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  1. Article ; Online: Nocturnal penile tumescence devices: past, present and future.

    Schardein, Jessica Nicole / Gross, Kelli

    International journal of impotence research

    2023  

    Abstract: Erectile function is an important part of men's health that can significantly impact quality of life. Naturally occurring nighttime erections experienced by men throughout their lifespan provides insight into penile health as well as overall health. ... ...

    Abstract Erectile function is an important part of men's health that can significantly impact quality of life. Naturally occurring nighttime erections experienced by men throughout their lifespan provides insight into penile health as well as overall health. Nocturnal penile tumescence (NPT) and nocturnal penile tumescence and rigidity (NPTR) devices that can non-invasively evaluate the presence and quality of erections can have valuable diagnostic and clinical utility. Early devices have several limitations that limit their current use. New, wearable devices have promising applications for the evaluation of erectile function over time. Continued advancements in this technology have the potential to render future generations of these devices as invaluable tools that are useful for both men and healthcare professionals.
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-023-00789-z
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  2. Article ; Online: Relaying quality: An incremental approach to quality improvement.

    Gross, Abby / Brooks, Nicole / French, Judith / Miller, Benjamin / Prabhu, Ajita

    Medical education

    2024  Volume 58, Issue 5, Page(s) 598–599

    MeSH term(s) Humans ; Quality Improvement
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.15354
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  3. Article ; Online: Surveillance Capitalism in Mental Health

    Nicole Gross / David Mothersill

    Social Sciences, Vol 12, Iss 12, p

    When Good Apps Go Rogue (and What Can Be Done about It)

    2023  Volume 679

    Abstract: Research shows that a large proportion of the world’s population has experience with mental health difficulties, and reliable as well as scalable care is urgently needed. Digital mental health seems to be an obvious solution to provide the better ... ...

    Abstract Research shows that a large proportion of the world’s population has experience with mental health difficulties, and reliable as well as scalable care is urgently needed. Digital mental health seems to be an obvious solution to provide the better delivery of care but also the delivery of better care. With an imagined future of real-time information sharing, improved diagnosis and monitoring of mental health conditions, and remote care, supported by advances in artificial intelligence, many tech companies have emerged over the last three decades to plug the treatment gap and provide services. The evidence base seems compelling: some online treatments have the capability to treat individuals quite successfully. However, the introduction, utilisation, and expansion of digital mental health technologies have not always focused on public health only. Using a surveillance capitalism perspective, this paper approaches the democratisation–privatisation dichotomy in digital mental health with a critical lens. In particular, the paper details how (commercially valuable) mental health data are extracted, “shared”, and claimed as an asset by big tech companies. Reviewing the terms, conditions, and practices of ten popular mental health apps, the paper polemically argues that mental digital health cannot unlock real value for society—better treatment, good quality care, and efficient delivery—if power, politics, and profits remain in the hands of big tech companies. To conclude, the paper draws attention to contemporary discourses that seek to promote democracy and public value for digital mental health apps, technologies, and solutions.
    Keywords mental health ; public health ; digital health ; surveillance capitalism ; data solidarity ; data justice ; Social Sciences ; H
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Thesis: Retrospektive Analyse des Wirkungsspektrums, der Nebenwirkungen und der Interaktionen des Antiepileptikums Oxcarbazepin

    Gross, Nicole

    1997  

    Author's details vorgelegt von Nicole Gross
    Language German
    Size 83 Bl. : graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1997
    HBZ-ID HT008607757
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Thesis: Die Herzfrequenzvariabilität bei Postinfarktpatienten

    Gross, Nicole

    ein Vergleich von Kurz- und Langzeit-EKG-Messungen

    1996  

    Author's details vorgelegt von Nicole Gross
    Language German
    Size 77 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1996
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT007489895
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: "Managing emotion": Open label trial and waitlist controlled trial of an emotion regulation program for university students.

    Hasking, Penelope / Chen, Nigel T M / Chiu, Vivian / Gray, Nicole / Gross, James J / Boyes, Mark

    Journal of American college health : J of ACH

    2023  , Page(s) 1–11

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2155468
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  7. Article ; Online: Insights into dasatinib use and outcomes in real-world patients with chronic myeloid leukemia.

    Adattini, Josephine A / Gross, Annette S / Doo, Nicole Wong / McLachlan, Andrew J

    Haematologica

    2023  Volume 108, Issue 8, Page(s) 2224–2228

    MeSH term(s) Humans ; Dasatinib/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Imatinib Mesylate/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Antineoplastic Agents/adverse effects ; Leukemia, Myeloid, Chronic-Phase/drug therapy
    Chemical Substances Dasatinib (RBZ1571X5H) ; Imatinib Mesylate (8A1O1M485B) ; Protein Kinase Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2023-08-01
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.282237
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  8. Article ; Online: Digital decision support for structural improvement of melanoma tumor boards: using standard cases to optimize workflow.

    Hoier, David / Groß-Ophoff-Müller, Carolin / Franklin, Cindy / Hallek, Michael / von Stebut, Esther / Elter, Thomas / Mauch, Cornelia / Kreuzberg, Nicole / Koll, Philipp

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 3, Page(s) 115

    Abstract: Purpose: Choosing optimal cancer treatment is challenging, and certified cancer centers must present all patients in multidisciplinary tumor boards (MDT). Our aim was to develop a decision support system (DSS) to provide treatment recommendations for ... ...

    Abstract Purpose: Choosing optimal cancer treatment is challenging, and certified cancer centers must present all patients in multidisciplinary tumor boards (MDT). Our aim was to develop a decision support system (DSS) to provide treatment recommendations for apparently simple cases already at conference registration and to classify these as "standard cases". According to certification requirements, discussion of standard cases is optional and would thus allow more time for complex cases.
    Methods: We created a smartphone query that simulated a tumor conference registration and requested all information needed to provide a recommendation. In total, 111 out of 705 malignant melanoma cases discussed at a skin cancer center from 2017 to 2020 were identified as potential standard cases, for which a digital twin recommendation was then generated by DSS.
    Results: The system provided reliable advice in all 111 cases and showed 97% concordance of MDT and DSS for therapeutic recommendations, regardless of tumor stage. Discrepancies included two cases (2%) where DSS advised discussions at MDT and one case (1%) with deviating recommendation due to advanced patient age.
    Conclusions: Our work aimed not to replace clinical expertise but to alleviate MDT workload and enhance focus on complex cases. Overall, our DSS proved to be a suitable tool for identifying standard cases as such, providing correct treatment recommendations, and thus reducing the time burden of tumor conferences in favor for the comprehensive discussion of complex cases. The aim is to implement the DSS in routine tumor board software for further qualitative assessment of its impact on oncological care.
    MeSH term(s) Humans ; Melanoma/therapy ; Workflow ; Medical Oncology
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-024-05627-3
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  9. Article ; Online: Acromioclavicular joint mobilizations for the management of grade I sternoclavicular joint sprain: a case report.

    Helvey-Byers, Rosemary / O'Laughlin, Jeffrey / Dickson, Nicole / Myer, Reuben / Gross, Michael

    Physiotherapy theory and practice

    2023  , Page(s) 1–9

    Abstract: Objective: Injury to the sternoclavicular joint is a rare phenomenon that has implications for the shoulder complex. Limited literature exists on optimal physical therapy rehabilitation after a sternoclavicular ligament sprain. This case report details ... ...

    Abstract Objective: Injury to the sternoclavicular joint is a rare phenomenon that has implications for the shoulder complex. Limited literature exists on optimal physical therapy rehabilitation after a sternoclavicular ligament sprain. This case report details the physical therapy management and outcomes of a patient with a posterior sternoclavicular joint sprain.
    Case description: The patient was a 34-year-old female who sustained a grade I posteriorly directed sternoclavicular sprain during a motor vehicle accident. She received a combination of acromioclavicular joint mobilizations and therapeutic exercise for her shoulder complex for five sessions over six weeks.
    Outcomes: At discharge, the patient surpassed the minimally clinically important difference (MCID) and the minimal detectable change (MDC) in her Quick-DASH score. She surpassed the MDC and MCID in her Numerical Pain Rating Scale score. She was able to regain full functional use of her involved upper extremity and returned to her work and original exercise regimen with no further limitations.
    Conclusion: The outcomes suggest that a combination of acromioclavicular joint mobilizations and therapeutic exercise for the shoulder complex was a suitable option for the conservative management of this patient's grade I sternoclavicular sprain.
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1045333-7
    ISSN 1532-5040 ; 0959-3985
    ISSN (online) 1532-5040
    ISSN 0959-3985
    DOI 10.1080/09593985.2023.2276378
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  10. Article ; Online: Workflow for Validating Specific Amino Acid Footprinting Reagents for Protein Higher Order Structure Elucidation.

    Moyle, Austin B / Wagner, Nicole D / Wagner, Wesley J / Cheng, Ming / Gross, Michael L

    Analytical chemistry

    2023  Volume 95, Issue 26, Page(s) 10119–10126

    Abstract: Protein footprinting mass spectrometry probes protein higher order structure and dynamics by labeling amino acid side-chains or backbone amides as a function of solvent accessibility. One category of footprinting uses residue-specific, irreversible ... ...

    Abstract Protein footprinting mass spectrometry probes protein higher order structure and dynamics by labeling amino acid side-chains or backbone amides as a function of solvent accessibility. One category of footprinting uses residue-specific, irreversible covalent modifications, affording flexibility of sample processing for bottom-up analysis. Although several specific amino acid footprinting technologies are becoming established in structural proteomics, there remains a need to assess fundamental properties of new reagents before their application. Often, footprinting reagents are applied to complex or novel protein systems soon after their discovery and sometimes without a thorough investigation of potential downsides of the reagent. In this work, we assemble and test a validation workflow that utilizes cyclic peptides and a model protein to characterize benzoyl fluoride, a recently published, next-generation nucleophile footprinter. The workflow includes the characterization of potential side-chain reactive groups, reaction "quench" efficacies, reagent considerations and caveats (e.g., buffer pH), residue-specific kinetics compared to those of established reagents, and protein-wide characterization of modification sites with considerations for proteolysis. The proposed workflow serves as a starting point for improved footprinting reagent discovery, validation, and introduction, the aspects of which we recommend before applying to unknown protein systems.
    MeSH term(s) Amino Acids/chemistry ; Workflow ; Proteins/chemistry ; Mass Spectrometry/methods ; Protein Footprinting/methods
    Chemical Substances Amino Acids ; Proteins
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01919
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