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Article ; Online: [The role of microRNA-210 in esophageal squamous cell carcinoma].

Tsuchiya, Soken

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2012 Volume 132, Issue 9, Page(s) 1069–1073

Abstract: In this review, we summarize our findings on microRNA-210 (miR-210) and the target gene, and discuss their significance in human esophageal squamous cell carcinoma (ESCC). MicroRNAs are evolutionarily conserved small noncoding RNAs (20-23 nucleotides) ... ...

Abstract	In this review, we summarize our findings on microRNA-210 (miR-210) and the target gene, and discuss their significance in human esophageal squamous cell carcinoma (ESCC). MicroRNAs are evolutionarily conserved small noncoding RNAs (20-23 nucleotides) that bind to complementary sequences in the 3' UTR of target mRNAs and regulate gene expression by the cleavage of target mRNAs and/or translational inhibition. MicroRNAs play important roles in the initiation and progression of cancer, and it has been shown that the expression of some microRNAs is altered in malignancies. Carcinomas are derived from epithelial cells, and poor prognosis in patients with carcinoma is associated with the disruption of characteristics of differentiated epithelial cells, such as cell junctions and polarity. Here, we identified miR-210 as one of the microRNAs that is markedly differentially expressed during the process of epithelial differentiation, though the clinical roles of miR-210 in carcinomas remained unknown. We show that the expression of miR-210 is downregulated in ESCC and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. Moreover, we found that miR-210 inhibits cancer cell survival and proliferation. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target gene of miR-210 in ESCC, and demonstrated that FGFRL1 accelerates cancer cell proliferation. Taken together, our findings show an important role for miR-210 as a tumor suppressive microRNA with effects on cancer cell proliferation.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Esophageal Neoplasms/pathology ; Humans ; MicroRNAs/physiology ; Receptor, Fibroblast Growth Factor, Type 5/physiology
Chemical Substances	FGFRL1 protein, human ; MIRN210 microRNA, human ; MicroRNAs ; Receptor, Fibroblast Growth Factor, Type 5
Language	Japanese
Publishing date	2012-09-18
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.132.1069
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior.

Tsurudome, Yuya / Yoshida, Yuya / Hamamura, Kengo / Ogino, Takashi / Yasukochi, Sai / Yasuo, Shinobu / Iwamoto, Ayaka / Yoshihara, Tatsuya / Inazumi, Tomoaki / Tsuchiya, Soken / Takeo, Toru / Nakagata, Naomi / Higuchi, Shigekazu / Sugimoto, Yukihiko / Tsuruta, Akito / Koyanagi, Satoru / Matsunaga, Naoya / Ohdo, Shigehiro

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor ( ...

Abstract	Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor (
MeSH term(s)	Mice ; Animals ; Dinoprost/metabolism ; Mice, Inbred C57BL ; Circadian Rhythm/genetics ; Biological Clocks ; Suprachiasmatic Nucleus/metabolism ; Gene Expression ; Cryptochromes/genetics ; Cryptochromes/metabolism
Chemical Substances	Dinoprost (B7IN85G1HY) ; Cryptochromes
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031841
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Article: Effects of an ω3 fatty acid-biased diet on luteolysis, parturition, and uterine prostanoid synthesis in pregnant mice

Hashimoto, Miho / Makino, Nagisa / Inazumi, Tomoaki / Yoshida, Rina / Sugimoto, Toshiko / Tsuchiya, Soken / Sugimoto, Yukihiko

Biochemical and biophysical research communications. 2022 Jan. 22, v. 589

2022

Abstract: The ω3 polyunsaturated fatty acids (PUFAs) are known to have beneficial effects on health and diseases, and hence their intake is encouraged. However, it remains unknown as to how ω3 PUFAs affect female reproduction processes, in which ω6 PUFA-derived ... ...

Abstract	The ω3 polyunsaturated fatty acids (PUFAs) are known to have beneficial effects on health and diseases, and hence their intake is encouraged. However, it remains unknown as to how ω3 PUFAs affect female reproduction processes, in which ω6 PUFA-derived prostaglandin (PG) E₂ and PGF₂α play crucial roles. We therefore compared female reproductive performance between ω3 PUFA-biased linseed oil diet-fed (Lin) mice and ω6 PUFA-biased soybean oil diet-fed (Soy) mice. In Lin mice, the uterine levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) were 0.42 fold and 16 fold of those in Soy mice, respectively, with the EPA/AA ratio being 0.7 (vs 0.02 in Soy mice). Lin mice showed no alterations in any of the fertility indexes, including luteolysis and parturition. The uterine PG synthesis profiles of Lin mice were similar to those of Soy mice, but the levels of PGF₂α and PGE₂ were 50% of those in Soy mice, as a result of the increased EPA/AA ratio. PGF₃α and PGE₃ were undetectable in the uterine tissues of Soy and Lin mice. Interestingly, in Lin mice, ‘luteolytic’ PGF₂α synthesis was considerably maintained even in the ω6 PUFA-reduced condition. These results suggest the existence of an elaborate mechanism securing PGF₂α synthesis to a level that is sufficient for triggering luteolysis and parturition, even under ω6 PUFA-reduced conditions.
Keywords	arachidonic acid ; diet ; eicosapentaenoic acid ; females ; linseed oil ; luteolysis ; parturition ; prostaglandins ; reproductive performance ; research ; soybean oil
Language	English
Dates of publication	2022-0122
Size	p. 139-146.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2021.12.029
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Article ; Online: Effects of an ω3 fatty acid-biased diet on luteolysis, parturition, and uterine prostanoid synthesis in pregnant mice.

Hashimoto, Miho / Makino, Nagisa / Inazumi, Tomoaki / Yoshida, Rina / Sugimoto, Toshiko / Tsuchiya, Soken / Sugimoto, Yukihiko

Biochemical and biophysical research communications

2021 Volume 589, Page(s) 139–146

Abstract	The ω3 polyunsaturated fatty acids (PUFAs) are known to have beneficial effects on health and diseases, and hence their intake is encouraged. However, it remains unknown as to how ω3 PUFAs affect female reproduction processes, in which ω6 PUFA-derived prostaglandin (PG) E
MeSH term(s)	Animals ; Diet ; Fatty Acids, Omega-3/pharmacology ; Female ; Luteolysis/drug effects ; Luteolysis/physiology ; Mice, Inbred C57BL ; Parturition/drug effects ; Parturition/physiology ; Placenta/drug effects ; Placenta/metabolism ; Pregnancy ; Prostaglandins/biosynthesis ; Reproduction/drug effects ; Uterus/drug effects ; Uterus/metabolism ; Mice
Chemical Substances	Fatty Acids, Omega-3 ; Prostaglandins
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2021.12.029
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Article ; Online: VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation

Yuma Horii / Shoichi Matsuda / Chikashi Toyota / Takumi Morinaga / Takeo Nakaya / Soken Tsuchiya / Masaki Ohmuraya / Takanori Hironaka / Ryo Yoshiki / Kotaro Kasai / Yuto Yamauchi / Noburo Takizawa / Akiomi Nagasaka / Akira Tanaka / Hidetaka Kosako / Michio Nakaya

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 19

Abstract: Heart fibrosis involves a feedback loop where stiffening increases fibrosis-related gene expression in myofibroblasts. Here authors reveal the mechanosensitive nuclear translocation of VGLL3, where it phase separates and promotes collagen production, and ...

Abstract	Heart fibrosis involves a feedback loop where stiffening increases fibrosis-related gene expression in myofibroblasts. Here authors reveal the mechanosensitive nuclear translocation of VGLL3, where it phase separates and promotes collagen production, and show that its knock-out is protective after myocardial infarction.
Keywords	Science ; Q
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.

Horii, Yuma / Matsuda, Shoichi / Toyota, Chikashi / Morinaga, Takumi / Nakaya, Takeo / Tsuchiya, Soken / Ohmuraya, Masaki / Hironaka, Takanori / Yoshiki, Ryo / Kasai, Kotaro / Yamauchi, Yuto / Takizawa, Noburo / Nagasaka, Akiomi / Tanaka, Akira / Kosako, Hidetaka / Nakaya, Michio

Nature communications

2023 Volume 14, Issue 1, Page(s) 550

Abstract: Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating ... ...

Abstract	Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating their ability to produce collagen remain poorly characterised. Here, we show that vestigial-like family member 3 (VGLL3) is specifically expressed in myofibroblasts from mouse and human fibrotic hearts and promotes collagen production. Further, substrate stiffness triggers VGLL3 translocation into the nucleus through the integrin β1-Rho-actin pathway. In the nucleus, VGLL3 undergoes liquid-liquid phase separation via its low-complexity domain and is incorporated into non-paraspeckle NONO condensates containing EWS RNA-binding protein 1 (EWSR1). VGLL3 binds EWSR1 and suppresses miR-29b, which targets collagen mRNA. Consistently, cardiac fibrosis after myocardial infarction is significantly attenuated in Vgll3-deficient mice, with increased miR-29b expression. Overall, our results reveal an unrecognised VGLL3-mediated pathway that controls myofibroblasts' collagen production, representing a novel therapeutic target for tissue fibrosis.
MeSH term(s)	Humans ; Mice ; Animals ; Myocardium/metabolism ; Transforming Growth Factor beta1/metabolism ; Fibrosis ; Collagen/metabolism ; Myofibroblasts/metabolism ; Transcription Factors/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Fibroblasts/metabolism ; Cells, Cultured
Chemical Substances	Transforming Growth Factor beta1 ; Collagen (9007-34-5) ; Transcription Factors ; MicroRNAs ; VGLL3 protein, human
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36189-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

Thomas Fleming / Yukiko Kikuchi / Mikoto Nakajo / Masaya Tachizawa / Tomoaki Inazumi / Soken Tsuchiya / Yukihiko Sugimoto / Daisuke Saito / Mikita Suyama / Yasuyuki Ohkawa / Takashi Baba / Ken-ichirou Morohashi / Kataaki Okubo

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 13

Abstract: Prostaglandin E2 signaling mediates the estrogenic regulation of peptidergic neuronal activity and female receptivity via the ptger4b gene pathway in Japanese rice fish. ...

Abstract	Prostaglandin E2 signaling mediates the estrogenic regulation of peptidergic neuronal activity and female receptivity via the ptger4b gene pathway in Japanese rice fish.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prostaglandin E

Fleming, Thomas / Kikuchi, Yukiko / Nakajo, Mikoto / Tachizawa, Masaya / Inazumi, Tomoaki / Tsuchiya, Soken / Sugimoto, Yukihiko / Saito, Daisuke / Suyama, Mikita / Ohkawa, Yasuyuki / Baba, Takashi / Morohashi, Ken-Ichirou / Okubo, Kataaki

Communications biology

2022 Volume 5, Issue 1, Page(s) 1215

Abstract: In vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide ... ...

Abstract	In vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide mediating female sexual receptivity, in response to ovarian estrogens. Here we show by transcriptomic analysis that these neurons express a multitude of neuropeptides, in addition to Npba, in an ovarian-dependent manner, and we thus termed them female-specific, sex steroid-responsive peptidergic (FeSP) neurons. Our results further revealed that FeSP neurons express a prostaglandin E
MeSH term(s)	Animals ; Female ; Male ; Oryzias/genetics ; Receptors, Prostaglandin E ; Estrogens ; Neurons ; Neuropeptides/genetics ; Prostaglandins
Chemical Substances	Receptors, Prostaglandin E ; 3-N-(2-fluoroethyl)spiperone (106114-42-5) ; Estrogens ; Neuropeptides ; Prostaglandins
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-04195-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Isolation, Synthesis, and Structure-Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents.

El-Desoky, Ahmed H H / Eguchi, Keisuke / Kishimoto, Naoki / Asano, Toshifumi / Kato, Hikaru / Hitora, Yuki / Kotani, Shunsuke / Nakamura, Teruya / Tsuchiya, Soken / Kawahara, Teppei / Watanabe, Masato / Wada, Mikiyo / Nakajima, Makoto / Watanabe, Takashi / Misumi, Shogo / Tsukamoto, Sachiko

Journal of medicinal chemistry

2022 Volume 65, Issue 4, Page(s) 3460–3472

Abstract: Three new diterpenes, stellejasmins A ( ...

Abstract	Three new diterpenes, stellejasmins A (
MeSH term(s)	Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/pharmacology ; Diterpenes/chemical synthesis ; Diterpenes/chemistry ; Diterpenes/pharmacology ; HIV/drug effects ; Models, Molecular ; Molecular Docking Simulation ; Phorbols/chemistry ; Phorbols/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Roots/chemistry ; Structure-Activity Relationship ; Thymelaeaceae/chemistry ; Virus Latency/drug effects ; Wikstroemia/chemistry
Chemical Substances	Anti-HIV Agents ; Diterpenes ; Phorbols ; Plant Extracts ; mezerein (34807-41-5)
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.1c01973
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Article ; Online: Roles of prostaglandin receptors in female reproduction.

Sugimoto, Yukihiko / Inazumi, Tomoaki / Tsuchiya, Soken

Journal of biochemistry

2015 Volume 157, Issue 2, Page(s) 73–80

Abstract: Prostaglandins (PGs) have long been known to play roles in various processes of female reproduction; however, the molecular mechanisms therein remained unsolved until recently. This review summarizes the recent progress towards understanding the ... ...

Abstract	Prostaglandins (PGs) have long been known to play roles in various processes of female reproduction; however, the molecular mechanisms therein remained unsolved until recently. This review summarizes the recent progress towards understanding the molecular mechanisms underlying PG actions in fertilization and parturition. A series of studies using EP2-deficient mice demonstrated that after ovulation chemokine signalling in the cumulus cells stimulates integrin activation and cumulus extracellular matrix (ECM) assembly through the RhoA/ROCK/actomyosin pathway, although excessive chemokine signalling disturbs sperm penetration. PGE2-EP2 signalling suppresses such a chemokine signalling and stimulates cumulus ECM disassembly, which contributes to successful fertilization. A series of studies using FP-deficient mice revealed that PGF(2α)-FP signalling induces parturition at least by terminating progesterone production; however, some other EP signals are likely to be involved in parturition by inducing myometrial contraction. Therefore, it should be clarified as to which EP and/or FP receptor signals are physiologically essential for myometrial contraction and successful parturition.
MeSH term(s)	Animals ; Cumulus Cells/metabolism ; Cumulus Cells/physiology ; Dinoprostone/metabolism ; Female ; Fertilization/genetics ; Mice ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/metabolism ; Receptors, Prostaglandin E, EP2 Subtype/genetics ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Reproduction/genetics ; Signal Transduction/genetics
Chemical Substances	Receptors, Prostaglandin ; Receptors, Prostaglandin E, EP2 Subtype ; prostaglandin F2alpha receptor ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvu081
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