LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 328

Search options

  1. Book: Non-coding RNAs in colorectal cancer

    Slaby, Ondrej / Calin, George A.

    (Advances in experimental medicine and biology ; 937)

    2016  

    Author's details Ondrej Slaby, George A. Calin editors
    Series title Advances in experimental medicine and biology ; 937
    Collection
    Language English
    Size viii, 252 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019113456
    ISBN 978-3-319-42057-8 ; 9783319420592 ; 3-319-42057-7 ; 3319420593
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -937- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online ; E-Book: Non-coding RNAs in colorectal cancer

    Slaby, Ondrej / Calin, George A.

    (Advances in experimental medicine and biology ; 937)

    2016  

    Author's details Ondrej Slaby, George A. Calin editors
    Series title Advances in experimental medicine and biology ; 937
    Collection
    Keywords Medicine ; Cancer research ; Human genetics ; Molecular biology ; Life sciences ; Cell biology
    Subject code 614.5999
    Language English
    Size 1 Online-Ressource (vii, 252 Seiten)
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019113418
    ISBN 978-3-319-42059-2 ; 3-319-42059-3
    DOI 10.1007/978-3-319-42059-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online: Precision/Personalized Pediatric Oncology and Immune Therapies: Rather Customize Than Randomize

    Slavc, Irene / Lakka Klement, Giannoula / Sterba, Jaroslav / Slaby, Ondrej / Valik, Dalibor

    2020  

    Keywords Medicine ; Oncology ; personalized medicine ; precision oncology ; pediatric oncology ; trial models ; drug models ; personalized precision pediatric oncology ; clinical trial designs
    Size 1 electronic resource (108 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230854
    ISBN 9782889637188 ; 2889637182
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Editorial: Strategic molecular biomarkers and microRNAs in cancer.

    López-Camarillo, César / Slaby, Ondrej / Silva-Cázares, Macrina Beatriz

    Frontiers in oncology

    2022  Volume 12, Page(s) 1031349

    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1031349
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies.

    Boudna, Marie / Campos, Andres Delgado / Vychytilova-Faltejskova, Petra / Machackova, Tana / Slaby, Ondrej / Souckova, Kamila

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 171

    Abstract: This review presents a comprehensive overview of labelling strategies for endogenous and exogenous extracellular vesicles, that can be utilised both in vitro and in vivo. It covers a broad spectrum of approaches, including fluorescent and bioluminescent ... ...

    Abstract This review presents a comprehensive overview of labelling strategies for endogenous and exogenous extracellular vesicles, that can be utilised both in vitro and in vivo. It covers a broad spectrum of approaches, including fluorescent and bioluminescent labelling, and provides an analysis of their applications, strengths, and limitations. Furthermore, this article presents techniques that use radioactive tracers and contrast agents with the ability to track EVs both spatially and temporally. Emphasis is also placed on endogenous labelling mechanisms, represented by Cre-lox and CRISPR-Cas systems, which are powerful and flexible tools for real-time EV monitoring or tracking their fate in target cells. By summarizing the latest developments across these diverse labelling techniques, this review provides researchers with a reference to select the most appropriate labelling method for their EV based research.
    MeSH term(s) Extracellular Vesicles
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-024-01548-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates.

    Stanikova, Andrea / Jouza, Martin / Bohosova, Julia / Slaby, Ondrej / Jabandziev, Petr

    BMJ paediatrics open

    2023  Volume 7, Issue 1

    Abstract: Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate ... ...

    Abstract Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC's pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.
    MeSH term(s) Infant, Newborn ; Humans ; Infant, Premature ; Enterocolitis, Necrotizing/etiology ; Enterocolitis, Necrotizing/prevention & control ; Dysbiosis/complications ; Infant, Newborn, Diseases ; Gastrointestinal Microbiome
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2023-002172
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

    Bratova, Monika / Brat, Kristian / Pavlovsky, Zdenek / Sana, Jiri / Slaby, Ondrej

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2023  Volume 167, Issue 2, Page(s) 152–156

    Abstract: Aims: The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations.: Methods: We collected retrospective data on ...

    Abstract Aims: The authors focused on a group of young lung cancer patients with the aim of better understanding the mechanisms of tumor pathogenesis in these patients and search for potential targetable mutations.
    Methods: We collected retrospective data on patients under 40 years diagnosed with lung cancer (NSCLC or small-cell lung cancer) from 2011-2020 at the Department of Respiratory Diseases, University Hospital Brno, Czech Republic. Tumor tissue of these patients was analysed by next-generation sequencing (NGS, a panel of 550 variants in 19 genes). Demographic characteristics, smoking history, histology, molecular-genetic results and clinical stage of the disesase were recorded in all eligible patients from accessible medical databases.
    Results: Of 17 identified patients in only 8 cases was successful NGS carried out due to lack of sufficient good quality material in the other cases. The most frequently found molecular genetic changes were EGFR, RICTOR and HER2 amplification and MET and FGFR1 amplification. In addition, we found rare pathogenic variants in BRAF and PIK3CA genes. Actionable variants were detected in 75% patients.
    Conclusion: We detected very frequent driver and potentially actionable alterations in young patients with lung cancer. This suggests different mechanisms of carcinogenesis in these patients and indicates that they might benefit more from a specific approach than older lung cancer patients.
    MeSH term(s) Humans ; Retrospective Studies ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/genetics ; Small Cell Lung Carcinoma ; Mutation
    Language English
    Publishing date 2023-03-31
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2023.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Non-coding RNAs as Biomarkers for Colorectal Cancer Screening and Early Detection.

    Slaby, Ondrej

    Advances in experimental medicine and biology

    2016  Volume 937, Page(s) 153–170

    Abstract: Early detection of colorectal cancer (CRC) is the key for prevention and the ability to impact long-term survival of CRC patients. Current CRC screening modalities are inadequate for global application because of low sensitivity and specificity in case ... ...

    Abstract Early detection of colorectal cancer (CRC) is the key for prevention and the ability to impact long-term survival of CRC patients. Current CRC screening modalities are inadequate for global application because of low sensitivity and specificity in case of conventional stool-based screening tests, and high costs and a low participation compliance in colonoscopy. An accurate stool- or blood-based screening test with use of innovative biomarkers is an appealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher compliance rates. Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes, such as proliferation, differentiation, migration, angiogenesis and apoptosis. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various cancers, including CRC. The discovery that ncRNAs (mainly microRNAs) are stable in stool and in blood plasma and serum presents the opportunity to develop novel strategies taking advantage of circulating ncRNAs as early diagnostic biomarkers of CRC. This chapter is a comprehensive examination of aberrant ncRNAs expression levels in tumor tissue, stool and blood of CRC patients and a summary of the current findings on ncRNAs, including microRNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, circular RNAs and long ncRNAs in regards to their potential usage for screening or early detection of CRC.
    MeSH term(s) Adenocarcinoma/chemistry ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenoma/chemistry ; Adenoma/diagnosis ; Adenoma/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Colonic Polyps/chemistry ; Colonic Polyps/diagnosis ; Colonic Polyps/genetics ; Colorectal Neoplasms/chemistry ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Early Detection of Cancer/methods ; Feces/chemistry ; Gene Expression Regulation, Neoplastic ; Humans ; Patient Acceptance of Health Care ; Plasma ; RNA, Untranslated/analysis ; RNA, Untranslated/blood ; Sensitivity and Specificity ; Serum
    Chemical Substances Biomarkers, Tumor ; RNA, Untranslated
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-42059-2_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Urinary microRNAs and Their Significance in Prostate Cancer Diagnosis: A 5-Year Update.

    Juracek, Jaroslav / Madrzyk, Marie / Stanik, Michal / Slaby, Ondrej

    Cancers

    2022  Volume 14, Issue 13

    Abstract: Current routine screening methods for the diagnosis of prostate cancer (PCa) have significantly increased early detection of the disease but often show unsatisfactory analytical parameters. A class of promising markers represents urinary microRNAs ( ... ...

    Abstract Current routine screening methods for the diagnosis of prostate cancer (PCa) have significantly increased early detection of the disease but often show unsatisfactory analytical parameters. A class of promising markers represents urinary microRNAs (miRNAs). In the last five years, there has been an extensive increase in the number of studies on this topic. Thus, this review aims to update knowledge and point out technical aspects affecting urinary miRNA analysis. The review of relevant literature was carried out by searching the PubMed database for the keywords: microRNA, miRNA, urine, urinary, prostate cancer, and diagnosis. Papers discussed in this review were retrieved using PubMed, and the search strategy was as follows: (urine OR urinary) WITH (microRNA OR miRNA) AND prostate cancer. The search was limited to the last 5 years, January 2017 to December 2021. Based on the defined search strategy, 31 original publications corresponding to the research topic were identified, read and reviewed to present the latest findings and to assess possible translation of urinary miRNAs into clinical practice. Reviews or older publications were read and cited if they valuably extended the context and contributed to a better understanding. Urinary miRNAs are potentially valuable markers for the diagnosis of prostate cancer. Despite promising results, there is still a need for independent validation of exploratory data, which follows a strict widely accepted methodology taking into account the shortcomings and factors influencing the analysis.
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Urinary MicroRNAs as Emerging Class of Noninvasive Biomarkers.

    Juracek, Jaroslav / Slaby, Ondrej

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2115, Page(s) 221–247

    Abstract: MicroRNAs (miRNAs) are endogenous noncoding RNAs, which regulate gene expression on the post-transcriptional level. Since miRNAs are involved in the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes, ...

    Abstract MicroRNAs (miRNAs) are endogenous noncoding RNAs, which regulate gene expression on the post-transcriptional level. Since miRNAs are involved in the regulation of apoptosis, cellular proliferation, differentiation, and other important cellular processes, their deregulation is important for the development of a wide range of diseases including cancer. Apart from tissue, specific disease-related miRNA signatures can be found in body fluids as well. Especially for urologic diseases or injuries, urine miRNAs represent a promising group of biomarkers. Despite a large number of studies describing the importance of urinary miRNAs, there is a lack of recommendations for urine management and subsequent miRNA analysis. Thus, in this chapter, we aim to describe the origin and functions of urinary miRNAs and discuss the technical aspects of their detection including the pre-analytical phase principles and new directions in quantification, which could forward urine miRNA into clinical practice.
    MeSH term(s) Animals ; Biomarkers/analysis ; Biomarkers/urine ; Humans ; MicroRNAs/analysis ; MicroRNAs/isolation & purification ; MicroRNAs/urine ; Polymerase Chain Reaction/methods ; RNA Stability ; Urinalysis/methods ; Urologic Diseases/diagnosis ; Urologic Diseases/urine
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0290-4_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top