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Article: An Online Version of Physical Exercise with Musical Accompaniment Might Facilitate Participation by Subjects Who Cannot Participate in Person: A Questionnaire-Based Study.

Satoh, Masayuki / Tabei, Ken-Ichi / Ogawa, Jun-Ichi / Abe, Makiko / Kamikawa, Chiaki / Ota, Yoshinori

Dementia and geriatric cognitive disorders extra

2023 Volume 13, Issue 1, Page(s) 10–17

Abstract: Introduction: Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several ... ...

Abstract	Introduction: Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several interesting differences were found in the characteristics of the online participants compared with our previous in-person interventions. Participants and methods: The total number of subjects was 88 (71.2 ± 4.9 years old; male 42, female 46). The questionnaire included the attributes of the participants, the perceived advantages of the exercise classes, and the presence or absence of noticeable changes in cognitive and physical function after participating in the classes. Results: The personal computers used to attend the online classes were operated by the participants themselves. About 42% of the participants felt that their sense of day of the week and volition were improved by attending the exercise classes for 3 months. The most frequent answer to the reason for participation was because it was free (81.8%). The second most frequent answer was because the classes were held online (75.0%). Almost half of the participants answered that they would not participate if it was held in person because of the risk of COVID-19 infection (75.0%) and the difficulty getting to the site where the exercise classes were held (59.1%). Conclusion: Online physical exercise with musical accompaniment improved the perceived orientation, volition, activity, exercise habits, and health condition in 30-40% of the participants and also stimulated greater participation by males compared to classes held in person.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2621464-7
ISSN	1664-5464
ISSN	1664-5464
DOI	10.1159/000529192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Online physical exercise program with music improves working memory.

Tabei, Ken-Ichi / Ogawa, Jun-Ichi / Kamikawa, Chiaki / Abe, Makiko / Ota, Yoshinori / Satoh, Masayuki

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1146060

Abstract: Objective: The spread of coronavirus disease (COVID-19) has limited the implementation of face-to-face non-pharmacological treatment for the prevention of dementia. As a result, online non-pharmacological treatment has become increasingly important. In ... ...

Abstract	Objective: The spread of coronavirus disease (COVID-19) has limited the implementation of face-to-face non-pharmacological treatment for the prevention of dementia. As a result, online non-pharmacological treatment has become increasingly important. In this study, we used an online conferencing system to implement an online version of a physical exercise program with music, and examined its effect on cognitive function. Methods: The participants were 114 healthy older adults [63 men and 51 women; mean age of 70.7 years (standard deviation = 4.6)]. Seventy-five participants were allocated to the physical exercise with music group (60 min, once a week, total 20 sessions), while the remaining 39 participants were assigned to the control group, and only underwent the examinations. In the physical exercise with music group, we performed neuropsychological examinations and brain tests both before and after the exercise program. Neuropsychological tests included the Mini-Mental State Examination, Raven's Colored Progressive Matrices (RCPM), the Rivermead Behavioral Memory Test, graphic imitation, word fluency (WF) (animal names and initial sounds), and the Trail Making Test-A/B. As an assessment of brain function, we developed an online examination of subtle cognitive decline, including tests of number and word memory, spatial grasp, the N-back task, and change inference. Results: In the N-back task, the physical exercise with music group improved significantly relative to the control group ( Discussion: The present findings suggest that the online version of the physical exercise with music program improved working memory, which mainly involves the frontal lobe.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1146060
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Article: [Molecular Pathogenesis of Nasu-Hakola Disease Brain Lesions].

Satoh, Jun-Ichi

Brain and nerve = Shinkei kenkyu no shinpo

2016 Volume 68, Issue 5, Page(s) 543–550

Abstract: Nasu-Hakola disease (NHD) is a rare intractable autosomal recessive disorder, characterized by pathological bone fractures and progressive dementia owing to multifocal bone cysts and leukoencephalopathy, caused by various genetic mutations of either ... ...

Abstract	Nasu-Hakola disease (NHD) is a rare intractable autosomal recessive disorder, characterized by pathological bone fractures and progressive dementia owing to multifocal bone cysts and leukoencephalopathy, caused by various genetic mutations of either DAP12 or TREM2. Loss-of-function of TREM2-DAP12, constituting a signaling complex on osteoclasts and microglia, plays a central role in the pathogenesis of NHD. Recently, NHD has been recognized as the disease entity designated "microgliopathy". However, at present, TREM2-specific ligands in microglia and the precise molecular mechanism underlying leukoencephalopathy remain to be investigated in order to establish an effective molecular targeted therapy for NHD.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Brain/metabolism ; Humans ; Lipodystrophy/genetics ; Lipodystrophy/metabolism ; Lipodystrophy/pathology ; Lipodystrophy/physiopathology ; Membrane Glycoproteins/metabolism ; Membrane Proteins/metabolism ; Osteochondrodysplasias/genetics ; Osteochondrodysplasias/metabolism ; Osteochondrodysplasias/pathology ; Osteochondrodysplasias/physiopathology ; Protein Binding ; Receptors, Immunologic/metabolism ; Signal Transduction ; Subacute Sclerosing Panencephalitis/genetics ; Subacute Sclerosing Panencephalitis/metabolism ; Subacute Sclerosing Panencephalitis/pathology ; Subacute Sclerosing Panencephalitis/physiopathology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Membrane Glycoproteins ; Membrane Proteins ; Receptors, Immunologic ; TREM2 protein, human ; TYROBP protein, human
Language	Japanese
Publishing date	2016-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416200435
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Article ; Online: Molecular network of ChIP-Seq-based NF-κB p65 target genes involves diverse immune functions relevant to the immunopathogenesis of multiple sclerosis.

Satoh, Jun-Ichi

Multiple sclerosis and related disorders

2014 Volume 3, Issue 1, Page(s) 94–106

Abstract: Background: The transcription factor nuclear factor-kappa B (NF-κB) acts as a central regulator of immune response, stress response, cell proliferation, and apoptosis. Aberrant regulation of NF-κB function triggers development of cancers, metabolic ... ...

Abstract	Background: The transcription factor nuclear factor-kappa B (NF-κB) acts as a central regulator of immune response, stress response, cell proliferation, and apoptosis. Aberrant regulation of NF-κB function triggers development of cancers, metabolic diseases, and autoimmune diseases. We attempted to characterize a global picture of the NF-κB target gene network relevant to the immunopathogenesis of multiple sclerosis (MS). Methods: We identified the comprehensive set of 918 NF-κB p65 binding sites on protein-coding genes from chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) dataset of TNFα-stimulated human B lymphoblastoid cells. The molecular network was studied by a battery of pathway analysis tools of bioinformatics. Results: The GenomeJack genome viewer showed that NF-κB p65 binding sites were accumulated in promoter (35.5%) and intronic (54.9%) regions with an existence of the NF-κB consensus sequence motif. A set of 52 genes (5.7%) corresponded to known NF-κB targets by database search. KEGG, PANTHER, and Ingenuity Pathways Analysis (IPA) revealed that the NF-κB p65 target gene network is linked to regulation of immune functions and oncogenesis, including B cell receptor signaling, T cell activation pathway, Toll-like receptor signaling, and apoptosis signaling, and molecular mechanisms of cancers. KeyMolnet indicated an involvement of the complex crosstalk among core transcription factors in the NF-κB p65 target gene network. Furthermore, the set of NF-κB p65 target genes included 10 genes among 98 MS risk alleles and 49 molecules among 709 MS brain lesion-specific proteins. Conclusions: These results suggest that aberrant regulation of NF-κB-mediated gene expression, by inducing dysfunction of diverse immune functions, is closely associated with development and progression of MS.
Language	English
Publishing date	2014-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-0356
ISSN (online)	2211-0356
DOI	10.1016/j.msard.2013.04.005
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Article ; Online: Nonthermal acceleration of protein hydration by sub-terahertz irradiation.

Sugiyama, Jun-Ichi / Tokunaga, Yuji / Hishida, Mafumi / Tanaka, Masahito / Takeuchi, Koh / Satoh, Daisuke / Imashimizu, Masahiko

Nature communications

2023 Volume 14, Issue 1, Page(s) 2825

Abstract: The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) ... ...

Abstract	The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) measurements to investigate how externally applied sub-THz electromagnetic fields perturb the rapid collective dynamics and influence the considerably slower chemical processes in protein-water systems. We analyzed an aqueous lysozyme solution, whose hydration is not thermally equilibrated. By detecting time-lapse differences in microwave DR, we demonstrated that sub-THz irradiation gradually decreases the dielectric permittivity of the lysozyme solution by reducing the orientational polarization of water molecules. Comprehensive analysis combining THz and nuclear magnetic resonance spectroscopies suggested that the gradual decrease in the dielectric permittivity is not induced by heating but is due to a slow shift toward the hydrophobic hydration structure in lysozyme. Our findings can be used to investigate hydration-mediated protein functions based on sub-THz irradiation.
MeSH term(s)	Muramidase/chemistry ; Proteins/chemistry ; Water/chemistry ; Chemical Phenomena
Chemical Substances	Muramidase (EC 3.2.1.17) ; Proteins ; Water (059QF0KO0R)
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38462-0
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Article ; Online: Nonthermal acceleration of protein hydration by sub-terahertz irradiation

Jun-ichi Sugiyama / Yuji Tokunaga / Mafumi Hishida / Masahito Tanaka / Koh Takeuchi / Daisuke Satoh / Masahiko Imashimizu

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) ...

Abstract	Abstract The collective intermolecular dynamics of protein and water molecules, which overlap in the sub-terahertz (THz) frequency region, are relevant for expressing protein functions but remain largely unknown. This study used dielectric relaxation (DR) measurements to investigate how externally applied sub-THz electromagnetic fields perturb the rapid collective dynamics and influence the considerably slower chemical processes in protein–water systems. We analyzed an aqueous lysozyme solution, whose hydration is not thermally equilibrated. By detecting time-lapse differences in microwave DR, we demonstrated that sub-THz irradiation gradually decreases the dielectric permittivity of the lysozyme solution by reducing the orientational polarization of water molecules. Comprehensive analysis combining THz and nuclear magnetic resonance spectroscopies suggested that the gradual decrease in the dielectric permittivity is not induced by heating but is due to a slow shift toward the hydrophobic hydration structure in lysozyme. Our findings can be used to investigate hydration-mediated protein functions based on sub-THz irradiation.
Keywords	Science ; Q
Subject code	541
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular network analysis of human microRNA targetome: from cancers to Alzheimer's disease.

Satoh, Jun-Ichi

BioData mining

2012 Volume 5, Issue 1, Page(s) 17

Abstract: MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or ... ...

Abstract	MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation. A single miRNA concurrently downregulates hundreds of target mRNAs designated "targetome", and thereby fine-tunes gene expression involved in diverse cellular functions, such as development, differentiation, proliferation, apoptosis and metabolism. Recently, we characterized the molecular network of the whole human miRNA targetome by using bioinformatics tools for analyzing molecular interactions on the comprehensive knowledgebase. We found that the miRNA targetome regulated by an individual miRNA generally constitutes the biological network of functionally-associated molecules in human cells, closely linked to pathological events involved in cancers and neurodegenerative diseases. We also identified a collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks. This review focuses on the workflow of molecular network analysis of miRNA targetome in silico. We applied the workflow to two representative datasets, composed of miRNA expression profiling of adult T cell leukemia (ATL) and Alzheimer's disease (AD), retrieved from Gene Expression Omnibus (GEO) repository. The results supported the view that miRNAs act as a central regulator of both oncogenesis and neurodegeneration.
Language	English
Publishing date	2012-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2438773-3
ISSN	1756-0381 ; 1756-0381
ISSN (online)	1756-0381
ISSN	1756-0381
DOI	10.1186/1756-0381-5-17
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Article ; Online: Molecular network of microRNA targets in Alzheimer's disease brains.

Satoh, Jun-ichi

Experimental neurology

2012 Volume 235, Issue 2, Page(s) 436–446

Abstract: MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of target mRNAs. The vast majority of presently identified miRNAs are expressed in the brain where they fine-tune the expression of a wide range of target ... ...

Abstract	MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of target mRNAs. The vast majority of presently identified miRNAs are expressed in the brain where they fine-tune the expression of a wide range of target molecules essential for neuronal and glial development, differentiation, proliferation, apoptosis and metabolism. Aberrant expression and dysfunction of brain-enriched miRNAs induce development of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Because a single miRNA concurrently downregulates hundreds of target mRNAs, the set of miRNA target genes coregulated by an individual miRNA generally constitutes the biologically integrated network of functionally associated molecules. Recent advances in systems biology enable us to characterize the global molecular network of experimentally validated targets for individual miRNAs by using pathway analysis tools of bioinformatics endowed with comprehensive knowledgebase. This review is conducted to summarize accumulating studies focused on aberrant miRNA expression in AD brains, and to propose the systems biological view that abnormal regulation of cell cycle progression as a result of deregulation of miRNA target networks plays a central role in the pathogenesis of AD.
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/therapy ; Animals ; Brain/metabolism ; Brain/pathology ; Brain Chemistry/genetics ; Gene Regulatory Networks/genetics ; Gene Targeting/methods ; Humans ; MicroRNAs/biosynthesis ; MicroRNAs/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2011.09.003
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Article: Reactive astrocytes express Aggregatin (

Satoh, Jun-Ichi / Kino, Yoshihiro / Yanaizu, Motoaki / Ishida, Tsuyoshi / Saito, Yuko

Intractable & rare diseases research

2020 Volume 9, Issue 4, Page(s) 217–221

Abstract: By combining genomic data and brain imaging data, a recent study has identified a novel gene ... ...

Abstract	By combining genomic data and brain imaging data, a recent study has identified a novel gene named
Language	English
Publishing date	2020-10-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2672570-8
ISSN	2186-361X ; 2186-3644
ISSN (online)	2186-361X
ISSN	2186-3644
DOI	10.5582/irdr.2020.03080
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Article ; Online: MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains.

Satoh, Jun-ichi

Journal of pharmacological sciences

2010 Volume 114, Issue 3, Page(s) 269–275

Abstract: MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are ...

Abstract	MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains.
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Brain/metabolism ; Gene Expression Regulation/physiology ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurons/metabolism ; Neurons/physiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	MIRN29a microRNA, human ; Membrane Proteins ; MicroRNAs ; NAV3 protein, human ; Nerve Tissue Proteins ; RNA, Messenger
Language	English
Publishing date	2010-10-09
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1254/jphs.10r11fm
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