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  1. Article ; Online: Percutaneous coronary intervention for chronic total occlusion of the left circumflex branch in mirror dextrocardia: a case report.

    Hailin, Du / Hongtu, Qiao / Wenyong, Zhang

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 486

    Abstract: Background: Mirror dextrocardia (MDC) is a condition in which the heart is located in a mirror-image position on the right side of the chest compared to the normal position in individuals with physiological variations. Patients with MDC and chronic ... ...

    Abstract Background: Mirror dextrocardia (MDC) is a condition in which the heart is located in a mirror-image position on the right side of the chest compared to the normal position in individuals with physiological variations. Patients with MDC and chronic total occlusion (CTO) of the left circumflex branch (LCX) are extremely rare in clinical practice. The treatment of MDC-CTO-LCX differs significantly from patients without mirror dextrocardia and the same condition in terms of instrument selection and procedural techniques. In this article, we report a successful case of interventional treatment in a patient with MDC-CTO-LCX. We summarize the anatomical and electrocardiographic variations in patients with MDC-CTO-LCX, and discuss the selection of interventional instruments and techniques that can be useful for interventionists as well as the diagnostic and therapeutic considerations that can be helpful for clinical physicians.
    Case presentation: A male Han Chinese patient, 51, was admitted, presenting recurrent chest pain for a year and recent onset of exertional fatigue over the past week.He reported episodes of chest pain following physical activities over the past year, lasting between 5 and 20 min.Despite these symptoms, the patient did not seek immediate medical attention, and the occurrence of his chest pain has progressively lessened within the year.A week prior, the patient developed exertional dyspnea after brief walks, though without any episodes of nocturnal paroxysmal dyspnea.Upon arrival at our hospital for evaluation, he was initially diagnosed with chronic coronary syndrome, previous inferior myocardial infarction, atrial arrhythmia, and classified under the New York Heart Association functional class III.Following his admission, a chest X-ray and coronary angiography were conducted.The results indicated mirror dextrocardia and total occlusion of the left circumflex branch. Percutaneous coronary intervention (PCI) was performed on the left circumflex branch. Subsequent angiography demonstrated optimal stent positioning without evidence of hematoma or dissection.Following the procedure, the patient's symptoms of chest pain and exertional dyspnea were resolved, which led to his subsequent discharge.A follow-up electrocardiogram, 10 months post-procedure, displayed a slow and regular atrial rhythm.
    Conclusions: The incidence of dextrocardia is very low, and it may appear normal on an electrocardiogram; however, careful diagnosis is required when there is an abnormal direction of the P wave in limb leads. During the operation for chronic occlusive lesions of the right-sided coronary artery, the anomalous anatomical structure necessitates specific requirements for instrument selection and operative techniques. After revascularization of chronic occlusive vessels in dextrocardia, routine electrocardiographic examination may show false normalization, requiring caution in interpretation.
    MeSH term(s) Humans ; Male ; Atrial Fibrillation ; Chest Pain/etiology ; Chronic Disease ; Coronary Angiography ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/surgery ; Dextrocardia/complications ; Dextrocardia/diagnostic imaging ; Dextrocardia/surgery ; Dyspnea ; Percutaneous Coronary Intervention/methods ; Treatment Outcome ; Middle Aged
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-04196-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on "An Injectable Hydrogel to Modulate T Cells for Cancer Immunotherapy".

    Lin, Liangbin / Zhang, Sunfu / Yang, Wenyong

    Small (Weinheim an der Bergstrasse, Germany)

    2023  , Page(s) e2302812

    Abstract: Recent clinical successes of immune checkpoint blockade (ICB) therapies represents a milestone as a novel anti-tumor strategy beyond surgery, radiotherapy, chemotherapy, and targeted therapy in cancer therapy. T cells, especially ... ...

    Abstract Recent clinical successes of immune checkpoint blockade (ICB) therapies represents a milestone as a novel anti-tumor strategy beyond surgery, radiotherapy, chemotherapy, and targeted therapy in cancer therapy. T cells, especially CD8
    Language English
    Publishing date 2023-12-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202302812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of EMT-associated prognostic features among grade II/III gliomas.

    Yang, Wenyong / Lin, Liangbin / Lu, Tianqi / Yu, Hui / Zhang, Sunfu

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2822

    Abstract: Grade II/III gliomas have a highly heterogeneous clinical course. Identifying prognostic biomarkers in grade II/III gliomas is essential to guide clinical management. We explored epithelial-mesenchymal transition (EMT)-related genes to uncover prognostic ...

    Abstract Grade II/III gliomas have a highly heterogeneous clinical course. Identifying prognostic biomarkers in grade II/III gliomas is essential to guide clinical management. We explored epithelial-mesenchymal transition (EMT)-related genes to uncover prognostic features in grade II/III gliomas. Consensus cluster analysis of 200 EMT-related genes classified 512 grade II/III glioma samples into two molecular subtypes, C1 and C2. The C1 subtype had significantly worse overall survival compared to the C2 subtype. Pathway analysis revealed C1 tumors were highly associated with tumor progression pathways and demonstrated higher immune cell infiltration scores. Differential expression analysis identified four genes (ACTN1, AQP1, LAMC3, NRM) that discriminated the two subtypes. Validation in external datasets confirmed that high expression of this four-gene signature predicted poor prognosis in grade II/III gliomas. Cellular experiments showed ACTN1, AQP1 and NRM promoted glioma cell proliferation, migration and invasion. We examined correlations of the signature genes with T cell exhaustion markers and found ACTN1 expression had the strongest association. Immunohistochemistry analysis further demonstrated that ACTN1 protein expression in grade II/III gliomas was negatively correlated with patient overall survival. In summary, our study identified a concise four-gene signature that robustly predicts grade II/III gliomas prognosis across multiple datasets. The signature provides clinical relevance in distinguishing more aggressive grade II/III glioma tumors. Targeting the ACTN1, AQP1 and NRM genes may offer new therapeutic opportunities to improve grade II/III gliomas patient outcomes.
    MeSH term(s) Humans ; Prognosis ; Brain Neoplasms/pathology ; Glioma/pathology ; Epithelial-Mesenchymal Transition/genetics ; Laminin
    Chemical Substances LAMC3 protein, human ; Laminin
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53399-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers

    Yujie Zhou / Songyan Yu / Wenyong Zhang

    International Journal of Molecular Sciences, Vol 24, Iss 14511, p

    2023  Volume 14511

    Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated ... ...

    Abstract Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.
    Keywords NOD-like receptor ; gastrointestinal inflammatory diseases ; esophageal cancer ; gastric cancer ; colorectal cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers.

    Zhou, Yujie / Yu, Songyan / Zhang, Wenyong

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated ... ...

    Abstract Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.
    MeSH term(s) Humans ; Immunity, Innate ; Neoplasms ; Signal Transduction ; Receptors, Pattern Recognition ; Gastrointestinal Diseases ; NLR Proteins/metabolism
    Chemical Substances Receptors, Pattern Recognition ; NLR Proteins
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Transformer Bridge Principle Circuit Using RF Admittance Technology.

    Liu, Fanfan / Zhang, Chaojie / Guo, Wenyong / Pan, Xinglong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 12

    Abstract: To investigate the problem of the lag stability of the capacitance value during the level drop of the dirty U-shaped liquid level sensor, the equivalent circuit of the dirty U-shaped liquid level sensor was analyzed, and the transformer bridge's ... ...

    Abstract To investigate the problem of the lag stability of the capacitance value during the level drop of the dirty U-shaped liquid level sensor, the equivalent circuit of the dirty U-shaped liquid level sensor was analyzed, and the transformer bridge's principle circuit that uses RF admittance technology was designed accordingly. Using the method of controlling a single variable, the measurement accuracy of the circuit was simulated when the dividing capacitance and the regulating capacitance had different values. Then, the right parameter values for the dividing capacitance and the regulating capacitance were found. On this basis, the change of the sensor output capacitance and the change of the length of the attached seawater mixture were controlled separately under the condition of removing the seawater mixture. The simulation outcomes showed that the measurement accuracy was excellent under various situations, validating the transformer principle bridge circuit's efficacy in minimizing the influence of the output capacitance value's lag stability.
    MeSH term(s) Computer Simulation ; Electric Power Supplies ; Electric Capacitance
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23125434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Research on an Evaluation Model of Urban Seismic Resilience Based on System Dynamics

    Xunchang Li / Yifan Liu / Wenyong Zhang / Yaqian Wang

    Sustainability, Vol 15, Iss 10112, p

    A Case Study of Chengdu, China

    2023  Volume 10112

    Abstract: In response to the frequent occurrence of earthquakes in Chengdu, which poses a great threat to the economy, social development, production, and people’s lives, in this study, we construct an index evaluation system and a system dynamics model for urban ... ...

    Abstract In response to the frequent occurrence of earthquakes in Chengdu, which poses a great threat to the economy, social development, production, and people’s lives, in this study, we construct an index evaluation system and a system dynamics model for urban seismic resilience based on an analysis of the interaction between earthquake disasters and the urban system. Four types of schemes, namely, the current continuity type, economic development type, government intervention type, and resilience construction type, were designed, and the dynamic evaluation and simulation prediction of Chengdu’s seismic resilience capacity under each scheme were conducted. The research results show that, compared with the other three schemes, the resilience construction type has better universality and expansibility in terms of improving Chengdu’s seismic resilience. Therefore, it is necessary to maintain a certain level of economic development, to attach importance to the construction of monitoring and warning systems, and to strive to improve emergency rescue capabilities and disaster awareness education. The model and evaluation indicators have strong applicability, and the research results can provide a theoretical reference for the evaluation of seismic resilience in Chengdu.
    Keywords public safety ; resilience ; urban system ; system dynamics ; earthquake disaster ; simulation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690 ; 710
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression.

    Lei, Dan / Xiao, Wenyong / Zhang, Bo

    Translational neuroscience

    2023  Volume 14, Issue 1, Page(s) 20220271

    Abstract: Background: Recent studies have highlighted that circular RNAs regulate cancer-related genes' expression by functioning as microRNA sponges in cancers. Herein, we investigated the function and molecular mechanism of circYIPF6 in glioma.: Methods: 5- ... ...

    Abstract Background: Recent studies have highlighted that circular RNAs regulate cancer-related genes' expression by functioning as microRNA sponges in cancers. Herein, we investigated the function and molecular mechanism of circYIPF6 in glioma.
    Methods: 5-Ethynyl-2'-deoxyuridine assay, colony formation, and flow cytometry were performed to assess the proliferation and apoptosis of glioma cells. The levels of glycolytic metabolism were evaluated by measuring the glucose uptake and lactate production. The protein levels of Bax, Bcl2, GLUT1, LDHA, and PTBP1 were examined by western blot. The interplay between miR-760 and circYIPF6 or PTBP1 was confirmed by a dual-luciferase reporter. The effect of circYIPF6 silencing on the growth of glioma
    Results: circYIPF6 was significantly upregulated in glioma. Knockdown of circYIPF6 suppressed glioma cell proliferation and glycolysis while promoting cell apoptosis. Mechanistic studies revealed that circYIPF6 targeted miR-760 and could abundantly sponge miR-760 to inhibit the expression of its downstream target gene PTBP1. Functional rescue experiments showed that both miR-760 inhibition and PTBP1 overexpression could attenuate the regulatory effect of circYIPF6 silencing on glioma cells. Furthermore, circYIPF6 knocking down effectively impeded glioma growth
    Conclusion: These findings suggested that circYIPF6 participated in the proliferation, apoptosis, and glycolysis of glioma through the miR-760/PTBP1 axis.
    Language English
    Publishing date 2023-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: On a framework of data assimilation for hyperparameter estimation of spiking neuronal networks.

    Zhang, Wenyong / Chen, Boyu / Feng, Jianfeng / Lu, Wenlian

    Neural networks : the official journal of the International Neural Network Society

    2023  Volume 171, Page(s) 293–307

    Abstract: When handling real-world data modeled by a complex network dynamical system, the number of the parameters is often much more than the size of the data. Therefore, in many cases, it is impossible to estimate these parameters and the exact value of each ... ...

    Abstract When handling real-world data modeled by a complex network dynamical system, the number of the parameters is often much more than the size of the data. Therefore, in many cases, it is impossible to estimate these parameters and the exact value of each parameter is frequently less interesting than the distribution of the parameters. In this paper, we aim to estimate the distribution of the parameters in the mesoscopic neuronal network model from the macroscopic experimental data, for example, the BOLD (blood oxygen level dependent) signal. Herein, we assume that the parameters of the neurons and synapses are inhomogeneous but independently and identically distributed from certain distributions with unknown hyperparameters. Thus, we estimate these hyperparameters of the distributions of the parameters, instead of estimating the parameters themselves. We formulate this problem under the framework of data assimilation and hierarchical Bayesian method and present an efficient method named Hierarchical Data Assimilation (HDA) to conduct the statistical inference on the neuronal network model with the BOLD signal data simulated by the hemodynamic model. We consider the Leaky Integral-Fire (LIF) neuronal networks with four synapses and show that the proposed algorithm can estimate the BOLD signals and the hyperparameters with high preciseness. In addition, we discuss the influence on the performance of the algorithm configuration and the LIF network model setup.
    MeSH term(s) Bayes Theorem ; Neurons/physiology ; Algorithms
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2023.11.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Guangdong-Hong Kong-Macau Greater Bay Area’s Construction promotes the Economic Development of Guangdong in the New era

    Li Wenyong / Zhang Xueyu

    E3S Web of Conferences, Vol 235, p

    2021  Volume 02014

    Abstract: The construction of urban agglomeration and regional economic integration have become a new trend of regional economic development in China. Bay area economy is an important force to drive regional development and lead technological innovation. Guangdong- ...

    Abstract The construction of urban agglomeration and regional economic integration have become a new trend of regional economic development in China. Bay area economy is an important force to drive regional development and lead technological innovation. Guangdong-Hong Kong-Macau Greater Bay Area arises at the historic moment. By analyzing the demonstration effect of the experience and characteristics of the construction of the international three major bay areas on the construction of Guangdong-Hong Kong-Macau Greater Bay Area, this paper analyzes the characteristics and advantages of Guangdong-Hong Kong-Macau Greater Bay Area in the process of development, and puts forward the main measures to promote the economic development of Guangdong in the new era.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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