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  1. Book ; Online: From "Junk DNA" to Clinically Relevant Tools for Cancer Diagnosis, Staging, and Tailored Therapies: The Incredible Case of Non-Coding RNAs

    Iorio, Marilena V. / Palmieri, Dario

    2019  

    Keywords Medicine ; Oncology ; ncRNA ; microRNA ; circRNA ; resistance ; cancer diagnosis and intervention
    Size 1 electronic resource (113 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229864
    ISBN 9782889459650 ; 2889459659
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial to the Special Issue "MicroRNA Dysregulation in Tumor Occurrence, Progression and Response to Therapy".

    Iorio, Marilena V

    International journal of molecular sciences

    2021  Volume 22, Issue 4

    Abstract: In the last 20 years, the involvement of microRNAs in the biology of human tumors has been clearly demonstrated, and the scientific community has switched from an initial skepticism to an increasing interest toward what was called the "dark side" of DNA [ ...

    Abstract In the last 20 years, the involvement of microRNAs in the biology of human tumors has been clearly demonstrated, and the scientific community has switched from an initial skepticism to an increasing interest toward what was called the "dark side" of DNA [...].
    MeSH term(s) Biomarkers, Tumor/genetics ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Radiation Tolerance/genetics
    Chemical Substances Biomarkers, Tumor ; MicroRNAs
    Language English
    Publishing date 2021-02-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22042156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial to the Special Issue “MicroRNA Dysregulation in Tumor Occurrence, Progression and Response to Therapy”

    Marilena V. Iorio

    International Journal of Molecular Sciences, Vol 22, Iss 4, p

    2021  Volume 2156

    Abstract: In the last 20 years, the involvement of microRNAs in the biology of human tumors has been clearly demonstrated, and the scientific community has switched from an initial skepticism to an increasing interest toward what was called the “dark side” of DNA [ ...

    Abstract In the last 20 years, the involvement of microRNAs in the biology of human tumors has been clearly demonstrated, and the scientific community has switched from an initial skepticism to an increasing interest toward what was called the “dark side” of DNA [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Editorial: From "Junk DNA" to Clinically Relevant Tools for Cancer Diagnosis, Staging, and Tailored Therapies: The Incredible Case of Non-Coding RNAs.

    Iorio, Marilena V / Palmieri, Dario

    Frontiers in oncology

    2019  Volume 9, Page(s) 389

    Language English
    Publishing date 2019-05-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.00389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Therapeutic Potential of MicroRNAs in Cancer: Illusion or Opportunity?

    Fortunato, Orazio / Iorio, Marilena V

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 13, Issue 12

    Abstract: The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their ... ...

    Abstract The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their expression to re-establish a lost equilibrium and counteract tumor growth and dissemination, and/or to improve responsiveness to standard therapies, is promising and fascinating. However, several issues need to be taken into account such as factors related to miRNA stability in the blood, tissue penetration and potential off-target effects, which might affect safety, tolerability and efficacy of an miRNA-based therapy. Here we describe the most relevant challenges related to miRNA-based therapy, review the delivery strategies exploited to date and the on-going clinical trials.
    Language English
    Publishing date 2020-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph13120438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Therapeutic Potential of MicroRNAs in Cancer

    Orazio Fortunato / Marilena V. Iorio

    Pharmaceuticals, Vol 13, Iss 438, p

    Illusion or Opportunity?

    2020  Volume 438

    Abstract: The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their ... ...

    Abstract The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulate their expression to re-establish a lost equilibrium and counteract tumor growth and dissemination, and/or to improve responsiveness to standard therapies, is promising and fascinating. However, several issues need to be taken into account such as factors related to miRNA stability in the blood, tissue penetration and potential off-target effects, which might affect safety, tolerability and efficacy of an miRNA-based therapy. Here we describe the most relevant challenges related to miRNA-based therapy, review the delivery strategies exploited to date and the on-going clinical trials.
    Keywords microRNA ; cancer ; therapy ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.

    Iorio, Marilena V / Croce, Carlo M

    EMBO molecular medicine

    2017  Volume 9, Issue 6, Page(s) 852

    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.201707779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Genetic Loss of miR-205 Causes Increased Mammary Gland Development.

    Cataldo, Alessandra / Cheung, Douglas G / Hagan, John P / Fassan, Matteo / Sandhu-Deol, Sukhinder / Croce, Carlo M / Di Leva, Gianpiero / Iorio, Marilena V

    Non-coding RNA

    2023  Volume 10, Issue 1

    Abstract: MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different ... ...

    Abstract MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna10010004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: miR-205 in Breast Cancer

    Ilaria Plantamura / Alessandra Cataldo / Giulia Cosentino / Marilena V. Iorio

    International Journal of Molecular Sciences, Vol 22, Iss 27, p

    State of the Art

    2021  Volume 27

    Abstract: Despite its controversial roles in different cancer types, miR-205 has been mainly described as an oncosuppressive microRNA (miRNA), with some contrasting results, in breast cancer. The role of miR-205 in the occurrence or progression of breast cancer ... ...

    Abstract Despite its controversial roles in different cancer types, miR-205 has been mainly described as an oncosuppressive microRNA (miRNA), with some contrasting results, in breast cancer. The role of miR-205 in the occurrence or progression of breast cancer has been extensively studied since the first evidence of its aberrant expression in tumor tissues versus normal counterparts. To date, it is known that the expression of miR-205 in the different subtypes of breast cancer is decreasing from the less aggressive subtype, estrogen receptor/progesterone receptor positive breast cancer, to the more aggressive, triple negative breast cancer, influencing metastasis capability, response to therapy and patient survival. In this review, we summarize the most important discoveries that have highlighted the functional role of this miRNA in breast cancer initiation and progression, in stemness maintenance, in the tumor microenvironment, its potential role as a biomarker and its relevance in normal breast physiology—the still open questions. Finally, emerging evidence reveals the role of some lncRNAs in breast cancer progression as sponges of miR-205. Here, we also reviewed the studies in this field.
    Keywords miR-205 ; breast cancer ; oncogenic pathways ; therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

    Cairo, Andrea / Iorio, Marilena V / Spena, Silvia / Tagliabue, Elda / Peyvandi, Flora

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0263705

    Abstract: The world is experiencing one of the most severe viral outbreaks in the last few years, the pandemic infection by SARS-CoV-2, the causative agent of COVID-19 disease. As of December 10th 2021, the virus has spread worldwide, with a total number of more ... ...

    Abstract The world is experiencing one of the most severe viral outbreaks in the last few years, the pandemic infection by SARS-CoV-2, the causative agent of COVID-19 disease. As of December 10th 2021, the virus has spread worldwide, with a total number of more than 267 million of confirmed cases (four times more in the last year), and more than 5 million deaths. A great effort has been undertaken to molecularly characterize the virus, track the spreading of different variants across the globe with the aim to understand the potential effects in terms of transmission capability and different fatality rates. Here we focus on the genomic diversity and distribution of the virus in the early stages of the pandemic, to better characterize the origin of COVID-19 and to define the geographical and temporal evolution of genetic clades. By performing a comparative analysis of 75401 SARS-CoV-2 reported sequences (as of December 2020), using as reference the first viral sequence reported in Wuhan in December 2019, we described the existence of 26538 genetic variants, the most frequent clustering into four major clades characterized by a specific geographical distribution. Notably, we found the most frequent variant, the previously reported missense p.Asp614Gly in the S protein, as a single mutation in only three patients, whereas in the large majority of cases it occurs in concomitance with three other variants, suggesting a high linkage and that this variant alone might not provide a significant selective advantage to the virus. Moreover, we evaluated the presence and the distribution in our dataset of the mutations characterizing the so called "british variant", identified at the beginning of 2021, and observed that 9 out of 17 are present only in few sequences, but never in linkage with each other, suggesting a synergistic effect in this new viral strain. In summary, this is a large-scale analysis of SARS-CoV-2 deposited sequences, with a particular focus on the geographical and temporal evolution of genetic clades in the early phase of COVID-19 pandemic.
    MeSH term(s) COVID-19/virology ; Evolution, Molecular ; Genetic Variation ; Genome, Viral ; Genomics ; Haplotypes ; Humans ; Mutation ; Pandemics ; Phylogeny ; Phylogeography ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0263705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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