical Substances Cadherins ; Snail Family Transcription Factors ; PAK5 protein, human (EC 2.7.1.11)
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2023.110803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Alternative splicing of HSPA12A pre‐RNA by SRSF11 contributes to metastasis potential of colorectal cancer

    Yao‐Jie Pan / Fu‐Chun Huo / Meng‐Jie Kang / Bo‐Wen Liu / Meng‐Di Wu / Dong‐Sheng Pei

    Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Background Dysregulation of alternative splicing (AS) induced by serine/arginine‐rich proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the serine/arginine‐rich protein family, the involvement of SRSF11 in ... ...

    Abstract Abstract Background Dysregulation of alternative splicing (AS) induced by serine/arginine‐rich proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the serine/arginine‐rich protein family, the involvement of SRSF11 in colorectal cancer (CRC) is unknown. Methods The TCGA dataset and clinical samples were used to assess SRSF11 expression levels in CRC. For SRSF11, functional experiments were conducted both in vitro and in vivo. RNA‐seq technology was used to analyze and screen SRSF11‐triggered AS events, which were then confirmed by in vivo UV crosslinking and immunoprecipitation (CLIP) and mini‐gene reporter assays. Jalview software was used to determine the preferential binding motif with relation to exon skipping (ES) events. Furthermore, coimmunoprecipitation (Co‐IP) and Phospho‐tag SDS‐PAGE experiments were used to investigate PAK5‐mediated phosphorylation regulation on SRSF11, and in vitro kinase experiments validated the interaction. Results In CRC, SRSF11 was discovered to be overexpressed and associated with a poor prognosis. And SRSF11 played a pro‐metastatic role in vitro and in vivo. By screening SRSF11‐regulated AS events, we identified the binding motif of SRSF11‐triggered splicing‐switching of HSPA12A AS, which specifically regulated HSPA12A AS by directly binding to a motif in exon 2. Mechanistically, the HSPA12A transcript with exon 2 retention increased N‐cadherin expression by promoting RNA stability. Furthermore, the oncogenic kinase PAK5 phosphorylated SRSF11 at serine 287, protecting it from ubiquitination degradation. Conclusions SRSF11 exerts pro‐metastatic effects in CRC by inhibiting the AS of HSPA12A pre‐RNA. Our findings point to SRSF11‐regulated HSPA12A splicing as a novel relationship between SRSF11‐regulated splicing and CRC metastasis and suggest a PAK5/SRSF11/HSPA12A axis as a potential therapeutic target and prognostic biomarker in CRC.
    Keywords alternative splicing ; colorectal cancer ; EMT ; metastasis ; phosphorylation ; ubiquitination ; Medicine (General) ; R5-920
    Subject code 500
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: MiR-326: Promising Biomarker for Cancer.

    Pan, Yao-Jie / Wan, Jian / Wang, Chun-Bin

    Cancer management and research

    2019  Volume 11, Page(s) 10411–10418

    Abstract: MicroRNAs (miRNAs) are small non-coding and highly conserved RNAs that act in biological processes including cell proliferation, invasion, apoptosis, metabolism, signal transduction, and tumorigenesis. The previously identified miRNA-326 (miR-326) has ... ...

    Abstract MicroRNAs (miRNAs) are small non-coding and highly conserved RNAs that act in biological processes including cell proliferation, invasion, apoptosis, metabolism, signal transduction, and tumorigenesis. The previously identified miRNA-326 (miR-326) has been reported to participate in cellular apoptosis, tumor growth, cell invasion, embryonic development, immunomodulation, chemotherapy resistance, and oncogenesis. This review presents a detailed overview of what is known about the effects of miR-326 on cell invasion, metastasis, drug resistance, proliferation, apoptosis, and its involvement in signaling pathways.
    Language English
    Publishing date 2019-12-11
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S223875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.

    Huo, Fu-Chun / Zhu, Zhi-Man / Du, Wen-Qi / Pan, Yao-Jie / Jiang, Xin / Kang, Meng-Jie / Liu, Bo-Wen / Mou, Jie / Pei, Dong-Sheng

    Pharmacological research

    2023  Volume 195, Page(s) 106863

    Abstract: Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicated in carcinogenesis and tumor progression. However, the involvement of m6A modification in HPV-involved CC remains ... ...

    Abstract Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicated in carcinogenesis and tumor progression. However, the involvement of m6A modification in HPV-involved CC remains unclear. Here we showed that HPV E6/7 oncoproteins affected the global m6A modification and E7 specifically promoted the expression of ALKBH5. We found that ALKBH5 was significantly upregulated in CC and might serve as a valuable prognostic marker. Forced expression of ALKBH5 enhanced the malignant phenotypes of CC cells. Mechanistically, we discovered that E7 increased ALKBH5 expression through E2F1-mediated activation of the H3K27Ac and H3K4Me3 histone modifications, as well as post-translational modification mediated by DDX3. ALKBH5-mediated m6A demethylation enhanced the expression of PAK5. The m6A reader YTHDF2 bound to PAK5 mRNA and regulated its stability in an m6A-dependent manner. Moreover, ALKBH5 promoted tumorigenesis and metastasis of CC by regulating PAK5. Overall, our findings herein demonstrate a significant role of ALKBH5 in CC progression in HPV-positive cells. Thus, we propose that ALKBH5 may serve as a prognostic biomarker and therapeutic target for CC patients.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Papillomavirus Infections/genetics ; Carcinogenesis/genetics ; AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism
    Chemical Substances ALKBH5 protein, human (EC 1.14.11.-) ; AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-)
    Language English
    Publishing date 2023-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.

    Pan, Yao-Jie / Huo, Fu-Chun / Kang, Meng-Jie / Liu, Bo-Wen / Wu, Meng-Di / Pei, Dong-Sheng

    Clinical and translational medicine

    2022  Volume 12, Issue 11, Page(s) e1113

    Abstract: Background: Dysregulation of alternative splicing (AS) induced by serine/arginine-rich proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the serine/arginine-rich protein family, the involvement of SRSF11 in colorectal ... ...

    Abstract Background: Dysregulation of alternative splicing (AS) induced by serine/arginine-rich proteins has recently been linked to cancer metastasis. Nonetheless, as a member of the serine/arginine-rich protein family, the involvement of SRSF11 in colorectal cancer (CRC) is unknown.
    Methods: The TCGA dataset and clinical samples were used to assess SRSF11 expression levels in CRC. For SRSF11, functional experiments were conducted both in vitro and in vivo. RNA-seq technology was used to analyze and screen SRSF11-triggered AS events, which were then confirmed by in vivo UV crosslinking and immunoprecipitation (CLIP) and mini-gene reporter assays. Jalview software was used to determine the preferential binding motif with relation to exon skipping (ES) events. Furthermore, coimmunoprecipitation (Co-IP) and Phospho-tag SDS-PAGE experiments were used to investigate PAK5-mediated phosphorylation regulation on SRSF11, and in vitro kinase experiments validated the interaction.
    Results: In CRC, SRSF11 was discovered to be overexpressed and associated with a poor prognosis. And SRSF11 played a pro-metastatic role in vitro and in vivo. By screening SRSF11-regulated AS events, we identified the binding motif of SRSF11-triggered splicing-switching of HSPA12A AS, which specifically regulated HSPA12A AS by directly binding to a motif in exon 2. Mechanistically, the HSPA12A transcript with exon 2 retention increased N-cadherin expression by promoting RNA stability. Furthermore, the oncogenic kinase PAK5 phosphorylated SRSF11 at serine 287, protecting it from ubiquitination degradation.
    Conclusions: SRSF11 exerts pro-metastatic effects in CRC by inhibiting the AS of HSPA12A pre-RNA. Our findings point to SRSF11-regulated HSPA12A splicing as a novel relationship between SRSF11-regulated splicing and CRC metastasis and suggest a PAK5/SRSF11/HSPA12A axis as a potential therapeutic target and prognostic biomarker in CRC.
    MeSH term(s) Humans ; Alternative Splicing/genetics ; Arginine/genetics ; Arginine/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; RNA/metabolism ; Serine/genetics ; Serine/metabolism
    Chemical Substances Arginine (94ZLA3W45F) ; HSP70 Heat-Shock Proteins ; HSPA12A protein, human ; RNA (63231-63-0) ; Serine (452VLY9402) ; SRSF11 protein, human
    Language English
    Publishing date 2022-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.

    Wu, Jin-Xia / Du, Wen-Qi / Wang, Xiu-Cun / Wei, Lu-Lu / Huo, Fu-Chun / Pan, Yao-Jie / Wu, Xiao-Jin / Pei, Dong-Sheng

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 14878

    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-93823-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Selective adsorption of trace morpholine impurities over

    Li, Shi-Yao / Yao, Huan / Hu, Hao / Chen, Wen-Jie / Yang, Liu-Pan / Wang, Li-Li

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 47, Page(s) 7204–7207

    Abstract: The separation and especially the removal of morpholine (MOR) impurities ... ...

    Abstract The separation and especially the removal of morpholine (MOR) impurities from
    MeSH term(s) Adsorption ; Morpholines ; Chemical Industry ; Hydrogen Bonding
    Chemical Substances Morpholines
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01164j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Full-length transcriptome, proteomics and metabolite analysis reveal candidate genes involved triterpenoid saponin biosynthesis in

    Pan, Jie / Huang, Chaokang / Yao, Weilin / Niu, Tengfei / Yang, Xiaolin / Wang, Rufeng

    Frontiers in plant science

    2023  Volume 14, Page(s) 1134352

    Abstract: ... Dipsacus ... ...

    Abstract Dipsacus asperoides
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1134352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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