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  1. Article ; Online: The Yun/Prohibitin complex regulates adult

    Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ren, Xuejing / Ma, Rui / Jia, Lemei / Ma, Meifang / Lu, Shan / Xu, Ran / Binari, Richard / Wang, Jian-Hua / Dong, Meng-Qiu / Perrimon, Norbert / Li, Zhouhua

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 6

    Abstract: Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, ... ...

    Abstract Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult
    MeSH term(s) Adult Stem Cells/metabolism ; Animals ; Animals, Genetically Modified ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; E2F1 Transcription Factor/metabolism ; Homeostasis/physiology ; Intestines/metabolism ; Prohibitins/metabolism ; RNA Interference/physiology ; Signal Transduction/physiology
    Chemical Substances Drosophila Proteins ; E2F1 Transcription Factor ; Prohibitins
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2111711119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  2. Article: Jian Yun Qing Hua Decoction inhibits malignant behaviors of gastric carcinoma cells via COL12A1 mediated ferroptosis signal pathway.

    Liu, Baoxinzi / Li, Yu / Xu, Yuanyuan / Xue, Weiwei / Jin, Zhichao

    Chinese medicine

    2023  Volume 18, Issue 1, Page(s) 118

    Abstract: Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction ...

    Abstract Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction, which has been applied in the treatment of gastric cancer (GC). We attempt to confirm the anti-gastric cancer effect of JYQHD and explore the mechanism of JYQHD.
    Methods: Acute toxicity test was used to understand the toxicity of JYQHD. We studied the expression and prognostic outcome of COL12A1 within GC tissues through the network databases. Using several web-based databases, we analyzed the major components and targets of JYQHD, as well as known therapeutic targets in gastric cancer. The Venn diagram was utilized to obtain the overlapped genes. Lentiviral vector, shRNAs and plasmids, were used to transfect GC cells. Cell counting kit-8 (CCK8), sphere formation, malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), Fe
    Results: The results showed that JYQHD was non-toxic and safe. JYQHD inhibited growth and sphere formation ability through inducing the ferroptosis of GC cells, and suppressed the GC cells induced subcutaneous xenograft tumor growth. COL12A1 was highly expressed in gastric cancer tissues, indicating poor prognosis. COL12A1 specifically enhanced GC cell progression and stemness via suppressing ferroptosis. JYQHD down-regulated COL12A1 in order to suppress the stemness of GC cells via inducing ferroptosis.
    Conclusion: COL12A1 inhibited ferroptosis and enhanced stemness in GC cells. JYQHD inhibited the development of GC cells by inhibiting cancer cell stemness via the ferroptosis pathway mediated by COL12A1.
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-023-00799-5
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  3. Article: [The prevent miscarriage effects of Yun Kang oral liquid on threatened abortion rat induced by kidney deficiency and luteum inhibition].

    Dai, Ming Zhu / Lyu, Gui Yuan / Xu, Yu Yue / Zheng, Xiang / Chen, Su Hong

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2019  Volume 35, Issue 1, Page(s) 9–12

    Abstract: Objective: Yun Kang oral liquid is a listed proprietary Chinese Medicine. To further evaluate ... model to observe the effects of Yun Kang oral liquid.: Methods: Sixty pregnant rats were randomly ... divided into normal control group (NC), model group (MG), dydrogesterone group (DT, 3.02 mg/kg), and Yun ...

    Abstract Objective: Yun Kang oral liquid is a listed proprietary Chinese Medicine. To further evaluate its efficacy, this experiment established a kidney deficiency and luteum inhibition threatened abortion rat model to observe the effects of Yun Kang oral liquid.
    Methods: Sixty pregnant rats were randomly divided into normal control group (NC), model group (MG), dydrogesterone group (DT, 3.02 mg/kg), and Yun Kang oral liquid low-dose group (YK-L, 4 ml/kg), medium dose group (YK-M, 6 ml/kg), high dose group (YK-H, 9 ml/kg), 10 in each group. On the first day of pregnancy, each administration group was treated with the test drug at the prescribed dose every morning, and the NC group and the MG group were given an equal volume of purified water for 10 days; the rats were intragastrically administrated every afternoon, except for the NC group. In addition, the other groups were intragastrically administered with hydroxyurea at a dose of 450 mg/kg for 9 days, and mifepristone was administered at a dose of 4.0 mg/kg on the 10th day. On the 9th day of pregnancy, behavioral signs such as back temperature, grasping force, pain threshold, and autonomic activity were measured in each group. On the 11th day of pregnancy, blood was collected from the abdominal aorta in each group to determine serum levels of estradiol (E
    Results: Compared with the NC group, the back temperature, grip, pain threshold, number of spontaneous activities, number of embryos, embryo diameter, uterus index and serum E
    Conclusion: Yun Kang oral liquid has a clear kidney-filling effect on rats with threatened abortion caused by kidney deficiency-luteal suppression. The mechanism may be related to raising serum E
    MeSH term(s) Abortion, Spontaneous/prevention & control ; Abortion, Threatened/prevention & control ; Animals ; Drugs, Chinese Herbal/pharmacology ; Estradiol ; Female ; Humans ; Kidney/physiopathology ; Luteal Phase ; Pregnancy ; Progesterone ; Rats ; Uterus
    Chemical Substances Drugs, Chinese Herbal ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Language Chinese
    Publishing date 2019-06-27
    Publishing country China
    Document type Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.5749.2019.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The application of simultaneous paver liquid cement sprinkling system in the road construction of Yun-Mao Highway

    He Boqian / Xu Ji

    E3S Web of Conferences, Vol 233, p

    2021  Volume 01135

    Abstract: The simultaneous paver liquid cement sprinkling system is the combination of a conventional paver and a simultaneous liquid cement sprinkler. During operation, the cement sprinkler can be installed onto a paver with the use of connectors. When paving the ...

    Abstract The simultaneous paver liquid cement sprinkling system is the combination of a conventional paver and a simultaneous liquid cement sprinkler. During operation, the cement sprinkler can be installed onto a paver with the use of connectors. When paving the stabilization aggregate mixture, this system sprinkles liquid cement on the working surface. This device can effectively solve the common quality issues such as the formation of cement isolation layer and road pollution, as a result of premature hardening of the pre-sprinkled liquid cement during road construction in high-temperature environments.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Bu-shen-zhu-yun decoction promotes synthesis and secretion of FSHβ and LHβ in anterior pituitary cells in vitro.

    Jiang, Xiaofei / Zhou, Huifang / Shi, Mingqing / Zhou, Boru / Liu, Bei / Yuan, Yizhen / Shan, Jinjun / Xu, Jianya / Xie, Tong

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2018  Volume 102, Page(s) 494–501

    Abstract: ... years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen ...

    Abstract Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats. Rats were treated with saline (control) or BSZY-D two times/day for three estrous cycles by gavage. The cerebrospinal fluid (CSF) were collected for further cell treatment. The components in BSZY-D, serum and CSF were analysed by High Performance Liquid Chromatography (HPLC). Cells were either pretreated with normal CSF or BSZY-D/CSF before being stimulated with or without cetrorelix. The mRNA and proteins levels of receptors, hormones, and transcription factors were detected by RT-PCR, western blot analysis and immunostaining. We show that non-toxic concentrations of cetrorelix, a GnRH antagonist, can reduce the mRNA and protein levels of GnRHR, LH, and FSH. This effect could be reversed by the addition of BSZY-D/CSF. We also show decreased mRNA and protein expression of transcription factors, such as CREB, and Egr-1 and secretory vescicles, including SNAP-25 and Munc-18 upon treatment with cetrorelix could be reversed post co-treatment with BSZY-D/CSF. These results indicate that BSZY-D/CSF treatment led to increased levels of GnRHR, transcription factors, and secretory vesicles leading to increased secretion of FSH and LH. Thus, BSZY-D presents a promising candidate to treat luteal phase defects and infertility.
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/pharmacology ; Early Growth Response Protein 1/metabolism ; Female ; Follicle Stimulating Hormone, beta Subunit/biosynthesis ; Follicle Stimulating Hormone, beta Subunit/secretion ; Gonadotropin-Releasing Hormone/analogs & derivatives ; Gonadotropin-Releasing Hormone/pharmacology ; Luteinizing Hormone, beta Subunit/biosynthesis ; Luteinizing Hormone, beta Subunit/secretion ; Munc18 Proteins/metabolism ; Pituitary Gland, Anterior/cytology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Receptors, LHRH/metabolism ; Synaptosomal-Associated Protein 25/metabolism ; Transcription Factors/metabolism ; Up-Regulation/drug effects
    Chemical Substances Drugs, Chinese Herbal ; Early Growth Response Protein 1 ; Egr1 protein, rat ; Follicle Stimulating Hormone, beta Subunit ; Luteinizing Hormone, beta Subunit ; Munc18 Proteins ; RNA, Messenger ; Receptors, LHRH ; Synaptosomal-Associated Protein 25 ; Transcription Factors ; Gonadotropin-Releasing Hormone (33515-09-2) ; cetrorelix (OON1HFZ4BA)
    Language English
    Publishing date 2018-03-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2018.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.198: Show issues Location:
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  6. Article ; Online: Seed germination schedule and environmental context shaped the population genetic structure of subtropical evergreen oaks on the Yun-Gui Plateau, Southwest China.

    Xu, Jin / Song, Yi-Gang / Deng, Min / Jiang, Xiao-Long / Zheng, Si-Si / Li, Ying

    Heredity

    2019  Volume 124, Issue 3, Page(s) 499–513

    Abstract: The evergreen broadleaved forests (EBLFs) of Southwest China have a long-term stable environment and support a diverse flora, thus forming a global biodiversity hotspot. However, the key drivers that have shaped the genetic diversity patterns of species ... ...

    Abstract The evergreen broadleaved forests (EBLFs) of Southwest China have a long-term stable environment and support a diverse flora, thus forming a global biodiversity hotspot. However, the key drivers that have shaped the genetic diversity patterns of species in these EBLFs are not well understood. Quercus delavayi, Q. schottkyana, and Q. kerrii are sympatric oak species with different seed biological traits that are typical for these EBLFs. This study combined multilocus phylogeography and ecological niche modeling to screen 33 Q. delavayi populations. Their population genetic structure was inferred in comparison with previous studies on Q. schottkyana and Q. kerrii. The seed germination traits of all three species were also investigated. cpDNAs showed a significant phylogeographic structure in Q. delavayi, which was not detected in Q. schottkyana or Q. kerrii. Quercus delavayi, Q. kerrii, and Q. schottkyana exhibited different pollen-to-seed migration ratios (r = 219, 117, and 22, respectively), which are linked to the germination schedules of acorns. The distributions of Q. delavayi and Q. schottkyana remained long-term stable since the last glacial maximum (LGM) with a similar nSSR genetic gradient change along latitude. Instead, Q. kerrii experienced a prominent range expansion since the LGM with genetic diversification between the East and the West of the Tanaka line due to environmental heterogeneity. These results identify seed traits and environmental heterogeneity as two key drivers that shape the population genetic structure of EBLF trees in Southwest China. These should be considered in regional forestry conservation and management.
    MeSH term(s) China ; Genetics, Population ; Germination ; Phylogeography ; Quercus/genetics ; Seeds/physiology
    Language English
    Publishing date 2019-11-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423-5
    ISSN 1365-2540 ; 0018-067X
    ISSN (online) 1365-2540
    ISSN 0018-067X
    DOI 10.1038/s41437-019-0283-2
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  7. Article: [Zhang Yun-Peng's treatment of one case of SARS based on syndrome differentiation].

    Xu, Ying / Chen, Xiao-Rong

    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

    2004  Volume 1, Issue 2, Page(s) 158–159

    MeSH term(s) Adult ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Male ; Severe Acute Respiratory Syndrome/drug therapy ; Treatment Outcome
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2004-07-05
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 2229154-4
    ISSN 1672-1977
    ISSN 1672-1977
    DOI 10.3736/jcim20030223
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  8. Book: Zhong yao kang ai yan jiu yu lin chuang yun yong

    Xu, Li

    2012  

    Author's details zhu bian Xu Li, Lu Jingwen
    MeSH term(s) Antineoplastic Agents/pharmacology ; Materia Medica/pharmacology ; Medicine, Chinese Traditional
    Language Chinese
    Size 9, 454 pages
    Edition Di 1 ban.
    Document type Book
    ISBN 9787117164238 ; 7117164239
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Xuan yun

    Xu, Guangyi

    1984  

    Author's details Xu Guangyi, Guo Yangchun bian zhu ; Xiao Shizhi shen yue
    MeSH term(s) Vertigo
    Language Chinese
    Size 2, 5, 330 p. :, ill.
    Edition Di 1 ban.
    Publisher Fujian ke xue ji shu chu ban she : Fujian sheng xin hua shu dian fa xing
    Publishing place Fuzhou
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: ZHANG Yun-Peng's treatment of one case of SARS based on syndrome differentiation

    XU Ying

    Journal of Integrative Medicine (JIM), Vol 1, Iss 2 , Pp 158-

    2003  Volume 159

    Keywords ZHANG Yun-Peng ; SARS ; inteagrted Chinese traditonal and Western medine therapy ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2003-07-01T00:00:00Z
    Publisher Journal of Chinese Integrative Medicine Press
    Document type Article ; Online
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