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  1. Book ; Thesis: Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy

    Wilczek, Adriana Luisa / Thum, Thomas

    2021  

    Institution Medizinische Hochschule Hannover
    Institut für Molekulare und Translationale Therapiestrategien
    Author's details vorgelegt von Adriana Luisa Wilczek ; aus dem Institut für Molekulare und Translationale Therapiestrategien der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. Dr. med. Thomas Thum, PhD
    Language German ; English
    Size 52 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus „Scientific Reports", Jg. 9 (2019)
    HBZ-ID HT021687183
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Online ; E-Book: Non-coding RNAs in the vasculature

    Thum, Thomas / Dimmeler, Stefanie

    (Cardiac and vascular biology)

    2017  

    Author's details Thomas Thum, Stefanie Dimmeler editors
    Series title Cardiac and vascular biology
    Language English
    Size 1 Online-Ressource (vii, 101 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019283965
    ISBN 978-3-319-52945-5 ; 9783319529431 ; 3-319-52945-5 ; 3319529439
    DOI 10.1007/978-3-319-52945-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

  3. Book ; Conference proceedings ; Thesis: Identifikation von miR-143 als möglicher Einflussfaktor der Pathogenese von Aortenklappenstenosen

    Park, Da-Hee / Thum, Thomas

    = Identification of miR-143 as a major contributor for human stenotic aortic valve disease

    2020  

    Title variant Identification of miR-143 as a major contributor for human stenotic aortic valve disease
    Institution Medizinische Hochschule Hannover
    Event/congress Institut für Molekulare und Translationale Therapiestrategien
    Author's details vorgelegt von Da-Hee Park ; aus dem Institut für Molekulare und Translationale Therapiestrategien (IMTTS) der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. med. Dr. Thomas Thum, PhD
    Language German ; English
    Size 36 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Conference proceedings ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2021
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus "Journal of Cardiovascular Translational Research", Jg. 12 (2019)
    HBZ-ID HT021118145
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Orchestration of vascular smooth muscle cell plasticity using epigenetic therapy.

    Thum, Thomas

    European heart journal

    2022  Volume 43, Issue 43, Page(s) 4577–4578

    MeSH term(s) Humans ; Muscle, Smooth, Vascular/metabolism ; NF-kappa B/metabolism ; Cell Plasticity ; Monocytes/metabolism ; Myocytes, Smooth Muscle/metabolism ; Atherosclerosis/metabolism ; Epigenesis, Genetic ; Histone-Lysine N-Methyltransferase/metabolism
    Chemical Substances NF-kappa B ; DOT1L protein, human (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Characterization of a murine lncRNA candidate involved in fibroblast cell biology

    Kirste, Dominique Fabienne / Thum, Thomas

    2019  

    Institution Medizinische Hochschule Hannover
    Institut für Molekulare und Translationale Therapiestrategien
    Author's details vorgelegt von Dominique Fabienne Kirste ; aus dem Institut für Molekulare und Translationale Therapiestrategien der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. Dr. med. Thomas Thum, PhD
    Language English ; German
    Size X, 81 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2021
    Note Text auf Englisch, Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT021012122
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  6. Book ; Thesis: Nicht- kodierende RNA als diagnostisches- und therapeutisches Mittel bei kardiovaskulären Erkrankungen

    Kleeberger, Jan Alphard / Thum, Thomas

    2017  

    Institution Medizinische Hochschule Hannover
    Institut für Molekulare und Translationale Therapiestrategien
    Author's details vorgelegt von Jan Alphard Kleeberger aus Ulm ; aus dem Institut für Molekulare und Translationale Therapiestrategien der Medizinischen Hochschule Hannover ; wissenschaftliche Betreuung: Prof. Dr. Dr. med. Thomas Thum, PhD
    Language German ; English
    Size 4 ungezählte Blätter, 107 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2019
    Note Enthält 1 Sonderabdruck aus: American journal of physiology - Heart and circulatory physiology ; Volume 313, Issue 6. 2017. Page H1261-H1266
    HBZ-ID HT020243803
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  7. Article ; Online: The ESC Working Group on Myocardial Function.

    Thum, Thomas

    European heart journal

    2020  Volume 41, Issue 25, Page(s) 2346–2348

    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure?

    Thum, Thomas

    European heart journal

    2020  Volume 41, Issue 19, Page(s) 1807–1809

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Heart Failure ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development of a Mechanism-Based Next-Generation Therapeutic for Heart Failure Derived From the Dark Genome.

    Viereck, Janika / Thum, Thomas

    JACC. Basic to translational science

    2023  Volume 8, Issue 12, Page(s) 1595–1598

    Abstract: The ability of nucleic acids for intramolecular interactions opens manifold opportunities for novel medicines that have the potential to treat intractable human disorders, including heart disease. In this context, microRNAs have been identified as ... ...

    Abstract The ability of nucleic acids for intramolecular interactions opens manifold opportunities for novel medicines that have the potential to treat intractable human disorders, including heart disease. In this context, microRNAs have been identified as pleiotropic regulators of disease pathways and consequently as powerful therapeutic targets. With antisense oligonucleotides novel drug modalities are available to specifically inhibit as well as correct derailed microRNAs including pathological downstream pathways potentially restoring hallmarks of disease. However, only a handful of microRNA-targeting drugs underwent clinical testing so far, and none in the cardiovascular field. In this paper, the authors introduce the first-ever microRNA-based therapy that entered clinical trials in heart disease and present the previous development from target identification to first-in-human studies.
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Accelerating developments in heart failure.

    Thum, Thomas / Lam, Carolyn S P

    Cardiovascular research

    2022  Volume 118, Issue 18, Page(s) 3401–3402

    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/therapy
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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