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Article ; Online: Urinary norepinephrine and epinephrine excretion rates are heritable, but not associated with office and ambulatory blood pressure.

Bosker, Fokko J / Wu, Ting / Gladkevich, Anatoliy / Ge, Dongliang / Treiber, Frank A / Snieder, Harold

Hypertension research : official journal of the Japanese Society of Hypertension

2012 Volume 35, Issue 12, Page(s) 1164–1170

Abstract: Genetic and environmental contributions to urinary excretion rates of norepinephrine (U(NE)V) and epinephrine (U(E)V) and their association with blood pressure (BP) were investigated in 91 African American (mean age, 17.3±2.6 years) and 101 European ... ...

Abstract	Genetic and environmental contributions to urinary excretion rates of norepinephrine (U(NE)V) and epinephrine (U(E)V) and their association with blood pressure (BP) were investigated in 91 African American (mean age, 17.3±2.6 years) and 101 European American (mean age, 18.7±3.4 years) mono- and di-zygotic twins. Genetic modeling was performed using Mx software. U(NE)V (1.9±1.3 μg h(-1)) and U(E)V (0.2±0.2 μg h(-1)) were highly correlated (r=0.81, P<0.001). Significant heritabilities for U(NE)V (0.68) and U(E)V (0.74) without ethnic and gender effects were observed. The genetic correlation between U(NE)V and U(E)V was 0.86. There was no clear pattern of correlations for U(NE)V and U(E)V with BP measures in European Americans, but African Americans showed some inverse correlations of moderate size. Measurements of U(NE)V and U(E)V provide a viable method for the study of sympathetic tone and are substantially heritable.
MeSH term(s)	Adolescent ; Adult ; African Americans ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Child ; Epinephrine/urine ; European Continental Ancestry Group ; Female ; Humans ; Male ; Norepinephrine/urine ; Sympathetic Nervous System/physiology
Chemical Substances	Norepinephrine (X4W3ENH1CV) ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2012-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/hr.2012.104
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Article ; Online: Major depressive disorder is associated with changes in a cluster of serum and urine biomarkers.

van Buel, Erin M / Meddens, Marcus J M / Arnoldussen, Eduard A / van den Heuvel, Edwin R / Bohlmeijer, Willem C / den Boer, Johan A / Muller Kobold, Anna / Boonman-de Winter, Leandra J M / van Rumpt, Dirk / Timmers, Lambertus F J / Veerman, Mattheus F A / Kamphuis, Johannes S / Gladkevich, Anatoliy V / Schoevers, Robert A / Luiten, Paul G M / Eisel, Ulrich L M / Bosker, Fokko J / Klein, Hans C

Journal of psychosomatic research

2019 Volume 125, Page(s) 109796

Abstract: Major Depressive Disorder (MDD) is a heterogeneous disorder with a considerable symptomatic overlap with other psychiatric and somatic disorders. This study aims at providing evidence for association of a set of serum and urine biomarkers with MDD. We ... ...

Abstract	Major Depressive Disorder (MDD) is a heterogeneous disorder with a considerable symptomatic overlap with other psychiatric and somatic disorders. This study aims at providing evidence for association of a set of serum and urine biomarkers with MDD. We analyzed urine and serum samples of 40 MDD patients and 47 age- and sex-matched controls using 40 potential MDD biomarkers (21 serum biomarkers and 19 urine biomarkers). All participants were of Caucasian origin. We developed an algorithm to combine the heterogeneity at biomarker level. This method enabled the identification of correlating biomarkers based on differences in variation and distribution between groups, combined the outcome of the selected biomarkers, and calculated depression probability scores (the "bio depression score"). Phenotype permutation analysis showed a significant discrimination between MDD and euthymic (control) subjects for biomarkers in urine (P < .001), in serum (P = .02) and in the combined serum plus urine result (P < .001). Based on this algorithm, a combination of 8 urine biomarkers and 9 serum biomarkers were identified to correlate with MDD, enabling an area under the curve (AUC) of 0.955 in a Receiver Operating Characteristic (ROC) analysis. Selection of either urine biomarkers or serum biomarkers resulted in AUC values of 0.907 and 0.853, respectively. Internal cross-validation (5-fold) confirmed the association of this set of biomarkers with MDD.
MeSH term(s)	Adult ; Algorithms ; Area Under Curve ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/urine ; Female ; Humans ; Male ; Middle Aged ; ROC Curve
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2019.109796
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Article: Lymphocytes as a neural probe: potential for studying psychiatric disorders.

Gladkevich, Anatoliy / Kauffman, Henk F / Korf, Jakob

Progress in neuro-psychopharmacology & biological psychiatry

2004 Volume 28, Issue 3, Page(s) 559–576

Abstract: There is an increasing body evidence pointing to a close integration between the central nervous system (CNS) and immunological functions with lymphocytes playing therein a central role. The authors provide arguments to consider blood lymphocytes as a ... ...

Abstract	There is an increasing body evidence pointing to a close integration between the central nervous system (CNS) and immunological functions with lymphocytes playing therein a central role. The authors provide arguments to consider blood lymphocytes as a convenient probe of--an albeit--limited number of cellular functions, including gene expression. The use of brain biopsies of living patients is unrealistic for biochemical investigation, therefore lymphocytes may be a convenient and accessible alternative. Numerous studies showed similarities between receptor expression and mechanisms of transduction processes of cells in the nervous system (e.g. neurons and glia) and lymphocytes. In several neuropsychiatric disorders, alteration of metabolism and cellular functions in the CNS, as well as disturbances in the main neurotransmitter and hormonal systems are concomitant with altered function and metabolism of blood lymphocytes. We summarize relevant investigations on depression, stress, Alzheimer's disease (AD) and schizophrenia. New techniques such as cDNA microarray gene expression and proteomics may give clues to define molecular abnormalities in psychiatric disorders and could eventually reveal information for diagnostic and treatment purposes. Taken together, these considerations suggest that lymphocyte could reflect the metabolism of brain cells, and may be exploited as a neural and possible genetic probe in studies of psychiatric disorders.
MeSH term(s)	Animals ; Carrier Proteins/physiology ; Circadian Rhythm/physiology ; Cytokines/metabolism ; DNA, Complementary/biosynthesis ; DNA, Complementary/genetics ; Humans ; Lymphocytes/metabolism ; Lymphocytes/physiology ; Mental Disorders/metabolism ; Mental Disorders/physiopathology
Chemical Substances	Carrier Proteins ; Cytokines ; DNA, Complementary
Language	English
Publishing date	2004-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2004.01.009
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Article ; Online: Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses.

Jentsch, Mike C / Van Buel, Erin M / Bosker, Fokko J / Gladkevich, Anatoliy V / Klein, Hans C / Oude Voshaar, Richard C / Ruhé, Eric G / Eisel, Uli L M / Schoevers, Robert A

Biomarkers in medicine

2015 Volume 9, Issue 3, Page(s) 277–297

Abstract: Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of symptomatic criteria alone. It would be of great help when specific biomarkers for various subtypes and symptom clusters of depression become available to assist in ... ...

Abstract	Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of symptomatic criteria alone. It would be of great help when specific biomarkers for various subtypes and symptom clusters of depression become available to assist in diagnosis and subtyping of depression, and to enable monitoring and prognosis of treatment response. However, currently known biomarkers do not reach sufficient sensitivity and specificity, and often the relation to underlying pathophysiology is unclear. In this review, we evaluate various biomarker approaches in terms of scientific merit and clinical applicability. Finally, we discuss how combined biomarker approaches in both preclinical and clinical studies can help to make the connection between the clinical manifestations of depression and the underlying pathophysiology.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/etiology ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/physiopathology ; Humans
Chemical Substances	Biomarkers
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm.14.114
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Article ; Online: Changes in winter depression phenotype correlate with white blood cell gene expression profiles: a combined metagene and gene ontology approach.

Bosker, Fokko J / Terpstra, Peter / Gladkevich, Anatoliy V / Janneke Dijck-Brouwer, D A / te Meerman, Gerard / Nolen, Willem A / Schoevers, Robert A / Meesters, Ybe

Progress in neuro-psychopharmacology & biological psychiatry

2015 Volume 58, Page(s) 8–14

Abstract: In the present study we evaluate the feasibility of gene expression in white blood cells as a peripheral marker for winter depression. Sixteen patients with winter type seasonal affective disorder were included in the study. Blood was taken by venous ... ...

Abstract	In the present study we evaluate the feasibility of gene expression in white blood cells as a peripheral marker for winter depression. Sixteen patients with winter type seasonal affective disorder were included in the study. Blood was taken by venous puncture at three time points; in winter prior and following bright light therapy and in summer. RNA was isolated, converted into cRNA, amplified and hybridized on Illumina® gene expression arrays. The raw optical array data were quantile normalized and thereafter analyzed using a metagene approach, based on previously published Affymetrix gene array data. The raw data were also subjected to a secondary analysis focusing on circadian genes and genes involved in serotonergic neurotransmission. Differences between the conditions were analyzed, using analysis of variance on the principal components of the metagene score matrix. After correction for multiple testing no statistically significant differences were found. Another approach uses the correlation between metagene factor weights and the actual expression values, averaged over conditions. When comparing the correlations of winter vs. summer and bright light therapy vs. summer significant changes for several metagenes were found. Subsequent gene ontology analyses (DAVID and GeneTrail) of 5 major metagenes suggest an interaction between brain and white blood cells. The hypothesis driven analysis with a smaller group of genes failed to demonstrate any significant effects. The results from the combined metagene and gene ontology analyses support the idea of communication between brain and white blood cells. Future studies will need a much larger sample size to obtain information at the level of single genes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Gene Expression Profiling ; Gene Ontology ; Humans ; Microarray Analysis ; Middle Aged ; Phenotype ; Phototherapy ; Psychiatric Status Rating Scales ; Seasonal Affective Disorder/blood ; Seasonal Affective Disorder/genetics ; Seasonal Affective Disorder/therapy ; Seasons ; Young Adult
Language	English
Publishing date	2015-04-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2014.10.015
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Article: Microarray profiling of lymphocytes in internal diseases with an altered immune response: potential and methodology.

Gladkevich, Anatoliy / Nelemans, S Adriaan / Kauffman, Henk F / Korf, Jakob

Mediators of inflammation

2005 Volume 2005, Issue 6, Page(s) 317–330

Abstract: Recently it has become possible to investigate expression of all human genes with microarray technique. The authors provide arguments to consider peripheral white blood cells and in particular lymphocytes as a model for the investigation of ... ...

Abstract	Recently it has become possible to investigate expression of all human genes with microarray technique. The authors provide arguments to consider peripheral white blood cells and in particular lymphocytes as a model for the investigation of pathophysiology of asthma, RA, and SLE diseases in which inflammation is a major component. Lymphocytes are an alternative to tissue biopsies that are most often difficult to collect systematically. Lymphocytes express more than 75% of the human genome, and, being an important part of the immune system, they play a central role in the pathogenesis of asthma, RA, and SLE. Here we review alterations of gene expression in lymphocytes and methodological aspects of the microarray technique in these diseases. Lymphocytic genes may become activated because of a general nonspecific versus disease-specific mechanism. The authors suppose that in these diseases microarray profiles of gene expression in lymphocytes can be disease specific, rather than inflammation specific. Some potentials and pitfalls of the array technologies are discussed. Optimal clinical designs aimed to identify disease-specific genes are proposed. Lymphocytes can be explored for research, diagnostic, and possible treatment purposes in these diseases, but their precise value should be clarified in future investigation.
MeSH term(s)	Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/physiopathology ; Asthma/genetics ; Asthma/immunology ; Asthma/physiopathology ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Immune System/physiology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology ; Lymphocytes/immunology ; Lymphocytes/physiology ; Oligonucleotide Array Sequence Analysis/methods
Language	English
Publishing date	2005-12-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	0962-9351
ISSN	0962-9351
DOI	10.1155/MI.2005.317
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Article ; Online: Microarray Profiling of Lymphocytes in Internal DiseasesWith an Altered Immune Response

Jakob Korf / Henk F. Kauffman / S. Adriaan Nelemans / Anatoliy Gladkevich

Mediators of Inflammation, Vol 2005, Iss 6, Pp 317-

Potential andMethodology

2005 Volume 330

Keywords	Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2005-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: Comparison of brain and blood gene expression in an animal model of negative symptoms in schizophrenia.

Bosker, Fokko J / Gladkevich, Anatoliy V / Pietersen, Charmaine Y / Kooi, Krista A / Bakker, Petra L / Gerbens, Frans / den Boer, Johan A / Korf, Jakob / te Meerman, Gerard

Progress in neuro-psychopharmacology & biological psychiatry

2012 Volume 38, Issue 2, Page(s) 142–148

Abstract: Objectives: To investigate the potential of white blood cells as probes for central processes we have measured gene expression in both the anterior cingulate cortex and white blood cells using a putative animal model of negative symptoms in ... ...

Abstract	Objectives: To investigate the potential of white blood cells as probes for central processes we have measured gene expression in both the anterior cingulate cortex and white blood cells using a putative animal model of negative symptoms in schizophrenia. Methods: The model is based on the capability of ketamine to induce psychotic symptoms in healthy volunteers and to worsen such symptoms in schizophrenic patients. Classical fear conditioning is used to assess emotional processing and cognitive function in animals exposed to sub-chronic ketamine vs. controls. Gene expression was measured using a commercially sourced whole genome rat gene array. Data analyses were performed using ANOVA (Systat 11). Results: In both anterior cingulate cortex and white blood cells a significant interaction between ketamine and fear conditioning could be observed. The outcome is largely supported by our subsequent metagene analysis. Moreover, the correlation between gene expression in brain and blood is about constant when no ketamine is present (r~0.4). With ketamine, however, the correlation becomes very low (r~0.2) when there is no fear, but it increases to ~0.6 when fear and ketamine are both present. Our results show that under normal conditions ketamine lowers gene expression in the brain, but this effect is completely reversed in combination with fear conditioning, indicating a stimulatory action. Conclusion: This paradoxical outcome indicates that extreme care must be taken when using gene expression data from white blood cells as marker for psychiatric disorders, especially when pharmacological and environmental interactions are at play.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/metabolism ; Conditioning (Psychology)/drug effects ; Disease Models, Animal ; Fear/drug effects ; Gene Expression/physiology ; Ketamine/pharmacology ; Rats ; Schizophrenia/blood ; Schizophrenia/genetics ; Schizophrenia/metabolism
Chemical Substances	Ketamine (690G0D6V8H)
Language	English
Publishing date	2012-08-07
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2012.03.003
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Article ; Online: Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors.

Bosker, Fokko J / Folgering, Joost H A / Gladkevich, Anatoliy V / Schmidt, Anne / van der Hart, Marieke C G / Sprouse, Jeffrey / den Boer, Johan A / Westerink, Ben H C / Cremers, Thomas I F H

Journal of neurochemistry

2009 Volume 108, Issue 5, Page(s) 1126–1135

Abstract: Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT(1A) autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. ... ...

Abstract	Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT(1A) autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. On the basis of a previous study, we decided to investigate the involvement of the 5-HT(7) receptors. Experiments were performed with the specific 5-HT(7) antagonist SB 258741 and the putative 5-HT(7) agonist AS19. In this study WAY 100.635 was used to block 5-HT(1A) receptors. Systemic administration of SB 258741 significantly reduced the effect of combined selective serotonin reuptake inhibitor and WAY 100.635 administration on extracellular 5-HT in the ventral hippocampus as well as 5-HT neuronal firing in the dorsal raphe nucleus. In the microdialysis study, co-administration of AS19 and WAY 100.635 showed a biphasic effect on extracellular 5-HT in ventral hippocampus, hinting at opposed 5-HT(7) receptor mediated effects. In the electrophysiological experiments, systemic administration of AS19 alone displayed a bell-shaped dose-effect curve: moderately increasing 5-HT neuronal firing at lower doses while decreasing it at higher doses. SB 258741 was capable of blocking the effect of AS19 at a low dose. This is consistent with the pharmacological profile of AS19, displaying high affinity for 5-HT(7) receptors and moderate affinity for 5-HT(1A) receptors. The data are in support of an excitatory effect of selective serotonin reuptake inhibitors on 5-HT neuronal activity mediated by 5-HT(7) receptors. It can be speculated, that the restoration of 5-HT neuronal firing upon chronic antidepressant treatment, which is generally attributed to desensitization of 5-HT(1A) receptors alone, in fact results from a shift in balance between 5-HT(1A) and 5-HT(7) receptor function.
MeSH term(s)	Action Potentials/drug effects ; Action Potentials/physiology ; Analysis of Variance ; Animals ; Brain/cytology ; Chromatography, High Pressure Liquid/methods ; Citalopram/pharmacology ; Drug Interactions ; Electrochemistry/methods ; Male ; Microdialysis/methods ; Neurons/drug effects ; Neurons/physiology ; Piperazines/pharmacology ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Pyrrolidines/pharmacology ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A/physiology ; Receptors, Serotonin/physiology ; Serotonin/metabolism ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin Agents/pharmacology ; Serotonin Uptake Inhibitors/pharmacology ; Tetrahydronaphthalenes/pharmacology ; Tosyl Compounds/pharmacology ; Wakefulness
Chemical Substances	5-HT(7) receptor, rat ; AS 19 compound ; Piperazines ; Piperidines ; Pyrazoles ; Pyridines ; Pyrrolidines ; Receptors, Serotonin ; SB258741 ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin Agents ; Serotonin Uptake Inhibitors ; Tetrahydronaphthalenes ; Tosyl Compounds ; Citalopram (0DHU5B8D6V) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (333DO1RDJY) ; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide (71IH826FEG)
Language	English
Publishing date	2009-03
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/j.1471-4159.2008.05850.x
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Article ; Online: Biochemical and behavioral effects of long-term citalopram administration and discontinuation in rats: role of serotonin synthesis.

Bosker, Fokko J / Tanke, Marit A C / Jongsma, Minke E / Cremers, Thomas I F H / Jagtman, Evelien / Pietersen, Charmaine Y / van der Hart, Marieke G C / Gladkevich, Anatoliy V / Kema, Ido P / Westerink, Ben H C / Korf, Jakob / den Boer, Johan A

Neurochemistry international

2010 Volume 57, Issue 8, Page(s) 948–957

Abstract: We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with ... ...

Abstract	We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with brain tissue assays and microdialysis; behavior was assessed as the acoustic startle reflex. Long-term SSRI administration to rats reduced the content of 5-HT and its main metabolite shortly after inhibition of 5-HT synthesis in many brain areas with more than 50%. Turnover was not appreciably decreased, but significantly increased within 48h of drug discontinuation. The microdialysis experiments indicate that neuronal release of 5-HT depends strongly on new synthesis and emphasize the role of 5-HT(1B) receptors in the regulation of these processes. Discontinuation of the SSRI rapidly increased behavioral reactivity to the external stimulus. Additional startle experiments suggest that the increased reactivity is more likely related to the reduced extracellular 5-HT levels than to impaired synthesis. The combination of the marked reduction of serotonin content and limited synthesis may destabilize brain serotonin transmission during long-term SSRI treatment. These combined effects may compromise the efficacy of an SSRI therapy and facilitate behavioral changes following non-compliance.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Brain Chemistry/drug effects ; Brain Chemistry/physiology ; Citalopram/pharmacology ; Depressive Disorder/drug therapy ; Depressive Disorder/metabolism ; Depressive Disorder/psychology ; Male ; Rats ; Rats, Wistar ; Serotonin/biosynthesis ; Serotonin/deficiency ; Serotonin Uptake Inhibitors/pharmacology ; Substance Withdrawal Syndrome/metabolism ; Substance Withdrawal Syndrome/psychology ; Time Factors
Chemical Substances	Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V) ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Journal Article
ZDB-ID	283190-9
ISSN	1872-9754 ; 0197-0186
ISSN (online)	1872-9754
ISSN	0197-0186
DOI	10.1016/j.neuint.2010.10.001
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