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Article: D.M.R. ("Double Reasoned Maturing"): innovative technique of agronomic ecologic control of grey mould on grapevine. trials and various considerations.

Cargnello, G / Pezza, L / Gallo, G / Camatta, T / Coccato, S / Pascarella, G / Di Gaetano, R / Casadei, G / La Torre, A / Spera, G / Scaglione, M / Moretti, S / Garofalo, A

Communications in agricultural and applied biological sciences

2006 Volume 71, Issue 3 Pt B, Page(s) 1055–1061

Abstract: ... D.M.R.) ("Doubles Reasoned Maturing") consists of far "completing" the maturing of the grape ... for wilting on the plant through the reasoned cut of the heads to fruit e/o of shoots. The application of D.M ... without problems of B. cinerea. The trials have shown the technical, economic, social sustainability of D.M.R ...

Abstract	A study was carried out in order to identify agronomic ecologic solutions in the indirect grey mould control on grapevine. These specific trials started since 1990 and, after years of validation, now they are applied by the entrepreneur to the business practice in the different pedological and climatic area and on different cultivars and forms of growing. The technique of "Doppia Maturazione Ragionata" (D.M.R.) ("Doubles Reasoned Maturing") consists of far "completing" the maturing of the grape for wilting on the plant through the reasoned cut of the heads to fruit e/o of shoots. The application of D.M.R., besides determining valid and important technical and qualitative (organoleptic, economic and social quality) improvements on the product, is particularly effective in the indirect grey mould control on grapevine. Such technique, in fact, allows us to vintage the grape during the business demands and not when imposed by Botrytis cinerea; it has been possible, in some cases, to vintage in December and over, without problems of B. cinerea. The trials have shown the technical, economic, social sustainability of D.M.R. application. This paper reports all trials that have brought, by now from years, to apply in the practice DMR (Double Reasoned Maturing).
MeSH term(s)	Agriculture/methods ; Fungi/pathogenicity ; Plant Diseases/microbiology ; Vitis/growth & development ; Vitis/microbiology
Language	English
Publishing date	2006
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	2124146-6
ISSN	1379-1176
ISSN	1379-1176
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Article ; Online: Importance of three physiological models for teaching the carbohydrates metabolism.

Garófalo, Sofía Judith / Galagovsky, Lydia / Alonso, Manuel

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2023 Volume 52, Issue 1, Page(s) 25–35

Abstract: In this work extensive misconceptions of university students' -from nutrition area- about the metabolism of carbohydrates (CHM) in the human organism have been documented. The results lead to consider their difficulties concerning the learning of a ... ...

Abstract	In this work extensive misconceptions of university students' -from nutrition area- about the metabolism of carbohydrates (CHM) in the human organism have been documented. The results lead to consider their difficulties concerning the learning of a complex set of imbricated biochemical models involved. Pursuant to these considerations, three physiological models are proposed as conceptual axes around which CHM in the human organism could be taught, in order to avoid fragmentation in students' knowledge and to give simple physiological contexts where to integrate those biochemical models. These contexts are: (a) a physiological model of the carbon cycle, (b) a physiological model of blood glucose uptake and homeostasis, and (c) a physiological model of the availability of small metabolites.
MeSH term(s)	Humans ; Students ; Carbohydrate Metabolism ; Learning ; Carbohydrates ; Teaching
Chemical Substances	Carbohydrates
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21785
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Article ; Online: Family Therapy in Corrections: Implications for Reentry Into the Community.

Garofalo, Micaela

Journal of correctional health care : the official journal of the National Commission on Correctional Health Care

2020 Volume 26, Issue 3, Page(s) 240–248

Abstract: Prison life is often characterized by drug use, racial intolerance, and violence. This culture of criminality is juxtaposed to treatment efforts that address the criminogenic needs and risks that are associated with inmate institutional rule violations ... ...

Abstract	Prison life is often characterized by drug use, racial intolerance, and violence. This culture of criminality is juxtaposed to treatment efforts that address the criminogenic needs and risks that are associated with inmate institutional rule violations and reoffending in the community, thereby creating seemingly insurmountable challenges for treating clinicians. Rather than fighting a losing battle between treating staff and inmate peers, a more effective strategy may be to utilize family members as resources and allies in the process of change for incarcerated individuals. Challenges and solutions to family therapy prison program implementation are discussed.
MeSH term(s)	Adult ; Correctional Facilities/organization & administration ; Family Therapy/organization & administration ; Humans ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/prevention & control ; Violence/prevention & control
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2233559-6
ISSN	1940-5200 ; 1078-3458
ISSN (online)	1940-5200
ISSN	1078-3458
DOI	10.1177/1078345820938350
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Article ; Online: Description of the characteristics of patients with diseases associated with immunosuppression and Cryptosporidium spp. infection seen at a referral children's hospital in Argentina, 2018-2023.

Dumas Marucci, Miguel / Genero, Sebastián / Degiuseppe, Juan I / Pérez Garófalo, Magali / Perazzo, Juliana

Archivos argentinos de pediatria

2024 , Page(s) e202310271

Abstract: Cryptosporidium spp. is a diarrhea-causing protozoan. Immunocompromised patients may develop severe and persistent clinical forms. Here we describe the characteristics of patients with an underlying disease associated with immunosuppression (DAI) and ... ...

Title translation	Caracterización de pacientes con enfermedades asociadas a inmunosupresión con infecciones por Cryptosporidium spp. atendidos en un hospital pediátrico referencial de Argentina, 2018-2023.
Abstract	Cryptosporidium spp. is a diarrhea-causing protozoan. Immunocompromised patients may develop severe and persistent clinical forms. Here we describe the characteristics of patients with an underlying disease associated with immunosuppression (DAI) and Cryptosporidium spp. infection seen at a referral children's hospital in Argentina between 2018 and 2023. Demographic data, DAI, diarrhea characteristics, and co-infections were analyzed. A total of 30 patients with DAI and cryptosporidiosis were included. Most of them had undergone a solid organ transplant, had a hematologic neoplasm, or primary immunodeficiency. Persistent diarrhea was observed in 18 patients at the time of diagnosis. Co-infections were recorded in 6 patients. Cryptosporidiosis should be considered in the differential diagnosis of acute or persistent diarrhea in children with different types of DAI, such as solid organ transplant, hematologic neoplasms, and primary immunodeficiencies.
Language	Spanish
Publishing date	2024-04-25
Publishing country	Argentina
Document type	Case Reports ; Journal Article
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2023-10271.eng
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Article ; Online: European waste management regulations and the transition towards circular economy. A shift-and-share analysis.

Agovino, Massimiliano / Cerciello, Massimiliano / Musella, Gaetano / Garofalo, Antonio

Journal of environmental management

2024 Volume 354, Page(s) 120423

Abstract: Environmental legislation in the European Union (EU) aims to bolster the transition towards circular economy. However, a recurring limitation in EU regulations, encompassing not only environmental but also economic, social, and demographic aspects, is ... ...

Abstract	Environmental legislation in the European Union (EU) aims to bolster the transition towards circular economy. However, a recurring limitation in EU regulations, encompassing not only environmental but also economic, social, and demographic aspects, is the lack of consideration for the unique characteristics of individual Member States when establishing common targets. The present work seeks to investigate the impact of EU waste management regulations on the attainment of circular economy objectives, taking into account national-level socio-economic and demographic characteristics. In order to do so, we employ Shift-and-Share Analysis, using data on 28 EU countries between 1995 and 2018. Our findings indicate that some Member States, namely Estonia, Finland, Hungary, Ireland, Italy, Luxembourg and Slovenia, effectively managed to align their regulatory frameworks with EU directives and create a socio-economic context where citizens and governmental bodies foster the necessary levels of cooperation. Cooperation in turn, with widespread pro-environmental attitudes on part of citizens, efficient waste management on part of specialised firms and proper oversight of waste collection activities on part of institutions, facilitated the achievement of significant circular economy goals.
MeSH term(s)	Refuse Disposal ; Solid Waste ; Waste Management ; European Union ; Ireland
Chemical Substances	Solid Waste
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120423
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Article ; Online: Childhood trauma and psychopathy: The moderating role of resilience.

Garofalo, Carlo / Delvecchio, Elisa / Bogaerts, Stefan / Sellbom, Martin / Mazzeschi, Claudia

Psychological trauma : theory, research, practice and policy

2024

Abstract: Objective: Despite accumulating evidence of significant albeit moderate associations between childhood trauma and psychopathy, little is known about the potential moderators of these associations. To advance knowledge in this area, the present study ... ...

Abstract	Objective: Despite accumulating evidence of significant albeit moderate associations between childhood trauma and psychopathy, little is known about the potential moderators of these associations. To advance knowledge in this area, the present study investigated the moderating role of resilience in the childhood trauma-psychopathy link. Method: A community sample of 521 adult participants from the Netherlands (40.1% men; Results: Childhood trauma had small positive associations with psychopathic traits across the board, with the exception of a small negative association with boldness traits, as well as a small negative association with resilience. Resilience was strongly and positively related to boldness, and negatively related to affective (callousness, meanness) and behavioral (antisocial, disinhibition) traits of psychopathy. Resilience moderated six out of seven associations between childhood trauma and psychopathic traits. Conclusions: Resilience appeared to represent a significant buffer in the associations between childhood traumatic experiences and psychopathic traits, such that these associations became weaker and nonsignificant (and even negative for boldness) at higher levels compared to lower levels of resilience. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2497028-1
ISSN	1942-969X ; 1942-9681
ISSN (online)	1942-969X
ISSN	1942-9681
DOI	10.1037/tra0001687
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Article ; Online: Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis.

Calafatti, Matteo / Cocozza, Germana / Limatola, Cristina / Garofalo, Stefano

Frontiers in immunology

2023 Volume 14, Page(s) 1223096

Abstract: In recent years, biomedical research efforts aimed to unravel the mechanisms involved in motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main causes of disease progression were first sought in the motor neurons, more ... ...

Abstract	In recent years, biomedical research efforts aimed to unravel the mechanisms involved in motor neuron death that occurs in amyotrophic lateral sclerosis (ALS). While the main causes of disease progression were first sought in the motor neurons, more recent studies highlight the gliocentric theory demonstrating the pivotal role of microglia and astrocyte, but also of infiltrating immune cells, in the pathological processes that take place in the central nervous system microenvironment. From this point of view, microglia-astrocytes-lymphocytes crosstalk is fundamental to shape the microenvironment toward a pro-inflammatory one, enhancing neuronal damage. In this review, we dissect the current state-of-the-art knowledge of the microglial dialogue with other cell populations as one of the principal hallmarks of ALS progression. Particularly, we deeply investigate the microglia crosstalk with astrocytes and immune cells reporting
MeSH term(s)	Mice ; Animals ; Humans ; Amyotrophic Lateral Sclerosis/genetics ; Microglia/pathology ; Astrocytes/pathology ; Motor Neurons/pathology
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1223096
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Article ; Online: The pathogenetic basis for a disease continuum in early- and late-onset ataxia-dystonia supports a unified genetic diagnostic approach.

Garofalo, M / Vansenne, F / Verbeek, D S / Sival, D A

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2023 Volume 43, Page(s) 44–51

Abstract: Introduction: Genetically inherited ataxic disorders are classified by their age of disease presentation into early- and late-onset ataxia (EOA and LOA, presenting before or after the 25th year-of-life). In both disease groups, comorbid dystonia co- ... ...

Abstract	Introduction: Genetically inherited ataxic disorders are classified by their age of disease presentation into early- and late-onset ataxia (EOA and LOA, presenting before or after the 25th year-of-life). In both disease groups, comorbid dystonia co-occurs frequently. Despite overlapping genes and pathogenetic features, EOA, LOA and dystonia are considered as different genetic entities with a separate diagnostic approach. This often leads to diagnostic delay. So far, the possibility of a disease continuum between EOA, LOA and mixed ataxia-dystonia has not been explored in silico. In the present study, we analyzed the pathogenetic mechanisms underlying EOA, LOA and mixed ataxia-dystonia. Methods: We analyzed the association of 267 ataxia genes with comorbid dystonia and anatomical MRI lesions in literature. We compared anatomical damage, biological pathways, and temporal cerebellar gene expression between EOA, LOA and mixed ataxia-dystonia. Results: The majority (≈65%) of ataxia genes were associated with comorbid dystonia in literature. Both EOA and LOA gene groups with comorbid dystonia were significantly associated with lesions in the cortico-basal-ganglia-pontocerebellar network. EOA, LOA and mixed ataxia-dystonia gene groups were enriched for biological pathways related to nervous system development, neural signaling and cellular processes. All genes revealed similar cerebellar gene expression levels before and after 25 years of age and during cerebellar development. Conclusion: In EOA, LOA and mixed ataxia-dystonia gene groups, our findings show similar anatomical damage, underlying biological pathways and temporal cerebellar gene expression patterns. These findings may suggest the existence of a disease continuum, supporting the diagnostic use of a unified genetic approach.
MeSH term(s)	Humans ; Dystonia/diagnosis ; Dystonia/genetics ; Delayed Diagnosis ; Age of Onset ; Ataxia/diagnosis ; Ataxia/genetics ; Cerebellar Ataxia ; Dystonic Disorders/diagnosis ; Dystonic Disorders/genetics
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2023.02.005
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Article ; Online: Psychopathy and gaze cueing.

Garofalo, Carlo / Jones, Andrew / Nentjes, Lieke / Gillespie, Steven M

Journal of behavior therapy and experimental psychiatry

2023 Volume 83, Page(s) 101936

Abstract: ... participants (M: Results: Linear mixed models showed no significant associations of emotional (versus ...

Abstract	Background and objectives: Psychopathic traits - and especially callous affective features - have been linked to altered processing of others' emotional expressions, and to reduced attention to the eyes. Despite the importance of gaze cueing (i.e., the tendency to orient attention toward where someone else is looking) for social functioning, few studies have investigated relationships between psychopathic traits and gaze cueing, and whether facial emotional expression influence these relationships, obtaining mixed results. To address this gap, the present study aimed to evaluate associations between psychopathic traits and gaze cueing for emotional and neutral expressions. Methods: 65 non-clinical male participants (M Results: Linear mixed models showed no significant associations of emotional (versus neutral) expressions, or psychopathy trait dimensions, with either gaze cueing or arrow cueing. Limitations: Reliance on a convenience sample of non-clinical men, assessed with self-reports measures of psychopathy, and using static emotional stimuli limit the generalizability of our findings. Conclusions: Findings suggest that psychopathic traits are not associated with individual differences in following others' gaze to direct attention, and that there was no advantage for affective relative to neutral expressions.
MeSH term(s)	Humans ; Male ; Adult ; Emotions ; Antisocial Personality Disorder/psychology ; Cues ; Eye ; Facial Expression
Language	English
Publishing date	2023-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	280250-8
ISSN	1873-7943 ; 0005-7916
ISSN (online)	1873-7943
ISSN	0005-7916
DOI	10.1016/j.jbtep.2023.101936
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Article ; Online: Exploring the effects of enzymatic and thermal treatments on banana starch characteristics.

Garofalo, Ma Angeles / Villon, Pedro / Cornejo, Fabiola / Rosell, Cristina M

International journal of biological macromolecules

2023 Volume 254, Issue Pt 1, Page(s) 127748

Abstract: Banana starch has a highly resistant starch (RS) and slow-digested starch (SDS) content, making it attractive as a functional ingredient. Unfortunately, banana starch requires modification processes due to the loss of RS and SDS during gelatinization ... ...

Abstract	Banana starch has a highly resistant starch (RS) and slow-digested starch (SDS) content, making it attractive as a functional ingredient. Unfortunately, banana starch requires modification processes due to the loss of RS and SDS during gelatinization because of its thermolabile characteristics. This study explores the effect of banana starch modification by enzymatic, heat moisture treatment (HMT) and dual modification (HMT+ enzymatic) on its nutritional (RS, SDS) and functional properties (hydration, structural, gelation, rheological). HMT and dual modifications decrease RS (from 44.62 g/100 g to 16.62 and 26.66 g/100 g, respectively) and increase SDS (from 21.72 g/100 g to 33.91 and 26.95 g/100 g, respectively) in raw starch but induce structural changes that enhance RS (from 3.10 g/100 g to 3.94 and 4.4 g/100 g, respectively) and SDS (from 2.58 g/100 g to 9.58 and 11.48 g/100 g) thermo-resistance in gelled starch. Also, changes in the functional properties of starches were evidenced, such as weaker gels (hardness < 41 g), lower water absorption (<12.35 g/g), high starch solubility (>1.77 g/100 g) and increased gelatinization temperature. Improved gelatinization temperature and RS thermostability resulted from modifications that could expand banana starch applications as a beverage and compote thickener agent.
MeSH term(s)	Starch/chemistry ; Musa/chemistry ; Chemical Phenomena ; Solubility ; Temperature ; Resistant Starch ; Hot Temperature
Chemical Substances	Starch (9005-25-8) ; Resistant Starch
Language	English
Publishing date	2023-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127748
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