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Article ; Online: Toceranib phosphate and firocoxib-mediated partial response in a dog with advanced intranasal sarcoma.

Osada, Hironari / Okazawa, Taiga / Kushida, Kazuya / Kishimoto, Miori / Ikeda, Mitsuhiro / Kondo, Hirotaka / Kimura, Junpei / Ohmori, Keitaro

The Journal of veterinary medical science

2023 Volume 85, Issue 9, Page(s) 1004–1009

Abstract: A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed ...

Abstract	A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed as intranasal sarcoma based on histopathological analysis. The tumor cells were immunohistochemically positive for KIT and platelet-derived growth factor receptor α/β and negative for vascular endothelial growth factor receptor 2 and cyclooxygenase-2. Treatment with toceranib phosphate (TOC) and firocoxib reduced the tumor size, which was defined as partial response (PR). After PR induction, TOC alone mediated survival for 205 days. This case report suggests that the combination of TOC and possibly firocoxib may be a therapeutic option for canine intranasal sarcoma.
MeSH term(s)	Dogs ; Male ; Animals ; Vascular Endothelial Growth Factor A ; Indoles/therapeutic use ; Sarcoma/drug therapy ; Sarcoma/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/drug therapy ; Dog Diseases/metabolism
Chemical Substances	toceranib phosphate (24F9PF7J3R) ; firocoxib (Y6V2W4S4WT) ; Vascular Endothelial Growth Factor A ; Indoles
Language	English
Publishing date	2023-08-02
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.22-0542
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Expression of genes encoding interleukin 15 and its receptor subunits in the duodenal and colonic mucosae of dogs with chronic enteropathy.

Furukawa, Rintaro / Hara, Yuna / Furuya, Keiko / Takahashi, Kaho / Nishimura, Rinka / Shingaki, Tomoaki / Osada, Hironari / Kondo, Hirotaka / Ohmori, Keitaro

Veterinary and animal science

2022 Volume 17, Page(s) 100256

Abstract: A pro-inflammatory role of interleukin (IL)-15 and IL-15 receptor (R) in chronic intestinal inflammation, such as inflammatory bowel disease, has been reported in humans. However, the contribution of IL-15 signaling in the pathogenesis of canine chronic ... ...

Abstract	A pro-inflammatory role of interleukin (IL)-15 and IL-15 receptor (R) in chronic intestinal inflammation, such as inflammatory bowel disease, has been reported in humans. However, the contribution of IL-15 signaling in the pathogenesis of canine chronic enteropathy (CE) remains unclear. Therefore, as a first step in elucidating the importance of IL-15 signaling in canine CE, we measured the mRNA expression of
Language	English
Publishing date	2022-06-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-943X
ISSN (online)	2451-943X
DOI	10.1016/j.vas.2022.100256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication.

Sato, Hirotaka / Fukui, Jun-Na / Hirano, Hiroyuki / Osada, Hiroyuki / Arimura, Yutaka / Masuda, Michiaki / Aida, Yoko

Viruses

2022 Volume 15, Issue 1

Abstract: Bovine leukemia virus (BLV) infection causes endemic bovine leukemia and lymphoma, resulting in lower carcass weight and reduced milk production by the infected cattle, leading to economic losses. Without effective measures for treatment and prevention, ... ...

Abstract	Bovine leukemia virus (BLV) infection causes endemic bovine leukemia and lymphoma, resulting in lower carcass weight and reduced milk production by the infected cattle, leading to economic losses. Without effective measures for treatment and prevention, high rates of BLV infection can cause problems worldwide. BLV research is limited by the lack of a model system to assay infection. To overcome this, we previously developed the luminescence syncytium induction assay (LuSIA), a highly sensitive and objectively quantifiable method for visualizing BLV infectivity. In this study, we applied LuSIA for the high-throughput screening of drugs that could inhibit BLV infection. We screened 625 compounds from a chemical library using LuSIA and identified two that markedly inhibited BLV replication. We then tested the chemical derivatives of those two compounds and identified BSI-625 and -679 as potent inhibitors of BLV replication with low cytotoxicity. Interestingly, BSI-625 and -679 appeared to inhibit different steps of the BLV lifecycle. Thus, LuSIA was applied to successfully identify inhibitors of BLV replication and may be useful for the development of anti-BLV drugs.
MeSH term(s)	Animals ; Cattle ; Leukemia Virus, Bovine ; Luminescence ; Enzootic Bovine Leukosis ; Biological Assay ; Giant Cells
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15010004
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Article ; Online: Clinical characteristics of dogs presenting with vomiting as a gastrointestinal sign of chronic enteropathy.

Furukawa, Rintaro / Takahashi, Kaho / Hara, Yuna / Nishimura, Rinka / Furuya, Keiko / Shingaki, Tomoaki / Osada, Hironari / Kondo, Hirotaka / Ohmori, Keitaro

Veterinary and animal science

2022 Volume 17, Page(s) 100255

Abstract: Vomiting is a major gastrointestinal (GI) sign of chronic enteropathy (CE) in dogs. Previous studies have reported clinical characteristics of dogs with CE, who developed diarrhea with or without vomiting as GI signs. However, to characterize clinical ... ...

Abstract	Vomiting is a major gastrointestinal (GI) sign of chronic enteropathy (CE) in dogs. Previous studies have reported clinical characteristics of dogs with CE, who developed diarrhea with or without vomiting as GI signs. However, to characterize clinical features of dogs with CE appropriately, dogs presenting with vomiting without diarrhea should be included in the analysis. Thus, this study aimed to characterize clinical features and outcomes of dogs that presented with vomiting without diarrhea. Based on their presenting GI signs, we retrospectively classified 66 dogs with CE into "Vomiting", "Diarrhea", or "Vomiting and diarrhea" groups and compared clinical and histological characteristics of each group. We found that 18 of the 66 dogs with CE (27%) presented with vomiting without diarrhea as a GI sign. Compared to the other 2 groups, the Vomiting group was significantly associated with food-responsive enteropathy (FRE), Beagle, lower clinical severity scores, higher plasma albumin levels, and higher histological scores for eosinophils in the duodenal lamina propria according to the univariate analysis. The multivariate analysis revealed that FRE and higher histological scores for eosinophils in the duodenal lamina propria were significant variables in the Vomiting group. Moreover, the survival time was the longest in the Vomiting group among dogs with CE. These findings are of clinical significance as they indicate that presenting with vomiting without diarrhea may not only be helpful in differentiating FRE from the other types of CE, but also in predicting the prognosis.
Language	English
Publishing date	2022-06-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2451-943X
ISSN (online)	2451-943X
DOI	10.1016/j.vas.2022.100255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Tuning of ion-release capability from bio-ceramic-polymer composites for enhancing cellular activity.

Osada, Naoki / Terada, Arisa / Maeda, Hirotaka / Obata, Akiko / Nishikawa, Yasutoshi / Kasuga, Toshihiro

Royal Society open science

2019 Volume 6, Issue 9, Page(s) 190612

Abstract: In our previous study, we investigated the synergetic effects of inorganic ions, such as silicate, ... ...

Abstract	In our previous study, we investigated the synergetic effects of inorganic ions, such as silicate, Mg
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.190612
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Article ; Online: Transgastric Jejunostomy (PEG-J) for Continuous Infusion of Levodopa-Carbidopa Intestinal Gel: An Approach for Parkinson's Disease Treatment.

Nomoto, Yusuke / Furihata, Makoto / Hagiwara, Haruka / Ishino, Hirotaka / Yano, Shintaro / Okawa, Hiroki / Nakatsu, Yoichi / Noda, Kumiko / Nishi, Shinjiro / Ogiwara, Shingo / Kitamura, Tsuneo / Osada, Taro

Medical science monitor : international medical journal of experimental and clinical research

2023 Volume 29, Page(s) e941285

Abstract: BACKGROUND Parkinson's disease (PD) is a neurodegenerative disorder that often requires long-term management of motor symptoms. Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) has shown promising results in alleviating motor fluctuations ... ...

Abstract	BACKGROUND Parkinson's disease (PD) is a neurodegenerative disorder that often requires long-term management of motor symptoms. Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) has shown promising results in alleviating motor fluctuations and improving quality of life. This study aimed to evaluate the efficacy and safety of transgastric jejunostomy (PEG-J) as a delivery method for LCIG in a cohort of 43 PD patients. MATERIAL AND METHODS Forty-three PD patients who were candidates for LCIG therapy underwent transgastric jejunostomy to facilitate continuous infusion of LCIG. The primary outcomes assessed were motor symptom improvement, reduction in motor fluctuations, and medication-related adverse events. Secondary outcomes included changes in quality of life, dyskinesia severity, and healthcare resource utilization. RESULTS The results of this study demonstrated significant improvements in motor symptoms, reduction in motor fluctuations, and enhanced quality of life following PEG-J for LCIG infusion. The treatment was generally well-tolerated, with a low incidence of procedure-related complications. Notably, the use of PEG-J allowed for precise and continuous delivery of LCIG, minimizing variations in drug absorption and ensuring consistent therapeutic levels. CONCLUSIONS Transgastric jejunostomy (PEG-J) offers an effective approach for the continuous infusion of LCIG in Parkinson's disease treatment. This method provides a stable and reliable delivery system, leading to improved symptom control and enhanced quality of life for PD patients.
MeSH term(s)	Humans ; Carbidopa/therapeutic use ; Levodopa/therapeutic use ; Parkinson Disease/drug therapy ; Antiparkinson Agents/therapeutic use ; Jejunostomy ; Quality of Life ; Drug Combinations ; Gels/therapeutic use
Chemical Substances	Carbidopa (MNX7R8C5VO) ; Levodopa (46627O600J) ; Antiparkinson Agents ; Drug Combinations ; Gels
Language	English
Publishing date	2023-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.941285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reduced gray matter volume in the default-mode network associated with insulin resistance.

Asano, Saki / Ogawa, Akitoshi / Osada, Takahiro / Oka, Satoshi / Nakajima, Koji / Oshima, Yasushi / Tanaka, Sakae / Kaga, Hideyoshi / Tamura, Yoshifumi / Watada, Hirotaka / Kawamori, Ryuzo / Konishi, Seiki

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 23, Page(s) 11225–11234

Abstract: Insulin resistance may lead to structural and functional abnormalities of the human brain. However, the mechanism by which insulin resistance impairs the brain remains elusive. In this study, we used two large neuroimaging databases to investigate the ... ...

Abstract	Insulin resistance may lead to structural and functional abnormalities of the human brain. However, the mechanism by which insulin resistance impairs the brain remains elusive. In this study, we used two large neuroimaging databases to investigate the brain regions where insulin resistance was associated with the gray matter volume and to examine the resting-state functional connectivity between these brain regions and each hypothalamic nucleus. Insulin resistance was associated with reduced gray matter volume in the regions of the default-mode and limbic networks in the cerebral cortex in older adults. Resting-state functional connectivity was prominent between these networks and the paraventricular nucleus of the hypothalamus, a hypothalamic interface connecting functionally with the cerebral cortex. Furthermore, we found a significant correlation in these networks between insulin resistance-related gray matter volume reduction and network paraventricular nucleus of the hypothalamus resting-state functional connectivity. These results suggest that insulin resistance-related gray matter volume reduction in the default-mode and limbic networks emerged through metabolic homeostasis mechanisms in the hypothalamus.
MeSH term(s)	Humans ; Aged ; Gray Matter/diagnostic imaging ; Default Mode Network ; Insulin Resistance ; Brain Mapping/methods ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Cerebral Cortex
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad358
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clinical characteristics of dogs presenting with vomiting as a gastrointestinal sign of chronic enteropathy

Rintaro Furukawa / Kaho Takahashi / Yuna Hara / Rinka Nishimura / Keiko Furuya / Tomoaki Shingaki / Hironari Osada / Hirotaka Kondo / Keitaro Ohmori

Veterinary and Animal Science, Vol 17, Iss , Pp 100255- (2022)

2022

Abstract	Vomiting is a major gastrointestinal (GI) sign of chronic enteropathy (CE) in dogs. Previous studies have reported clinical characteristics of dogs with CE, who developed diarrhea with or without vomiting as GI signs. However, to characterize clinical features of dogs with CE appropriately, dogs presenting with vomiting without diarrhea should be included in the analysis. Thus, this study aimed to characterize clinical features and outcomes of dogs that presented with vomiting without diarrhea. Based on their presenting GI signs, we retrospectively classified 66 dogs with CE into “Vomiting”, “Diarrhea”, or “Vomiting and diarrhea” groups and compared clinical and histological characteristics of each group. We found that 18 of the 66 dogs with CE (27%) presented with vomiting without diarrhea as a GI sign. Compared to the other 2 groups, the Vomiting group was significantly associated with food-responsive enteropathy (FRE), Beagle, lower clinical severity scores, higher plasma albumin levels, and higher histological scores for eosinophils in the duodenal lamina propria according to the univariate analysis. The multivariate analysis revealed that FRE and higher histological scores for eosinophils in the duodenal lamina propria were significant variables in the Vomiting group. Moreover, the survival time was the longest in the Vomiting group among dogs with CE. These findings are of clinical significance as they indicate that presenting with vomiting without diarrhea may not only be helpful in differentiating FRE from the other types of CE, but also in predicting the prognosis.
Keywords	Chronic enteropathy ; Dog ; Food-responsive enteropathy ; Vomiting ; Diarrhea ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Clinical characteristics of dogs presenting with vomiting as a gastrointestinal sign of chronic enteropathy

Furukawa, Rintaro / Takahashi, Kaho / Hara, Yuna / Nishimura, Rinka / Furuya, Keiko / Shingaki, Tomoaki / Osada, Hironari / Kondo, Hirotaka / Ohmori, Keitaro

Veterinary and Animal Science. 2022 Sept., v. 17

2022

Abstract	Vomiting is a major gastrointestinal (GI) sign of chronic enteropathy (CE) in dogs. Previous studies have reported clinical characteristics of dogs with CE, who developed diarrhea with or without vomiting as GI signs. However, to characterize clinical features of dogs with CE appropriately, dogs presenting with vomiting without diarrhea should be included in the analysis. Thus, this study aimed to characterize clinical features and outcomes of dogs that presented with vomiting without diarrhea. Based on their presenting GI signs, we retrospectively classified 66 dogs with CE into “Vomiting”, “Diarrhea”, or “Vomiting and diarrhea” groups and compared clinical and histological characteristics of each group. We found that 18 of the 66 dogs with CE (27%) presented with vomiting without diarrhea as a GI sign. Compared to the other 2 groups, the Vomiting group was significantly associated with food-responsive enteropathy (FRE), Beagle, lower clinical severity scores, higher plasma albumin levels, and higher histological scores for eosinophils in the duodenal lamina propria according to the univariate analysis. The multivariate analysis revealed that FRE and higher histological scores for eosinophils in the duodenal lamina propria were significant variables in the Vomiting group. Moreover, the survival time was the longest in the Vomiting group among dogs with CE. These findings are of clinical significance as they indicate that presenting with vomiting without diarrhea may not only be helpful in differentiating FRE from the other types of CE, but also in predicting the prognosis.
Keywords	Beagle ; animal science ; diarrhea ; digestive system diseases ; eosinophils ; gastrointestinal system ; histology ; multivariate analysis ; prognosis ; serum albumin
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2451-943X
DOI	10.1016/j.vas.2022.100255
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Expression of genes encoding interleukin 15 and its receptor subunits in the duodenal and colonic mucosae of dogs with chronic enteropathy

Rintaro Furukawa / Yuna Hara / Keiko Furuya / Kaho Takahashi / Rinka Nishimura / Tomoaki Shingaki / Hironari Osada / Hirotaka Kondo / Keitaro Ohmori

Veterinary and Animal Science, Vol 17, Iss , Pp 100256- (2022)

2022

Abstract	A pro-inflammatory role of interleukin (IL)-15 and IL-15 receptor (R) in chronic intestinal inflammation, such as inflammatory bowel disease, has been reported in humans. However, the contribution of IL-15 signaling in the pathogenesis of canine chronic enteropathy (CE) remains unclear. Therefore, as a first step in elucidating the importance of IL-15 signaling in canine CE, we measured the mRNA expression of IL-15 and IL-15R subunits, including IL-15Rα, IL-15Rβ, and IL-15Rγ, in the duodenal and colonic mucosae of healthy dogs and those with CE, including food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE). Real-time PCR analysis revealed significantly lower IL-15Rα mRNA expression levels in the duodenal mucosa of dogs with IRE compared to healthy dogs. In contrast, the mRNA expression levels of IL-15, IL-15Rβ, and IL-15Rγ in the duodenal mucosa and IL-15, IL-15Rα, IL-15Rβ, and IL-15Rγ in the colonic mucosa did not differ among healthy dogs and those with FRE, ARE, or IRE. These findings suggest that decreased mRNA expression of IL-15Rα might be involved in the pathogenesis of duodenitis in dogs with IRE. Moreover, even in canine CE, IL-15 signaling appears to play different roles in duodenitis and colitis in dogs with FRE, ARE, and IRE. However, there were no correlations between the gene expression levels of IL-15Rα and clinical severity or histopathological scores in the duodenum of dogs with IRE. Further studies are necessary to investigate the IL-15Rα protein localization and to determine how impaired IL-15Rα expression contributes to the development of duodenitis in dogs with IRE.
Keywords	Chronic enteropathy ; Dog ; Inflammatory bowel disease ; Interleukin-15 ; Veterinary medicine ; SF600-1100
Subject code	630 ; 610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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