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Article ; Online: Drone Applications for Emergency and Urgent Care: A Systematic Review.

Sanz-Martos, Sebastián / López-Franco, María Dolores / Álvarez-García, Cristina / Granero-Moya, Nani / López-Hens, José María / Cámara-Anguita, Sixto / Pancorbo-Hidalgo, Pedro Luis / Comino-Sanz, Inés María

Prehospital and disaster medicine

2022 Volume 37, Issue 4, Page(s) 502–508

Abstract: Introduction: In recent years, the use of drones in health emergencies has increased. Among their main benefits are avoiding endangering rescuers, travelling long distances in a short time, or contacting victims in risky situations; but despite their ... ...

Abstract	Introduction: In recent years, the use of drones in health emergencies has increased. Among their main benefits are avoiding endangering rescuers, travelling long distances in a short time, or contacting victims in risky situations; but despite their multiple advantages, their use has not been fully demonstrated. Study objective: This study aims to identify the available evidence on the use of drones in emergency health care compared to traditional health care. Methods: Systematic review of the literature was conducted. Search protocols were developed to locate studies that met the established selection criteria. Six experimental or quasi-experimental studies with high methodological quality published from the beginning of indexing until 2020 were included. Results: Drones covered a significantly larger area than other traditional tracking methods and were very useful for performing preliminary triage, determining needs, and knowing the scene prior to the arrival of rescuers. In addition, drones reduced the time required to locate the victim. Conclusions: Drones are an element to be taken into account when attending health emergencies as they significantly improve the distance travelled to locate accident victims, have the possibility of performing triage prior to the arrival of the health care units, and improve the time and quality of the care provided.
MeSH term(s)	Emergency Medical Services/methods ; Humans ; Unmanned Aerial Devices
Language	English
Publishing date	2022-06-09
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1025975-2
ISSN	1945-1938 ; 1049-023X
ISSN (online)	1945-1938
ISSN	1049-023X
DOI	10.1017/S1049023X22000887
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Zs.A 2859: Show issues

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Article ; Online: Respiratory Center Function and Its Impact in Obesity Hypoventilation Syndrome Treatment.

Ruiz Álvarez, Inés / Fernández Álvarez, Ramón / Rubinos Cuadrado, Gemma / Vázquez López, María José / García Clemente, Marta

Archivos de bronconeumologia

2023 Volume 59, Issue 8, Page(s) 497–501

Abstract: Introduction: Patients with obesity hypoventilation syndrome (OHS) need treatment with positive pressure either with continuous (CPAP) or double pressure (NIV). The apnea-hypopnea index (AHI) is considered a key data for making therapeutic decisions. We ...

Abstract	Introduction: Patients with obesity hypoventilation syndrome (OHS) need treatment with positive pressure either with continuous (CPAP) or double pressure (NIV). The apnea-hypopnea index (AHI) is considered a key data for making therapeutic decisions. We hypothesized that HR may be an useful tool to establish different phenotypes and individualize treatment in patients with OHS. Our objective was to analyze the role of the respiratory center response to hypercapnia (HR) in the adequacy of positive airway pressure therapy. Method: We included subjects with OHS treated with CPAP or NIV according to AHI and baseline pCO Results: 67 subjects were included of 68(11) years old, 37 (55%) males, initially 45 (67%) treated with NIV and 22 (33%) with CPAP, one case was excluded and in 25 (38%) the treatment was changed. Finally, CPAP was adequate for 29 subjects (44%) and NIV for 37 (56%). The CPAP group showed AHI 57/h (24) and p0.1/pEtCO Conclusion: Measuring the RH of the respiratory center helps to select the most appropriate treatment for patients with OHS.
MeSH term(s)	Male ; Female ; Humans ; Obesity Hypoventilation Syndrome/therapy ; Respiratory Center ; Continuous Positive Airway Pressure ; Noninvasive Ventilation ; Respiratory Physiological Phenomena ; Hypercapnia/etiology ; Hypercapnia/therapy
Language	Spanish
Publishing date	2023-06-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2023.05.013
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Zs.B 2655: Show issues

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Article ; Online: Development of the Aerial Remote Triage System using drones in mass casualty scenarios: A survey of international experts.

Álvarez-García, Cristina / Cámara-Anguita, Sixto / López-Hens, José María / Granero-Moya, Nani / López-Franco, María Dolores / María-Comino-Sanz, Inés / Sanz-Martos, Sebastián / Pancorbo-Hidalgo, Pedro Luis

PloS one

2021 Volume 16, Issue 5, Page(s) e0242947

Abstract: The use of drones for triage in mass-casualty incidents has recently emerged as a promising technology. However, there is no triage system specifically adapted to a remote usage. Our study aimed to develop a remote triage procedure using drones. The ... ...

Abstract	The use of drones for triage in mass-casualty incidents has recently emerged as a promising technology. However, there is no triage system specifically adapted to a remote usage. Our study aimed to develop a remote triage procedure using drones. The research was performed in three stages: literature review, the development of a remote triage algorithm using drones and evaluation of the algorithm by experts. Qualitative synthesis and the calculation of content validity ratios were done to achieve the Aerial Remote Triage System. This algorithm assesses (in this order): major bleeding, walking, consciousness and signs of life; and then classify the injured people into several priority categories: priority 1 (red), priority 2 (yellow), priority 3 (green) and priority * (violet). It includes the possibility to indicate save-living interventions to injured people and bystanders, like the compression of bleeding injuries or the adoption of the recovery position. The Aerial Remote Triage System may be a useful way to perform triage by drone in complex emergencies when it is difficult to access to the scene due to physical, chemical or biological risks.
MeSH term(s)	Aircraft ; Emergencies ; Emergency Medical Services ; Hemorrhage/prevention & control ; Humans ; Mass Casualty Incidents/prevention & control ; Triage/methods
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0242947
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Article ; Online: Secuestro pulmonar.

Martínez-Besteiro, Elisa / Eiros Bachiller, José María / Solís García, Marta / Ruiz-Álvarez, Inés

Medicina clinica

2022 Volume 158, Issue 9, Page(s) 449

Title translation	Pulmonary sequestration.
MeSH term(s)	Bronchopulmonary Sequestration/diagnostic imaging ; Humans ; Tomography, X-Ray Computed
Language	Spanish
Publishing date	2022-01-31
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2021.11.004
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Article ; Online: Characterization of a novel interaction of the Nup159 nucleoporin with asymmetrically localized spindle pole body proteins and its link with autophagy.

de Oya, Inés García / Manzano-López, Javier / Álvarez-Llamas, Alejandra / Vázquez-Aroca, María de la Paz / Cepeda-García, Cristina / Monje-Casas, Fernando

PLoS biology

2023 Volume 21, Issue 8, Page(s) e3002224

Abstract: Both the spindle microtubule-organizing centers and the nuclear pore complexes (NPCs) are convoluted structures where many signaling pathways converge to coordinate key events during cell division. Interestingly, despite their distinct molecular ... ...

Abstract	Both the spindle microtubule-organizing centers and the nuclear pore complexes (NPCs) are convoluted structures where many signaling pathways converge to coordinate key events during cell division. Interestingly, despite their distinct molecular conformation and overall functions, these structures share common components and collaborate in the regulation of essential processes. We have established a new link between microtubule-organizing centers and nuclear pores in budding yeast by unveiling an interaction between the Bfa1/Bub2 complex, a mitotic exit inhibitor that localizes on the spindle pole bodies, and the Nup159 nucleoporin. Bfa1/Bub2 association with Nup159 is reduced in metaphase to not interfere with proper spindle positioning. However, their interaction is stimulated in anaphase and assists the Nup159-dependent autophagy pathway. The asymmetric localization of Bfa1/Bub2 during mitosis raises the possibility that its interaction with Nup159 could differentially promote Nup159-mediated autophagic processes, which might be relevant for the maintenance of the replicative lifespan.
MeSH term(s)	Cell Cycle Proteins/metabolism ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Spindle Pole Bodies/metabolism ; Cytoskeletal Proteins/metabolism ; Spindle Apparatus/genetics ; Spindle Apparatus/metabolism ; Mitosis/genetics
Chemical Substances	Cell Cycle Proteins ; Nuclear Pore Complex Proteins ; Saccharomyces cerevisiae Proteins ; Cytoskeletal Proteins
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3002224
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Zs.A 6193: Show issues

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Article ; Online: Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension.

García-Lunar, Inés / Pereda, Daniel / Ibanez, Borja / García-Álvarez, Ana

Cells

2020 Volume 9, Issue 11

Abstract: The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and ... ...

Abstract	The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin-aldosterone signaling drugs) and invasive procedures, such as pulmonary artery denervation, is provided.
MeSH term(s)	Animals ; Humans ; Hypertension, Pulmonary/drug therapy ; Rats ; Receptors, Neurotransmitter/antagonists & inhibitors
Chemical Substances	Receptors, Neurotransmitter
Language	English
Publishing date	2020-11-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9112521
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Article ; Online: Síndrome de Rapunzel: diagnóstico radiológico.

Lara-Zavala, Yhessica Yhazmin / Álvarez-Ciaca, Inés / Montiel-Jarquin, Álvaro José / Bertado-Ramírez, Nancy Rosalía / García-Galicia, Arturo / Alonso-Torres, Gisela

Revista medica del Instituto Mexicano del Seguro Social

2023 Volume 61, Issue 4, Page(s) 539–542

Abstract: Background: Rapunzel syndrome is a rare presentation of trichobezoar, secondary to the ingestion of hair known as trichophagia. This bezoar has been found mainly in women, it invades the stomach and extends to the small intestine. Clinically, patients ... ...

Title translation	Rapunzel syndrome: Radiological diagnosis.
Abstract	Background: Rapunzel syndrome is a rare presentation of trichobezoar, secondary to the ingestion of hair known as trichophagia. This bezoar has been found mainly in women, it invades the stomach and extends to the small intestine. Clinically, patients present weight loss and chronic obstructive symptoms at the intestinal level. A case of Rapunzel syndrome is presented. Clinical case: A 13-year-old female presented with a weight loss of 10kg in two months, chronic constipation, predominantly nocturnal vomiting, and abdominal pain of seven days' duration. Physical examination revealed decreased peristalsis and a palpable mass in the epigastrium. Laboratories taken on admission: normal blood count, kidney function tests, and liver function tests. The abdominal X-ray showed opacity in the fundus, body and gastric antrum, the abdominal ultrasound showed non-specific findings in the epigastrium, later an abdominal tomography was performed with a swallow of water-soluble contrast medium and showed occupation in the gastric lumen. She underwent exploratory laparotomy and the finding was a trichobezoar in the stomach with extension to the duodenum and part of the jejunum, which was removed without complications. The evolution of the patient was favorable. Conclusions: For the diagnosis of Rapunzel Syndrome, the use of contrast imaging studies is necessary, and the treatment of choice is surgical.
MeSH term(s)	Humans ; Female ; Adolescent ; Bezoars/diagnostic imaging ; Bezoars/complications ; Trichotillomania/complications ; Stomach ; Hair ; Tomography, X-Ray Computed ; Syndrome
Language	Spanish
Publishing date	2023-07-31
Publishing country	Mexico
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	732133-8
ISSN	2448-5667 ; 0443-5117 ; 0484-7849
ISSN (online)	2448-5667
ISSN	0443-5117 ; 0484-7849
DOI	10.5281/zenodo.8200619
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Article ; Online: Assessment of COVID-19 lockdown effect on early Alzheimer Disease progression.

Peña-Bautista, Carmen / Álvarez-Sánchez, Lourdes / Ferrer-Cairols, Inés / García-Vallés, Lorena / Baquero, Miguel / Cháfer-Pericás, Consuelo

Journal of neurology

2023 Volume 270, Issue 10, Page(s) 4585–4592

Abstract: Introduction: Recently, many aspects of daily life have changed due to the COVID-19 pandemic. Patients with Alzheimer Disease (AD) could be more vulnerable to those daily life changes as experts expected. Mainly, the lockdown involved reduced social ... ...

Abstract	Introduction: Recently, many aspects of daily life have changed due to the COVID-19 pandemic. Patients with Alzheimer Disease (AD) could be more vulnerable to those daily life changes as experts expected. Mainly, the lockdown involved reduced social contact and cognitive stimulation. So, it could affect the AD expression, increasing the patients' disabilities development. Objective: The aim of this study is to evaluate the effect of COVID-19 lockdown on cognitive impairment progression in early AD patients. Methodology: The participants were patients with mild cognitive impairment due to AD (MCI-AD) from the Neurology Unit (La Fe Hospital), who were neuropsychologically evaluated (cognitive impairment, daily activity tests) twice over 2 years. They were classified into a case group (n = 21), evaluated before and after lockdown condition, and a control group (n = 20), evaluated entirely before the lockdown condition. Results: All the participants showed increasing cognitive impairment and functional deterioration over the 2-year period of evaluation (p < 0.05). However, a faster worsening was not observed as a consequence of the COVID-19 pandemic and the lockdown condition. In fact, the statistical significance observed between the two study groups for daily life activities showed that the worsening was even lesser in the group evaluated under the lockdown condition. Conclusion: Medium-term effects of COVID-19 lockdown could not involve an acceleration of the cognitive decline in MCI-AD patients in a 2-year evaluation period. In addition, the least worsening observed for daily living activities in the case group was probably due to the change in routines. Therefore, the common assumption of cognitive worsening of AD progression due to the lockdown in comparison with normal disease progression was not demonstrated in this study, at least for MCI-AD cases. However, more longitudinal studies are required to evaluate long-term effects in these patients.
MeSH term(s)	Humans ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Pandemics ; COVID-19/prevention & control ; Communicable Disease Control ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Neuropsychological Tests
Language	English
Publishing date	2023-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11899-5
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Article ; Online: Atropine in topical formulations for the management of anterior and posterior segment ocular diseases.

García Del Valle, Ines / Alvarez-Lorenzo, Carmen

Expert opinion on drug delivery

2021 Volume 18, Issue 9, Page(s) 1245–1260

Abstract: Introduction: Atropine is an old-known drug which is gaining increasing attention due to the myriad of therapeutic effects it may trigger on eye structures. Nevertheless, novel applications may require more adequate topical formulations.: Areas ... ...

Abstract	Introduction: Atropine is an old-known drug which is gaining increasing attention due to the myriad of therapeutic effects it may trigger on eye structures. Nevertheless, novel applications may require more adequate topical formulations. Areas covered: This review aims to gather the existing knowledge about atropine and its clinical applications in the ophthalmological field when administered topically. Atropine ocular pharmacokinetics is paid a special attention, including recent evidences of the capability of the drug to access to the posterior segment. Ocular bioavailability and systemic bioavailability are counterbalanced. Finally, limitations of traditional dosage forms and potential advantages of under investigation delivery systems are analyzed. Expert opinion: Mydriasis and cyclopegia have been widely exploited for eye examination, management of anterior segment diseases, and more recently as antidotes of chemical weapons. Improved knowledge on drug receptors and related pathways explains atropine repositioning as an outstanding tool to prevent myopia. The ease with which atropine penetrates ocular tissues is a double edged sword, that is, while it ensures therapeutic levels in the posterior segment, the unspecific distribution causes a wide variety of untoward effects. The design of formulations that can selectively deliver atropine to the target tissue for each specific application is an urgent unmet need.
MeSH term(s)	Atropine/therapeutic use ; Drug Compounding ; Drug Delivery Systems ; Eye ; Eye Diseases/drug therapy ; Humans
Chemical Substances	Atropine (7C0697DR9I)
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2021.1909568
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Article ; Online: Unveiling the crystal and magnetic texture of iron oxide nanoflowers.

Moya, Carlos / Escoda-Torroella, Mariona / Rodríguez-Álvarez, Javier / Figueroa, Adriana I / García, Íker / Ferrer-Vidal, Inés Batalla / Gallo-Cordova, A / Puerto Morales, M / Aballe, Lucía / Fraile Rodríguez, Arantxa / Labarta, Amílcar / Batlle, Xavier

Nanoscale

2024 Volume 16, Issue 4, Page(s) 1942–1951

Abstract: Iron oxide nanoflowers (IONF) are densely packed multi-core aggregates known for their high saturation magnetization and initial susceptibility, as well as low remanence and coercive field. This study reports on how the local magnetic texture originating ...

Abstract	Iron oxide nanoflowers (IONF) are densely packed multi-core aggregates known for their high saturation magnetization and initial susceptibility, as well as low remanence and coercive field. This study reports on how the local magnetic texture originating at the crystalline correlations among the cores determines the special magnetic properties of individual IONF over a wide size range from 40 to 400 nm. Regardless of this significant size variation in the aggregates, all samples exhibit a consistent crystalline correlation that extends well beyond the IONF cores. Furthermore, a nearly zero remnant magnetization, together with the presence of a persistently blocked state, and almost temperature-independent field-cooled magnetization, support the existence of a 3D magnetic texture throughout the IONF. This is confirmed by magnetic transmission X-ray microscopy images of tens of individual IONF, showing, in all cases, a nearly demagnetized state caused by the vorticity of the magnetic texture. Micromagnetic simulations agree well with these experimental findings, showing that the interplay between the inter-core direct exchange coupling and the demagnetizing field is responsible for the highly vortex-like spin configuration that stabilizes at low magnetic fields and appears to have partial topological protection. Overall, this comprehensive study provides valuable insights into the impact of crystalline texture on the magnetic properties of IONF over a wide size range, offering a deeper understanding of their potential applications in fields such as biomedicine and water remediation.
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr04608g
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