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Article ; Online: An electrochemiluminescence immunosensor based on multipath signal catalytic amplification integrated in a Cu

Wang, Haijun / Song, Yuhang / Chai, Yaqin / Yuan, Ruo

2023 Volume 148, Issue 14, Page(s) 3354–3358

Abstract: Here, the nanocomposite ... ...

Abstract	Here, the nanocomposite Cu
MeSH term(s)	Polyethyleneimine/chemistry ; Biosensing Techniques/methods ; Hydrogen Peroxide ; Luminescent Measurements/methods ; Electrochemical Techniques/methods ; Limit of Detection ; Immunoassay/methods ; Nanocomposites/chemistry ; Metal Nanoparticles/chemistry
Chemical Substances	Polyethyleneimine (9002-98-6) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an00721a
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Article ; Online: PEDOT/FeOOH/BiVO

Wang, Shuai / Chai, Yaqin / Yuan, Ruo / Liu, Hongyan

Analytical chemistry

2023 Volume 95, Issue 11, Page(s) 4896–4903

Abstract: Herein, a novel photoactive poly(3,4-ethyl-enedioxythiophene) (PEDOT)/FeOOH/ ... ...

Abstract	Herein, a novel photoactive poly(3,4-ethyl-enedioxythiophene) (PEDOT)/FeOOH/BiVO
MeSH term(s)	Electrochemical Techniques ; Limit of Detection ; MicroRNAs ; Nucleic Acid Hybridization ; Biosensing Techniques
Chemical Substances	poly(3,4-ethylene dioxythiophene) ; MicroRNAs
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04656
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Article ; Online: A simple and reliable interenzyme distance regulation strategy based on a DNA quadrangular prism scaffold for ultrasensitive ochratoxin A detection.

Wang, Rong / Kong, Lingqi / Liu, Ying / Chai, Yaqin / Yuan, Ruo

Food chemistry

2024 Volume 446, Page(s) 138872

Abstract: Developing sensitive and accurate Ochratoxin A (OTA) detection methods is essential for food safety. Herein, a simple and reliable strategy for regulating interenzyme distance based on a rigid DNA quadrangular prism as a scaffold was proposed to ... ...

Abstract	Developing sensitive and accurate Ochratoxin A (OTA) detection methods is essential for food safety. Herein, a simple and reliable strategy for regulating interenzyme distance based on a rigid DNA quadrangular prism as a scaffold was proposed to establish a new electrochemical biosensor for ultrasensitive detection of OTA. The interenzyme distances were precisely adjusted by changing the sequences of the hybridized portions of hairpins SH1 and SH2 to the DNA quadrangular prism, avoiding the complexity and instability of the previous DNA scaffold-based enzyme spacing adjustment strategies. The electrochemical biosensor constructed at the optimal interenzyme distance (10.4 nm) achieved sensitive detection of OTA in a dynamic concentration range from 10 fg/mL to 250 ng/mL with a detection limit of 3.1 fg/mL. In addition, the biosensor was applied to quantify OTA in real samples, exhibiting great application potential in food safety.
MeSH term(s)	DNA ; Ochratoxins/analysis ; Biosensing Techniques/methods ; Limit of Detection ; Aptamers, Nucleotide ; Electrochemical Techniques/methods
Chemical Substances	ochratoxin A (1779SX6LUY) ; DNA (9007-49-2) ; Ochratoxins ; Aptamers, Nucleotide
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138872
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Article ; Online: Recent Advances in DNA Nanostructures Applied in Sensing Interfaces and Cellular Imaging.

Zhang, Pu / Ouyang, Yu / Zhuo, Ying / Chai, Yaqin / Yuan, Ruo

Analytical chemistry

2023 Volume 95, Issue 1, Page(s) 407–419

MeSH term(s)	Nanostructures/chemistry ; DNA/chemistry ; Nanotechnology/methods
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04540
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Article ; Online: Difference in mortality risk predicted by leukocyte and lymphocyte levels in COVID-19 patients infected with the Wild-type, Delta, and Omicron strains.

Zhang, Hongjun / Zhao, Yanjun / Li, Wenjie / Chai, Yaqin / Gu, Xing

Medicine

2024 Volume 103, Issue 10, Page(s) e37516

Abstract: This study aimed to investigate the changing trends, level differences, and prognostic performance of the leukocyte and lymphocyte levels of patients infected with the Wild strains, Delta strains and Omicron strains to provide a reference for prognostic ... ...

Abstract	This study aimed to investigate the changing trends, level differences, and prognostic performance of the leukocyte and lymphocyte levels of patients infected with the Wild strains, Delta strains and Omicron strains to provide a reference for prognostic assessment. In the current study, we conducted a retrospective cross-sectional study to evaluate the changing trends, level differences, and prognostic performance of leukocyte and lymphocyte of different strains at admission and discharge may already exist in patients with coronavirus disease-2019 (COVID-19) infected with the Wild type, Delta, and Omicron strains. A retrospective cross-sectional study was conducted. We recruited and screened the 243 cases infected with the Wild-type strains in Wuhan, the 629 cases infected with the Delta and 116 cases infected strains with the Omicron strains in Xi'an. The leukocyte and lymphocyte levels were compared the cohort of Wild-type infection with the cohort of Delta and the Omicron. The changes in the levels of leukocytes and lymphocytes exhibit a completely opposite trend in patients with COVID-19 infected with the different strains. The lymphocyte level at admission and discharge in patients with COVID-19 infected with Omicron strains (area under curve [AUC] receiver operating characteristic curve [ROC] 72.8-90.2%, 82.8-97.2%) presented better performance compared patients with COVID-19 infected with Wild type strains (AUC ROC 60.9-80.7%, 82.3-97.2%) and Delta strains (AUC ROC 56.1-84.7%, 40.3-93.3%). Kaplan-Meier curves showed that the leukocyte levels above newly established cutoff values and the lymphocyte levels below newly established cutoff values had a significantly higher risk of in-hospital mortality in COVID-19 patients with Wild-type and Omicron strains (P < .01). The levels of leukocyte and lymphocyte at admission and discharge in patients with COVID-19 infected with the Wild type, Delta, and Omicron strains may be differences among strains, which indicates different death risks. Our research may help clinicians identify patients with a poor prognosis for severe acute respiratory syndrome coronavirus 2 infection.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Retrospective Studies ; COVID-19 ; Leukocytes ; Lymphocytes
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037516
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Article ; Online: Ultrasensitive Photocathodic Biosensor Based on the Cu

Zhou, Yuying / Ai, Simin / Chai, Yaqin / Yuan, Ruo / Liu, Hongyan

Analytical chemistry

2023 Volume 95, Issue 33, Page(s) 12383–12390

Abstract: Herein, an ultrasensitive photocathodic biosensor was fabricated based on ... ...

Abstract	Herein, an ultrasensitive photocathodic biosensor was fabricated based on Cu
MeSH term(s)	Electrochemical Techniques/methods ; MicroRNAs ; Biosensing Techniques ; DNA ; Electrodes ; Limit of Detection
Chemical Substances	MicroRNAs ; DNA (9007-49-2)
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c01935
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Article ; Online: Ultrasensitive photoelectrochemical biosensor amplified by target induced assembly of cruciform DNA nanostructure for the detection of dibutyl phthalate.

Yang, Jie / Zeng, Hongmei / Chai, Yaqin / Yuan, Ruo / Liu, Hongyan

Analytica chimica acta

2023 Volume 1262, Page(s) 341242

Abstract: In this work, an ultra-sensitive signal quenched photoelectrochemical (PEC) aptasensor for dibutyl phthalate (DBP) detection was constructed by using a target induced cruciform DNA structure as signal amplifier and g- ... ...

Abstract	In this work, an ultra-sensitive signal quenched photoelectrochemical (PEC) aptasensor for dibutyl phthalate (DBP) detection was constructed by using a target induced cruciform DNA structure as signal amplifier and g-C
MeSH term(s)	DNA, Cruciform ; Dibutyl Phthalate ; Biosensing Techniques ; Nanostructures/chemistry ; DNA ; Electrochemical Techniques ; Limit of Detection
Chemical Substances	DNA, Cruciform ; Dibutyl Phthalate (2286E5R2KE) ; DNA (9007-49-2)
Language	English
Publishing date	2023-04-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341242
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Article ; Online: Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress.

Chai, Yaqin / Gu, Xing / Zhang, HongJun / Xu, Xinting / Chen, Lizhan

Aging

2024 Volume 16, Issue 6, Page(s) 5027–5037

Abstract: Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g body weight daily), hypoxia, hypoxia+PHN-20 (100 ng/g body weight daily), respectively. A signally elevated RVSP, mPAP, RV/LV + S, and W%, increased secretion of cytokines, enhanced malondialdehyde (MDA) level, repressed superoxide dismutase (SOD) activity, and activated NLRP3 signaling were observed in hypoxia-stimulated rats, which were notably reversed by PHN-20 administration. Pulmonary microvascular endothelial cells (PMECs) were treated with hypoxia with or without PHN-20 (10 and 20 nM). Marked elevation of inflammatory cytokine secretion, increased MDA level, repressed SOD activity, and activated NLRP3 signaling were observed in hypoxia-stimulated PMECs, accompanied by a downregulation of SIRT1. Furthermore, the repressive effect of PHN-20 on the domains-containing protein 3 (NLRP3) pathway in hypoxia-stimulated PMECs was abrogated by sirtuin1 (SIRT1) knockdown. Collectively, PHN-20 alleviated PAH via inhibiting OS and inflammation by mediating the transcriptional function of SIRT1.
MeSH term(s)	Rats ; Mice ; Animals ; Pulmonary Arterial Hypertension/drug therapy ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/metabolism ; Sirtuin 1/metabolism ; Endothelial Cells/metabolism ; Familial Primary Pulmonary Hypertension ; Oxidative Stress ; Inflammation ; Hypoxia ; Superoxide Dismutase/metabolism ; Body Weight ; Peptide Hormones
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; phoenixin-20 ; Sirtuin 1 (EC 3.5.1.-) ; Superoxide Dismutase (EC 1.15.1.1) ; Peptide Hormones
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205468
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Article ; Online: Boron Carbon Nitride Nanosheets-Ru Nanocomposite Self-Enhancement Electrochemiluminescence Emitter with a Three-Dimensional DNA Network Structure as a Signal Amplifier for Ultrasensitive Detection of TK1 mRNA.

Hu, Jicui / Zhang, Yue / Chai, Yaqin / Yuan, Ruo

Analytical chemistry

2022 Volume 94, Issue 32, Page(s) 11345–11351

Abstract: In this study, a neoteric self-enhanced nanocomposite boron carbon nitride nanosheets (BCN NSs)-Ru obtained by chemical crosslinking between boron carbon nitride nanosheets (BCN NSs) and tris (4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium(II) ... ...

Abstract	In this study, a neoteric self-enhanced nanocomposite boron carbon nitride nanosheets (BCN NSs)-Ru obtained by chemical crosslinking between boron carbon nitride nanosheets (BCN NSs) and tris (4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)
MeSH term(s)	Biosensing Techniques/methods ; Boron ; DNA/chemistry ; Electrochemical Techniques/methods ; Humans ; Limit of Detection ; Luminescent Measurements/methods ; Nanocomposites ; Nitriles ; RNA, Messenger/genetics ; Thymidine Kinase
Chemical Substances	Nitriles ; RNA, Messenger ; cyanogen (534Q0F66RK) ; DNA (9007-49-2) ; Thymidine Kinase (EC 2.7.1.21) ; thymidine kinase 1 (EC 2.7.1.21) ; Boron (N9E3X5056Q)
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c02110
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Article ; Online: PEDOT/FeOOH/BiVO₄ Nanohybrids with Excellent Photoelectric Performance Promoted by Photothermal Effects for the Ultrasensitive Detection of MicroRNA-375-3p

Wang, Shuai / Chai, Yaqin / Yuan, Ruo / Liu, Hongyan

Analytical Chemistry. 2023 Mar. 08, v. 95, no. 11 p.4896-4903

2023

Abstract: Herein, a novel photoactive poly(3,4-ethyl-enedioxythiophene) (PEDOT)/FeOOH/BiVO₄ nanohybrid with excellent photoelectrochemical (PEC) efficiency was assembled for the construction of an ultrasensitive biosensor for microRNA-375-3p (miRNA-375-3p) ... ...

Abstract	Herein, a novel photoactive poly(3,4-ethyl-enedioxythiophene) (PEDOT)/FeOOH/BiVO₄ nanohybrid with excellent photoelectrochemical (PEC) efficiency was assembled for the construction of an ultrasensitive biosensor for microRNA-375-3p (miRNA-375-3p) detection. In comparison with the traditional FeOOH/BiVO₄ photoactive composite, the PEDOT/FeOOH/BiVO₄ nanohybrids exhibited markedly enhanced photocurrent due to the promoted interfacial charge separation by PEDOT, which was used not only as an electron conductor but also as a localized photothermal heater to enhance the photogenerated carrier separation. Based on this PEDOT/FeOOH/BiVO₄ photoelectrode and an enzyme-free signal amplification strategy including a target-induced catalytic hairpin assembly (CHA) and hybridization chain reaction (HCR), a PEC sensing platform for the detection of miRNA-375-3p was established, achieving a wide linear range from 1 fM to 10 pM with a low detection limit of 0.3 fM. Moreover, this work provides a general photocurrent enhancement strategy for the development of high-performing PEC biosensors for sensitive detection of biomarkers and early disease diagnosis.
Keywords	analytical chemistry ; biomarkers ; biosensors ; detection limit ; disease diagnosis ; electric current ; hybridization chain reaction ; nanohybrids ; photoelectrodes
Language	English
Dates of publication	2023-0308
Size	p. 4896-4903.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04656
Database	NAL-Catalogue (AGRICOLA)

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