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Article ; Online: Controlled synthesis of monodispersed ZnSe microspheres for enhanced photo-catalytic application and its corroboration using density functional theory.

Chopade, Prachi / Kashid, Vikas / Jawale, Niteen / Rane, Sunit / Jagtap, Shweta / Kshirsagar, Anjali / Gosavi, Suresh

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 15, Page(s) 10567–10582

Abstract: The present work reports enhanced photocatalytic performance of highly crystalline, monodisperse ZnSe microspheres, synthesized by the size-selective, ETDA-assisted hydrothermal method. Systematic studies on time-dependent reaction kinetics and growth ... ...

Abstract	The present work reports enhanced photocatalytic performance of highly crystalline, monodisperse ZnSe microspheres, synthesized by the size-selective, ETDA-assisted hydrothermal method. Systematic studies on time-dependent reaction kinetics and growth parameters indicate dependency of morphology and crystal structure on the volume % of EDTA and dependency of size on the volume % of hydrazine hydrate for ZnSe microspheres. X-ray diffraction studies confirm highly crystalline cubic zinc blende crystal structure with crystallite size in the range of 10-15 nm. Diffuse reflectance spectra show blue shift having a broad absorption peak between 415 and 425 nm, with a band gap of ∼2.6 eV from the K-M plot. Photoluminescence spectra show higher ratio of near band edge emission to deep level emission, confirming the decrease in defect related emission and depicting the higher crystallinity of ZnSe. Raman spectroscopy also confirms the crystalline and pure nature of ZnSe microspheres, from the observation of a high intensity dominant peak at 248 cm
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01016c
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Article: Enzyme Patterns and Factors Associated with Mortality among Patients with Carbapenem Resistant

Prayag, Parikshit Shirish / Patwardhan, Sampada A / Joshi, Rasika S / Panchakshari, Shweta P / Rane, Tejashree / Prayag, Amrita P

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2023 Volume 27, Issue 9, Page(s) 663–668

Abstract: ... SA, Joshi RS, Panchakshari SP, Rane T, Prayag AP. Enzyme Patterns and Factors Associated ...

Abstract	Introduction: In the Indian setting, antimicrobial resistance in Materials and methods: A retrospective analysis of 50 episodes of bacteremia caused by CRAB. We analyzed the enzyme patterns and the susceptibility rates to various antibiotics. Results: The resistance rates for amikacin, tigecycline, minocycline, and fluoroquinolones were 88, 82, 50, and 88% respectively. OXA-23 was the most commonly isolated enzyme (86% of the isolates produced OXA-23) followed by OXA-51 and NDM. The overall mortality was high (58%). On univariate analysis, pneumonia, and higher Pitt's bacteremia score were significantly associated with mortality ( Conclusion: A. baumannii How to cite this article: Prayag PS, Patwardhan SA, Joshi RS, Panchakshari SP, Rane T, Prayag AP. Enzyme Patterns and Factors Associated with Mortality among Patients with Carbapenem Resistant
Language	English
Publishing date	2023-09-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24534
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Article: Serum and Urine Interferon Gamma-Induced Protein 10 (IP-10) Levels in Lupus Nephritis.

Brady, Makayla P / Chava, Saiteja / Tandon, Shweta / Rane, Madhavi J / Barati, Michelle T / Caster, Dawn J / Powell, David W

Journal of clinical medicine

2022 Volume 11, Issue 11

Abstract: Background: Lupus nephritis (LN) is a prevalent and severe complication of systemic lupus erythematosus (SLE). Non-invasive diagnostics are limited, and current therapies have inadequate response rates. Expression of the chemokine Interferon-γ-induced ... ...

Abstract	Background: Lupus nephritis (LN) is a prevalent and severe complication of systemic lupus erythematosus (SLE). Non-invasive diagnostics are limited, and current therapies have inadequate response rates. Expression of the chemokine Interferon-γ-induced protein 10 (IP-10) is regulated by Interferon-γ signaling and NF-κB, and its molecular activity and enhanced urine concentrations are implicated in LN, but its utility as a diagnostic marker and association with demographic, clinical, or pathologic features is not defined. Methods: 38 LN patients and 11 patients with non-LN glomerular diseases (GD) with active disease were included. Eighteen of the LN patients had achieved remission at one follow-up during the study time. Serum and urine were obtained from these samples, and the IP-10 levels were measured. Results: Serum and urine IP-10 levels are significantly enhanced in LN patients with active disease as compared with normal individuals (serum average 179.7 pg/mL vs. 7.2 pg/mL, p < 0.0001; urine average 28.7 pg/mg vs. 1.6 pg/mg, p = 0.0019) and patients with other forms of glomerular disease (serum average 179.7 pg/mL vs. 84.9 pg/mL, p = 0.0176; urine average 28.7 pg/mg vs. 0.18 pg/mg, p = 0.0011). Urine IP-10 levels are significantly higher in patients with proliferative LN (PLN) than those with membranous LN (MLN) (average 32.8 pg/mg vs. 7.6 pg/mg, p = 0.0155). Urine IP-10 levels are also higher in MLN versus primary membranous nephropathy (MN) (average 7.6 pg/mg vs. 0.2 pg/mg, p = 0.0193). Importantly, serum IP-10 levels remain elevated during active LN and LN remission, but urine IP-10 levels are decreased from active LN to remission in 72% of our patients. Lastly, serum, but not urine IP-10 levels are significantly higher in African American than White American LN patients in active LN (average 227.8 pg/mL vs. 103.4 pg/mL, p = 0.0309) and during LN remission (average 254.6 pg/mL vs. 89.2 pg/mL, p = 0.0399). Conclusions: Our findings suggest that serum and urine IP-10 measurements provide promising tests for monitoring LN activity, differentiation between classifications of LN, and differentiation between LN and other forms of glomerular disease. We also conclude that further assessment of elevated IP-10 levels in the serum and urine of high-risk populations (i.e., African American) could be beneficial in determining why many of these patients have worse outcomes and are non-responsive to standard therapeutics.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11113199
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Article ; Online: Serum and Urine Interferon Gamma-Induced Protein 10 (IP-10) Levels in Lupus Nephritis

Makayla P. Brady / Saiteja Chava / Shweta Tandon / Madhavi J. Rane / Michelle T. Barati / Dawn J. Caster / David W. Powell

Journal of Clinical Medicine, Vol 11, Iss 3199, p

2022 Volume 3199

Abstract	Background: Lupus nephritis (LN) is a prevalent and severe complication of systemic lupus erythematosus (SLE). Non-invasive diagnostics are limited, and current therapies have inadequate response rates. Expression of the chemokine Interferon-γ-induced protein 10 (IP-10) is regulated by Interferon-γ signaling and NF-κB, and its molecular activity and enhanced urine concentrations are implicated in LN, but its utility as a diagnostic marker and association with demographic, clinical, or pathologic features is not defined. Methods: 38 LN patients and 11 patients with non-LN glomerular diseases (GD) with active disease were included. Eighteen of the LN patients had achieved remission at one follow-up during the study time. Serum and urine were obtained from these samples, and the IP-10 levels were measured. Results: Serum and urine IP-10 levels are significantly enhanced in LN patients with active disease as compared with normal individuals (serum average 179.7 pg/mL vs. 7.2 pg/mL, p < 0.0001; urine average 28.7 pg/mg vs. 1.6 pg/mg, p = 0.0019) and patients with other forms of glomerular disease (serum average 179.7 pg/mL vs. 84.9 pg/mL, p = 0.0176; urine average 28.7 pg/mg vs. 0.18 pg/mg, p = 0.0011). Urine IP-10 levels are significantly higher in patients with proliferative LN (PLN) than those with membranous LN (MLN) (average 32.8 pg/mg vs. 7.6 pg/mg, p = 0.0155). Urine IP-10 levels are also higher in MLN versus primary membranous nephropathy (MN) (average 7.6 pg/mg vs. 0.2 pg/mg, p = 0.0193). Importantly, serum IP-10 levels remain elevated during active LN and LN remission, but urine IP-10 levels are decreased from active LN to remission in 72% of our patients. Lastly, serum, but not urine IP-10 levels are significantly higher in African American than White American LN patients in active LN (average 227.8 pg/mL vs. 103.4 pg/mL, p = 0.0309) and during LN remission (average 254.6 pg/mL vs. 89.2 pg/mL, p = 0.0399). Conclusions: Our findings suggest that serum and urine IP-10 measurements provide promising tests ...
Keywords	systemic lupus erythematosus ; lupus nephritis ; urinary biomarkers ; serum biomarkers ; IP10 ; interferon ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients.

Frontiers in immunology

2022 Volume 13, Page(s) 879686

Abstract: Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil clusters in COVID-19, including the emergence of low density neutrophils (LDN) that are associated ... ...

Abstract	Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil clusters in COVID-19, including the emergence of low density neutrophils (LDN) that are associated with severe disease. The functional capabilities of these neutrophil clusters and correlation with gene and protein expression are unknown. To define host defense and immunosuppressive functions of normal density neutrophils (NDN) and LDN from COVID-19 patients, we recruited 64 patients with severe COVID-19 and 26 healthy donors (HD). Phagocytosis, respiratory burst activity, degranulation, neutrophil extracellular trap (NET) formation, and T-cell suppression in those neutrophil subsets were measured. NDN from severe/critical COVID-19 patients showed evidence of priming with enhanced phagocytosis, respiratory burst activity, and degranulation of secretory vesicles and gelatinase and specific granules, while NET formation was similar to HD NDN. COVID LDN response was impaired except for enhanced NET formation. A subset of COVID LDN with intermediate CD16 expression (CD16
MeSH term(s)	COVID-19 ; Extracellular Traps/metabolism ; Humans ; Neutrophils/metabolism ; Respiratory Burst ; SARS-CoV-2
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.879686
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Article ; Online: Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent.

Rane, Rajesh A / Gutte, Shweta D / Sahu, Niteshkumar U

Bioorganic & medicinal chemistry letters

2012 Volume 22, Issue 20, Page(s) 6429–6432

Abstract: In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1,3,4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for ... ...

Abstract	In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1,3,4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for their antibacterial, antifungal and antitubercular activities. Hybrids 5d, 5i, 5j and 5k exhibited equivalent antibacterial activity (MIC of 1.56 μg/mL) compared with standard drug ciprofloxacin against Staphylococcus aureus and Escherichia coli. Equal antifungal activity (MIC of 1.56 μg/mL) was shown by of hybrids 5j, 5k and 7d compared with standard Amphotericin-B. The inhibition of Mycobacterium tuberculosis at concentrations as low as 1.6 and 1.5 μg/mL by compounds 5f and 7d respectively indicates that these compounds can act as leads for development of newer anti-TB compounds.
MeSH term(s)	Alkaloids/chemical synthesis ; Alkaloids/chemistry ; Alkaloids/pharmacology ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Fungi/drug effects ; Halogenation ; Humans ; Microbial Sensitivity Tests ; Mycoses/drug therapy ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Pyrroles/pharmacology
Chemical Substances	Alkaloids ; Anti-Infective Agents ; Antitubercular Agents ; Oxadiazoles ; Pyrroles
Language	English
Publishing date	2012-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.08.061
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Article: Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent

Rane, Rajesh A / Gutte, Shweta D / Sahu, Niteshkumar U

Bioorganic & medicinal chemistry letters. 2012 Oct. 15, v. 22, no. 20

2012

Abstract	In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1,3,4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for their antibacterial, antifungal and antitubercular activities. Hybrids 5d, 5i, 5j and 5k exhibited equivalent antibacterial activity (MIC of 1.56μg/mL) compared with standard drug ciprofloxacin against Staphylococcus aureus and Escherichia coli. Equal antifungal activity (MIC of 1.56μg/mL) was shown by of hybrids 5j, 5k and 7d compared with standard Amphotericin-B. The inhibition of Mycobacterium tuberculosis at concentrations as low as 1.6 and 1.5μg/mL by compounds 5f and 7d respectively indicates that these compounds can act as leads for development of newer anti-TB compounds.
Keywords	Escherichia coli ; Mycobacterium tuberculosis ; Staphylococcus aureus ; alkaloids ; amphotericin B ; antibacterial properties ; antifungal properties ; chemistry ; ciprofloxacin ; drugs ; hybridization
Language	English
Dates of publication	2012-1015
Size	p. 6429-6432.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.08.061
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Article ; Online: MicroRNAs challenge the status quo of therapeutic targeting.

Sayed, Danish / Rane, Shweta / Abdellatif, Maha

Journal of cardiovascular translational research

2008 Volume 2, Issue 1, Page(s) 100–107

Abstract: MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger ... ...

Abstract	MicroRNAs (miRNAs) are recently discovered posttranscriptional regulators of gene expression that have become a cause célèbre. There are currently more than 600 miRNAs identified in humans that are estimated to regulate about one third of all messenger RNA (mRNA). Because miRNA levels were found widely deregulated in diseases, they have been implicated in the underlying pathogenesis. In addition, the changes in their expression patterns are proving to be reliable diagnostic and prognostic measures. But the specific mRNA targets and, hence, function of each miRNA is still work-in-progress. This information would be necessary before fully exploiting miRNA for therapeutic purposes. In this review we will discuss why miRNAs are considered major posttranscriptional regulators and how they impact gene expression and cell function during cardiac hypertrophy and failure. In addition, we will highlight their potential for therapeutic targeting.
MeSH term(s)	Animals ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genetic Therapy/methods ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Heart Diseases/therapy ; Humans ; MicroRNAs/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism
Chemical Substances	MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2008-09-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-008-9052-y
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Article ; Online: MicroRNA with a MacroFunction.

Rane, Shweta / Sayed, Danis / Abdellatif, Maha

Cell cycle (Georgetown, Tex.)

2007 Volume 6, Issue 15, Page(s) 1850–1855

Abstract: With the advent of microRNA (miRNA) we are compelled to revise our understanding of the mechanisms underlying gene regulation during health and disease. A miRNA is approximately 21 ribonucleotides-long, genetically encoded, with a potential to recognize ... ...

Abstract	With the advent of microRNA (miRNA) we are compelled to revise our understanding of the mechanisms underlying gene regulation during health and disease. A miRNA is approximately 21 ribonucleotides-long, genetically encoded, with a potential to recognize multiple mRNA targets guided by sequence complementarity and RNA-binding proteins. This class of molecules is functionally versatile, with the capacity to specifically inhibit translation initiation or elongation, as well as, induce mRNA degradation, through predominantly targeting the 3'-untranslated regions of mRNA. Early on it was realized that the levels of individual miRNA varied under different developmental, biological, or pathological conditions, thus, implicating these molecules in normal and pathological cellular attributes. In this article we will share our views on how the functions of miRNA conform to our existing knowledge on post-transcriptional regulation of gene expression and disease mechanisms, and their potential as biomarkers and therapeutic targets in diseases.
MeSH term(s)	Animals ; Disease ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; MicroRNAs/therapeutic use ; Prognosis ; RNA Interference ; Transcription, Genetic/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2007-06-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.6.15.4551
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Article: Infrared properties of ‘lead free’ thick film NTC thermo-resistive sensor based on the mixture of spinel material and RuO₂

Jagtap, Shweta / Rane, Sunit / Gosavi, Suresh / Mulik, Uttam / Amalnerkar, Dinesh

Sensors & Actuators: A. Physical. 2013 Aug. 1, v. 197

2013

Abstract: Thermistors fit into the category of infra-red detectors commonly called thermal detectors which operate through the heating effects of the incident radiation. This thermal detector converts the infra-red radiation into an electrical signal and the basic ...

Abstract	Thermistors fit into the category of infra-red detectors commonly called thermal detectors which operate through the heating effects of the incident radiation. This thermal detector converts the infra-red radiation into an electrical signal and the basic property defining the performance in the ratio of electrical output to the incident energy on the sensitive area of the detector called the resonsitivity. The radiation used may either monochromatic or black body from a source at a specified temperature. This paper deals with the study of infrared properties of ‘lead free’ thick film NTC thermo-resistive sensor based on the mixture of spinel material and RuO₂. Thick film thermistor was characterized using the basic physical techniques such XRD and SEM; XRD confirmed the formation of spinel phases whereas SEM showed the denser and smoother film surface. The thermo sensor showed exponential decrease in the resistance with respect to increase in temperature, very good responsivity (28.79/mW), repeatability and, the reproducibility.
Keywords	X-ray diffraction ; detectors ; energy ; heat ; lead ; scanning electron microscopy ; temperature
Language	English
Dates of publication	2013-0801
Size	p. 166-170.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500729-7
ISSN	0924-4247
ISSN	0924-4247
DOI	10.1016/j.sna.2013.03.037
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