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  1. Article ; Online: The Role of Autopsy in Quality Assurance: Pilot Study of a Method for Prospective Reporting of Diagnostic Errors Discovered at Autopsy.

    Miller, Catherine R / Johnston, Robert D / Blake, Brooke H / Aronson, Judith F

    The American journal of forensic medicine and pathology

    2023  

    Abstract: Abstract: Hospital autopsies frequently reveal errors in diagnosis that could have affected the patient's clinical outcome. The aims of this study were (1) to investigate the ability of autopsy at our institution to elucidate unrecognized antemortem ... ...

    Abstract Abstract: Hospital autopsies frequently reveal errors in diagnosis that could have affected the patient's clinical outcome. The aims of this study were (1) to investigate the ability of autopsy at our institution to elucidate unrecognized antemortem diagnoses and (2) to pilot a method for tabulating diagnostic discrepancies on a prospective basis. The study sample consisted of 296 cases from our hybrid hospital/forensic autopsy service during the period 2016 to 2018. Discrepancies in autopsy and clinical diagnosis were reported by pathologists at the time of autopsy report generation using a standard form. The rates of major discrepancies between autopsy and clinical diagnoses were 37.5% for in-hospital cases and 25% for patients who died outside our hospital (P < 0.05). The most common discrepant category was infection. The overall rates of discrepant causes of death were 14% (in hospital) and 8% (out of hospital) (ns). Overall percentages of cases with major diagnostic discrepancies were higher in our study than have been previously reported. It is possible that the nature of our patient population plays a role in this result. This study describes an important prospective reporting tool that will allow us to track rates of medical errors and improve diagnosis and treatment of the critically ill.
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604537-6
    ISSN 1533-404X ; 0195-7910
    ISSN (online) 1533-404X
    ISSN 0195-7910
    DOI 10.1097/PAF.0000000000000857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial

    Kate Britton / Brooke E. Crowley / Clément P. Bataille / Joshua H. Miller / Matthew J. Wooller

    Frontiers in Ecology and Evolution, Vol

    A Golden Age for Strontium Isotope Research? Current Advances in Paleoecological and Archaeological Research

    2022  Volume 9

    Keywords mobility ; provenance ; migrations ; landscape use ; 87Sr/86Sr ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Male mastodon landscape use changed with maturation (late Pleistocene, North America).

    Miller, Joshua H / Fisher, Daniel C / Crowley, Brooke E / Secord, Ross / Konomi, Bledar A

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 25, Page(s) e2118329119

    Abstract: Under harsh Pleistocene climates, migration and other forms of seasonally patterned landscape use were likely critical for reproductive success of mastodons ( ...

    Abstract Under harsh Pleistocene climates, migration and other forms of seasonally patterned landscape use were likely critical for reproductive success of mastodons (
    MeSH term(s) Animal Migration ; Animals ; Cuspid ; Extinction, Biological ; Fossils ; Indiana ; Male ; Mastodons/growth & development ; Reproduction ; Seasons ; Sexual Behavior, Animal
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2118329119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The impact of delayed diagnosis and treatment due to COVID-19 on Australian thyroid cancer patients: a qualitative interview study.

    D'souza, Bianka / Glover, Anthony / Bavor, Claire / Brown, Benjamin / Dodd, Rachael H / Lee, James C / Millar, Jeremy / Miller, Julie A / Zalcberg, John R / Serpell, Jonathan / Ioannou, Liane J / Nickel, Brooke

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e069236

    Abstract: Objectives: The study aims to investigate the perceptions of patients with thyroid cancer on the potential impact of diagnosis and treatment delays during the COVID-19 pandemic.: Design: This study involved qualitative semi-structured telephone ... ...

    Abstract Objectives: The study aims to investigate the perceptions of patients with thyroid cancer on the potential impact of diagnosis and treatment delays during the COVID-19 pandemic.
    Design: This study involved qualitative semi-structured telephone interviews. The interviews were transcribed verbatim, analysed using the thematic framework analysis method and reported using the Consolidated Criteria for Reporting Qualitative Research.
    Setting: Participants in the study were treated and/or managed at hospital sites across New South Wales and Victoria, Australia.
    Participants: 17 patients with thyroid cancer were interviewed and included in the analysis (14 females and 3 males).
    Results: The delays experienced by patients ranged from <3 months to >12 months. The patients reported about delays to diagnostic tests, delays to surgery and radioactive iodine treatment, perceived disease progression and, for some, the financial burden of choosing to go through private treatment to minimise the delay. Most patients also reported not wanting to experience delays any longer than they did, due to unease and anxiety.
    Conclusions: This study highlights an increased psychological burden in patients with thyroid cancer who experienced delayed diagnosis and/or treatment during COVID-19. The impacts experienced by patients during this time may be similar in the case of other unexpected delays and highlight the need for regular clinical review during delays to diagnosis or treatment.
    MeSH term(s) Male ; Female ; Humans ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; COVID-19 ; Delayed Diagnosis ; Iodine Radioisotopes ; Pandemics ; Victoria ; Qualitative Research ; COVID-19 Testing
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Strontium isotopes (

    Crowley, Brooke E / Miller, Joshua H / Bataille, Clément P

    Biological reviews of the Cambridge Philosophical Society

    2017  Volume 92, Issue 1, Page(s) 43–59

    Abstract: Strontium (Sr) isotope analysis can provide detailed biogeographical and ecological information about modern and ancient organisms. Because Sr isotope ratios ( ...

    Abstract Strontium (Sr) isotope analysis can provide detailed biogeographical and ecological information about modern and ancient organisms. Because Sr isotope ratios (
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1423558-4
    ISSN 1469-185X ; 0006-3231 ; 1464-7931
    ISSN (online) 1469-185X
    ISSN 0006-3231 ; 1464-7931
    DOI 10.1111/brv.12217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Silver Linings at the Dawn of a “Golden Age”

    Kate Britton / Brooke E. Crowley / Clément P. Bataille / Joshua H. Miller / Matthew J. Wooller

    Frontiers in Ecology and Evolution, Vol

    2021  Volume 9

    Abstract: Nearly four decades after the first applications of strontium isotope analyses in archaeology and paleoecology research, it could be said that we are entering a “Golden Age”. Here, we reflect on major past developments and current strengths in strontium ... ...

    Abstract Nearly four decades after the first applications of strontium isotope analyses in archaeology and paleoecology research, it could be said that we are entering a “Golden Age”. Here, we reflect on major past developments and current strengths in strontium isotope research, as well as speculate on future directions. We review (1) the currently limited number of (but much needed) controlled feeding experiments, (2) recent advances in isoscape mapping and spatial assignment, and (3) the strength of multi-proxy approaches (including both the integration of strontium isotopes with other isotope systems and complementary techniques such as ancient DNA analyses). We also explore the integration of strontium isotope research with other types of paleoecological or archaeology data, as well as with evidence and interpretative frameworks from other fields (such as conservation ecology, conservation paleobiology or history). This blending is critical as we seek to advance the field beyond simply distinguishing local or relatively sedentary individuals from those that were non-local or highly mobile. We finish with a call for future research centered on balancing methodological developments and novel applications with critical self-reflection, deeper theoretical considerations and cross-disciplinarity.
    Keywords mobility ; provenance ; migrations ; landscape use ; 87Sr/86Sr ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 930
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Epigenetic mechanisms in schizophrenia.

    Shorter, Kimberly R / Miller, Brooke H

    Progress in biophysics and molecular biology

    2015  Volume 118, Issue 1-2, Page(s) 1–7

    Abstract: Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have been implicated in a number of complex diseases. Schizophrenia and other major psychiatric and neurodevelopmental disorders are associated with ... ...

    Abstract Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have been implicated in a number of complex diseases. Schizophrenia and other major psychiatric and neurodevelopmental disorders are associated with abnormalities in multiple epigenetic mechanisms, resulting in altered gene expression during development and adulthood. Polymorphisms and copy number variants in schizophrenia risk genes contribute to the high heritability of the disease, but environmental factors that lead to epigenetic modifications may either reduce or exacerbate the expression of molecular and behavioral phenotypes associated with schizophrenia and related disorders. In the present paper, we will review the current understanding of molecular dysregulation in schizophrenia, including disruption of the dopamine, NMDA, and GABA signaling pathways, and discuss the role of epigenetic factors underlying disease pathology.
    MeSH term(s) Animals ; Chromatin/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Histones/metabolism ; Humans ; MicroRNAs/genetics ; Schizophrenia/genetics
    Chemical Substances Chromatin ; Histones ; MicroRNAs
    Language English
    Publishing date 2015-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2015.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A COVID-19 Vaccination Program to Promote Uptake and Equity for People Experiencing Homelessness in Los Angeles County.

    Rosen, Allison D / Senturia, Alexander / Howerton, Isabelle / Kantrim, Emily Uyeda / Evans, Vanessa / Malluche, Tiffany / Miller, Jonni / Gonzalez, Miriam / Robie, Brooke / Shover, Chelsea L / Chang, Alicia H / Behforouz, Heidi / Nguyen, Anh / Thomas, Emily H

    American journal of public health

    2022  Volume 113, Issue 2, Page(s) 170–174

    Abstract: People experiencing homelessness (PEH) have been disproportionately affected by COVID-19, yet their vaccination coverage is lower than is that of the general population. We implemented a COVID-19 vaccination program that used evidence-based and ... ...

    Abstract People experiencing homelessness (PEH) have been disproportionately affected by COVID-19, yet their vaccination coverage is lower than is that of the general population. We implemented a COVID-19 vaccination program that used evidence-based and culturally tailored approaches to promote vaccine uptake and equity for PEH in Los Angeles County, California. From February 2021 through February 2022, 33 977 doses of vaccine were administered at 2658 clinics, and 9275 PEH were fully vaccinated. This program may serve as a model for future service delivery in vulnerable populations. (
    MeSH term(s) Humans ; COVID-19 Vaccines ; Los Angeles/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Ill-Housed Persons ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.307147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Central circadian control of female reproductive function.

    Miller, Brooke H / Takahashi, Joseph S

    Frontiers in endocrinology

    2014  Volume 4, Page(s) 195

    Abstract: ... of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 h ...

    Abstract Over the past two decades, it has become clear just how much of our physiology is under the control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 h. The SCN prepares our digestive system for meals, our adrenal axis for the stress of waking up in the morning, and the genes expressed in our muscles when we prepare to exercise. Long before molecular studies of genes such as Clock, Bmal1, and the Per homologs were possible, it was obvious that female reproductive function was under strict circadian control at every level of the hypothalamic-pituitary-gonadal axis, and in the establishment and successful maintenance of pregnancy. This review highlights our current understanding of the role that the SCN plays in regulating female reproductive physiology, with a special emphasis on the advances made possible through the use of circadian mutant mice.
    Language English
    Publishing date 2014-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2013.00195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Historical Landscape Use of Migratory Caribou

    Joshua H. Miller / Brooke E. Crowley / Clément P. Bataille / Eric J. Wald / Abigail Kelly / Madison Gaetano / Volker Bahn / Patrick Druckenmiller

    Frontiers in Ecology and Evolution, Vol

    New Insights From Old Antlers

    2021  Volume 8

    Abstract: Accumulations of shed caribou antlers (Rangifer tarandus) are valuable resources for expanding the temporal scope with which we evaluate seasonal landscape use of herds. Female caribou shed their antlers within days of giving birth, thus marking calving ... ...

    Abstract Accumulations of shed caribou antlers (Rangifer tarandus) are valuable resources for expanding the temporal scope with which we evaluate seasonal landscape use of herds. Female caribou shed their antlers within days of giving birth, thus marking calving ground locations. Antler geochemistry (87Sr/86Sr) reflects the isotopic signature of regions used during antler growth, thereby providing data on a second component of seasonal landscape use. Here, we evaluate shed caribou antlers from the Coastal Plain of the Arctic National Wildlife Refuge, Alaska. The Central and Eastern regions of the Coastal Plain are calving grounds for the Porcupine Caribou Herd, while the Western Coastal Plain supports calving by the Central Arctic Herd. We found that antler 87Sr/86Sr from the Central and Eastern Coastal Plain were isotopically indistinguishable, while antler 87Sr/86Sr from the Western Coastal Plain was significantly smaller. For each region, we compared isotopic data for “recent” antlers, which overlap the bulk of standardized state and federal caribou monitoring (early 1980s and younger), with “historical” antlers shed in years predating these records (from the 1300s to the 1970s). For Porcupine Herd females calving in the Arctic Refuge, comparisons of antler 87Sr/86Sr through time indicate that summer ranges have been consistent since at least the 1960s. However, changes between historical and recent antler 87Sr/86Sr for the Central Arctic Herd indicate a shift in summer landscape use after the late 1970s. The timing of this shift is coincident with multiple factors including increased infrastructural development in their range related to hydrocarbon extraction. Accumulations of shed caribou antlers and their isotope geochemistry extend modern datasets by decades to centuries and provide valuable baseline data for evaluating potential anthropogenic and other influences on caribou migration and landscape use.
    Keywords conservation paleobiology ; historical ecology ; seasonal landscape use ; strontium isotope ratios ; ANWR ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 550 ; 710
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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