LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 583

Search options

  1. Book: Critical heart disease in infants and children

    Ungerleider, Ross M. / Meliones, Jon N. / McMillan, Kristen Nelson / Cooper, David S. / Jacobs, Jeffery P.

    2019  

    Author's details Ross M. Ungerleider, Jon N. Meliones, Kristen Nelson McMillan, David S. Cooper, Jeffrey P. Jacobs [und weitere]
    Keywords Heart Diseases / therapy ; Child ; Infant ; Critical Care
    Subject code 618.9212
    Language English
    Size xxi, 933 Seiten, Illustrationen, Diagramme, 29 cm
    Edition Third edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu Enhanced Digital Version über Code
    HBZ-ID HT020018035
    ISBN 978-1-4557-0760-7 ; 1-4557-0760-0
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  2. Article ; Online: Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts.

    Nelson, Anders R / Christiansen, Steven L / Naegle, Kristen M / Saucerman, Jeffrey J

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 5, Page(s) e2303513121

    Abstract: Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti- ...

    Abstract Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high-content microscopy screen of human cardiac fibroblasts treated with 13 clinically relevant drugs in the context of TGFβ and/or IL-1β, measuring phenotype across 137 single-cell features. We used the phenotypic data from our high-content imaging to train a logic-based mechanistic machine learning model (LogiMML) for fibroblast signaling. The model predicted how pirfenidone and Src inhibitor WH-4-023 reduce actin filament assembly and actin-myosin stress fiber formation, respectively. Validating the LogiMML model prediction that PI3K partially mediates the effects of Src inhibition, we found that PI3K inhibition reduces actin-myosin stress fiber formation and procollagen I production in human cardiac fibroblasts. In this study, we establish a modeling approach combining the strengths of logic-based network models and regularized regression models. We apply this approach to predict mechanisms that mediate the differential effects of drugs on fibroblasts, revealing Src inhibition acting via PI3K as a potential therapy for cardiac fibrosis.
    MeSH term(s) Humans ; Actins ; Fibroblasts ; Machine Learning ; Fibrosis ; Myosins ; Phosphatidylinositol 3-Kinases
    Chemical Substances Actins ; Myosins (EC 3.6.4.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2303513121
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Consent Laws for Minors Regarding Sexually Transmitted Infection and HIV Services-Reply.

    Underhill, Kristen / Nelson, Kimberly M

    JAMA

    2022  Volume 328, Issue 23, Page(s) 2364

    MeSH term(s) Humans ; HIV Infections/prevention & control ; HIV Infections/therapy ; Informed Consent/legislation & jurisprudence ; Minors/legislation & jurisprudence ; Parental Consent/legislation & jurisprudence ; Sexually Transmitted Diseases/prevention & control ; Sexually Transmitted Diseases/therapy
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.19040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts.

    Nelson, Anders R / Christiansen, Steven L / Naegle, Kristen M / Saucerman, Jeffrey J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti- ...

    Abstract Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high content microscopy screen of human cardiac fibroblasts treated with 13 clinically relevant drugs in the context of TGFβ and/or IL-1β, measuring phenotype across 137 single-cell features. We used the phenotypic data from our high content imaging to train a logic-based mechanistic machine learning model (LogiMML) for fibroblast signaling. The model predicted how pirfenidone and Src inhibitor WH-4-023 reduce actin filament assembly and actin-myosin stress fiber formation, respectively. Validating the LogiMML model prediction that PI3K partially mediates the effects of Src inhibition, we found that PI3K inhibition reduces actin-myosin stress fiber formation and procollagen I production in human cardiac fibroblasts. In this study, we establish a modeling approach combining the strengths of logic-based network models and regularized regression models, apply this approach to predict mechanisms that mediate the differential effects of drugs on fibroblasts, revealing Src inhibition acting via PI3K as a potential therapy for cardiac fibrosis.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.01.530599
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Minor Consent Laws for Sexually Transmitted Infection and HIV Services.

    Nelson, Kimberly M / Skinner, Alexandra / Underhill, Kristen

    JAMA

    2022  Volume 328, Issue 7, Page(s) 674–676

    MeSH term(s) Delivery of Health Care/legislation & jurisprudence ; HIV Infections ; Humans ; Informed Consent/legislation & jurisprudence ; Informed Consent By Minors/legislation & jurisprudence ; Minors/legislation & jurisprudence ; Sexually Transmitted Diseases
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.10777
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Effect of Extremely Preterm Birth on Adolescent Brain Network Organization.

    Molloy, M Fiona / Yu, Emily J / Mattson, Whitney I / Hoskinson, Kristen R / Taylor, H Gerry / Osher, David E / Nelson, Eric E / Saygin, Zeynep M

    Brain connectivity

    2023  Volume 13, Issue 7, Page(s) 394–409

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Infant ; Female ; Adult ; Humans ; Infant, Newborn ; Adolescent ; Brain/diagnostic imaging ; Infant, Extremely Premature ; Premature Birth ; Magnetic Resonance Imaging/methods ; Connectome/methods
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609017-X
    ISSN 2158-0022 ; 2158-0014
    ISSN (online) 2158-0022
    ISSN 2158-0014
    DOI 10.1089/brain.2022.0077
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Utility of tele-guidance for point-of-care ultrasound: a single center prospective diagnostic study.

    Cal, Eric M / Gunnell, Elias / Olinger, Kristen / Benefield, Thad / Nelson, Jacob / Maggioncalda, Elise / McGinty, Katrina

    Journal of ultrasound

    2024  

    Abstract: Background: Point-of-care-ultrasound (POCUS) improves diagnostic accuracy and expedites lifesaving procedures. Remote areas disproportionately underuse ultrasound (US) due to a dearth of US trained professionals, imaging tools, and lack of quality ... ...

    Abstract Background: Point-of-care-ultrasound (POCUS) improves diagnostic accuracy and expedites lifesaving procedures. Remote areas disproportionately underuse ultrasound (US) due to a dearth of US trained professionals, imaging tools, and lack of quality assurance. Handheld US probes have been approved for diagnostic imaging but there have been limited studies examining their tele-guidance features. This study investigates whether physician tele-guidance improved ultrasound image acquisition by untrained scanners.
    Methods: To determine the effectiveness of tele-guidance for ultrasound image acquisition, 30 participants (15 in each study arm: experimental and control) with no ultrasound or medical experience gathered images of the heart, right kidney, and gallbladder of a standardized patient using a handheld ultrasound probe (Butterfly iQ +). All participants watched a standardized ultrasound tutorial video and were randomized into the control or experimental group. A physician assisted the experimental group using ultrasound probe's tele-guidance feature while the control group received no assistance. Time to image acquisition was recorded for both groups, and the images were graded by 3 blinded radiologists using the RACE tool to determine image and diagnostic quality.
    Results: There was evidence that mean imaging time was greater in the control group for the heart, right kidney, and gallbladder (p < 0.0001, all; Cohen's DL: 2.0, 1.7, 3.0, respectively). Similarly, there was evidence that the predicted mean image quality for the heart, right kidney, and gallbladder was higher for the experimental group compared to the control group (3.46 versus 1.86, 4.49 versus 1.58, and 3.93 versus 1.5, respectively; p < 0.0001, all). There was also evidence that the diagnostic quality of images had a statistically higher predicted probability of meaningful interpretation for the experimental group for pericardial fluid, intraperitoneal fluid, and acute cholecystitis (p = 0.003, p < 0.0001, p < 0.0001, respectively).
    Conclusions: Tele-guidance improves time to image acquisition and clinical applicability of ultrasound images obtained by untrained scanners.
    Language English
    Publishing date 2024-02-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-023-00860-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Factors Associated With Use of the Preventive Health Inventory in US Veterans.

    Wheat, Chelle L / Wong, Edwin S / Gray, Kristen E / Stockdale, Susan E / Nelson, Karin M / Reddy, Ashok

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e242717

    Abstract: Importance: The COVID-19 pandemic caused significant declines in the quality of preventive and chronic disease care. The Veterans Health Administration (VHA) used the Preventive Health Inventory (PHI), a multicomponent care management intervention, to ... ...

    Abstract Importance: The COVID-19 pandemic caused significant declines in the quality of preventive and chronic disease care. The Veterans Health Administration (VHA) used the Preventive Health Inventory (PHI), a multicomponent care management intervention, to catch up on care disrupted by the pandemic.
    Objective: To identify key factors associated with PHI use.
    Design, setting, and participants: This cohort study of veterans receiving primary care used administrative data from national VHA primary care clinics for February 1, 2021, through February 1, 2022.
    Exposure: Patient PHI receipt.
    Main outcomes and measures: The main outcomes were patient, practitioner, and clinic factors associated with PHI receipt. Binomial generalized linear models with fixed effects for clinic were used to analyze factors associated with receipt of PHI. Least absolute shrinkage and selection operator procedures were used for variable selection.
    Results: A total of 4 358 038 veterans (mean [SD] age, 63.7 [16.0] years; 90% male; 76% non-Hispanic White) formed the study cohort, of whom 389 757 (9%) received the PHI. Veterans who received the PHI had higher mean Care Assessment Need (CAN) scores, which indicate the likelihood of hospitalization or death within 1 year (mean [SD], 51.9 [28.6] vs 47.2 [28.6]; standardized mean difference [SMD], -0.16). They were also more likely to live in urban areas (77% vs 64%; SMD, 0.28) and have a shorter drive distance to primary care (mean [SD], 13.2 [12.4] vs 15.7 [14.6] miles; SMD, 0.19). The mean outpatient use was higher among PHI recipients compared with non-PHI recipients (mean [SD], 18.4 [27.8] vs 15.1 [24.1] visits; SMD, -0.13). In addition, veterans with primary care practitioners with higher caseloads were more likely to receive the PHI (mean [SD], 778 [231] vs 744 [249] patients; SMD, -0.14), and they were more likely to be seen at larger clinics (mean [SD], 9670 [6876] vs 8786 [6892] patients; SMD, -0.13). Prior outpatient use and CAN score were associated with PHI receipt in the final model.
    Conclusions and relevance: In this cohort study of the VHA's PHI, patients with higher CAN scores and more outpatient use in the previous year were more likely to receive the PHI. This study identifies potential intervention points to improve care coordination for veterans.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Cohort Studies ; Pandemics ; Veterans ; Outpatients ; Preventive Health Services
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.2717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Gender and ethnic/racial diversity in clinical neuropsychology: Updates from the AACN, NAN, SCN 2020 practice and "salary survey".

    Klipfel, Kristen M / Sweet, Jerry J / Nelson, Nathaniel W / Moberg, Paul J

    The Clinical neuropsychologist

    2022  Volume 37, Issue 2, Page(s) 231–285

    Abstract: Objective: Examination of gender and diversity issues within clinical neuropsychology, using data from the 2020 professional practice and "salary survey.": Methods: Clinical neuropsychologists in the U.S. and Canada were invited to participate in an ... ...

    Abstract Objective: Examination of gender and diversity issues within clinical neuropsychology, using data from the 2020 professional practice and "salary survey."
    Methods: Clinical neuropsychologists in the U.S. and Canada were invited to participate in an online survey. The final sample consisted of 1677 doctoral-level practitioners.
    Results: Approximately, 60% of responding neuropsychologists are women and 53.8% of those women identify as early career psychologists (ECPs). Conversely, a majority of men in the sample are advanced career psychologists (ACPs). Both genders work predominantly in institutions, but more men than women work in private practice. ACP men produce a greater number of peer-reviewed publications and conference presentations. Across all work settings, women earn significantly less than men, and are less satisfied with their incomes. Establishing and maintaining family life is the biggest obstacle to attaining greater income and job satisfaction for both genders. Ethnic/racial minority status was identified in 12.9% of respondents, with 59.2% being ECPs. Job satisfaction and hostility in the workplace vary across ethnic/racial minority groups. Hispanic/Latino(a) and White neuropsychologists report higher incomes, but there were no statistically significant differences between any of the groups.
    Conclusions: Income and select practice differences persist between female and male neuropsychologists. There is a slow rate of increased ethnic/racial diversity over time, which is much more apparent among early career practitioners. Trajectories and demographics suggest that the gender income gap is unlikely to be improved by the next survey iteration in 2025, whereas it is very likely that ethnic/racial diversity will continue to increase gradually.
    MeSH term(s) Humans ; Female ; Male ; Neuropsychology ; Neuropsychological Tests ; Salaries and Fringe Benefits ; Surveys and Questionnaires ; Income
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639080-8
    ISSN 1744-4144 ; 0920-1637 ; 1385-4046
    ISSN (online) 1744-4144
    ISSN 0920-1637 ; 1385-4046
    DOI 10.1080/13854046.2022.2054360
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Clinical neuropsychology in Canada: Results from the 2020 AACN, NAN, SCN professional practice and "salary survey".

    Nelson, Nathaniel W / Sweet, Jerry J / Klipfel, Kristen M / Moberg, Paul J

    The Clinical neuropsychologist

    2021  Volume 35, Issue 7, Page(s) 1205–1231

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Canada ; Female ; Humans ; Neuropsychological Tests ; Neuropsychology ; Professional Practice ; Salaries and Fringe Benefits ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639080-8
    ISSN 1744-4144 ; 0920-1637 ; 1385-4046
    ISSN (online) 1744-4144
    ISSN 0920-1637 ; 1385-4046
    DOI 10.1080/13854046.2021.1926543
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top