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Article: Contributions of the Abductor Muscles to Rotational and Distractive Stability of the Hip in a Biomechanical Cadaveric Model.

Lim, Daniel P / Lazaro, Lionel E / Kyhos, Justin F / Chau, Michael M / Ladnier, Karen J / Nelson, Trevor J / Eberlein, Samuel A / Banffy, Michael B / Metzger, Melodie F

Orthopaedic journal of sports medicine

2024 Volume 12, Issue 3, Page(s) 23259671241231984

Abstract: Background: The gluteus minimus (GMin) and gluteus medius (GMed) are important dynamic stabilizers of the hip, but quantitative data on their biomechanical roles in stabilizing the hip are currently lacking.: Purpose: To (1) establish a reproducible ... ...

Abstract	Background: The gluteus minimus (GMin) and gluteus medius (GMed) are important dynamic stabilizers of the hip, but quantitative data on their biomechanical roles in stabilizing the hip are currently lacking. Purpose: To (1) establish a reproducible biomechanical cadaveric model of the hip abductor complex and (2) characterize the effects of loading the GMin and GMed on extraneous femoral rotation and distraction. Study design: Controlled laboratory study. Methods: A total of 10 hemipelvises were tested in 4 muscle loading states: (1) unloaded, (2) the GMin loaded, (3) the GMed loaded, and (4) both the GMin and GMed loaded. Muscle loads were applied via cables, pulleys, and weights attached to the tendons to replicate the anatomic lines of action. Specimens were tested under internal rotation; external rotation; and axial traction forces at 0°, 15°, 30°, 60°, and 90° of hip flexion. Results: When loaded together, the GMin and GMed reduced internal rotation motion at all hip flexion angles ( Conclusion: The results of this study demonstrated that the GMin and GMed provide stability against rotational torques and distractive forces and that the amount of contribution depends on the degree of hip flexion. Clinical relevance: Improved understanding of the roles of the GMin and GMed in preventing rotational and distractive instability of the hip will better guide treatment of hip pathologies and optimize nonoperative and operative therapies.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671241231984
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Article ; Online: The effect of taking blood pressure lowering medication at night on cardiovascular disease risk. A systematic review.

Ho, Chau L B / Chowdhury, Enayet K / Doust, Jenny / Nelson, Mark R / Reid, Christopher M

Journal of human hypertension

2021 Volume 35, Issue 4, Page(s) 308–314

Abstract: To investigate the effect of night-time BP-lowering drug treatment on the risk of major CVD and mortality, we systematically reviewed randomized controlled trials comparing night-time versus morning dosing. Two studies were found relevant to the clinical ...

Abstract	To investigate the effect of night-time BP-lowering drug treatment on the risk of major CVD and mortality, we systematically reviewed randomized controlled trials comparing night-time versus morning dosing. Two studies were found relevant to the clinical question (the MAPEC and Hygia trials). They were similar in study design and population and were conducted by the same study group. As the Hygia trial had more power with a significantly larger sample size, we did not perform a meta-analysis. Both studies reported a reduction of ~50% in major CVD events and all-cause mortality with night-time dosing and a reduction of 60% in CVD mortality. The results from these studies support the implementation of night-time BP-lowering drug treatment in the prevention of CVD and mortality. However there is an on-going discussion on the validity and methodology of MAPEC and Hygia trials, the interpretation of the results should be cautious. Stronger evidence is needed prior to changing clinical practice. Questions that remain to be answered relate to the generalisability of the results across different populations at different levels of BP related risk and the importance of morning versus evening timing of medication on CVD prevention as determined though a well-designed randomised controlled trial.
MeSH term(s)	Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Blood Pressure Determination ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Humans
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-020-00469-1
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Zs.A 2380: Show issues

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Article ; Online: Real-world effectiveness of repeated intravenous ketamine infusions for treatment-resistant depression in transitional age youth.

Chisamore, Noah / Danayan, Kevork / Rodrigues, Nelson B / Di Vincenzo, Joshua D / Meshkat, Shakila / Doyle, Zoe / Mansur, Rodrigo / Phan, Lee / Fancy, Farhan / Chau, Edmond / Tabassum, Aniqa / Kratiuk, Kevin / Arekapudi, Anil / McIntyre, Roger S / Rosenblat, Joshua D

Journal of psychopharmacology (Oxford, England)

2023 Volume 37, Issue 8, Page(s) 775–783

Abstract: Background: Ketamine is an emerging treatment for treatment-resistant depression (TRD) associated with rapid and robust improvements in depressive symptoms and suicidality. However, the efficacy and safety of ketamine in transitional age youth (TAY; age ...

Abstract	Background: Ketamine is an emerging treatment for treatment-resistant depression (TRD) associated with rapid and robust improvements in depressive symptoms and suicidality. However, the efficacy and safety of ketamine in transitional age youth (TAY; age 18-25) populations remains understudied. Methods: In this retrospective analysis, TAY patients ( Results: A significant main effect of infusions on reduction of total QIDS-SR16 ( Conclusion: Ketamine was associated with comparable clinical benefits, safety, and tolerability in a TAY sample as compared to a matched GA TRD sample.
MeSH term(s)	Adult ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Ketamine/adverse effects ; Depression/diagnosis ; Retrospective Studies ; Depressive Disorder, Treatment-Resistant/drug therapy ; Depressive Disorder, Treatment-Resistant/diagnosis ; Infusions, Intravenous
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639313-5
ISSN	1461-7285 ; 0269-8811
ISSN (online)	1461-7285
ISSN	0269-8811
DOI	10.1177/02698811231171531
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Zs.A 2311: Show issues

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Article ; Online: Non-inhibited miRNAs shape the cellular response to anti-miR.

Androsavich, John R / Chau, B Nelson

Nucleic acids research

2014 Volume 42, Issue 11, Page(s) 6945–6955

Abstract: Identification of primary microRNA (miRNA) gene targets is critical for developing miRNA-based therapeutics and understanding their mechanisms of action. However, disentangling primary target derepression induced by miRNA inhibition from secondary ... ...

Abstract	Identification of primary microRNA (miRNA) gene targets is critical for developing miRNA-based therapeutics and understanding their mechanisms of action. However, disentangling primary target derepression induced by miRNA inhibition from secondary effects on the transcriptome remains a technical challenge. Here, we utilized RNA immunoprecipitation (RIP) combined with competitive binding assays to identify novel primary targets of miR-122. These transcripts physically dissociate from AGO2-miRNA complexes when anti-miR is spiked into liver lysates. mRNA target displacement strongly correlated with expression changes in these genes following in vivo anti-miR dosing, suggesting that derepression of these targets directly reflects changes in AGO2 target occupancy. Importantly, using a metric based on weighted miRNA expression, we found that the most responsive mRNA target candidates in both RIP competition assays and expression profiling experiments were those with fewer alternative seed sites for highly expressed non-inhibited miRNAs. These data strongly suggest that miRNA co-regulation modulates the transcriptomic response to anti-miR. We demonstrate the practical utility of this 'miR-target impact' model, and encourage its incorporation, together with the RIP competition assay, into existing target prediction and validation pipelines.
MeSH term(s)	Animals ; Argonaute Proteins/isolation & purification ; Binding, Competitive ; Biomarkers ; Gene Expression Regulation ; Immunoprecipitation ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Models, Genetic ; Oligonucleotides ; RNA, Messenger/metabolism ; Transcriptome
Chemical Substances	Ago2 protein, mouse ; Argonaute Proteins ; Biomarkers ; MicroRNAs ; Oligonucleotides ; RNA, Messenger
Language	English
Publishing date	2014-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gku344
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Zs.A 1067: Show issues

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Article ; Online: Real world effectiveness of repeated ketamine infusions for treatment-resistant depression with comorbid borderline personality disorder.

Danayan, Kevork / Chisamore, Noah / Rodrigues, Nelson B / Vincenzo, Joshua D Di / Meshkat, Shakila / Doyle, Zoe / Mansur, Rodrigo / Phan, Lee / Fancy, Farhan / Chau, Edmond / Tabassum, Aniqa / Kratiuk, Kevin / Arekapudi, Anil / Teopiz, Kayla M / McIntyre, Roger S / Rosenblat, Joshua D

Psychiatry research

2023 Volume 323, Page(s) 115133

Abstract: Borderline personality disorder (BPD) has high rates of comorbidity with mood disorders, including treatment-resistant depression (TRD). Comorbidity of BPD with depression is associated with poorer response to antidepressants. Intravenous ketamine is a ... ...

Abstract	Borderline personality disorder (BPD) has high rates of comorbidity with mood disorders, including treatment-resistant depression (TRD). Comorbidity of BPD with depression is associated with poorer response to antidepressants. Intravenous ketamine is a novel treatment for TRD that has not been specifically evaluated in patients with comorbid BPD. In this retrospective analysis of data collected from participants who received care at the Canadian Rapid Treatment Centre of Excellence (CRTCE; Braxia Health; ClinicalTrials.gov: NCT04209296), we evaluated the effectiveness of intravenous ketamine in a TRD population with comorbid BPD (N=100; n=50 BPD-positive compared with n=50 BPD-negative). Participants were administered four doses of intravenous ketamine (0.5-0.75mg/kg over 40 minutes) over two weeks. The primary outcome measures were changes in depressive symptom severity (as measured by Quick Inventory of Depressive Symptomatology-Self Report 16-item (QIDS-SR
MeSH term(s)	Humans ; Borderline Personality Disorder/complications ; Borderline Personality Disorder/drug therapy ; Borderline Personality Disorder/epidemiology ; Canada/epidemiology ; Depression/epidemiology ; Depressive Disorder, Treatment-Resistant/complications ; Depressive Disorder, Treatment-Resistant/drug therapy ; Depressive Disorder, Treatment-Resistant/epidemiology ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Retrospective Studies
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2023-03-05
Publishing country	Ireland
Document type	Clinical Trial ; Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115133
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Zs.A 1541: Show issues

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Article ; Online: Real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression.

Fancy, Farhan / Rodrigues, Nelson B / Di Vincenzo, Joshua D / Chau, Edmond H / Sethi, Rickinder / Husain, Muhammad I / Gill, Hartej / Tabassum, Aniqa / Mckenzie, Andrea / Phan, Lee / McIntyre, Roger S / Rosenblat, Joshua D

Bipolar disorders

2022 Volume 25, Issue 2, Page(s) 99–109

Abstract: Background: Clinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real-world effectiveness ... ...

Abstract	Background: Clinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression. Methods: This study was conducted in a community clinic in Mississauga, Ontario (Canadian Rapid Treatment Centre of Excellence; Braxia Health). In this observational study (NCT04209296), patients with treatment-resistant bipolar I/II depression (n = 66) received four sub-anesthetic doses of IV ketamine (0.5-0.75 mg/kg) over a two-week period. Symptoms of depression, suicidality, anxiety, and functioning were assessed with validated self-report measures. Results: Statistically and clinically significant antidepressant effects were observed in the overall sample, as measured by the Quick Inventory for Depression Symptomatology-Self Report-16 (QIDS-SR Conclusions: Real-world effectiveness of IV ketamine for bipolar depression was observed. Repeated doses were associated with greater symptom reduction and adequate tolerability.
MeSH term(s)	Humans ; Ketamine ; Bipolar Disorder/drug therapy ; Depressive Disorder, Major/diagnosis ; Canada ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Treatment-Resistant/drug therapy ; Infusions, Intravenous ; Depression/diagnosis
Chemical Substances	Ketamine (690G0D6V8H) ; Antidepressive Agents
Language	English
Publishing date	2022-12-26
Publishing country	Denmark
Document type	Observational Study ; Journal Article
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/bdi.13284
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Zs.A 5604: Show issues

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Article ; Online: Author Correction: Isolated detection of elastic waves driven by the momentum of light.

Požar, Tomaž / Laloš, Jernej / Babnik, Aleš / Petkovšek, Rok / Bethune-Waddell, Max / Chau, Kenneth J / Lukasievicz, Gustavo V B / Astrath, Nelson G C

Nature communications

2019 Volume 10, Issue 1, Page(s) 3949

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2019-08-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-019-11969-1
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Article ; Online: Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

2022 Volume 132, Issue 10

MeSH term(s)	Cell Proliferation ; Humans ; Hypertension, Pulmonary/genetics ; MicroRNAs/genetics ; Myocytes, Smooth Muscle ; Pulmonary Artery
Chemical Substances	MIRN130 microRNA, human ; MicroRNAs
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI161077
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Article ; Online: What goes up must come down: the emerging role of microRNA in fibrosis.

Chau, B Nelson / Brenner, David A

Hepatology (Baltimore, Md.)

2011 Volume 53, Issue 1, Page(s) 4–6

MeSH term(s)	Animals ; Biomarkers/blood ; Carbon Tetrachloride Poisoning/physiopathology ; Down-Regulation ; Extracellular Matrix/drug effects ; Extracellular Matrix/genetics ; Hepatic Stellate Cells/metabolism ; Humans ; Liver Cirrhosis/pathology ; Liver Cirrhosis/physiopathology ; Mice ; MicroRNAs/physiology
Chemical Substances	Biomarkers ; MIRN29 microRNA, mouse ; MicroRNAs
Language	English
Publishing date	2011-01-21
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.24071
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Zs.A 1660: Show issues

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Article ; Online: Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia.

Zhang, Shengwen / Bastille, Amy / Gordo, Susana / Ramesh, Nikhil / Vora, Jenisha / McCarthy, Elizabeth / Zhang, Xiaohan / Frank, Dylan / Ko, Chih-Wei / Wu, Carmen / Walsh, Noel / Amarwani, Shreya / Liao, Jing / Xiong, Qiang / Drouin, Lauren / Hebben, Matthias / Chiang, Kyle / Chau, B Nelson

PloS one

2022 Volume 17, Issue 9, Page(s) e0274774

Abstract: Methylmalonic acidemia (MMA) is an inborn error of metabolism mostly caused by mutations in the mitochondrial methylmalonyl-CoA mutase gene (MMUT). MMA patients suffer from frequent episodes of metabolic decompensation, which can be life threatening. To ... ...

Abstract	Methylmalonic acidemia (MMA) is an inborn error of metabolism mostly caused by mutations in the mitochondrial methylmalonyl-CoA mutase gene (MMUT). MMA patients suffer from frequent episodes of metabolic decompensation, which can be life threatening. To mimic both the dietary restrictions and metabolic decompensation seen in MMA patients, we developed a novel protein-controlled diet regimen in a Mmut deficient mouse model of MMA and demonstrated the therapeutic benefit of mLB-001, a nuclease-free, promoterless recombinant AAV GeneRideTM vector designed to insert the mouse Mmut into the endogenous albumin locus via homologous recombination. A single intravenous administration of mLB-001 to neonatal or adult MMA mice prevented body weight loss and mortality when challenged with a high protein diet. The edited hepatocytes expressed functional MMUT protein and expanded over time in the Mmut deficient mice, suggesting a selective growth advantage over the diseased cells. In mice with a humanized liver, treatment with a human homolog of mLB-001 resulted in site-specific genome editing and transgene expression in the transplanted human hepatocytes. Taken together, these findings support the development of hLB-001 that is currently in clinical trials in pediatric patients with severe forms of MMA.
MeSH term(s)	Adult ; Albumins/genetics ; Amino Acid Metabolism, Inborn Errors/genetics ; Amino Acid Metabolism, Inborn Errors/therapy ; Animals ; Child ; Disease Models, Animal ; Gene Editing ; Humans ; Methylmalonyl-CoA Mutase/genetics ; Methylmalonyl-CoA Mutase/metabolism ; Mice
Chemical Substances	Albumins ; Methylmalonyl-CoA Mutase (EC 5.4.99.2)
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274774
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