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  1. Article: Variable effects of

    Dodson, Brittany L / Pujhari, Sujit / Brustolin, Marco / Metz, Hillery C / Rasgon, Jason L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Wolbachia ... ...

    Abstract Wolbachia pipientis
    Language English
    Publishing date 2023-01-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.20.524939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Wolbachia

    Pujhari, Sujit / Hughes, Grant L / Pakpour, Nazzy / Suzuki, Yasutsugu / Rasgon, Jason L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Enhanced host immunity and competition for metabolic resources are two main competing hypotheses for the mechanism ... ...

    Abstract Enhanced host immunity and competition for metabolic resources are two main competing hypotheses for the mechanism of
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.31.543096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness.

    Pujhari, Sujit / Rasgon, Jason L

    Virulence

    2020  Volume 11, Issue 1, Page(s) 486–488

    Abstract: Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology ... ...

    Abstract Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
    MeSH term(s) Animals ; COVID-19 ; Coronavirus Infections/pathology ; Disease Models, Animal ; Humans ; Mice ; Pandemics ; Pluripotent Stem Cells/transplantation ; Pneumonia, Viral/pathology ; Research/legislation & jurisprudence ; Research/standards ; Research/trends ; Respiratory Tract Infections/pathology ; Transplantation, Heterologous/legislation & jurisprudence ; Transplantation, Heterologous/trends
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2020.1763637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Sindbis virus is suppressed in the yellow fever mosquito

    Pujhari, Sujit / Heu, Chan C / Brustolin, Marco / Johnson, Rebecca M / Kim, Donghun / Rasgon, Jason L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Autophagy is a critical modulator of pathogen invasion response in vertebrates and invertebrates. However, how it affects mosquito-borne viral pathogens that significantly burden public health remains underexplored. To address this gap, we use a genetic ... ...

    Abstract Autophagy is a critical modulator of pathogen invasion response in vertebrates and invertebrates. However, how it affects mosquito-borne viral pathogens that significantly burden public health remains underexplored. To address this gap, we use a genetic approach to activate macroautophagy/autophagy in the yellow fever mosquito (
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.02.526867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

    Sujit Pujhari / Jason L Rasgon

    Virulence, Vol 11, Iss 1, Pp 486-

    2020  Volume 488

    Abstract: Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology ... ...

    Abstract Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
    Keywords sars-cov-2 ; respiratory infectious diseases ; pluripotent stem cell ; animal model ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

    Pujhari, Sujit / Rasgon, Jason L

    Virulence

    2020  Volume 11, Issue 1, Page(s) 486–488

    Keywords Immunology ; Microbiology (medical) ; Microbiology ; Parasitology ; Infectious Diseases ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2020.1763637
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: In Vitro

    Brustolin, Marco / Pujhari, Sujit / Terradas, Gerard / Werling, Kristine / Asad, Sultan / Metz, Hillery C / Henderson, Cory A / Kim, Donghun / Rasgon, Jason L

    Journal of virology

    2023  Volume 97, Issue 1, Page(s) e0177822

    Abstract: Globalization and climate change have contributed to the simultaneous increase and spread of arboviral diseases. Cocirculation of several arboviruses in the same geographic region provides an impetus to study the impacts of multiple concurrent infections ...

    Abstract Globalization and climate change have contributed to the simultaneous increase and spread of arboviral diseases. Cocirculation of several arboviruses in the same geographic region provides an impetus to study the impacts of multiple concurrent infections within an individual vector mosquito. Here, we describe coinfection and superinfection with the Mayaro virus (Togaviridae,
    MeSH term(s) Animals ; Humans ; Aedes/virology ; Alphavirus ; Alphavirus Infections/complications ; Alphavirus Infections/virology ; Coinfection ; Mosquito Vectors/virology ; Superinfection ; Vertebrates/virology ; Zika Virus ; Zika Virus Infection/complications ; Zika Virus Infection/virology
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01778-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness

    Pujhari, Sujit / Rasgon, Jason L

    Virulence

    Abstract: Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology ... ...

    Abstract Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327357
    Database COVID19

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  9. Article ; Online: Identification of MicroRNAs in the West Nile Virus Vector Culex tarsalis (Diptera: Culicidae).

    Asad, Sultan / Mehdi, Ahmed M / Pujhari, Sujit / Rückert, Claudia / Ebel, Gregory D / Rasgon, Jason L

    Journal of medical entomology

    2022  Volume 60, Issue 2, Page(s) 182–293

    Abstract: MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate gene expression during important biological processes including development and pathogen defense in most living organisms. Presently, no miRNAs have been identified in the mosquito ... ...

    Abstract MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate gene expression during important biological processes including development and pathogen defense in most living organisms. Presently, no miRNAs have been identified in the mosquito Culex tarsalis (Diptera: Culicidae), one of the most important vectors of West Nile virus (WNV) in North America. We used small RNA sequencing data and in vitro and in vivo experiments to identify and validate a repertoire of miRNAs in Cx. tarsalis mosquitoes. Using bioinformatic approaches we analyzed small RNA sequences from the Cx. tarsalis CT embryonic cell line to discover orthologs for 86 miRNAs. Consistent with other mosquitoes such as Aedes albopictus and Culex quinquefasciatus, miR-184 was found to be the most abundant miRNA in Cx. tarsalis. We also identified 20 novel miRNAs from the recently sequenced Cx. tarsalis genome, for a total of 106 miRNAs identified in this study. The presence of selected miRNAs was biologically validated in both the CT cell line and in adult Cx. tarsalis mosquitoes using RT-qPCR and sequencing. These results will open new avenues of research into the role of miRNAs in Cx. tarsalis biology, including development, metabolism, immunity, and pathogen infection.
    MeSH term(s) Animals ; West Nile virus/genetics ; Culex/genetics ; Culicidae/genetics ; MicroRNAs/genetics ; West Nile Fever ; Mosquito Vectors/genetics ; Aedes/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 410635-0
    ISSN 1938-2928 ; 0022-2585
    ISSN (online) 1938-2928
    ISSN 0022-2585
    DOI 10.1093/jme/tjac182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Characterization of Mayaro virus (strain BeAn343102) biology in vertebrate and invertebrate cellular backgrounds.

    Pujhari, Sujit / Brustolin, Marco / Heu, Chan C / Smithwick, Ronald / Larrosa, Mireia / Hafenstein, Susan / Rasgon, Jason L

    The Journal of general virology

    2022  Volume 103, Issue 10

    Abstract: Mayaro virus (MAYV) is an emerging New World alphavirus ( ... ...

    Abstract Mayaro virus (MAYV) is an emerging New World alphavirus (genus
    MeSH term(s) Alphavirus/genetics ; Amiloride/pharmacology ; Ammonium Chloride ; Animals ; Biology ; Clathrin ; Culicidae ; Vertebrates
    Chemical Substances Clathrin ; Ammonium Chloride (01Q9PC255D) ; Amiloride (7DZO8EB0Z3)
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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