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Article ; Online: Evaluation of Transport Properties and Energy Conversion of Bacterial Cellulose Membrane Using Peusner Network Thermodynamics.

Ślęzak-Prochazka, Izabella / Batko, Kornelia M / Ślęzak, Andrzej

2022 Volume 25, Issue 1

Abstract: We evaluated the transport properties of a bacterial cellulose (BC) membrane for aqueous ethanol solutions. Using ... ...

Abstract	We evaluated the transport properties of a bacterial cellulose (BC) membrane for aqueous ethanol solutions. Using the
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25010003
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Article: A method for evaluating the transport and energy conversion properties of polymer biomembranes using the Kedem-Katchalsky-Peusner equations.

Ślęzak, Andrzej / Grzegorczyn, Sławomir Marek / Pilis, Anna / Ślęzak-Prochazka, Izabella

Polimery w medycynie

2023 Volume 53, Issue 1, Page(s) 25–36

Abstract: Background: A basic parameter in non-equilibrium thermodynamics is the production of entropy (S-entropy), which is a consequence of the irreversible processes of mass, charge, energy, and momentum transport in various systems. The product of S-entropy ... ...

Abstract	Background: A basic parameter in non-equilibrium thermodynamics is the production of entropy (S-entropy), which is a consequence of the irreversible processes of mass, charge, energy, and momentum transport in various systems. The product of S-entropy production and absolute temperature (T) is called the dissipation function and is a measure of energy dissipation in non-equilibrium processes. Objectives: This study aimed to estimate energy conversion in membrane transport processes of homogeneous non-electrolyte solutions. The stimulus version of the R, L, H, and P equations for the intensity of the entropy source achieved this purpose. Material and methods: The transport parameters for aqueous glucose solutions through Nephrophan® and Ultra-Flo 145 dialyser® synthetic polymer biomembranes were experimentally determined. Kedem-Katchalsky-Peusner (KKP) formalism was used for binary solutions of non-electrolytes, with Peusner coefficients introduced. Results: The R, L, H, and P versions of the equations for the S-energy dissipation were derived for the membrane systems based on the linear non-equilibrium Onsager and Peusner network thermodynamics. Using the equations for the S-energy and the energy conversion efficiency factor, equations for F-energy and U-energy were derived. The S-energy, F-energy and U-energy were calculated as functions of osmotic pressure difference using the equations obtained and presented as suitable graphs. Conclusions: The R, L, H, and P versions of the equations describing the dissipation function had the form of second-degree equations. Meanwhile, the S-energy characteristics had the form of second-degree curves located in the 1st and 2nd quadrants of the coordinate system. These findings indicate that the R, L, H, and P versions of S-energy, F-energy and U-energy are not equivalent for the Nephrophan® and Ultra-Flo 145 dialyser® membranes.
MeSH term(s)	Polymers ; Solutions ; Permeability ; Membranes, Artificial ; Models, Chemical ; Renal Dialysis
Chemical Substances	Polymers ; Solutions ; Membranes, Artificial
Language	English
Publishing date	2023-05-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	193157-x
ISSN	0370-0747
ISSN	0370-0747
DOI	10.17219/pim/161743
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Article: The Role of the Gravitational Field in Generating Electric Potentials in a Double-Membrane System for Concentration Polarization Conditions.

Batko, Kornelia / Ślęzak-Prochazka, Izabella / Sokołowska, Weronika / Rak, Małgorzata / Płonka, Wiktoria / Ślęzak, Andrzej

Membranes

2023 Volume 13, Issue 10

Abstract: Electric potentials referred to as the gravielectric effect (∆ΨS) are generated in a double-membrane system containing identical polymer membranes set in horizontal planes and separating non-homogenous electrolyte solutions. The gravielectric effect ... ...

Abstract	Electric potentials referred to as the gravielectric effect (∆ΨS) are generated in a double-membrane system containing identical polymer membranes set in horizontal planes and separating non-homogenous electrolyte solutions. The gravielectric effect depends on the concentration and composition of the solutions and is formed due to the gravitational field breaking the symmetry of membrane complexes/concentration boundary layers formed under concentration polarization conditions. As a part of the Kedem-Katchalsky formalism, a model of ion transport was developed, containing the transport parameters of membranes and solutions and taking into account hydrodynamic (convective) instabilities. The transition from non-convective to convective or vice versa can be controlled by a dimensionless concentration polarization factor or concentration Rayleigh number. Using the original measuring set, the time dependence of the membrane potentials was investigated. For steady states, the ∆ΨS was calculated and then the concentration characteristics of this effect were determined for aqueous solutions of NaCl and ethanol. The results obtained from the calculations based on the mathematical model of the gravitational effect are consistent with the experimental results within a 7% error range. It has been shown that a positive or negative gravielectric effect appeared when a density of the solution in the inter-membrane compartment was higher or lower than the density in the outer compartments. The values of the ∆ΨS were in a range from 0 to 27 mV. It was found that, the lower the concentration of solutions in the outer compartments of the two-membrane system (C0), for the same values of Cm/C0, the higher the ∆ΨS, which indicates control properties of the double-membrane system. The considered two-membrane electrochemical system is a source of electromotive force and functions as an electrochemical gravireceptor.
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes13100833
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Article: Cytotoxicity and Microbiological Properties of Copolymers Comprising Quaternary Ammonium Urethane-Dimethacrylates with Bisphenol A Glycerolate Dimethacrylate and Triethylene Glycol Dimethacrylate.

Chrószcz-Porębska, Marta W / Barszczewska-Rybarek, Izabela M / Kazek-Kęsik, Alicja / Ślęzak-Prochazka, Izabella

Materials (Basel, Switzerland)

2023 Volume 16, Issue 10

Abstract: Using dental composite restorative materials with a copolymeric matrix chemically modified towards bioactive properties can help fight secondary caries. In this study, copolymers of 40 wt.% bisphenol A glycerolate dimethacrylate, 40 wt.% quaternary ... ...

Abstract	Using dental composite restorative materials with a copolymeric matrix chemically modified towards bioactive properties can help fight secondary caries. In this study, copolymers of 40 wt.% bisphenol A glycerolate dimethacrylate, 40 wt.% quaternary ammonium urethane-dimethacrylates (QAUDMA-m, where m represents 8, 10, 12, 14, 16 and 18 carbon atoms in the N-alkyl substituent), and 20 wt.% triethylene glycol dimethacrylate (BG:QAm:TEGs) were tested for (i) cytotoxicity on the L929 mouse fibroblast cell line; (ii) fungal adhesion, fungal growth inhibition zone, and fungicidal activity against
Language	English
Publishing date	2023-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16103855
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Article ; Online: Modelling of the Electrical Membrane Potential for Concentration Polarization Conditions.

Batko, Kornelia M / Ślęzak-Prochazka, Izabella / Ślęzak, Andrzej / Bajdur, Wioletta M / Ščurek, Radomir

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 1

Abstract: Based on Kedem-Katchalsky formalism, the model equation of the membrane potential (Δψs) generated in a membrane system was derived for the conditions of concentration polarization. In this system, a horizontally oriented electro-neutral biomembrane ... ...

Abstract	Based on Kedem-Katchalsky formalism, the model equation of the membrane potential (Δψs) generated in a membrane system was derived for the conditions of concentration polarization. In this system, a horizontally oriented electro-neutral biomembrane separates solutions of the same electrolytes at different concentrations. The consequence of concentration polarization is the creation, on both sides of the membrane, of concentration boundary layers. The basic equation of this model includes the unknown ratio of solution concentrations (Ci/Ce) at the membrane/concentration boundary layers. We present the calculation procedure (Ci/Ce) based on novel equations derived in the paper containing the transport parameters of the membrane (Lp, σ, and ω), solutions (ρ, ν), concentration boundary layer thicknesses (δl, δh), concentration Raileigh number (RC), concentration polarization factor (ζs), volume flux (Jv), mechanical pressure difference (ΔP), and ratio of known solution concentrations (Ch/Cl). From the resulting equation, Δψs was calculated for various combinations of the solution concentration ratio (Ch/Cl), the Rayleigh concentration number (RC), the concentration polarization coefficient (ζs), and the hydrostatic pressure difference (ΔP). Calculations were performed for a case where an aqueous NaCl solution with a fixed concentration of 1 mol m
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24010138
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Article: Energy conversion in Textus Bioactiv Ag membrane dressings using Peusner's network thermodynamic descriptions.

Batko, Kornelia M / Ślęzak-Prochazka, Izabella / Grzegorczyn, Sławomir Marek / Pilis, Anna / Dolibog, Paweł / Ślęzak, Andrzej

Polimery w medycynie

2022

Abstract: Background: The Textus Bioactiv Ag membrane is an active dressing for the treatment of chronic wounds such as venous stasis ulcers and burns.: Objectives: Determination of the transport and internal energy conversion properties of the Textus Bioactiv ...

Abstract	Background: The Textus Bioactiv Ag membrane is an active dressing for the treatment of chronic wounds such as venous stasis ulcers and burns. Objectives: Determination of the transport and internal energy conversion properties of the Textus Bioactiv Ag membrane using the Kedem-Katchalsky-Peusner model. This model introduces the coefficients Lij necessary to calculate the degree of coupling (lij, QL), energy conversion efficiency (eij), dissipated energy (S-energy), free energy (F-energy), and internal energy (U-energy). Material and methods: The research material was the Textus Bioactiv Ag membrane that is used as an active dressing in the treatment of difficult-to-heal wounds, and KCl aqueous solutions. The research methods employed Peusner's formalism of network thermodynamics and Kedem and Katchalsky's thermodynamics of membrane processes. To calculate the Lij coefficients, we used hydraulic conductivity (Lp), diffusion conductivity (ů) and reflection (ó) coefficients to perform experimental measurements in different conditions. Results: The Lp coefficient for the Textus Bioactiv Ag membrane is nonlinearly dependent on the average concentrations of the solutions. In turn, the ů and ó coefficients are nonlinearly dependent on the differences in osmotic pressures (Äđ). An increase in the Äđ causes the Textus Bioactiv Ag membrane to become more permeable and less selective for KCl solutions. The coefficients of Peusner (Lij), couplings (lij, QL), energy conversion efficiency (eij), S-energy, F-energy, and U-energy also depend nonlinearly on Äđ. Our results showed that for higher concentrations of KCl solutions transported through the Textus Bioactiv Ag membrane, the coupling and energy conversion coefficients were greater for larger Äđ up to their maximum values for large Äđ. Coupling of the membrane structure with the electrolyte flux through the membrane is observed for Äđ greater than 10 kPa. Conclusions: Textus Bioactiv Ag membrane dressings possess the properties of a solution component separator as well as an internal energy converter.
Language	English
Publishing date	2022-11-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	193157-x
ISSN	0370-0747
ISSN	0370-0747
DOI	10.17219/pim/153522
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Article ; Online: Modelling of the Electrical Membrane Potential for Concentration Polarization Conditions

Kornelia M. Batko / Izabella Ślęzak-Prochazka / Andrzej Ślęzak / Wioletta M. Bajdur / Radomir Ščurek

Entropy, Vol 24, Iss 138, p

2022 Volume 138

Abstract: Based on Kedem–Katchalsky formalism, the model equation of the membrane potential ( ... Δ ... ψ ... s ... ) generated in a ... ...

Abstract	Based on Kedem–Katchalsky formalism, the model equation of the membrane potential ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>Δ</mo><msub><mi>ψ</mi><mi>s</mi></msub></mrow></semantics></math> ) generated in a membrane system was derived for the conditions of concentration polarization. In this system, a horizontally oriented electro-neutral biomembrane separates solutions of the same electrolytes at different concentrations. The consequence of concentration polarization is the creation, on both sides of the membrane, of concentration boundary layers. The basic equation of this model includes the unknown ratio of solution concentrations ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>C</mi><mi>i</mi></msub><mo>/</mo><msub><mi>C</mi><mi>e</mi></msub><mo stretchy="false">)</mo></mrow></semantics></math> at the membrane/concentration boundary layers. We present the calculation procedure ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>C</mi><mi>i</mi></msub><mo>/</mo><msub><mi>C</mi><mi>e</mi></msub><mo stretchy="false">)</mo></mrow></semantics></math> based on novel equations derived in the paper containing the transport parameters of the membrane ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>L</mi><mi>p</mi></msub></mrow></semantics></math> , <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>σ</mi></semantics></math> , and <math ...<br />
Keywords	membrane transport ; membrane potential ; concentration polarization ; Kedem–Katchalsky equations ; polymeric membrane ; concentration Rayleigh number ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Micro RNAs in Regulation of Cellular Redox Homeostasis.

Ciesielska, Sylwia / Slezak-Prochazka, Izabella / Bil, Patryk / Rzeszowska-Wolny, Joanna

International journal of molecular sciences

2021 Volume 22, Issue 11

Abstract: In living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and ... ...

Abstract	In living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and other oxidases or nitric oxide synthases, and ROS-neutralizing enzymes such as catalase, peroxiredoxins, thioredoxins, thioredoxin reductases, glutathione reductases, and many others. Most of the genes coding for these enzymes contain sequences targeted by micro RNAs (miRNAs), which are components of RNA-induced silencing complexes and play important roles in inhibiting translation of their targeted messenger RNAs (mRNAs). In this review we describe miRNAs that directly target and can influence enzymes responsible for scavenging of ROS and their possible role in cellular redox homeostasis. Regulation of antioxidant enzymes aims to adjust cells to survive in unstable oxidative environments; however, sometimes seemingly paradoxical phenomena appear where oxidative stress induces an increase in the levels of miRNAs which target genes which are supposed to neutralize ROS and therefore would be expected to decrease antioxidant levels. Here we show examples of such cellular behaviors and discuss the possible roles of miRNAs in redox regulatory circuits and further cell responses to stress.
MeSH term(s)	Antioxidants/metabolism ; Glutathione Reductase/genetics ; Glutathione Reductase/metabolism ; Homeostasis/genetics ; Humans ; MicroRNAs/genetics ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism ; Oxidation-Reduction ; Oxidative Stress/genetics ; Peroxiredoxins/genetics ; Peroxiredoxins/metabolism ; Thioredoxins/genetics ; Thioredoxins/metabolism
Chemical Substances	Antioxidants ; MicroRNAs ; Thioredoxins (52500-60-4) ; Peroxiredoxins (EC 1.11.1.15) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Glutathione Reductase (EC 1.8.1.7)
Language	English
Publishing date	2021-06-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22116022
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Article ; Online: Micro RNAs in Regulation of Cellular Redox Homeostasis

Sylwia Ciesielska / Izabella Slezak-Prochazka / Patryk Bil / Joanna Rzeszowska-Wolny

International Journal of Molecular Sciences, Vol 22, Iss 6022, p

2021 Volume 6022

Abstract	In living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and other oxidases or nitric oxide synthases, and ROS-neutralizing enzymes such as catalase, peroxiredoxins, thioredoxins, thioredoxin reductases, glutathione reductases, and many others. Most of the genes coding for these enzymes contain sequences targeted by micro RNAs (miRNAs), which are components of RNA-induced silencing complexes and play important roles in inhibiting translation of their targeted messenger RNAs (mRNAs). In this review we describe miRNAs that directly target and can influence enzymes responsible for scavenging of ROS and their possible role in cellular redox homeostasis. Regulation of antioxidant enzymes aims to adjust cells to survive in unstable oxidative environments; however, sometimes seemingly paradoxical phenomena appear where oxidative stress induces an increase in the levels of miRNAs which target genes which are supposed to neutralize ROS and therefore would be expected to decrease antioxidant levels. Here we show examples of such cellular behaviors and discuss the possible roles of miRNAs in redox regulatory circuits and further cell responses to stress.
Keywords	reactive oxygen and nitrogen species ; miRNAs ; ROS/RNS neutralization ; ROS scavenging enzymes ; ROS producing enzymes ; ROS/miRNA mutual regulation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ocena macierzy współczynników Peusnera membrany polimerowej i ternarnych roztworów nieelektrolitów.

Jasik-Slęzak, Jolanta / Slęzak-Prochazka, Izabella / Slęzak, Andrzej

Polimery w medycynie

2014 Volume 44, Issue 3, Page(s) 167–178

Abstract: Background: A system of network forms of Kedem-Katchalsky (K-K) equations for ternary non-electrolyte solutions is made of eight matrix equations containing Peusner's coefficients R(ij), L(ij), H(ij), W(ij), K(ij), N(ij), S(ij) or P(ij) (i, j ∈ {1, 2, 3} ...

Title translation	Evaluation of the Peusner's coefficients matrix for polymeric membrane and ternary non-electrolyte solutions.
Abstract	Background: A system of network forms of Kedem-Katchalsky (K-K) equations for ternary non-electrolyte solutions is made of eight matrix equations containing Peusner's coefficients R(ij), L(ij), H(ij), W(ij), K(ij), N(ij), S(ij) or P(ij) (i, j ∈ {1, 2, 3}). The equations are the result of symmetric or hybrid transformation of the classic form of K-K equations by the use of methods of Peusner's network thermodynamics (PNT). Objectives: Calculating concentration dependences of the determinant of Peusner's coefficients matrixes R(ij), L(ij), H(ij), W(ij), S(ij), N(ij), K(ij) and P(ij) (i, j ∈ {1, 2, 3}). Material and methods: The material used in the experiment was a hemodialysis Nephrophan membrane with specified transport properties (L(p), σ, Ω) in aqueous glucose and ethanol solution. The method involved equations for determinants of the matrixes coefficients R(ij), L(ij), H(ij), W(ij), S(ij), N(ij), K(ij) or P(ij) (i, j ∈ {1, 2, 3}). Results: The objective of calculations were dependences of determinants of Peusner's coeffcients matrixes R(ij), L(ij), H(ij), W(ij), S(ij), N(ij), K(ij) or P(ij) (i, j ∈ {1, 2, 3}) within the conditions of solution homogeneity upon an average concentration of one component of solution in the membrane (C1) with a determined value of the second component (C2). Conclusions: The method of calculating the determinants of Peusner's coeffcients matrixes R(ij), L(ij), H(ij), W(ij), S(ij), N(ij), K(ij) or P(ij) (i, j ∈ {1, 2, 3}) is a new tool that may be applicable in studies on membrane transport. Calculations showed that the coefficients are sensitive to concentration and composition of solutions separated by a polymeric membrane.
MeSH term(s)	Diffusion ; Excipients ; Membranes, Artificial ; Models, Chemical ; Osmotic Pressure ; Permeability ; Polymers/chemistry ; Solutions/chemistry ; Thermodynamics
Chemical Substances	Excipients ; Membranes, Artificial ; Polymers ; Solutions
Language	Polish
Publishing date	2014-07
Publishing country	Poland
Document type	English Abstract ; Evaluation Studies ; Journal Article
ZDB-ID	193157-x
ISSN	0370-0747
ISSN	0370-0747
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