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  1. Book ; Online ; E-Book: Marine macro- and microalgae

    Malcata, F. Xavier / Isabel, Sousa Pinto / Guedes, Ana Catarina Afonso

    an overview

    2019  

    Author's details editors F. Xavier Malcata, Isabel Sousa Pinto, A. Catarina Guedes
    Language English
    Size 1 Online-Ressource (viii, 333 Seiten)
    Publisher CRC Press
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019931496
    ISBN 978-1-4987-0534-9 ; 9781498705332 ; 1-4987-0534-0 ; 1498705332
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Surgical management of glaucoma secondary to indirect carotid-cavernous fistula: A case report.

    Lopes, Edgar Miguel Pontes / Ludovico, Inês Cerqueira / Mota, Catarina Dinis Mateus Guedes / Xavier, Ana Catarina Maltez / Duarte, Ana Filipa / Cardigos, Joana Sofia Dionísio

    International journal of surgery case reports

    2024  Volume 116, Page(s) 109317

    Abstract: Introduction: Indirect carotid-cavernous fistula (CCF) can lead to secondary glaucoma, posing significant treatment challenges. This paper discusses a case where standard embolization failed, and an Ahmed FP7 valved glaucoma tube shunt was crucial for ... ...

    Abstract Introduction: Indirect carotid-cavernous fistula (CCF) can lead to secondary glaucoma, posing significant treatment challenges. This paper discusses a case where standard embolization failed, and an Ahmed FP7 valved glaucoma tube shunt was crucial for managing the increased intraocular pressure (IOP), highlighting the necessity for individualized surgical approaches.
    Case presentation: A 48-year-old female presented in the emergency department with conjunctival hyperemia, proptosis and elevated IOP; initial imaging findings were indicative of orbital inflammatory disease. Further evaluation with cerebral CT angiography revealed a possible CCF. Subsequent angiography confirmed an indirect CCF type D, leading to the patient undergoing endovascular embolization. Final monitoring revealed a subtotal occlusion of the fistula. Although there was some improvement post-procedure, IOP remained elevated despite medication, and subsequent attempts of embolization were unsuccessful. Surgical intervention with a tube shunt was performed, allowing IOP to decreased to a normal range. Optic nerve head optical coherence tomography, standard automated perimetry, and best-corrected visual acuity remained stable during the 33-month follow-up.
    Discussion: In managing glaucoma linked to CCF, a multidisciplinary approach is critical. Conservative methods are often adequate, with spontaneous CCF closure observed in a significant percentage. Endovascular embolization is reserved for refractory cases, with embolization showing a higher rate of IOP normalization compared to medication alone. Yet, when fistula closure is challenging or contraindicated, individualized management strategies like glaucoma surgery may be employed.
    Conclusions: When fistula closure is not achievable, the Ahmed FP7 valved tube shunt can successfully regulate IOP with minimal complications, providing an effective alternative for refractory cases.
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Factorial Optimization of Ultrasound-Assisted Extraction of Phycocyanin from

    Assunção, Joana / Amaro, Helena M / Malcata, Francisco Xavier / Guedes, Ana Catarina

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: PC is a bioactive and colorant compound widely sought in the food, nutraceutical and cosmetic industries, and one of the most important pigments produced ... ...

    Abstract PC is a bioactive and colorant compound widely sought in the food, nutraceutical and cosmetic industries, and one of the most important pigments produced by
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12091389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Ruthenium(II)-Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs.

    Teixeira-Guedes, Catarina / Brás, Ana Rita / Teixeira, Ricardo G / Valente, Andreia / Preto, Ana

    Pharmaceutics

    2022  Volume 14, Issue 6

    Abstract: Colorectal cancer (CRC) is one of the most common malignancies and one of the leading causes of cancer-related death worldwide, urging the need for new and more efficient therapeutic approaches. Ruthenium complexes have emerged as attractive alternatives ...

    Abstract Colorectal cancer (CRC) is one of the most common malignancies and one of the leading causes of cancer-related death worldwide, urging the need for new and more efficient therapeutic approaches. Ruthenium complexes have emerged as attractive alternatives to traditional platinum-based compounds in the treatment of CRC. This work aims to evaluate anti-CRC properties, as well as to identify the mechanisms of action of ruthenium complexes with the general formula [Ru(η
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14061293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Healthy Social Network Use and Well-Being during Adolescence: A Biopsychosocial Approach.

    Gaspar, Tania / Carvalho, Marina / Noronha, Catarina / Guedes, Fábio Botelho / Cerqueira, Ana / de Matos, Margarida Gaspar

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: Screen time and the use of social networks is the most frequent form of leisure time occupation and socializing for adolescents. The present study is aimed at understanding and characterizing, from an ecological perspective, what distinguishes healthy ... ...

    Abstract Screen time and the use of social networks is the most frequent form of leisure time occupation and socializing for adolescents. The present study is aimed at understanding and characterizing, from an ecological perspective, what distinguishes healthy and less healthy or even dependent use of social media in young people and the influence on adolescents' well-being. This paper is based on the Health Behaviour in School-aged Children (HBSC) from 2022, a survey carried out every 4 years, in collaboration with the World Health Organisation (WHO), following an international protocol. A total of 7643 students from the 6th, 8th, 10th, and 12th school grades responded, of which 53.9% were female, with an average age of 15.05 (
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10101649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies.

    Pagels, Fernando / Vasconcelos, Vitor / Guedes, Ana Catarina

    Biomolecules

    2021  Volume 11, Issue 5

    Abstract: Carotenoids are tetraterpenoids molecules present in all photosynthetic organisms, responsible for better light-harvesting and energy dissipation in photosynthesis. In cyanobacteria, the biosynthetic pathway of carotenoids is well described, and apart ... ...

    Abstract Carotenoids are tetraterpenoids molecules present in all photosynthetic organisms, responsible for better light-harvesting and energy dissipation in photosynthesis. In cyanobacteria, the biosynthetic pathway of carotenoids is well described, and apart from the more common compounds (e.g., β-carotene, zeaxanthin, and echinenone), specific carotenoids can also be found, such as myxoxanthophyll. Moreover, cyanobacteria have a protein complex called orange carotenoid protein (OCP) as a mechanism of photoprotection. Although cyanobacteria are not the organism of choice for the industrial production of carotenoids, the optimisation of their production and the evaluation of their bioactive capacity demonstrate that these organisms may indeed be a potential candidate for future pigment production in a more environmentally friendly and sustainable approach of biorefinery. Carotenoids-rich extracts are described as antioxidant, anti-inflammatory, and anti-tumoral agents and are proposed for feed and cosmetical industries. Thus, several strategies for the optimisation of a cyanobacteria-based bioprocess for the obtention of pigments were described. This review aims to give an overview of carotenoids from cyanobacteria not only in terms of their chemistry but also in terms of their biotechnological applicability and the advances and the challenges in the production of such compounds.
    MeSH term(s) Biosynthetic Pathways ; Biotechnology/methods ; Biotechnology/standards ; Carotenoids/metabolism ; Cyanobacteria/chemistry ; Cyanobacteria/metabolism ; Photosynthesis ; beta Carotene/metabolism
    Chemical Substances beta Carotene (01YAE03M7J) ; Carotenoids (36-88-4)
    Language English
    Publishing date 2021-05-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11050735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prognostic significance of specific EEG patterns after cardiac arrest in a Lisbon Cohort.

    Guedes, Beatriz / Manita, Manuel / Rita Peralta, Ana / Catarina Franco, Ana / Bento, Luís / Bentes, Carla

    Clinical neurophysiology practice

    2020  Volume 5, Page(s) 147–151

    Abstract: Objective: To evaluate if EEG patterns considered highly malignant are reliable predictors not only of poor neurological outcome but also reliable predictors of death.: Methods: Retrospectively, EEGs from Cardiac Arrest (CA) patients of two teaching ... ...

    Abstract Objective: To evaluate if EEG patterns considered highly malignant are reliable predictors not only of poor neurological outcome but also reliable predictors of death.
    Methods: Retrospectively, EEGs from Cardiac Arrest (CA) patients of two teaching hospitals in Lisbon were classified into 3 groups: highly malignant, malignant, and benign groups. Outcome was assessed at 6 months after CA by CPC (Cerebral Performance Categories) scale. We evaluated the accuracy of these patterns to predict poor neurological outcome and death.
    Results: We included 106 patients for analysis. All patients with a highly malignant EEG (n = 37) presented a poor neurological outcome. Those patterns were also associated with death. Malignant EEG patterns were not associated with poor neurological outcome. Benign EEG patterns were associated with good neurological recovery (p < 0.0001).
    Conclusion: Highly malignant EEG patterns were strongly associated with poor neurological outcome and can be considered to be predictors of death.
    Significance: This study increased the knowledge about the value of EEG as a tool in outcome prediction of patients after cardiac arrest.
    Language English
    Publishing date 2020-07-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2467-981X
    ISSN (online) 2467-981X
    DOI 10.1016/j.cnp.2020.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Colon microbiota modulation by dairy-derived diet: new strategy for prevention and treatment of colorectal cancer.

    Gomes, Sara / Teixeira-Guedes, Catarina / Silva, Elisabete / Baltazar, Fátima / Preto, Ana

    Food & function

    2022  Volume 13, Issue 18, Page(s) 9183–9194

    Abstract: An unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and ... ...

    Abstract An unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and therapeutic approaches. It is already known that CRC patients have alterations in the microbial community and metabolism. In this regard, a concept that has been recently attracting the attention of the scientific community is the development of functional food or nutraceuticals, as a new and more effective strategy to overcome CRC patient-associated dysbiosis. Particularly, dairy product enriched diets are the major dairy source of dietary calcium, vitamin D and folate intake, which are well-known to have a protective effect against CRC development. In addition, these products are rich in both pre- and probiotics, constituting a double strategy to modulate both the intestinal microbiota composition and the production of microbial metabolites. Short-chain fatty acids (SCFA), namely, acetate, butyrate, and propionate, are major contributors to colonic homeostasis since they regulate several biological and metabolic processes. In this review, we performed a state of art study concerning the use of dietary patterns, specifically the dairy-derived diet, in the modulation of the human microbiota and their potential use as pre-, pro- or synbiotics for the development of new preventive and therapeutic strategies for CRC.
    MeSH term(s) Butyrates ; Calcium, Dietary ; Colorectal Neoplasms/prevention & control ; Diet ; Fatty Acids, Volatile ; Folic Acid ; Gastrointestinal Microbiome ; Humans ; Propionates ; Vitamin D/therapeutic use
    Chemical Substances Butyrates ; Calcium, Dietary ; Fatty Acids, Volatile ; Propionates ; Vitamin D (1406-16-2) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo01720b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How Is Leisure Related to Wellbeing and to Substance Use? The Probable Key Role of Autonomy and Supervision.

    Tomé, Gina / Guedes, Fábio Botelho / Cerqueira, Ana / Noronha, Catarina / de Freitas, Joaquim Castro / Freire, Teresa / de Matos, Margarida Gaspar

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: The present research is based on a large and representative national survey and intends to analyse the correlation of several leisure activities with risk, and with health and well-being outcomes. This work is part of the Health Behaviour in School-aged ... ...

    Abstract The present research is based on a large and representative national survey and intends to analyse the correlation of several leisure activities with risk, and with health and well-being outcomes. This work is part of the Health Behaviour in School-aged Children (HBSC) study, a collaborative WHO international study that aims to explore the school-aged children behaviour regarding health and risk behaviours in their life contexts. Participants were 8215 Portuguese adolescents, randomly chosen from those attending the 6th, 8th, 10th and 12th grades in 2018. The sample included 52.7% of girls and the mean age was 14.36 years old. Descriptive and comparative analyses were performed (ANOVAS and Chi-Square). The results of the present study suggested that several leisure activities, namely sports and social engagement activities (politic involvement and participation, religious activities, scouting and volunteer work), are associated with the adolescents' well-being and life satisfaction. However, these types of activities can also be associated with an increase in substance use. However, some activities are also associated with risky behaviour. Identifying activities that promote well-being in young people can be important for professionals, families and public policies.
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10050773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Colon microbiota modulation by dairy-derived diet: new strategy for prevention and treatment of colorectal cancer

    Gomes, Sara / Teixeira-Guedes, Catarina / Silva, Elisabete / Baltazar, Fátima / Preto, Ana

    Food & function. 2022 Sept. 22, v. 13, no. 18 p.9183-9194

    2022  

    Abstract: An unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and ... ...

    Abstract An unbalanced diet is one of the well-known risk factors for the development of colorectal cancer (CRC). This type of cancer is currently the main cause of cancer-related deaths worldwide, urging the need for new and more effective preventive and therapeutic approaches. It is already known that CRC patients have alterations in the microbial community and metabolism. In this regard, a concept that has been recently attracting the attention of the scientific community is the development of functional food or nutraceuticals, as a new and more effective strategy to overcome CRC patient-associated dysbiosis. Particularly, dairy product enriched diets are the major dairy source of dietary calcium, vitamin D and folate intake, which are well-known to have a protective effect against CRC development. In addition, these products are rich in both pre- and probiotics, constituting a double strategy to modulate both the intestinal microbiota composition and the production of microbial metabolites. Short-chain fatty acids (SCFA), namely, acetate, butyrate, and propionate, are major contributors to colonic homeostasis since they regulate several biological and metabolic processes. In this review, we performed a state of art study concerning the use of dietary patterns, specifically the dairy-derived diet, in the modulation of the human microbiota and their potential use as pre-, pro- or synbiotics for the development of new preventive and therapeutic strategies for CRC.
    Keywords acetates ; butyrates ; colon ; colorectal neoplasms ; dairy products ; dietary calcium ; dysbiosis ; folic acid ; functional foods ; homeostasis ; humans ; intestinal microorganisms ; metabolism ; metabolites ; microbial communities ; probiotics ; propionic acid ; protective effect ; risk ; therapeutics
    Language English
    Dates of publication 2022-0922
    Size p. 9183-9194.
    Publishing place The Royal Society of Chemistry
    Document type Article ; Online
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo01720b
    Database NAL-Catalogue (AGRICOLA)

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