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Article ; Online: Purinergic Dysfunction in Pulmonary Arterial Hypertension.

Cai, Zongye / Tu, Ly / Guignabert, Christophe / Merkus, Daphne / Zhou, Zhichao

Journal of the American Heart Association

2020 Volume 9, Issue 18, Page(s) e017404

Abstract: Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, which result in an increase in afterload imposed onto the right ventricle, leading to right ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, which result in an increase in afterload imposed onto the right ventricle, leading to right heart failure. Current therapies are incapable of reversing the disease progression. Thus, the identification of novel and potential therapeutic targets is urgently needed. An alteration of nucleotide- and nucleoside-activated purinergic signaling has been proposed as a potential contributor in the pathogenesis of PAH. Adenosine-mediated purinergic 1 receptor activation, particularly A
MeSH term(s)	Animals ; Humans ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/physiopathology ; Purinergic Agents/pharmacology ; Receptors, Purinergic/drug effects ; Receptors, Purinergic/metabolism ; Receptors, Purinergic/physiology
Chemical Substances	Purinergic Agents ; Receptors, Purinergic
Language	English
Publishing date	2020-09-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.120.017404
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Article ; Online: Positive Progesterone Receptor Expression in Meningioma May Increase the Transverse Relaxation: First Prospective Clinical Trial Using Single-Shot Ultrafast T

Li, Zongye / Wang, Xiao / Zhang, Hongyan / Yang, Yijie / Zhang, Yue / Zhuang, Yuchuan / Yang, Qinqin / Gao, Eryuan / Ren, Yanan / Zhang, Yong / Cai, Shuhui / Chen, Zhong / Cai, Congbo / Dong, Yanbo / Bao, Jianfeng / Cheng, Jingliang

Academic radiology

2023 Volume 31, Issue 1, Page(s) 187–198

Abstract: Rationale and objectives: This project aims to investigate the diagnostic performance of multiple overlapping-echo detachment imaging (MOLED) technique-derived transverse relaxation time (T: Materials and methods: 63 meningioma patients were enrolled ...

Abstract	Rationale and objectives: This project aims to investigate the diagnostic performance of multiple overlapping-echo detachment imaging (MOLED) technique-derived transverse relaxation time (T Materials and methods: 63 meningioma patients were enrolled from October 2021 to August 2022, who underwent a complete routine magnetic resonance imaging and T Results: PR-positive group had significantly elevated T Conclusion: The MOLED technique-derived T
MeSH term(s)	Humans ; Meningioma/diagnostic imaging ; Meningioma/surgery ; Meningioma/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Prospective Studies ; Receptors, Progesterone ; Magnetic Resonance Imaging/methods ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery ; Meningeal Neoplasms/pathology ; Retrospective Studies
Chemical Substances	Receptors, Progesterone
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.05.012
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Zs.A 4594: Show issues

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Article ; Online: Preoperative Subtyping of WHO Grade 1 Meningiomas Using a Single-Shot Ultrafast MR T2 Mapping.

Li, Zongye / Zhang, Hongyan / Wang, Xiao / Yang, Yijie / Zhang, Yue / Zhuang, Yuchuan / Wei, Zhiliang / Yang, Qinqin / Gao, Eryuan / Zhang, Yong / Cai, Shuhui / Chen, Zhong / Cai, Congbo / Bao, Jianfeng / Cheng, Jingliang

Journal of magnetic resonance imaging : JMRI

2023

Abstract: Background: Meningioma subtype is crucial in treatment planning and prognosis delineation, for grade 1 meningiomas. T2 relaxometry could provide detailed microscopic information but is often limited by long scanning times.: Purpose: To investigate ... ...

Abstract	Background: Meningioma subtype is crucial in treatment planning and prognosis delineation, for grade 1 meningiomas. T2 relaxometry could provide detailed microscopic information but is often limited by long scanning times. Purpose: To investigate the potential of T2 maps derived from multiple overlapping-echo detachment imaging (MOLED) for predicting meningioma subtypes and Ki-67 index, and to compare the diagnostic efficiency of two different region-of-interest (ROI) placements (whole-tumor and contrast-enhanced, respectively). Study type: Prospective. Phantom/subjects: A phantom containing 11 tubes of MnCl Field strength/sequence: 3 T scanner. MOLED, T2-weighted spin-echo sequence, T2-dark-fluid sequence, and postcontrast T1-weighted gradient echo sequence. Assessment: Two ROIs were delineated: the whole-tumor area (ROI1) and contrast-enhanced area (ROI2). Histogram parameters were extracted from T2 maps. Meningioma subtypes and Ki-67 index were reviewed by a neuropathologist according to the 2021 classification criteria. Statistical tests: Linear regression, Bland-Altman analysis, Pearson's correlation analysis, independent t test, Mann-Whitney U test, Kruskal-Wallis test with Bonferroni correction, and multivariate logistic regression analysis with the P-value significance level of 0.05. Results: The MOLED T2 sequence demonstrated excellent accuracy for phantoms and volunteers (Mean Data conclusion: MOLED T2 maps can effectively differentiate between meningothelial, fibrous, and transitional meningiomas. Moreover, T2 histogram parameters were significantly correlated with the Ki-67 index. Level of evidence: 1 TECHNICAL EFFICACY: Stage 2.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29183
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article ; Online: Anti-motion Ultrafast T

Zhang, Yue / Wang, Xiao / Ye, Ming / Li, Zongye / Zhuang, Yuchuan / Yang, Qinqin / Fu, Qichang / Chen, Rui / Gao, Eryuan / Ren, Yanan / Zhang, Yong / Cai, Shuhui / Chen, Zhong / Cai, Congbo / Dong, Yanbo / Bao, Jianfeng / Cheng, Jingliang

Academic radiology

2023

Abstract: Rationale and objectives: Stroke patients commonly face challenges during magnetic resonance imaging (MRI) examinations due to involuntary movements. This study aims to overcome these challenges by utilizing multiple overlapping-echo detachment (MOLED) ... ...

Abstract	Rationale and objectives: Stroke patients commonly face challenges during magnetic resonance imaging (MRI) examinations due to involuntary movements. This study aims to overcome these challenges by utilizing multiple overlapping-echo detachment (MOLED) quantitative technology. Through this technology, we also seek to detect microstructural changes of the normal-appearing corticospinal tract (NA-CST) in subacute-chronic stroke patients. Materials and methods: 79 patients underwent 3.0 T MRI scans, including routine scans and MOLED technique. A deep learning network was utilized for image reconstruction, and the accuracy, reliability, and resistance to motion of the MOLED technique were validated on phantoms and volunteers. Subsequently, we assessed motor dysfunction severity, ischemic lesion volume, T Results: The MOLED technique showed high accuracy (P < 0.001) and excellent repeatability, with a mean coefficient of variation (CoV) of 1.11%. It provided reliable quantitative results even under head movement, with a mean difference (Mean Conclusion: The MOLED technique offers significant advantages for quantitatively imaging stroke patients with involuntary movements. Additionally, T
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2023.11.036
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Article ; Online: Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.

Tian, Siyu / Cai, Zongye / Sen, Payel / van Uden, Denise / van de Kamp, Esther / Thuillet, Raphael / Tu, Ly / Guignabert, Christophe / Boomars, Karin / Van der Heiden, Kim / Brandt, Maarten M / Merkus, Daphne

American journal of physiology. Heart and circulatory physiology

2022 Volume 323, Issue 5, Page(s) H958–H974

Abstract: Mechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to ... ...

Abstract	Mechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure, as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial cells (MVECs) from patients with PAH, in lung tissue from mice with a
MeSH term(s)	Rats ; Mice ; Animals ; Swine ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; Endothelial Cells/metabolism ; Calcium/metabolism ; Nitric Oxide/metabolism ; Mechanotransduction, Cellular ; Cells, Cultured ; Pulmonary Arterial Hypertension/genetics ; Lung/metabolism ; Hypoxia ; Pulmonary Artery ; Disease Models, Animal ; Ion Channels/genetics ; Ion Channels/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Nitric Oxide (31C4KY9ESH) ; Piezo2 protein, mouse ; Ion Channels ; piezo2 protein, rat
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00220.2022
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Article: Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension.

Cai, Zongye / Klein, Theo / Geenen, Laurie W / Tu, Ly / Tian, Siyu / van den Bosch, Annemien E / de Rijke, Yolanda B / Reiss, Irwin K M / Boersma, Eric / Duncker, Dirk J / Boomars, Karin A / Guignabert, Christophe / Merkus, Daphne

Journal of clinical medicine

2020 Volume 9, Issue 5

Abstract: ...

Abstract	:
Language	English
Publishing date	2020-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9051248
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Article ; Online: Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.

Cai, Zongye / Tian, Siyu / Klein, Theo / Tu, Ly / Geenen, Laurie W / Koudstaal, Thomas / van den Bosch, Annemien E / de Rijke, Yolanda B / Reiss, Irwin K M / Boersma, Eric / van der Ley, Claude / Van Faassen, Martijn / Kema, Ido / Duncker, Dirk J / Boomars, Karin A / Tran-Lundmark, Karin / Guignabert, Christophe / Merkus, Daphne

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12326

Abstract: Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate ... ...

Abstract	Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and identify cytokines responsible for altered KP-metabolism. KP-metabolite levels were determined in plasma from PAH patients (median follow-up 42 months) and in rats with monocrotaline- and Sugen/hypoxia-induced PH. Blood sampling of PAH patients was performed at the time of diagnosis, six months and one year after PAH therapy. KP activation with lower tryptophan, higher kynurenine (Kyn), 3-hydroxykynurenine (3-HK), quinolinic acid (QA), kynurenic acid (KA), and anthranilic acid was observed in treatment-naïve PAH patients compared with controls. A similar KP-metabolite profile was observed in monocrotaline, but not Sugen/hypoxia-induced PAH. Human lung primary cells (microvascular endothelial cells, pulmonary artery smooth muscle cells, and fibroblasts) were exposed to different cytokines in vitro. Following exposure to interleukin-6 (IL-6)/IL-6 receptor α (IL-6Rα) complex, all cell types exhibit a similar KP-metabolite profile as observed in PAH patients. PAH therapy partially normalized this profile in survivors after one year. Increased KP-metabolites correlated with higher pulmonary vascular resistance, shorter six-minute walking distance, and worse functional class. High levels of Kyn, 3-HK, QA, and KA measured at the latest time-point were associated with worse long-term survival. KP-metabolism was activated in treatment-naïve PAH patients, likely mediated through IL-6/IL-6Rα signaling. KP-metabolites predict response to PAH therapy and survival of PAH patients.
MeSH term(s)	Animals ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Hypoxia/metabolism ; Interleukin-6/metabolism ; Kynurenic Acid/metabolism ; Kynurenine/metabolism ; Monocrotaline ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/pathology ; Quinolinic Acid/metabolism ; Rats ; Receptors, Interleukin-6/metabolism
Chemical Substances	IL6 protein, human ; IL6R protein, human ; Il6 protein, rat ; Interleukin-6 ; Receptors, Interleukin-6 ; Kynurenine (343-65-7) ; Monocrotaline (73077K8HYV) ; Quinolinic Acid (F6F0HK1URN) ; Kynurenic Acid (H030S2S85J)
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-15039-3
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Article ; Online: Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension.

Cai, Zongye / van Duin, Richard W B / Stam, Kelly / Uitterdijk, André / van der Velden, Jolanda / Vonk Noordegraaf, Anton / Duncker, Dirk J / Merkus, Daphne

American journal of physiology. Heart and circulatory physiology

2019 Volume 317, Issue 4, Page(s) H840–H850

Abstract: Assessing right ventricular (RV) functional reserve is important for determining clinical status and prognosis in patients with pulmonary hypertension (PH). In this study, we aimed to establish RV oxygen ( ... ...

Abstract	Assessing right ventricular (RV) functional reserve is important for determining clinical status and prognosis in patients with pulmonary hypertension (PH). In this study, we aimed to establish RV oxygen (O
MeSH term(s)	Age Factors ; Animals ; Chronic Disease ; Disease Models, Animal ; Exercise Tolerance ; Female ; Heart Ventricles/metabolism ; Heart Ventricles/physiopathology ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/physiopathology ; Male ; Oxygen/blood ; Oxygen Consumption ; Physical Exertion ; Sus scrofa ; Ventricular Dysfunction, Right/blood ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Right ; Ventricular Pressure
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00130.2019
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Article ; Online: Exercise facilitates early recognition of cardiac and vascular remodeling in chronic thromboembolic pulmonary hypertension in swine.

Stam, Kelly / van Duin, Richard W B / Uitterdijk, André / Cai, Zongye / Duncker, Dirk J / Merkus, Daphne

American journal of physiology. Heart and circulatory physiology

2017 Volume 314, Issue 3, Page(s) H627–H642

Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) develops in 4% of patients after pulmonary embolism and is accompanied by an impaired exercise tolerance, which is ascribed to the increased right ventricular (RV) afterload in combination with a ... ...

Abstract	Chronic thromboembolic pulmonary hypertension (CTEPH) develops in 4% of patients after pulmonary embolism and is accompanied by an impaired exercise tolerance, which is ascribed to the increased right ventricular (RV) afterload in combination with a ventilation/perfusion (V/Q) mismatch in the lungs. The present study aimed to investigate changes in arterial Po
MeSH term(s)	Animals ; Chronic Disease ; Disease Models, Animal ; Disease Progression ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Female ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Hypertrophy, Right Ventricular/etiology ; Hypertrophy, Right Ventricular/metabolism ; Hypertrophy, Right Ventricular/physiopathology ; Male ; Physical Exertion ; Pulmonary Artery/metabolism ; Pulmonary Artery/physiopathology ; Pulmonary Embolism/complications ; Pulmonary Embolism/metabolism ; Pulmonary Embolism/physiopathology ; Sus scrofa ; Vascular Remodeling ; Ventricular Dysfunction, Right/etiology ; Ventricular Dysfunction, Right/metabolism ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Right ; Ventricular Remodeling
Language	English
Publishing date	2017-11-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00380.2017
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Article ; Online: Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

Zongye Cai / Theo Klein / Laurie W. Geenen / Ly Tu / Siyu Tian / Annemien E. van den Bosch / Yolanda B. de Rijke / Irwin K. M. Reiss / Eric Boersma / Dirk J. Duncker / Karin A. Boomars / Christophe Guignabert / Daphne Merkus

Journal of Clinical Medicine, Vol 9, Iss 1248, p

2020 Volume 1248

Abstract: Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms are involved, with melatonin exerting anti-oxidant and anti-inflammatory effects, as well as inducing ... ...

Abstract	: Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms are involved, with melatonin exerting anti-oxidant and anti-inflammatory effects, as well as inducing vasodilation and cardio-protection. However, endogenous levels of melatonin in treatment-naïve patients with PH and their clinical significance are still unknown. Plasma levels of endogenous melatonin were measured by liquid chromatography-tandem mass spectrometry in PH patients ( n = 64, 43 pulmonary arterial hypertension (PAH) and 21 chronic thromboembolic PH (CTEPH)) and healthy controls ( n = 111). Melatonin levels were higher in PH, PAH, and CTEPH patients when compared with controls (Median 118.7 (IQR 108.2–139.9), 118.9 (109.3–147.7), 118.3 (106.8–130.1) versus 108.0 (102.3–115.2) pM, respectively, p all < 0.001). The mortality was 26% (11/43) in the PAH subgroup during a long-term follow-up of 42 (IQR: 32–58) months. Kaplan–Meier analysis showed that, in the PAH subgroup, patients with melatonin levels in the 1st quartile (<109.3 pM) had a worse survival than those in quartile 2–4 (Mean survival times were 46 (95% CI: 30–65) versus 68 (58–77) months, Log-rank, p = 0.026) with an increased hazard ratio of 3.5 (95% CI: 1.1–11.6, p = 0.038). Endogenous melatonin was increased in treatment-naïve patients with PH, and lower levels of melatonin were associated with worse long-term survival in patient with PAH.
Keywords	melatonin ; pulmonary hypertension ; survival ; clinical outcome ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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