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  1. Article ; Online: Determination of antihistaminic drugs alcaftadine and olopatadine hydrochloride via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: application to dosage forms.

    Derayea, Sayed M / Badr El-Din, Khalid M / Ahmed, Ahmed S / Khorshed, Ahmed A / Oraby, Mohamed

    BMC chemistry

    2024  Volume 18, Issue 1, Page(s) 40

    Abstract: ... of Alcaftadine or Olopatadine hydrochloride on the intrinsic fluorescence of eosin Y in a 0.1 M acetate buffer ...

    Abstract Four sensitive and fast analytical approaches relied on ion pairing with eosin Y were built up and evaluated using spectroscopy for determination of Alcaftadine and Olopatadine hydrochloride with high sensitivity and selectivity. Two spectrofluorimetric techniques were employed to observe the quenching effect of Alcaftadine or Olopatadine hydrochloride on the intrinsic fluorescence of eosin Y in a 0.1 M acetate buffer solution at pH 3.8 and 3.3 for Alcaftadine and Olopatadine hydrochloride, respectively. Those methods are considered the first spectrofluorimetric methods for Alcaftadine and Olopatadine hydrochloride assay. The fluorescence quenching effect was linear with concentration ranging from 150 to 2000 and 200 to 2000 ng mL
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01137-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Audio / Video ; Thesis: CT-Perfusion und Dual-energy-CT von Tumoren in der Hals-Nasen-Ohren Region

    Tawfik Mohamed Sayed Ahmed, Ahmed Mohamed

    2011  

    Author's details vorgelegt von Ahmed Mohamed Tawfik Mohamed Sayed Ahmed
    Language English
    Size III, 104 S., Ill., graph. Darst. ; 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2011
    HBZ-ID HT016929833
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 MO 521 order for loan Magazin

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  3. Article ; Online: Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations.

    Derayea, Sayed M / Badr El-Din, Khalid M / Ahmed, Ahmed S / Khorshed, Ahmed A / Oraby, Mohamed

    BMC chemistry

    2024  Volume 18, Issue 1, Page(s) 18

    Abstract: For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective ... ...

    Abstract For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective spectroscopic approach for estimating Montelukast sodium and Bilastine in pharmaceutical dosage form without previous separation. The selected technique focuses on measuring the synchronized fluorescence of the studied medications at a fixed wavelength range (Δλ) = 110 nm, and using the amplitude of the first derivative's peak at 381 and 324 nm, for quantitative estimation of Montelukast sodium and Bilastine, respectively. The impacts of different factors on the referred drugs' synchronized fluorescence intensity were investigated and adjusted. The calibration plots for were found to be linear over concentration ranges of 50-2000 ng mL
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-024-01116-3
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  4. Article ; Online: Imaging of Bifid Fourth Rib Presenting as a Chest Wall Mass in an Infant.

    Garg, Pankaj / El-Sayed Ahmed, Magdy M

    Texas Heart Institute journal

    2023  Volume 50, Issue 1

    MeSH term(s) Humans ; Infant ; Thoracic Wall/diagnostic imaging ; Ribs/diagnostic imaging ; Ribs/surgery ; Diagnostic Imaging
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-22-7975
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    Zs.A 1452: Show issues Location:
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    Zs.MO 484: Show issues

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  5. Article ; Online: Metabolic profiling, antimicrobial, anticancer, and in vitro and in silico immunomodulatory investigation of Aspergillus niger OR730979 isolated from the Western Desert, Egypt.

    Baz, Amira M / Elwy, Esmat / Ahmed, Wafaa A / El-Sayed, Heba

    International microbiology : the official journal of the Spanish Society for Microbiology

    2024  

    Abstract: Ten fungal species were isolated from soil in the Western Desert and Wadi El-Natron in Egypt. All fungal isolates were morphologically recognized down to the species level. Methanol extracts of fungal mycelia and ethyl acetate extracts of culture ... ...

    Abstract Ten fungal species were isolated from soil in the Western Desert and Wadi El-Natron in Egypt. All fungal isolates were morphologically recognized down to the species level. Methanol extracts of fungal mycelia and ethyl acetate extracts of culture filtrate from the isolated fungi were evaluated for antimicrobial activity against six pathogenic bacteria and one pathogenic yeast (Candida albicans ATCC20231). Only ethyl acetate extracts of Fusarium circinatum, Aspergillus niger, and Aspergillus terreus culture filtrates showed significant antimicrobial activity against the majority of the investigated pathogens. The culture filtrate extract of Aspergillus niger exhibited notable cytotoxicity towards the breast cancer (MCF-7) cell line, with the lowest detected IC
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-024-00503-z
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    Zs.A 4964: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings.

    Sroor, Farid M / El-Sayed, Ahmed F / Abdelraof, Mohamed

    Archiv der Pharmazie

    2024  , Page(s) e2300738

    Abstract: The targeted compounds were prepared using both (9H-fluoren-9-ylidene)hydrazine (1) and 10H-phenothiazine (2) as starting materials. The treatment of 1 or 2 with different isocyanates afforded the title compounds 7a-d, 8a, and 8b in excellent yield. All ... ...

    Abstract The targeted compounds were prepared using both (9H-fluoren-9-ylidene)hydrazine (1) and 10H-phenothiazine (2) as starting materials. The treatment of 1 or 2 with different isocyanates afforded the title compounds 7a-d, 8a, and 8b in excellent yield. All compounds were characterized and ascertained by infrared, nuclear magnetic resonance, and elemental analyses as well as single-crystal X-ray diffraction. The antimicrobial efficiency of all was tested in vitro, and a noticeable inhibition activity against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans was obtained by compounds 7a, 7b, 8a, and 8b. Moreover, the biofilm mechanism activity was strongly inhibited by compounds 7b and 8b for all bacterial pathogens, with a percentage ratio of more than 55%. The findings from the molecular docking simulation revealed that compounds 7a, 7b, 8a, and 8b exhibited favorable binding energies and interacted effectively with the active sites of sterol 14-demethylase, dihydropteroate synthase, gyrase B, LasR (major transcriptional activator of P. aeruginosa), and carbapenemase for C. albicans, S. aureus, B. subtills, K. pneumoniae, and P. aeruginosa, respectively. These results suggest that the compounds have the potential to inhibit the activity of these enzymes and demonstrate promising antimicrobial properties. Moreover, the in silico evaluation of drug likeness and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles for compounds 7a, 7b, 8a, and 8b demonstrated their compatibility with Lipinski's, Ghose's, Veber's, Muegge's, and Egan's rules. These findings suggest that these compounds possess favorable physicochemical properties, making them promising candidates for continued drug development efforts.
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202300738
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  7. Article ; Online: Value of Serum Asymmetric Dimethylarginine (ADMA) As a Novel Biomarker for Uveitis in Behçet's Disease.

    Sayed, Omima Ahmed / Abdel-Magied, Rasha Ali / Ahmed Abu Elela, Mostafa / Safwat, Abdallah Mm / Abdel-Nasser, Ahmed M

    Ocular immunology and inflammation

    2024  , Page(s) 1–7

    Abstract: Purpose: To evaluate the serum asymmetric dimethylarginine (ADMA) level as a biomarker for uveitis in Behçet's Disease (BD).: Methods: In this cross-sectional study, two groups of BD patients were examined: 33 with uveitis and 27 without uveitis. All ...

    Abstract Purpose: To evaluate the serum asymmetric dimethylarginine (ADMA) level as a biomarker for uveitis in Behçet's Disease (BD).
    Methods: In this cross-sectional study, two groups of BD patients were examined: 33 with uveitis and 27 without uveitis. All patients were clinically evaluated, with disease activity measured by Behçet's Disease Current Activity Form (BDCAF) score. They also underwent thorough ophthalmic evaluation, and routine laboratory investigations, including serum ADMA.
    Results: Patients with BD who experienced active or inactive uveitis had higher levels of serum ADMA compared to those without uveitis. Anterior (ρ = 0.34,
    Conclusion: Serum ADMA level can serve as a novel biomarker of uveitis in BD and its severity with good diagnostic accuracy, regardless of its site or activity.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2024.2342378
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    Zs.A 4004: Show issues Location:
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  8. Article: Emerging Pathogens Causing Acute Hepatitis.

    Sayed, Ibrahim M / El-Shamy, Ahmed / Abdelwahab, Sayed F

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Acute hepatitis is defined as an inflammation or injury in the hepatocytes that continues for a short period of time (less than 6 months) [ ... ]. ...

    Abstract Acute hepatitis is defined as an inflammation or injury in the hepatocytes that continues for a short period of time (less than 6 months) [...].
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122952
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  9. Article ; Online: Unveiling the Antiviral Efficacy of Forskolin: A Multifaceted In Vitro and In Silico Approach.

    Amen, Yhiya / Selim, Mohamed A / Suef, Reda A / Sayed, Ahmed M / Othman, Ahmed

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: ... Coleus ... ...

    Abstract Coleus forskohlii
    MeSH term(s) Colforsin/pharmacology ; Colforsin/chemistry ; Cathepsin L ; Molecular Docking Simulation ; Herpesvirus 1, Human/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry
    Chemical Substances Colforsin (1F7A44V6OU) ; Cathepsin L (EC 3.4.22.15) ; Antiviral Agents
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030704
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    Zs.MO 81: Show issues

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  10. Article ; Online: A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration.

    Ahmed, Sadek / Amin, Maha M / Sayed, Sinar

    Drug delivery

    2023  Volume 30, Issue 1, Page(s) 2179129

    Abstract: This review aims to comprehensively highlight the recent nanosystems enclosing Fenticonazole nitrate (FTN) and to compare between them regarding preparation techniques, studied factors and responses. Moreover, the optimum formulae were compared in terms ... ...

    Abstract This review aims to comprehensively highlight the recent nanosystems enclosing Fenticonazole nitrate (FTN) and to compare between them regarding preparation techniques, studied factors and responses. Moreover, the optimum formulae were compared in terms of
    MeSH term(s) Rats ; Animals ; Female ; Drug Delivery Systems/methods ; Antifungal Agents/pharmacology ; Administration, Cutaneous ; Nitrates ; Rats, Wistar ; Imidazoles ; Surface-Active Agents/chemistry ; Particle Size ; Drug Carriers
    Chemical Substances Antifungal Agents ; fenticonazole (QG05NRB077) ; Nitrates ; Imidazoles ; Surface-Active Agents ; Drug Carriers
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2023.2179129
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