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Article: Agression à l’hôpital ou à domicile : des séquelles psychologiques similaires.

Franzin-Garrec, Martine

2020 Volume 65, Issue 848, Page(s) 43

Abstract: Whether it occurs in emergency departments or in private practice, violence can have a significant and long-term psychological impact on caregivers. Between doubt, fear, guilt and incomprehension, two nurses from the Ile de France share their experience. ...

Title translation	Aggression in hospital or home-based care: similar psychological sequelae.
Abstract	Whether it occurs in emergency departments or in private practice, violence can have a significant and long-term psychological impact on caregivers. Between doubt, fear, guilt and incomprehension, two nurses from the Ile de France share their experience.
MeSH term(s)	Aggression/psychology ; Emergency Service, Hospital ; France ; Home Care Services ; Humans ; Nurses ; Violence
Language	French
Publishing date	2020-11-05
Publishing country	France
Document type	Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/S0038-0814(20)30183-3
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Article: [No title information]

Franzin-Garrec, Martine

Soins; la revue de reference infirmiere

2021 Volume 66, Issue 858, Page(s) 1

Title translation	De l’adaptabilité des soignants.
MeSH term(s)	Adaptation, Psychological ; Caregivers ; Depression ; Humans
Language	French
Publishing date	2021-07-15
Publishing country	France
Document type	Editorial
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/j.soin.2021.07.001
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Article ; Online: Development and Validation of an HPLC-UV Method for the Quantification of Acyclovir and Ganciclovir in the Plasma of Pediatric Immunocompromised Patients.

Franzin, Martina / Ruoso, Rachele / Del Savio, Rossella / Addobbati, Riccardo

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: ... of 0.2 mL/min. The linearity range (0.5-40 mg/L) of the method allowed us to quantify both the Cmin and ...

Abstract	Acyclovir and ganciclovir comprise the prophylaxis and treatment of herpesvirus and cytomegalovirus infections occurring in immunocompromised patients. Their therapeutic drug monitoring is fundamental because of interindividual variability leading to side effects and drug resistance and is performed through several techniques, such as liquid chromatography coupled with UV spectrophotometry (HPLC-UV) or mass spectrometry (LC-MS/MS). Therefore, we developed and validated a low-cost, non-time-consuming, and low-sample-consuming HPLC-UV method. Briefly, 100 µL of sample was used for sample preparation, mainly consisting of precipitation through organic solvent. In total, 20 µL was injected into the instrument. Chromatographic separation was obtained eluting mobile phases A (10 mM ammonium formiate 0.01% formic acid) and B (acetonitrile) on a Poroshell 120 SB-C8 2.1 × 150 mm, 2.7 µm for 12 min isocratically (97:3; A:B) at a flow rate of 0.2 mL/min. The linearity range (0.5-40 mg/L) of the method allowed us to quantify both the Cmin and Cmax of acyclovir and ganciclovir. Plasma concentrations measured on a small cohort of patients undergoing acyclovir (31) and ganciclovir (9) treatment by the proposed method and the LC-MS/MS methods, already in use, were significantly correlated. The proposed HPLC-UV method may be implemented in diagnostics as an alternative method in case of the unavailability of the LC-MS/MS system.
MeSH term(s)	Humans ; Child ; Acyclovir ; Ganciclovir ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Tandem Mass Spectrometry/methods ; Sensitivity and Specificity ; Reproducibility of Results
Chemical Substances	Acyclovir (X4HES1O11F) ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052685
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Article ; Online: Estudo do potencial de Jatropha curcas L. (Euphorbiaceae) sobre o manejo da cochonilha da roseta

Anderson Mathias Holtz / Thais Coffler / Jessica Mayara Coffler Botti / Mayara Loss Franzin / Hágabo Honorato de Paulo / Johnathan Jair de Paula Marchiori

Revista Agrogeoambiental, Vol 8, Iss

2015 Volume 3

Abstract: O alto custo socioeconômico e ambiental dos agroquímicos proporcionou a busca de alternativas eficientes e ecologicamente compatíveis no controle de pragas. O emprego de produtos derivados de plantas torna-se uma alternativa promissora. Devido à ... ...

Abstract	O alto custo socioeconômico e ambiental dos agroquímicos proporcionou a busca de alternativas eficientes e ecologicamente compatíveis no controle de pragas. O emprego de produtos derivados de plantas torna-se uma alternativa promissora. Devido à utilização indiscriminada de produtos não registrados para o controle de Planococcus citri, objetivou-se avaliar no presente trabalho o potencial de uso de Jatropha curcas. Foram utilizados indivíduos com 10, 15, 20 e 25 dias de idade. As concentrações usadas no experimento foram 0,0; 0,5; 1,0; 1,5; 2,0; 2,5 e 3,0 %. Na aplicação direta, empregaram-se discos de folhas de café (4 cm de diâmetro) inoculados com cochonilhas e pulverizados com auxílio de torre de Potter. Na aplicação indireta, esses foram imersos durante 5 segundos nas soluções e, em seguida, inoculadas as cochonilhas. Foram realizadas 6 repetições por concentração. Na aplicação direta não houve interação entre os fatores idade do inseto, extratos das estruturas da planta e concentrações. A maior mortalidade ocorreu com indivíduos de 10 dias de idade, em óleo de pinhão manso. Na aplicação indireta, houve interação entre os fatores idade do inseto, extratos das estruturas e concentrações. Na concentração de 0,5 %, idade de 10 dias, as maiores mortalidades foram para o óleo, extratos de casca do caule e de raiz. Resultados semelhantes foram observados nas outras concentrações, principalmente no óleo e casca do caule. Conclui-se que estruturas e óleo de pinhão manso são eficientes no manejo da cochonilha da roseta. Palavras-chave: Controle alternativo. Planococcus citri. Jatropha curcas.
Keywords	Controle alternativo ; Planococcus citri ; Jatropha curcas. ; Agriculture (General) ; S1-972 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treating multiple myeloma in the era of new drugs: What is the right choice?

Perego, Gianluca / Paris, Laura / Nozza, Silvia / Stefanoni, Paola / Franzin, Michela

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2023 Volume 29, Issue 5, Page(s) 1234–1236

MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Thalidomide/therapeutic use ; Drug Resistance, Neoplasm
Chemical Substances	Thalidomide (4Z8R6ORS6L)
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552231176499
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Article ; Online: Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing.

Franzin, Rossana / Stasi, Alessandra / Castellano, Giuseppe / Gesualdo, Loreto

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2325, Page(s) 79–95

Abstract: Immunosenescence is the general term used to describe the aging-associated decline of immunological function that explains the higher susceptibility to infectious diseases and cancer, increased autoimmunity, or the reduced effectiveness of vaccinations. ... ...

Abstract	Immunosenescence is the general term used to describe the aging-associated decline of immunological function that explains the higher susceptibility to infectious diseases and cancer, increased autoimmunity, or the reduced effectiveness of vaccinations. Senescence of CD8+ T-cells has been described in all these conditions.The most important classical markers of T senescent cells are the cell cycle inhibitors p16ink4a, p21, and p53, together with positivity for SA-βgal expression and the acquirement of a peculiar IFNγ -based secretory phenotype commonly defined SASP (Senescence Associated Secretory Phenotype). Other surface markers are the CD28 and CD27 loss together with gain of expression of CD45RA, CD57, TIGIT, and/or KLRG1. However, this characterization could not be sufficient to distinguish from truly senescent cells and exhausted T-cells. Furthermore, more complexity is added by the wide heterogeneity of T-cells subset in aged individuals or in the tumor microenvironment. A combined analysis by multicolor flow cytometry for surface and intracellular markers integrated with gene-expression arrays and single-cell RNA sequencing is required to develop effective interventions for therapeutic modulation of specific T-cell subsets. The RNASeq offers the great possibility to reveal at single-cell resolution the exact molecular hallmarks of senescent CD8+ T-cells without the limitations of bulk analysis. Furthermore, the comprehensive integration of multidimensional approaches (genomics, epigenomics, proteomics, metabolomics) will increase our global understanding of how immunosenescence of T-cells is interlinked to human aging.
MeSH term(s)	CD28 Antigens/metabolism ; Cellular Senescence/genetics ; Cellular Senescence/immunology ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Flow Cytometry/methods ; Genomics/methods ; Humans ; Immunosenescence/genetics ; Immunosenescence/immunology ; Lectins, C-Type/metabolism ; Leukocyte Common Antigens/metabolism ; Metabolomics/methods ; RNA-Seq ; Receptors, Immunologic/metabolism ; Single-Cell Analysis/methods ; T-Lymphocyte Subsets/metabolism ; Tumor Microenvironment
Chemical Substances	CD28 Antigens ; CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; KLRG1 protein, human ; Lectins, C-Type ; Receptors, Immunologic ; Leukocyte Common Antigens (EC 3.1.3.48) ; PTPRC protein, human (EC 3.1.3.48)
Language	English
Publishing date	2021-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1507-2_6
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Article ; Online: Update on the Role of Polymethylmethacrylate Membrane Hemofilter in Acute and Chronic Renal Dysfunction.

Stasi, Alessandra / Franzin, Rossana / Losapio, Rosa / Alfieri, Carlo / Gesualdo, Loreto / Castellano, Giuseppe

Contributions to nephrology

2023 Volume 200, Page(s) 45–54

Abstract: Despite recent technical advances in dialysis care over the past decades, the mortality rate of critically ill patients with acute kidney injury (AKI) requiring dialysis and of chronic kidney disease (CKD) remains unacceptably high. Several preclinical ... ...

Abstract	Despite recent technical advances in dialysis care over the past decades, the mortality rate of critically ill patients with acute kidney injury (AKI) requiring dialysis and of chronic kidney disease (CKD) remains unacceptably high. Several preclinical studies have increased our knowledge of the principal mechanisms involved in the pathophysiology of AKI and CKD. Additionally, the development of efficient and specific compensatory sorbent systems in renal replacement therapy to remove unwanted compounds has created the possibility to treat renal diseases and their underlying pathological triggers. Recently, several biomedical blood purification materials have been developed to improve the removal of waste and inflammatory compounds, improve the quality of treatment, and reduce the duration of treatment. This chapter is focused on the principal mechanisms involved in AKI and CKD and the current state of the art for blood purification strategies to identify the most feasible solution to reduce immunological dysfunction and waste compound clearance. In this regard, the current literature underlines the high efficacy of polymethyl methacrylate membrane hemofilters to overcome the shortcomings in the efficiency of current methodologies in removing the excess of metabolic waste and inflammatory mediators from blood. The purpose of this chapter is therefore to enhance physicians' knowledge about PMMA.
MeSH term(s)	Humans ; Polymethyl Methacrylate ; Renal Dialysis ; Renal Insufficiency, Chronic/therapy ; Renal Replacement Therapy ; Acute Kidney Injury/therapy
Chemical Substances	Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2023-06-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	1662-2782 ; 0302-5144
ISSN (online)	1662-2782
ISSN	0302-5144
DOI	10.1159/000530476
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Article ; Online: Mini-review: Interaction between intestinal microbes and enteric glia in health and disease.

Seguella, Luisa / Palenca, Irene / Franzin, Silvia Basili / Zilli, Aurora / Esposito, Giuseppe

Neuroscience letters

2023 Volume 806, Page(s) 137221

Abstract: Enteric glia are a unique population of peripheral neuroglia associated with the enteric nervous system (ENS) throughout the digestive tract. The emerging data from the latest glial biology studies unveiled enteric glia as a heterogenic population with ... ...

Abstract	Enteric glia are a unique population of peripheral neuroglia associated with the enteric nervous system (ENS) throughout the digestive tract. The emerging data from the latest glial biology studies unveiled enteric glia as a heterogenic population with plastic and adaptative abilities that display phenotypic and functional changes upon distinct extrinsic cues. This aspect is essential in the dynamic signaling that enteric glia engage with neurons and other neighboring cells within the intestinal wall, such as epithelial, endocrine, and immune cells to maintain local homeostasis. Likewise, enteric glia sense signals from luminal microbes, although the extent of this active communication is still unclear. In this minireview, we discuss the recent findings that support glia-microbes crosstalk in the intestine in health and disease, pointing out the critical aspects that require further investigation.
MeSH term(s)	Humans ; Biodiversity ; Disease ; Enteric Nervous System/cytology ; Enteric Nervous System/physiology ; Enteric Nervous System/physiopathology ; Gastrointestinal Microbiome/physiology ; Health ; Host Microbial Interactions ; Inflammation/microbiology ; Neuroglia/physiology ; Probiotics ; Animals
Chemical Substances	S100B protein, human
Language	English
Publishing date	2023-04-07
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2023.137221
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Article ; Online: Quantification of 108 illicit drugs and metabolites in bile matrix by LC-MS/MS for the toxicological testing of sudden death cases.

Franzin, Martina / Ruoso, Rachele / Peruch, Michela / Stocco, Gabriele / D'Errico, Stefano / Addobbati, Riccardo

Archives of toxicology

2023 Volume 98, Issue 1, Page(s) 135–149

Abstract: ... to identify low amounts of drugs (e.g., morphine limit of detection = 0.2 µg/L; limit of quantification = 1.1 ... µg/L). There is no significant matrix effect, except for buprenorphine and 11-Nor-9-carboxy-Δ9 ...

Abstract	Sudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in children, and toxicological testing would help identify the cause of the death. Analytical methods sensitive and specific for the quantification of a great number of drugs and metabolites in at least 2 matrices should be used. Bile, collected postmortem, may be considered a specimen alternative to blood and urine to perform toxicological testing because of its extended detection window. The present study proposed a LC-MS/MS method to quantify 108 drugs and metabolites in bile. Compounds belonging to the drugs of abuse classes of amphetamines, benzodiazepines, cocaine derivatives, barbiturates, opioids, z-drugs, and psychedelics were analyzed. The sample preparation is simple and does not require solid-phase extraction. The proposed method showed an appropriate selectivity, specificity, accuracy, and precision of the calibrators and quality controls tested (precision < 15%; accuracy < 100 ± 15%). The sensitivity allowed to identify low amounts of drugs (e.g., morphine limit of detection = 0.2 µg/L; limit of quantification = 1.1 µg/L). There is no significant matrix effect, except for buprenorphine and 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol. Carry-over was not present. Analytes were stable at least for 1 month at - 20 °C. Analyzing 13 postmortem specimens, methadone (50%), and cocaine (37.5%) resulted to be the most prevalent consumed substances; the concentrations quantified in bile resulted to be higher than the ones in blood suggesting bile as a potential new matrix for identifying illicit drugs and their metabolites.
MeSH term(s)	Adult ; Humans ; Child ; Chromatography, Liquid/methods ; Liquid Chromatography-Mass Spectrometry ; Bile ; Tandem Mass Spectrometry/methods ; Illicit Drugs ; Substance Abuse Detection/methods ; Cocaine ; Forensic Toxicology/methods
Chemical Substances	Illicit Drugs ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	2023-12-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-023-03631-z
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Article: Acute Kidney Injury in Kidney Transplant Patients in Intensive Care Unit: From Pathogenesis to Clinical Management.

Fiorentino, Marco / Bagagli, Francesca / Deleonardis, Annamaria / Stasi, Alessandra / Franzin, Rossana / Conserva, Francesca / Infante, Barbara / Stallone, Giovanni / Pontrelli, Paola / Gesualdo, Loreto

Biomedicines

2023 Volume 11, Issue 5

Abstract: Kidney transplantation is the first-choice treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at higher risk of experiencing a life-threatening event requiring intensive care unit (ICU) admission, mainly in the late ... ...

Abstract	Kidney transplantation is the first-choice treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at higher risk of experiencing a life-threatening event requiring intensive care unit (ICU) admission, mainly in the late post-transplant period (more than 6 months after transplantation). Urosepsis and bloodstream infections account for almost half of ICU admissions in this population; in addition, potential side effects related to immunosuppressive treatment should be accounted for cytotoxic and ischemic changes induced by calcineurin inhibitor (CNI), sirolimus/CNI-induced thrombotic microangiopathy and posterior reversible encephalopathy syndrome. Throughout the ICU stay, Acute Kidney Injury (AKI) incidence is common and ranges from 10% to 80%, and up to 40% will require renal replacement therapy. In-hospital mortality can reach 30% and correlates with acute illness severity and admission diagnosis. Graft survival is subordinated to baseline estimated glomerular filtration rate (eGFR), clinical presentation, disease severity and potential drug nephrotoxicity. The present review aims to define the impact of AKI events on short- and long-term outcomes in KTRs, focusing on the epidemiologic data regarding AKI incidence in this subpopulation; the pathophysiological mechanisms underlying AKI development and potential AKI biomarkers in kidney transplantation, graft and patients' outcomes; the current diagnostic work up and management of AKI; and the modulation of immunosuppression in ICU-admitted KTRs.
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11051474
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