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  1. Article ; Online: Levels of persistent organic pollutants in cane toads (Rhinella marina) differ among sites with varying industrial and agricultural activities.

    Cruz-Santiago, Omar / Flores-Ramírez, Rogelio / Ilizaliturri-Hernández, César A / Méndez-Rodríguez, Karen B / Cilia-López, Virginia G / Espinosa-Reyes, Guillermo / González-Mille, Donaji J

    Environmental toxicology and pharmacology

    2023  Volume 103, Page(s) 104280

    Abstract: In this study, we captured cane toads (Rhinella marina) in four sites located in different regions ... indicate that R. marina is suitable bioindicator of sites impacted by anthropogenic activities. ...

    Abstract In this study, we captured cane toads (Rhinella marina) in four sites located in different regions affected by anthropogenic activities in Mexico. Subsequently we analyzed liver tissue for the presence of organochlorine pesticides (OCs) and polychlorinated biphenyls (PCBs) The levels of these POPs in the toads' livers ranged from 863.2 to 3109.6 ng/g of lipid weight across all sites. A multivariate statistical analysis highlighted two sites with the highest POPs levels, with the most polluted site displaying a high level of PCBs, suggesting influence of industrial activities. The second most polluted site displayed significant amounts of OCs, linking this location to agricultural activity. Additionally, we found pesticide metabolites and isomers that allowed us to distinguish past and recent exposure events. Our observations indicate that R. marina is suitable bioindicator of sites impacted by anthropogenic activities.
    Language English
    Publishing date 2023-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2023.104280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
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  2. Article ; Online: Giant Toads (Rhinella marina) From the Industrial Zones of Low Basin of the Coatzacoalcos River (Veracruz, MX) Presents Genotoxicity in Erythrocytes.

    Cruz-Santiago, Omar / Castillo, Claudia G / Espinosa-Reyes, Guillermo / Pérez-Maldonado, Iván N / González-Mille, Donaji J / Cuevas-Díaz, María Del Carmen / Ilizaliturri-Hernández, César A

    Bulletin of environmental contamination and toxicology

    2021  Volume 108, Issue 1, Page(s) 64–70

    Abstract: ... of giant toads (Rhinella marina) from Coatzacoalcos' rural and industrial zones, and compared with laboratory ...

    Abstract The lower basin of Coatzacoalcos River is one of the most polluted regions of the southern Gulf of Mexico. Organochlorine compounds, polybrominated diphenyl ethers, polycyclic aromatic hydrocarbons, and heavy metals have been registered in this region. In the present study, genotoxicity was evaluated in the blood of giant toads (Rhinella marina) from Coatzacoalcos' rural and industrial zones, and compared with laboratory toads. Determination of the frequency of micronucleus and erythrocyte nuclear abnormalities by the light microscope and cell cycle and apoptosis by flow cytometry were used as biomarkers of genotoxicity. We found more variability in micronucleus and more nuclear buds in toads from industrial zones. Also, cell cycle alterations and an increase of apoptosis in erythrocytes were found in toads from rural and industrial zones. Multivariate statistics show that the toads from the industrial zone were more affected than toads from laboratory and rural zones.
    MeSH term(s) Animals ; Bufo marinus ; Environmental Monitoring ; Erythrocytes ; Polycyclic Aromatic Hydrocarbons/analysis ; Rivers
    Chemical Substances Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 6895-0
    ISSN 1432-0800 ; 0007-4861
    ISSN (online) 1432-0800
    ISSN 0007-4861
    DOI 10.1007/s00128-021-03162-2
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Giant Toads (Rhinella marina) From the Industrial Zones of Low Basin of the Coatzacoalcos River (Veracruz, MX) Presents Genotoxicity in Erythrocytes

    Cruz-Santiago, Omar / Castillo, Claudia G. / Espinosa-Reyes, Guillermo / Pérez-Maldonado, Iván N. / González-Mille, Donaji J. / Cuevas-Díaz, María del Carmen / Ilizaliturri-Hernández, César A.

    Bulletin of environmental contamination and toxicology. 2022 Jan., v. 108, no. 1

    2022  

    Abstract: ... of giant toads (Rhinella marina) from Coatzacoalcos’ rural and industrial zones, and compared with laboratory ...

    Abstract The lower basin of Coatzacoalcos River is one of the most polluted regions of the southern Gulf of Mexico. Organochlorine compounds, polybrominated diphenyl ethers, polycyclic aromatic hydrocarbons, and heavy metals have been registered in this region. In the present study, genotoxicity was evaluated in the blood of giant toads (Rhinella marina) from Coatzacoalcos’ rural and industrial zones, and compared with laboratory toads. Determination of the frequency of micronucleus and erythrocyte nuclear abnormalities by the light microscope and cell cycle and apoptosis by flow cytometry were used as biomarkers of genotoxicity. We found more variability in micronucleus and more nuclear buds in toads from industrial zones. Also, cell cycle alterations and an increase of apoptosis in erythrocytes were found in toads from rural and industrial zones. Multivariate statistics show that the toads from the industrial zone were more affected than toads from laboratory and rural zones.
    Keywords Rhinella marina ; apoptosis ; basins ; biomarkers ; biphenyl ; cell cycle ; chlorinated hydrocarbons ; erythrocytes ; flow cytometry ; genotoxicity ; light microscopes ; multivariate analysis ; pollution ; rivers ; toxicology ; Gulf of Mexico
    Language English
    Dates of publication 2022-01
    Size p. 64-70.
    Publishing place Springer US
    Document type Article
    ZDB-ID 6895-0
    ISSN 1432-0800 ; 0007-4861
    ISSN (online) 1432-0800
    ISSN 0007-4861
    DOI 10.1007/s00128-021-03162-2
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    In stock of ZB MED Bonn / Germany

    Z 4303: Show issues

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  4. Article ; Online: Nondestructive biomarkers in giant toad (Rhinella marina) to assess the effect of complex mixture of pollutants in Coatzacoalcos River, Mexico.

    Cruz-Santiago, Omar / Pérez-Maldonado, Iván Nelinho / González-Mille, Donaji Josefina / Espinosa-Reyes, Guillermo / Martínez-Toledo, Ángeles / Ilizaliturri-Hernández, César Arturo

    Environmental toxicology and pharmacology

    2020  Volume 82, Page(s) 103558

    Abstract: ... Rhinella marina). We obtained blood samples and the residual condition index of toads from rural and ...

    Abstract In this study, we evaluated the usefulness of nondestructive biomarkers approach in giant toads (Rhinella marina). We obtained blood samples and the residual condition index of toads from rural and industrial zones from Coatzacoalcos River, Mexico (COA). In the blood samples, we determined the activity of enzymes, lipid peroxidation, and the presence of cell death (apoptosis). We found that the activity of the enzyme delta-aminolevulinic dehydratase was lower. Still, the glutathione s-transferase activity and the percentage of apoptosis in erythrocytes were higher in the toads of COA than laboratory toads. Meanwhile, some biomarkers in toads showed differences when compared between Industrial and Rural zones. These results and correlations between biomarkers showed how the response changed in the toads living near the industrial zones. We demonstrate that a nondestructive biomarkers approach can be useful in environmental studies with anuran amphibians.
    MeSH term(s) Animals ; Apoptosis ; Biomarkers/blood ; Bufo marinus ; Butyrylcholinesterase/blood ; Erythrocytes/drug effects ; Female ; Glutathione Transferase/blood ; Male ; Malondialdehyde/blood ; Mexico ; Porphobilinogen Synthase/blood ; Rivers ; Water Pollutants/toxicity
    Chemical Substances Biomarkers ; Water Pollutants ; Malondialdehyde (4Y8F71G49Q) ; Glutathione Transferase (EC 2.5.1.18) ; Butyrylcholinesterase (EC 3.1.1.8) ; Porphobilinogen Synthase (EC 4.2.1.24)
    Language English
    Publishing date 2020-12-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2020.103558
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Identification of Na+/K+-ATPase α/β isoforms in Rhinella marina tissues by RNAseq and a molecular docking approach at the protein level to evaluate α isoform affinities for bufadienolides

    Medina-Ortiz, Katherine / López-Alvarez, Diana / Navia, Felipe / Hansen, Thomas / Fierro, Leonardo / Castaño, Santiago

    Comparative biochemistry and physiology. 2021 Apr., v. 254

    2021  

    Abstract: ... CTS) primarily produced by anurans of the Bufonidae family, such as Rhinella marina. This study ... characterized the presence of α and β NKA subunit isoforms in R. marina via RNAseq in four tissues: oocytes ... identity with the α₁ isoform previously published for R. marina. Sequences for α₂, α₃, and β₄ from R ...

    Abstract Na⁺/K⁺-ATPase (NKA) function is inhibited by Bufadienolides (BD), a group of cardiotonic steroids (CTS) primarily produced by anurans of the Bufonidae family, such as Rhinella marina. This study characterized the presence of α and β NKA subunit isoforms in R. marina via RNAseq in four tissues: oocytes, skin, heart, and skeletal muscle. Transcripts encoding three α-like isoforms (α₁, α₂, α₃) and three β-like isoforms (β₁, β₂, β₄) were identified. The amino acid sequence of α₁-like isoform shared 99.4% identity with the α₁ isoform previously published for R. marina. Sequences for α₂, α₃, and β₄ from R. marina were previously unavailable. The first extracellular loop in the α₂-like isoform in R. marina showed similar substitutions to those found in their susceptible homologues in other taxa (L/Q111T and S119T); in contrast, this same loop in α₃-like isoform showed similar substitutions (Q111L and G120R) to those reported for toad-eating animals such as snakes, which suggests relatively lower affinity for CTS. Docking results showed that all three α-like isoforms identified in R. marina transcriptomes have low affinity to CTS compared to the susceptible α₁ isoform of Sus scrofa (pig), with α₁-like isoform being the most resistant. The tissue-specific RNAseq results showed the following expression of NKA α-like and β-like subunit isoforms: Oocytes expressed α₁ and β₁; skin α₁, β₁, and low levels of β₂; heart α₁, α₃, and β₁; skeletal muscle α₁, β₄, with low levels of α₂, α₃, and β₁. R. marina could be used as an important model for future structural, functional and pharmacological studies of NKA and its isoforms.
    Keywords Rhinella marina ; Sus scrofa ; amino acid sequences ; bufadienolides ; heart ; models ; oocytes ; physiology ; protein content ; skeletal muscle ; sodium-potassium-exchanging ATPase ; swine ; transcriptome
    Language English
    Dates of publication 2021-04
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2021.110906
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    In stock of ZB MED Bonn / Germany

    Z 71/715: Show issues

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  6. Book ; Online: Delivery of Molecules Using Nanoscale Systems for Cancer Treatment and/or Diagnosis

    Franco, Marina Santiago / Youn, Yu Seok

    2022  

    Keywords Pharmacology ; nanostructured lipid carriers ; doxorubicin ; mucositis ; cell internalization ; albumin ; BSA ; CPP ; gold nanorods ; gold nanoprisms ; arginine-rich peptide ; glutathione ; nanoparticles ; oxidative stress ; breast cancer ; gastric cancer ; nanoparticle ; fucoidan ; d-alpha-tocopherylpoly (ethylene glycol) succinate ; combination chemotherapy ; G-quadruplex ; nucleolin ; DNA nanocages ; intracellular localization ; cancer targeting ; molecular dynamics simulations ; mesoporous silica nanoparticles ; radiotherapy ; immunotherapy ; tumor microenvironment ; abscopal effect ; magnetofection in vivo ; magnetic nanoparticles ; iron oxide ; gene delivery ; gene vectors ; codelivery nanocarriers ; photodynamic therapy ; anticancer therapies ; combination therapy ; phthalocyanine ; uterine cervical neoplasms ; photochemotherapy ; in vitro ; in vivo ; nanocarrier ; polyplexes ; siRNA delivery ; glioblastoma therapy ; amphiphilic poly(α)glutamate ; P-selectin ; prodrug ; drug delivery ; targeted therapy ; chemotherapy ; prostate cancer ; prostate-specific membrane antigen ; targeted delivery ; encapsulation ; cabazitaxel ; nanocarriers ; nanosystems ; radiosensitizer ; hypoxia ; synergism ; cancer ; photothermal therapy ; combined antitumor effect ; oxygenation ; hydrogel ; hypoxic tumor ; n/a
    Language English
    Size 1 electronic resource (302 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030374314
    ISBN 9783036549620 ; 3036549625
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online: Curso Aristotélico Jesuíta Conimbricense. Tomo I: Comentários aos 'Parva Naturalia'

    Marques, Bernardino Fernando da Costa / Carvalho, Mário Santiago de / Pinho, Sebastião Tavares de / Fernandes, Marina

    2020  

    Abstract: Under the title 'Parva Naturalia' this Aristotelian text knew an unusual international diffusion; among all the Commentaries on the 'Parva Naturalia' stands the Coimbra Commentary (16th Century), written by Manuel de Góis, as a part of the widely known ... ...

    Abstract Under the title 'Parva Naturalia' this Aristotelian text knew an unusual international diffusion; among all the Commentaries on the 'Parva Naturalia' stands the Coimbra Commentary (16th Century), written by Manuel de Góis, as a part of the widely known Jesuit Coimbra Commentaries. Indeed, they soon spread throughout European Universities and Colleges and even arrived to South American territories, as well as China, thanks to its several Chinese translations or adaptations published as soon as the 17th Century
    Size 1 electronic resource (332 pages)
    Publisher Coimbra University Press
    Document type Book ; Online
    Note Aristotelianism; Coimbra Jesuit Course;Natural History ; Open Access
    HBZ-ID HT020589142
    ISBN 9789892614861 ; 9892614860
    DOI 10.14195/978-989-26-1487-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Two New Species and New Records of Metopiinae (Hymenoptera, Ichneumonidae) from Ecuador.

    Mazón, Marina / Bordera, Santiago

    Neotropical entomology

    2023  Volume 52, Issue 4, Page(s) 718–724

    Abstract: The Ecuadorian Metopiinae fauna currently includes 17 species, but recent intensive samplings carried out at Southern Ecuador have increased this number. In the present paper, two new species, Exochus tapiarum sp. nov. and Leurus tapichalacae sp. nov., ... ...

    Abstract The Ecuadorian Metopiinae fauna currently includes 17 species, but recent intensive samplings carried out at Southern Ecuador have increased this number. In the present paper, two new species, Exochus tapiarum sp. nov. and Leurus tapichalacae sp. nov., are described and illustrated. Furthermore, four new records of Metopiinae from Ecuador are provided: Colpotrochia beluga Gauld & Sithole, Exochus famellus Gauld & Sithole, E. izbus Gauld & Sithole, and E. ravetus Gauld & Sithole.
    MeSH term(s) Animals ; Hymenoptera ; Ecuador ; Wasps
    Language English
    Publishing date 2023-06-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2105363-7
    ISSN 1678-8052 ; 1519-566X
    ISSN (online) 1678-8052
    ISSN 1519-566X
    DOI 10.1007/s13744-023-01053-1
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  9. Article ; Online: Left upper abdomen: surgical anatomy.

    Domingo, Santiago / Marina, Tiermes

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 8, Page(s) 1190–1191

    MeSH term(s) Abdomen/anatomy & histology ; Abdomen/surgery ; Humans ; Spleen/anatomy & histology ; Spleen/blood supply ; Spleen/surgery
    Language English
    Publishing date 2021-06-26
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-002332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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  10. Article: Delivery of Molecules Using Nanoscale Systems for Cancer Treatment and/or Diagnosis.

    Franco, Marina Santiago / Youn, Yu Seok

    Pharmaceutics

    2022  Volume 14, Issue 4

    Abstract: Since clinical approval of the first liposomal formulation encapsulating a chemotherapeutic agent, nanoscale delivery systems have been a rapidly developing science [ ... ]. ...

    Abstract Since clinical approval of the first liposomal formulation encapsulating a chemotherapeutic agent, nanoscale delivery systems have been a rapidly developing science [...].
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14040851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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