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  1. Article ; Online: Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys.

    Wang, Meng / Wang, Lingchen / Zhou, Liang / Xu, Yizeng / Wang, Chen

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 126, Page(s) 155450

    Abstract: Background: Shen Shuai Ⅱ Recipe (SSR) is clinically used to treat chronic kidney diseases (CKDs ...

    Abstract Background: Shen Shuai Ⅱ Recipe (SSR) is clinically used to treat chronic kidney diseases (CKDs) with remarkable efficacy and safety. In earlier research, we found the anti-inflammatory, antioxidant, and mitochondrial protective properties of SSR in hypoxic kidney injury model, which is closely related to its renal protection. Further work is needed to understand the underlying molecular mechanisms.
    Purpose: Further investigation of the mechanisms of action of SSR against renal interstitial fibrosis (RIF) building on previous research leads.
    Methods: Rats receiving CKD model surgery were given with Fenofibrate or SSR once a day for eight weeks. In vitro, the NRK-52E cells were treated with SSR in the presence or absence of 10 μM Sc75741, 0.5 μM PMA, or 1 μM fenofibrate under 1% O
    Results: SSR attenuated the release of IL-18, VEGF, and MCP1 cytokines, inhibited the activation of NF-κB/NLRP3 cascade, increased the PPARα, CPT-1α, CPT-2, ACADL, and MCAD protein expression, and improved the lipid accumulation. Further studies have demonstrated that one of the ways in which SSR suppresses the inflammatory response to protect renal tubular cells is through the restoration of PPARα-mediated FAO. In addition, by means of co-culture ways, the results demonstrated that SSR attenuated secretion of inflammatory mediators in NRK-52E cells by PPARα/NF-κB/NLRP3 pathway, thereby inhibiting renal fibroblast activation.
    Conclusion: SSR inhibits RIF by suppressing inflammatory response of hypoxia-exposed RTECs through PPARα-mediated FAO.
    MeSH term(s) Rats ; Animals ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; PPAR alpha/metabolism ; NF-kappa B/metabolism ; Fenofibrate/metabolism ; Fenofibrate/pharmacology ; Kidney ; Renal Insufficiency, Chronic ; Inflammation/metabolism ; Cytokines/metabolism ; Fatty Acids/metabolism ; Fibrosis ; Fibroblasts/metabolism
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein ; PPAR alpha ; NF-kappa B ; Fenofibrate (U202363UOS) ; Cytokines ; Fatty Acids
    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging.

    Xu, Yizeng / Lu, Fang / Wang, Meng / Wang, Lingchen / Ye, Chaoyang / Yang, Shuohui / Wang, Chen

    Renal failure

    2024  Volume 46, Issue 1, Page(s) 2338565

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Rats ; Animals ; Creatinine/metabolism ; Uric Acid/pharmacology ; Rats, Sprague-Dawley ; Rats, Wistar ; Kidney ; Renal Insufficiency, Chronic ; Ischemia ; Infarction/metabolism ; Infarction/pathology ; Hypoxia/drug therapy ; Hypoxia/metabolism ; Hypoxia/pathology ; Fibrosis ; Proteinuria/pathology ; Magnetic Resonance Imaging/methods ; Hemoglobins/metabolism
    Chemical Substances Creatinine (AYI8EX34EU) ; Uric Acid (268B43MJ25) ; Hemoglobins
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2024.2338565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1331: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis.

    Chen, Xujiao / Gao, Shouhong / Ruan, Mengna / Chen, Sixiu / Xu, Jing / Xing, Xiaohong / Pan, Xiaohong / Mei, Changlin / Mao, Zhiguo

    Bioscience reports

    2018  Volume 38, Issue 5

    Abstract: ... of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used ...

    Abstract Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease (CKD) patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs. Participants with SSN intervention took 5 g SSN granule three times daily for 12 weeks, while the baseline medications and dialysis prescriptions remained during the study in all patients. The serum concentrations of indoxyl sulphate (IS) and
    MeSH term(s) Adult ; Cresols/blood ; Drugs, Chinese Herbal/pharmacology ; Female ; Humans ; Indican/blood ; Kidney Failure, Chronic/therapy ; Kidney Function Tests ; Male ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Sulfuric Acid Esters/blood ; Treatment Outcome ; Uremia/blood ; Uremia/drug therapy
    Chemical Substances Cresols ; Drugs, Chinese Herbal ; Shenshuaining ; Sulfuric Acid Esters ; 4-cresol sulfate (56M34ZQY1S) ; Indican (N187WK1Y1J)
    Language English
    Publishing date 2018-09-13
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20171694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: [Clinical study on Shen Shuai Fang in treating chronic renal failure].

    Wu, Xin-Lin / Li, Zhi-Jian / Zhang, Wei-Jun / Ao, Qin-Xing / Xu, Yuan-Wen

    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

    2008  Volume 31, Issue 5, Page(s) 796–798

    Abstract: Objective: To explore the effect of Shen Shuai Fang in treating Chronic Renal Failure (CRF ... divided into two groups, 75 patients in treatment group were treated with Shen Shuai Fang adding western ... P < 0.05 or P < 0.01).: Conclusion: Shen Shuai Fang is effective to treat CRF of deficiency ...

    Abstract Objective: To explore the effect of Shen Shuai Fang in treating Chronic Renal Failure (CRF) of deficiency of spleen and kidney with turbid damp and blood stagnation symptom.
    Methods: 125 patients with CRF of deficiency of spleen and kidney with turbid damp and blood stagnation symptom were randomly divided into two groups, 75 patients in treatment group were treated with Shen Shuai Fang adding western medicine and the other patients in control group were treated only with western medicine. We observed the effect and indexes change including renal function, Hb, proteinuria, lipid before and after treatment.
    Results: After six months' treatment, the general effective rate in treatment group was 77.33%, which was higher than that in control group obviously (44.00%, P < 0.01). So treatment group was obviously better than control group on decreasing proteinuria, improving renal function, increasing Hb, ameliorating lipid metabolism (P < 0.05 or P < 0.01).
    Conclusion: Shen Shuai Fang is effective to treat CRF of deficiency of spleen and kidney with turbid damp and blood stagnation symptom.
    MeSH term(s) Adolescent ; Adult ; Aged ; Drug Combinations ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Kidney Failure, Chronic/drug therapy ; Kidney Failure, Chronic/pathology ; Kidney Function Tests ; Male ; Middle Aged ; Phytotherapy ; Plants, Medicinal/chemistry ; Ramipril/therapeutic use ; Treatment Outcome ; Yin Deficiency/drug therapy ; Young Adult
    Chemical Substances Drug Combinations ; Drugs, Chinese Herbal ; Ramipril (L35JN3I7SJ)
    Language Chinese
    Publishing date 2008-05
    Publishing country China
    Document type English Abstract ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1001-4454
    ISSN 1001-4454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Cai tu yan huan shuai lao fang yao ji jin

    Yin, Guangyao / Xu, Fuchang

    Zhong Ying dui zhao

    2001  

    Title variant Yan huan shuai lao fang yao ji jin ; Collection of ageing delaying traditional Chinese medicines with color illustration. ; Collection of ageing delaying traditional Chinese medicines with color illustration ; Zhong Ying dui zhao
    Author's details Yin Guangyao, Xu Fuchang bian zhu
    MeSH term(s) Aging/drug effects ; Longevity/drug effects ; Materia Medica/therapeutic use
    Language Chinese ; English
    Size 10, 38, 250 p. :, col. ill. ;, 30 cm.
    Edition Di 1 ban.
    Publisher Bai jia chu ban she
    Publishing place Shanghai
    Document type Book
    Note Chinese and English. ; Includes indexes.
    ISBN 9787806562970 ; 7806562974
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book ; Online: Nonparametric Bayesian Learning for Collaborative Robot Multimodal Introspection

    Zhou, Xuefeng / Wu, Hongmin / Rojas, Juan / Xu, Zhihao / Li, Shuai

    2020  

    Author's details by Xuefeng Zhou, Hongmin Wu, Juan Rojas, Zhihao Xu, Shuai Li
    Keywords Robotics ; Automation ; Statistics  ; Control engineering ; Mechatronics ; Machine learning ; Mathematical models
    Subject code 629.892
    Language English
    Size 1 Online-Ressource (XVII, 137 p. 50 illus., 44 illus. in color)
    Edition 1st ed. 2020
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT020543980
    ISBN 978-981-15-6263-1 ; 9789811562624 ; 9789811562648 ; 9789811562655 ; 981-15-6263-6 ; 9811562628 ; 9811562644 ; 9811562652
    DOI 10.1007/978-981-15-6263-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book: Kang shuai lao yao wu di yao li yu ying yong

    Xu, Shikai

    1987  

    Title translation Pharmacology and uses of antiaging drugs.
    Author's details Xu Shikai bian zhu
    MeSH term(s) Aging/drug effects ; Drugs, Chinese Herbal/pharmacology
    Language Chinese
    Size 3, 3, 208 p. :, ill.
    Edition Di 1 ban.
    Publisher Shanghai Zhong yi xue yuan chu ban she
    Publishing place Shanghai
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book ; Online: AI based Robot Safe Learning and Control

    Zhou, Xuefeng / Xu, Zhihao / Li, Shuai / Wu, Hongmin / Cheng, Taobo / Lv, Xiaojing

    2020  

    Author's details by Xuefeng Zhou, Zhihao Xu, Shuai Li, Hongmin Wu, Taobo Cheng, Xiaojing Lv
    Keywords Robotics ; Automation ; Control engineering ; Artificial intelligence ; Künstliche Intelligenz ; Robotik ; Maschinelles Lernen
    Subject Robotertechnik ; Robotics ; Artificial intelligence ; Computerunterstützte Intelligenz ; Maschinelle Intelligenz ; KI ; Algorithmisches Lernen ; Lernen ; Automated learning ; Machine learning
    Subject code 629.892
    Language English
    Size 1 Online-Ressource (XVII, 127 p. 42 illus., 35 illus. in color)
    Edition 1st ed. 2020
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT020521439
    ISBN 978-981-15-5503-9 ; 9789811555022 ; 9789811555046 ; 9789811555053 ; 981-15-5503-6 ; 9811555028 ; 9811555044 ; 9811555052
    DOI 10.1007/978-981-15-5503-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Book ; Online: AI based Robot Safe Learning and Control

    Zhou, Xuefeng / Xu, Zhihao / Li, Shuai / Wu, Hongmin / Cheng, Taobo / Lv, Xiaojing

    2020  

    Abstract: This open access book mainly focuses on the safe control of robot manipulators. The control schemes are mainly developed based on dynamic neural network, which is an important theoretical branch of deep reinforcement learning. In order to enhance the ... ...

    Abstract This open access book mainly focuses on the safe control of robot manipulators. The control schemes are mainly developed based on dynamic neural network, which is an important theoretical branch of deep reinforcement learning. In order to enhance the safety performance of robot systems, the control strategies include adaptive tracking control for robots with model uncertainties, compliance control in uncertain environments, obstacle avoidance in dynamic workspace. The idea for this book on solving safe control of robot arms was conceived during the industrial applications and the research discussion in the laboratory. Most of the materials in this book are derived from the authors' papers published in journals, such as IEEE Transactions on Industrial Electronics, neurocomputing, et cetera This book can be used as a reference book for researcher and designer of the robotic systems and AI based controllers, and can also be used as a reference book for senior undergraduate and graduate students in colleges and universities
    Keywords Agriculture (General) ; Information technology ; Künstliche Intelligenz ; Robotik ; Maschinelles Lernen
    Subject Algorithmisches Lernen ; Lernen ; Automated learning ; Machine learning ; Robotertechnik ; Robotics ; Artificial intelligence ; Computerunterstützte Intelligenz ; Maschinelle Intelligenz ; KI
    Size 1 electronic resource (127 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020589656
    ISBN 9789811555039 ; 9811555036
    DOI 10.1007/978-981-15-5503-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Book ; Online: Nonparametric Bayesian Learning for Collaborative Robot Multimodal Introspection

    Zhou, Xuefeng / Wu, Hongmin / Rojas, Juan / Xu, Zhihao / Li, Shuai

    2020  

    Abstract: This open access book focuses on robot introspection, which has a direct impact on physical human-robot interaction and long-term autonomy, and which can benefit from autonomous anomaly monitoring and diagnosis, as well as anomaly recovery strategies. In ...

    Abstract This open access book focuses on robot introspection, which has a direct impact on physical human-robot interaction and long-term autonomy, and which can benefit from autonomous anomaly monitoring and diagnosis, as well as anomaly recovery strategies. In robotics, the ability to reason, solve their own anomalies and proactively enrich owned knowledge is a direct way to improve autonomous behaviors. To this end, the authors start by considering the underlying pattern of multimodal observation during robot manipulation, which can effectively be modeled as a parametric hidden Markov model (HMM). They then adopt a nonparametric Bayesian approach in defining a prior using the hierarchical Dirichlet process (HDP) on the standard HMM parameters, known as the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM). The HDP-HMM can examine an HMM with an unbounded number of possible states and allows flexibility in the complexity of the learned model and the development of reliable and scalable variational inference methods. This book is a valuable reference resource for researchers and designers in the field of robot learning and multimodal perception, as well as for senior undergraduate and graduate university students
    Keywords Agriculture (General) ; Mathematics ; Information technology
    Size 1 electronic resource (137 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020676445
    ISBN 9789811562631 ; 9811562636
    DOI 10.1007/978-981-15-6263-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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