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Article ; Online: Advancing parathyroid anatomy understanding through single-cell RNA sequencing in uremic secondary hyperparathyroidism.

Ben-Dov, Iddo Z

2023 Volume 105, Issue 3, Page(s) 433–435

Abstract: This commentary explores the recent application of single-cell RNA sequencing in the study of uremic secondary hyperparathyroidism, shedding light on the cellular dynamics within parathyroid glands. The use of single-cell RNA sequencing reveals new ... ...

Abstract	This commentary explores the recent application of single-cell RNA sequencing in the study of uremic secondary hyperparathyroidism, shedding light on the cellular dynamics within parathyroid glands. The use of single-cell RNA sequencing reveals new insights into the differentiation processes of chief and oxyphil cells, challenging traditional views and highlighting the potential of this technology in advancing our understanding of parathyroid anatomy.
MeSH term(s)	Humans ; Parathyroid Glands ; Hyperparathyroidism, Secondary/genetics ; Oxyphil Cells ; Exome Sequencing ; Sequence Analysis, RNA
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.12.005
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Zs.A 797: Show issues

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Article ; Online: Prophylactic Phosphate Restriction: A Strategy to Mitigate AKI-Associated Complications.

Ben-Dov, Iddo Z / Potruch, Assaf / Abbasi, Momen

Journal of the American Society of Nephrology : JASN

2024 Volume 35, Issue 3, Page(s) 255–256

MeSH term(s)	Humans ; Phosphates ; Acute Kidney Injury/prevention & control ; Acute Kidney Injury/etiology ; Risk Factors
Chemical Substances	Phosphates
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.0000000000000308
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Zs.A 3344: Show issues

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Article: The Role of Blood Pressure Load in Ambulatory Blood Pressure Monitoring in Adults: A Literature Review of Current Evidence.

Eyal, Ophir / Ben-Dov, Iddo Z

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 15

Abstract: Background: The blood pressure load (BPL) is commonly defined as the percentage of readings in a 24-h ambulatory blood pressure monitoring (ABPM) study above a certain threshold, usually the upper normal limit. While it has been studied since the 1990s, ...

Abstract	Background: The blood pressure load (BPL) is commonly defined as the percentage of readings in a 24-h ambulatory blood pressure monitoring (ABPM) study above a certain threshold, usually the upper normal limit. While it has been studied since the 1990s, the benefits of using this index have not been clearly demonstrated in adults. We present the first review on the associations of BPL with target organ damage (TOD) and clinical outcomes in adults, the major determinants for its role and utility in blood pressure measurement. We emphasize studies which evaluated whether BPL has added benefit to the average blood pressure indices on ABPM in predicting adverse outcomes. Methods: PubMed search for all English language papers mentioning ABPM and BPL. Results: While multiple studies assessed this question, the cumulative sample size is small. Whereas the associations of BPL with various TODs are evident, the available literature fails to demonstrate a clear and consistent added value for the BPL over the average blood pressure indices. Conclusions: There is a need for prospective studies evaluating the role of BPL in blood pressure measurement. The current literature does not provide sound support for the use of BPL in clinical decisions.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13152485
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Article: [CATHETER-BASED RENAL DENERVATION FOR THE TREATMENT OF HYPERTENSION].

Podjarny, Eduardo / Ben-Dov, Iddo Z / Leiba, Adi

Harefuah

2021 Volume 160, Issue 4, Page(s) 250–255

Abstract: Introduction: Hypertension is a significant risk factor for cardiovascular morbidity and mortality. Despite a large variety of pharmacological treatment options, many patients remain uncontrolled. Medical inertia and patients' non-adherence to ... ...

Abstract	Introduction: Hypertension is a significant risk factor for cardiovascular morbidity and mortality. Despite a large variety of pharmacological treatment options, many patients remain uncontrolled. Medical inertia and patients' non-adherence to medications are the main reasons for lack of control. Experimental evidence shows that increased renal sympathetic nerve activity increases blood pressure and surgical denervation lowers blood pressure. In studies published between the years 2010-2013, radiofrequency endovascular ablation of renal sympathetic nerves (RDN) seemed to produce antihypertensive effects. However, a randomized sham-control study failed to prove active treatment-specific benefit. One of the main reasons for failure was the small number of ablations in each procedure. In recent years, technological progress has been made with the possibility to quadruple the number of ablation sites and extend them to the branches of the main renal arteries. Small sham-controlled studies were conducted in patients with grade 1-2 hypertension, either untreated or treated with up to three drugs. At three to six months follow-up, modest yet significant decrease of blood pressure was found, both in office and ambulatory measurements. Data from the Global SYMPLICITY Registry, which collects data from consecutive patients undergoing RDN with Medtronic radiofrequency ablation catheters, most of them with resistant hypertension, also showed significant improvement in blood pressure. However, in the absence of a control group, these real-life results should be interpreted with caution. Selection criteria of patients more likely to benefit from RDN have not been defined and will be discussed in the current review. In summary, RDN is a promising new treatment for hypertension. Randomized sham-controlled studies with a longer follow-up are still needed to confirm long-lasting treatment-specific effects and to show cardiovascular protection and safety.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure ; Catheter Ablation ; Catheters ; Humans ; Hypertension/drug therapy ; Hypertension/surgery ; Randomized Controlled Trials as Topic ; Sympathectomy ; Treatment Outcome
Chemical Substances	Antihypertensive Agents
Language	Hebrew
Publishing date	2021-04-25
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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Zs.B 291: Show issues

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Article: [RENAL DENERVATION IN REFRACTORY HYPERTENSION].

Ben-Dov, Iddo Z / Yusuf, Amal / Varshitski, Boris / Danenberg, Haim D

Harefuah

2021 Volume 160, Issue 4, Page(s) 205–209

Abstract: Introduction: Resistant hypertension is a commonplace condition among patients referred to specialty hypertension clinics, which is associated with increased morbidity and mortality. Refractory hypertension however is a rare extreme subtype of resistant ...

Abstract	Introduction: Resistant hypertension is a commonplace condition among patients referred to specialty hypertension clinics, which is associated with increased morbidity and mortality. Refractory hypertension however is a rare extreme subtype of resistant hypertension in which blood pressure is uncontrolled despite treatment with five antihypertensive drug classes including a diuretic and a mineralocorticoid receptor antagonist, and is associated with even worse prognosis. We herein describe a 40-year-old woman with severe refractory hypertension and target organ damage for who percutaneous renal sympathetic denervation successfully reduced blood pressure to normal levels and alleviated chronic headaches. Renal denervation should be considered in patients with refractory hypertension, especially when sympathetic over-activity is suspected.
MeSH term(s)	Adult ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Female ; Humans ; Hypertension/drug therapy ; Kidney ; Sympathectomy ; Treatment Outcome
Chemical Substances	Antihypertensive Agents
Language	Hebrew
Publishing date	2021-04-25
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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Zs.B 291: Show issues

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Article ; Online: Associations of Arterial Stiffness Indices With Measures of Insulin Resistance and Renal Sodium Reabsorption.

Ben-Dov, Iddo Z / Bursztyn, Michael

American journal of hypertension

2019 Volume 32, Issue 9, Page(s) 810–812

MeSH term(s)	Humans ; Hypertension ; Insulin Resistance ; Sodium ; Sodium, Dietary ; Vascular Stiffness
Chemical Substances	Sodium, Dietary ; Sodium (9NEZ333N27)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpz082
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Zs.A 2329: Show issues

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Article ; Online: Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model.

Amleh, Athar / Chen, Hadass Pri / Watad, Lana / Abramovich, Ifat / Agranovich, Bella / Gottlieb, Eyal / Ben-Dov, Iddo Z / Nechama, Morris / Volovelsky, Oded

Cell reports. Medicine

2023 Volume 4, Issue 6, Page(s) 101073

Abstract: Cystic kidney disease is a leading cause of morbidity in patients with tuberous sclerosis complex (TSC). We characterize the misregulated metabolic pathways using cell lines, a TSC mouse model, and human kidney sections. Our study reveals a substantial ... ...

Abstract	Cystic kidney disease is a leading cause of morbidity in patients with tuberous sclerosis complex (TSC). We characterize the misregulated metabolic pathways using cell lines, a TSC mouse model, and human kidney sections. Our study reveals a substantial perturbation in the arginine biosynthesis pathway in TSC models with overexpression of argininosuccinate synthetase 1 (ASS1). The rise in ASS1 expression is dependent on the mechanistic target of rapamycin complex 1 (mTORC1) activity. Arginine depletion prevents mTORC1 hyperactivation and cell cycle progression and averts cystogenic signaling overexpression of c-Myc and P65. Accordingly, an arginine-depleted diet substantially reduces the TSC cystic load in mice, indicating the potential therapeutic effects of arginine deprivation for the treatment of TSC-associated kidney disease.
MeSH term(s)	Humans ; Mice ; Animals ; Tuberous Sclerosis Complex 2 Protein/metabolism ; Tuberous Sclerosis/metabolism ; Arginine/metabolism ; Mechanistic Target of Rapamycin Complex 1 ; Kidney/metabolism
Chemical Substances	Tuberous Sclerosis Complex 2 Protein ; Arginine (94ZLA3W45F) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101073
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Article ; Online: Posttranscriptional regulation of the prostaglandin E receptor spliced-isoform EP3-γ and its implication in pancreatic β-cell failure.

Srivastava, Rohit / Horwitz, Margalit / Hershko-Moshe, Anat / Bronstein, Shirly / Ben-Dov, Iddo Z / Melloul, Danielle

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 6, Page(s) e22958

Abstract: In Type 2 diabetes (T2D), elevated lipid levels have been suggested to contribute to insulin resistance and β-cell dysfunction. We previously reported that the expression of the PGE2 receptor EP3 is elevated in islets of T2D individuals and is ... ...

Abstract	In Type 2 diabetes (T2D), elevated lipid levels have been suggested to contribute to insulin resistance and β-cell dysfunction. We previously reported that the expression of the PGE2 receptor EP3 is elevated in islets of T2D individuals and is preferentially stimulated by palmitate, leading to β-cell failure. The mouse EP3 receptor generates three isoforms by alternative splicing which differ in their C-terminal domain and are referred to as mEP3α, mEP3β, and mEP3γ. We bring evidence that the expression of the mEP3γ isoform is elevated in islets of diabetic db/db mice and is selectively upregulated by palmitate. Specific knockdown of the mEP3γ isoform restores the expression of β-cell-specific genes and rescues MIN6 cells from palmitate-induced dysfunction and apoptosis. This study indicates that palmitate stimulates the expression of the mEP3γ by a posttranscriptional mechanism, compared to the other spliced isoforms, and that the de novo synthesized ceramide plays an important role in FFA-induced mEP3γ expression in β-cells. Moreover, induced levels of mEP3γ mRNA by palmitate or ceramide depend on p38 MAPK activation. Our findings suggest that mEP3γ gene expression is regulated at the posttranscriptional level and defines the EP3 signaling axis as an important pathway mediating β-cell-impaired function and demise.
MeSH term(s)	Mice ; Animals ; Receptors, Prostaglandin E/metabolism ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Insulin-Secreting Cells/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Palmitates/metabolism ; Ceramides/metabolism ; Receptors, Prostaglandin E, EP3 Subtype/genetics ; Receptors, Prostaglandin E, EP3 Subtype/metabolism
Chemical Substances	Receptors, Prostaglandin E ; Protein Isoforms ; Palmitates ; Ceramides ; Receptors, Prostaglandin E, EP3 Subtype
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202201984R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article: Dialysis Therapy for Volume Overload: A Feasible Option to Reduce Heart Failure Hospitalizations in Advanced Heart Failure.

Koev, Ivelin / Bloch, Aharon / Ouzan, Elisha / Zwas, Donna R / Ben-Dov, Iddo Z / Gotsman, Israel

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 7, Page(s) 475–479

Abstract: Background: Advanced heart failure (HF) carries a high rate of recurrent HF hospitalizations and a very high mortality rate. Mechanical devices and heart transplantation are limited to a select few. Dialysis may be a good alternative for advanced HF ... ...

Abstract	Background: Advanced heart failure (HF) carries a high rate of recurrent HF hospitalizations and a very high mortality rate. Mechanical devices and heart transplantation are limited to a select few. Dialysis may be a good alternative for advanced HF patients with volume overload despite maximal pharmacological therapy. Objectives: To assess the net clinical outcome of peritoneal dialysis or hemodialysis in patients with advanced HF. Methods: We analyzed all advanced HF patients who were referred for dialysis due to volume overload in our institution. Patients were followed for complications, HF hospitalizations, and survival. Results: We assessed 35 patients; 10 (29%) underwent peritoneal dialysis and 25 (71%) underwent hemodialysis; 71% were male; median (interquartile range) age was 74 (67-78) years. Estimated glomerular filtration rate was 20 (13-32) ml/min per 1.73 m2. New York Heart Association functional capacity was III. Median follow-up time was 719 days (interquartile range 658-780). One-year mortality rate was 8/35 (23%) and overall mortality rate was 16/35 (46%). Three patients (9%) died during the first year due to line or peritoneal dialysis related sepsis, and 6 (17%) died during the entire follow-up. The median number of HF hospitalizations was significantly reduced during the year on dialysis compared to the year prior to dialysis (0.0 [0.0-1.0] vs. 2.0 [0.0-3.0], P < 0.001). Conclusions: Dialysis is reasonably safe and significantly reduced HF hospitalization in advanced HF patients. Dialysis could be a good alternative for advanced HF patients with intractable volume overload.
MeSH term(s)	Aged ; Female ; Glomerular Filtration Rate ; Heart Failure/complications ; Heart Failure/therapy ; Hospitalization ; Humans ; Male ; Peritoneal Dialysis ; Renal Dialysis ; Water-Electrolyte Imbalance
Language	English
Publishing date	2022-07-12
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: MicroRNAs expression in semen and testis of azoospermic men.

Wainstein, Amit / Hassan, Sarah / Barda, Shimi / Lehavi, Ofer / Azem, Foad / Ben-Dov, Iddo Z / Hauser, Ron / Kleiman, Sandra E

Andrology

2023 Volume 11, Issue 4, Page(s) 687–697

Abstract: Background: MicroRNAs are involved in the regulation of spermatogenesis, are detected in semen and may be useful as molecular markers for predicting residual complete spermatogenesis in azoospermic men.: Objectives: To study the biomarker potential ... ...

Abstract	Background: MicroRNAs are involved in the regulation of spermatogenesis, are detected in semen and may be useful as molecular markers for predicting residual complete spermatogenesis in azoospermic men. Objectives: To study the biomarker potential of microRNAs that are detected in semen and testicular tissue. Materials and methods: MicroRNA profiles were analyzed in semen fractions of normozoospermic (n = 3) and azoospermic (n = 6) men by small RNA deep sequencing. Specific microRNAs were further analyzed by reverse transcription and quantitative polymerase chain reaction in eight testicular samples and 46 semen supernatants. The semen supernatant samples included 18 normozoospermic and 28 azoospermic men with various pathologies. Results: The sequenced microRNA profiles of semen supernatant fraction samples were distinct from the other fractions. Significant expression differences were observed between the semen supernatant of normozoospermic and azoospermic men. Further analysis by reverse transcription and quantitative polymerase chain reaction revealed that expression of miR-202-3p was considerably reduced (undetectable in most samples) in the azoospermic semen supernatants. The expression of miR-202-3p was significantly lower in the azoospermic specimens than in the normozoospermic specimens and a trend was observed for miR-629-5p (p = 0.03 and 0.06, respectively). Differences in expression levels in the semen supernatant were observed among the various pathologies but not to a level of significance, possibly because of the small subgroups. miRNA-370-3p was significantly higher in semen supernatant samples from azoospermic men without sperm cells in testis (p = 0.05). In testes, the three microRNAs were expressed at higher levels in the obstructive and spermatocyte maturation arrest pathologies than in mixed atrophy and Sertoli cell only. miR-202-3p was detected in all testicular samples. Conclusions: MicroRNA expression profiles in semen were distinguishable between azoospermic and normozoospermic men. The microRNA profile also diverged among azoospermic men subdivided according to their testicular pathologies. The levels of specific microRNAs in testis and in the semen supernatant were not directly correlated.
MeSH term(s)	Humans ; Male ; Testis/metabolism ; Semen/metabolism ; Azoospermia ; Spermatogenesis/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Biomarkers/metabolism
Chemical Substances	MicroRNAs ; Biomarkers ; MIRN370 microRNA, human ; MIRN202 microRNA, human ; MIRN629 microRNA, human
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13394
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Zs.A 6983: Show issues

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