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Article ; Online: Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial.

Slovarp, Laurie J / Reynolds, Jane E / Tolbert, Sophia / Campbell, Sarah / Welby, Shannon / Morkrid, Paige

2023 Volume 23, Issue 1, Page(s) 148

Abstract: ... suppressing cough; n = 11) or a sham treatment (repeated exposure to aerosolized saline; n = 9). The Leicester Cough ...

Abstract	Objective: The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT). Design and methods: In this parallel cohort, sham-controlled, randomized controlled trial, 21 adults with RCC were randomly assigned to 12 sessions of either CDT (progressive doses of aerosolized capsaicin while behaviorally suppressing cough; n = 11) or a sham treatment (repeated exposure to aerosolized saline; n = 9). The Leicester Cough Questionnaire (LCQ) was the primary outcome measure. Perceived cough severity with a visual analogue scale and cough challenge testing (for measuring cough-reflex sensitivity) were secondary outcome measures. Data were analyzed with mixed effects linear regression and follow-up contrasts. Results: Results on all measures favored CDT. Excluding one sham participant, whose baseline LCQ scores were deemed unreliable, mean change in LCQ at 3-weeks post treatment was 6.35 and 2.17 in the CDT and sham groups, respectively. There was moderate to strong evidence of a greater improvement in the CDT group in total LCQ score (p = .058) and LCQ Psychological domain (p = .026) and Physical domain (p = .045) scores. Strong evidence was found for a greater reduction in urge-to-cough during CCT in the CDT group (p = .037) and marginal for a reduction in the capsaicin cough-reflex sensitivity (p = .094). There was weak evidence of a greater reduction in cough severity in the CDT group (p = .103). Discussion: Although the study is limited due to the small sample size, the data provide additional evidence supporting further research on CDT. CDT resulted in a greater change in the primary efficacy measure (LCQ) than both pharmaceutical and behavioral treatments currently found in the literature. Trial registration: This trial (NCT05226299) was registered on Clinicaltrials.gov on 07/02/2022.
MeSH term(s)	Adult ; Humans ; Chronic Disease ; Cough/drug therapy ; Capsaicin ; Carcinoma, Renal Cell ; Pilot Projects ; Surveys and Questionnaires ; Kidney Neoplasms
Chemical Substances	Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02423-6
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Article ; Online: Outcomes of esophageal and gastric bone foreign bodies in dogs.

Barash, Nanelle R / Lashnits, Erin / Kern, Zachary T / Tolbert, Mary Katherine / Lunn, Katharine F

Journal of veterinary internal medicine

2022 Volume 36, Issue 2, Page(s) 500–507

Abstract: ... foreign bodies (E-bFBs) warrant removal, whereas gastric bone foreign bodies might not.: Objectives: Describe ... twenty-nine dogs with esophageal (n = 45) or gastric (n = 84) bone foreign bodies.: Methods ... Retrospective review of medical records.: Results: Dogs with E-bFBs were younger than dogs with gastric bone ...

Abstract	Background: Bone foreign bodies are commonly encountered in small animal practice. Esophageal bone foreign bodies (E-bFBs) warrant removal, whereas gastric bone foreign bodies might not. Objectives: Describe management and outcomes for dogs with esophageal or gastric bone foreign bodies. Animals: One hundred twenty-nine dogs with esophageal (n = 45) or gastric (n = 84) bone foreign bodies. Methods: Retrospective review of medical records. Results: Dogs with E-bFBs were younger than dogs with gastric bone foreign bodies (median age esophageal, 4 years [IQR 2-8]; median age gastric, 6 years [IQR 3-10]; P = .03), and had a higher bone cross-sectional area relative to body weight (median esophageal, 98.21 mm Conclusions and clinical importance: While all E-bFBs were dislodged either by advancement into the stomach, endoscopic removal, or esophagotomy, the majority of gastric bone foreign bodies were left in situ for dissolution, with no reported complications. Gastric advancement of E-bFBs should be considered when oral removal is not feasible, and dissolution can be considered even with large bones.
MeSH term(s)	Animals ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery ; Dogs ; Endoscopy/veterinary ; Esophageal Diseases/veterinary ; Foreign Bodies/complications ; Foreign Bodies/surgery ; Foreign Bodies/veterinary ; Retrospective Studies ; Stomach
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16383
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Article ; Online: Qualitative Findings From a Survey on Patient Experiences and Satisfaction with Lung Cancer Screening.

Pérez-Morales, Jaileene / Pathak, Rashmi / Reyes, Monica / Tolbert, Haley / Tirbene, Rajwantee / Gray, Jhanelle E / Simmons, Vani N / Schabath, Matthew B / Quinn, Gwendolyn P

Cancer control : journal of the Moffitt Cancer Center

2023 Volume 30, Page(s) 10732748231167963

Abstract: Background: To reveal successes and potential limitations of the lung cancer screening program, we conducted a survey that included both quantitative and open-ended questions to measure patient experiences and satisfaction with screening.: Methods: ... ...

Abstract	Background: To reveal successes and potential limitations of the lung cancer screening program, we conducted a survey that included both quantitative and open-ended questions to measure patient experiences and satisfaction with screening. Methods: We report on the five open-ended items related to barriers to returning for screening, experience with other cancer prevention screenings, positive and negative experiences, and suggestions for improving future appointments. The open-ended responses were analyzed using constant comparison method and inductive content analysis. Results: Respondents (182 patients, 86% response rate for open-ended questions) provided generally positive comments about their lung cancer screening experience. Negative comments were related to desire for more information about results, long wait times for results, and billing issues. Suggestions for improvements included: scheduling on-line appointments and text or email reminders, lower costs, and responding to uncertainty about eligibility criteria. Conclusion: Findings provide insights about patient experiences and satisfaction with lung cancer screening which is important given low uptake. Ongoing patient-centered feedback may improve the lung cancer screening experience and increase follow-up screening rates.
MeSH term(s)	Humans ; Early Detection of Cancer ; Lung Neoplasms/diagnosis ; Patient Satisfaction ; Surveys and Questionnaires ; Personal Satisfaction ; Patient Outcome Assessment
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
DOI	10.1177/10732748231167963
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Article ; Online: Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures.

Klein, Pavel / Tolbert, Dwain / Gidal, Barry E

Epilepsy & behavior : E&B

2019 Volume 99, Page(s) 106459

Abstract: ... i.e., N-clobazam), on seizure protection in patients with Lennox-Gastaut syndrome using data ... developed to characterize the combined effect of clobazam and its active metabolite, N-desmethylclobazam ... upon our population pharmacokinetic/pharmacodynamic model, we predict that an increase in N-clobazam levels ...

Abstract	Objective: The goal of this study was to characterize the drug-drug interactions between clobazam and 2 antiseizure drugs, cannabidiol and stiripentol, for treatment of refractory seizures through the use of pharmacokinetic modeling. Methods: A population pharmacokinetic/pharmacodynamic model was developed to characterize the combined effect of clobazam and its active metabolite, N-desmethylclobazam (i.e., N-clobazam), on seizure protection in patients with Lennox-Gastaut syndrome using data from the phase 3 CONTAIN trial. Drug-drug interactions between clobazam and cannabidiol were examined by comparing model-generated data to data from a study of 13 patients taking concomitant clobazam and cannabidiol. Modeling data were also descriptively compared with studies of patients administered both clobazam and stiripentol. Sedation-related adverse events from CONTAIN were analyzed to determine the exposure-somnolence relationship of clobazam. Results: Exposure-efficacy analysis from the pharmacokinetic/pharmacodynamic model using CONTAIN data indicated that clobazam (half-maximal effective concentration [EC Significance: Awareness of drug-drug interactions between clobazam and cannabidiol is needed when adding cannabidiol or stiripentol to a regimen of clobazam or vice versa. Based upon our population pharmacokinetic/pharmacodynamic model, we predict that an increase in N-clobazam levels, which patient data show may enhance efficacy and/or make adverse events such as somnolence more likely.
MeSH term(s)	Adolescent ; Adult ; Anticonvulsants/blood ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Biomarkers/blood ; Cannabidiol/blood ; Cannabidiol/pharmacokinetics ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Child ; Child, Preschool ; Clobazam/blood ; Clobazam/pharmacokinetics ; Clobazam/pharmacology ; Clobazam/therapeutic use ; Dioxolanes/blood ; Dioxolanes/pharmacokinetics ; Dioxolanes/pharmacology ; Dioxolanes/therapeutic use ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Therapy, Combination ; Female ; Humans ; Lennox Gastaut Syndrome/blood ; Lennox Gastaut Syndrome/drug therapy ; Male ; Models, Biological ; Sleep/drug effects ; Sleepiness ; Treatment Outcome ; Young Adult
Chemical Substances	Anticonvulsants ; Biomarkers ; Dioxolanes ; Cannabidiol (19GBJ60SN5) ; Clobazam (2MRO291B4U) ; stiripentol (R02XOT8V8I)
Language	English
Publishing date	2019-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2019.106459
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Zs.A 5289: Show issues

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Article: (2-Chloroethyl) Trimethylammonium Chloride and Related Compounds as Plant Growth Substances. II. Effect on Growth of Wheat.

Tolbert, N E

Plant physiology

2006 Volume 35, Issue 3, Page(s) 380–385

Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.35.3.380
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Article ; Online: Using small angle x-ray scattering to examine the aggregation mechanism in silica nanoparticle-based ambigels for improved optical clarity.

Kashanchi, Glareh N / King, Sophia C / Ju, Susan E / Dashti, Ali / Martinez, Ricardo / Lin, Yu-Keng / Wall, Vivian / McNeil, Patricia E / Marszewski, Michal / Pilon, Laurent / Tolbert, Sarah H

The Journal of chemical physics

2022 Volume 158, Issue 3, Page(s) 34702

Abstract: Silica-based aerogels are a promising low-cost solution for improving the insulation efficiency of single-pane windows and reducing the energy consumption required for space heating and cooling. Two key material properties required are high porosity and ... ...

Abstract	Silica-based aerogels are a promising low-cost solution for improving the insulation efficiency of single-pane windows and reducing the energy consumption required for space heating and cooling. Two key material properties required are high porosity and small pore sizes, which lead to low thermal conductivity and high optical transparency, respectively. However, porosity and pore size are generally directly linked, where high porosity materials also have large pore sizes. This is unfavorable as large pores scatter light, resulting in reduced transmittance in the visible regime. In this work, we utilized preformed silica colloids to explore methods for reducing pore size while maintaining high porosity. The use of preformed colloids allows us to isolate the effect of solution conditions on porous gel network formation by eliminating simultaneous nanoparticle growth and aggregation found when using typical sol-gel molecular-based silica precursors. Specifically, we used in situ synchrotron-based small-angle x-ray scattering during gel formation to better understand how pH, concentration, and colloid size affect particle aggregation and pore structure. Ex situ characterization of dried gels demonstrates that peak pore widths can be reduced from 15 to 13 nm, accompanied by a narrowing of the overall pore size distribution, while maintaining porosities of 70%-80%. Optical transparency is found to increase with decreasing pore sizes while low thermal conductivities ranging from 95 +/- 13 mW/m K are maintained. Mechanical performance was found to depend primarily on effective density and did not show a significant dependence on solution conditions. Overall, our results provide insights into methods to preserve high porosity in nanoparticle-based aerogels while improving optical transparency.
MeSH term(s)	Silicon Dioxide/chemistry ; X-Rays ; Gels/chemistry ; Colloids ; Nanoparticles ; Porosity
Chemical Substances	Silicon Dioxide (7631-86-9) ; Gels ; Colloids
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0130811
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Article: Activation of polyphenol oxidase of chloroplasts.

Tolbert, N E

Plant physiology

2006 Volume 51, Issue 2, Page(s) 234–244

Abstract: ... treated with 10% trichloroacetic acid, 1.0 n HCl or boiled for 30 minutes. No single peptide ...

Abstract	Polyphenol oxidase of leaves is located mainly in chloroplasts isolated by differential or sucrose density gradient centrifugation. This activity is part of the lamellar structure that is not lost on repeated washing of the plastids. The oxidase activity was stable during prolonged storage of the particles at 4 C or -18 C. The Km (dihydroxyphenylalanine) for spinach leaf polyphenol oxidase was 7 mm by a spectrophotometric assay and 2 mm by the manometric assay. Polyphenol oxidase activity in the leaf peroxisomal fraction, after isopycnic centrifugation on a linear sucrose gradient, did not coincide with the peroxisomal enzymes but was attributed to proplastids at nearly the same specific density.Plants were grouped by the latency properties for polyphenol oxidase in their isolated chloroplasts. In a group including spinach, Swiss chard, and beet leaves the plastids immediately after preparation from fresh leaves required a small amount of light for maximal rates of oxidation of dihydroxyphenylalanine. Polyphenol oxidase activity in the dark or light increased many fold during aging of these chloroplasts for 1 to 5 days. Soluble polyphenol oxidase of the cytoplasm was not so stimulated. Chloroplasts prepared from stored leaves were also much more active than from fresh leaves. Maximum rates of dihydroxyphenylalanine oxidation were 2 to 6 mmoles x mg(-1) chlorophyll x hr(-1). Equal stimulation of latent polyphenol oxidase in fresh or aged chloroplasts in this group was obtained by either light, an aged trypsin digest, 3-(4-chlorophenyl)-1, 1-dimethylurea, or antimycin A. A variety of other treatments did not activate or had little effect on the oxidase, including various peptides, salts, detergents, and other proteolytic enzymes.Activation of latent polyphenol oxidase in spinach chloroplasts by trypsin amounted to as much as 30-fold. The trypsin activation occurred even after the trypsin had been treated with 10% trichloroacetic acid, 1.0 n HCl or boiled for 30 minutes. No single peptide from the digested trypsin was found to be the sole activating factor. About 0.25 mug of trypsin activated 50% the polyphenol oxidase activity in a standard chloroplast assay containing 2.1 mug of chlorophyll. Treatment of spinach chloroplasts with tris buffer or ethylenediamine tetraacetate extracted the ATPase activity, but the polyphenol oxidase activity remained with the broken plastids. However these treatments increased the latent polyphenol oxidase activity 50- to 100-fold.Chloroplasts from a second group of plants, including alfalfa, wheat, oats, peas, and sugarcane leaves, oxidized dihydroxyphenylalanine at a rate of 11 to 120 mumoles x mg(-1) chlorophyll x hr(-1). Polyphenol oxidase in these chloroplasts required a low intensity of red light for activity. Fifty or 75% activation of the oxidase in wheat chloroplasts required 4 to 6 foot candles of light and more light was required for alfalfa chloroplasts. Blue or far red light were ineffective. Trypsin was inhibitory. Upon aging chloroplasts from wheat leaves, but not alfalfa or peas, for 5 to 7 days at 4 C the total polyphenol oxidase activity did not increase, but the activation characteristics changed to those of chloroplasts from the spinach group. Chloroplasts from a third group of plants, including bean, tomato, and corn leaves, slowly oxidized dihydroxyphenylalanine in the dark and exhibited no latency.
Language	English
Publishing date	2006-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.51.2.234
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Article ; Online: Evaluation of surface antigen TF1.17 in feline Tritrichomonas foetus isolates.

Gould, E N / Corbeil, L B / Kania, S A / Tolbert, M K

Veterinary parasitology

2017 Volume 244, Page(s) 144–153

Abstract: Tritrichomonas foetus (T. foetus) is a flagellated protozoa that infects the distal ileum and proximal colon of domestic cats, as well as the urogenital tract of cattle. Feline trichomonosis is recognized as a prevalent cause of chronic diarrhea in cats ... ...

Abstract	Tritrichomonas foetus (T. foetus) is a flagellated protozoa that infects the distal ileum and proximal colon of domestic cats, as well as the urogenital tract of cattle. Feline trichomonosis is recognized as a prevalent cause of chronic diarrhea in cats worldwide. The suspected route of transmission is fecal-oral, with cats in densely crowded environments at highest risk for infection. Thus, the recommended strategy for minimizing spread of infection is to identify and isolate T. foetus-positive cats from the general population. Rapid identification of infected cats can be challenging due to the inability to accurately and quickly detect the organism in samples at point of care facilities. Thus, identification of targets for use in development of a novel diagnostic test, as well as a vaccine or therapy for T. foetus infection is a significant area of research. Despite a difference in organ tropism between T. foetus genotypes, evidence exists for conserved virulence factors between feline and bovine T. foetus. The bovine T. foetus surface antigen, TF1.17, is an adhesin that is conserved across isolates. Vaccination with the purified antigen results in amelioration of cytopathogenicity and more rapid clearance of infection in cattle. We previously showed that three feline isolates of T. foetus were positive for TF1.17 antigen so we further hypothesized that TF1.17 is conserved across feline T. foetus isolates and that this antigen would represent an attractive target for development of a novel diagnostic test or therapy for feline trichomonosis. In these studies, we used monoclonal antibodies previously generated against 1.15 and 1.17 epitopes of the bovine T. foetus TF1.17 antigen, to evaluate for the presence and role of TF1.17 in the cytopathogenicity of feline T. foetus. A previously validated in vitro co-culture approach was used to model feline T. foetus infection. Immunoblotting, immunofluorescence assays, and flow cytometric analysis confirmed the presence and surface localization of antigen TF1.17 across all feline T. foetus isolates tested. Antigen TF1.17 was notably absent in the presumably nonpathogenic intestinal trichomonad, Pentatrichomonas hominis, a parasite that can be confused microscopically with T. foetus. Similar to bovine trichomoniasis, TF1.17 was found to promote T. foetus adhesion to the intestinal epithelium. These results support further characterization and development of the TF1.17 antigen as a possible target for the diagnosis and prevention of feline T. foetus infection.
Language	English
Publishing date	2017-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2017.08.001
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Zs.A 4380: Show issues

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Article ; Online: Esomeprazole induces structural changes and apoptosis and alters function of in vitro canine neoplastic mast cells.

Gould, Emily N / Szule, Joseph A / Wilson-Robles, Heather / Steiner, Jörg M / Lennon, Elizabeth M / Tolbert, M Katherine

Veterinary immunology and immunopathology

2022 Volume 256, Page(s) 110539

Abstract: ... representing a single healthy (i.e., BMMCs) MC model and multiple neoplastic MC models (i.e., LAD2, C2, BR ... Degranulation was assessed by quantification of β-hexosaminidase (i.e., LAD2 and RBL-2H3). Esomeprazole-treated ... i.e., increased vacuolization, compromise of cell membrane), increased apoptosis, and altered ...

Abstract	Histamine-2 receptor antagonists such as famotidine and proton pump inhibitors such as esomeprazole are commonly used in canine MCT disease, but direct effects on dog MCs have not been evaluated. Omeprazole is a proton pump inhibitor which has been demonstrated to cause structural and functional changes to in vitro murine mast cells (MCs). It has not yet been determined if esomeprazole, the commercially available and commonly prescribed S-isomer of omeprazole, has similar effects. Our primary study objective was to evaluate and compare the effects of acid suppressants (esomeprazole and famotidine) on MC ultrastructure, viability, and function in vitro using both healthy and neoplastic MCs. Murine bone marrow derived mast cells (BMMC), human LAD2, and canine C2 and BR cells, were used for these studies, representing a single healthy (i.e., BMMCs) MC model and multiple neoplastic MC models (i.e., LAD2, C2, BR), respectively. The rat basophilic leukemic (RBL-2H3) and canine B cell lymphoma 17-71 cell lines served as granulocytic and agranulocytic control lines for experiments, respectively. The treatment effect of acid suppressants on MC ultrastructure was assessed via both light and transmission electron microscopy. Differences in MC viability was assessed between groups via MTS-based, colorimetric assays and flow cytometry. Degranulation was assessed by quantification of β-hexosaminidase (i.e., LAD2 and RBL-2H3). Esomeprazole-treated MCs of all lines exhibited dramatic time and concentration-dependent alterations in ultrastructure (i.e., increased vacuolization, compromise of cell membrane), increased apoptosis, and altered degranulation responses in comparison to famotidine and vehicle-treated cells. The canine B cell lymphoma cells consistently exhibited either no significant (i.e., cytotoxicity assays) or greatly diminished treatment responses (i.e., apoptosis) compared to MCs. Esomeprazole, but not famotidine, induces significant cytotoxicity, as well as alterations to cell structure and function to multiple lines of in vitro neoplastic MCs. Continued in vitro work investigating the specific mechanisms by which proton pump inhibitors induce these effects, as well as prospective, in vivo work comparing the treatment effects of acid suppressants on canine MCTs, are warranted.
MeSH term(s)	Rats ; Mice ; Dogs ; Humans ; Animals ; Mast Cells ; Esomeprazole/pharmacology ; Esomeprazole/metabolism ; Proton Pump Inhibitors/pharmacology ; Proton Pump Inhibitors/metabolism ; Prospective Studies ; Famotidine/metabolism ; Famotidine/pharmacology ; Apoptosis
Chemical Substances	Esomeprazole (N3PA6559FT) ; Proton Pump Inhibitors ; Famotidine (5QZO15J2Z8)
Language	English
Publishing date	2022-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2022.110539
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Article ; Online: Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project.

Bray, Emily E / Zheng, Zihan / Tolbert, M Katherine / McCoy, Brianah M / Kaeberlein, Matt / Kerr, Kathleen F

GeroScience

2022 Volume 44, Issue 3, Page(s) 1779–1790

Abstract: ... associations between feeding frequency and cognitive function (n = 10,474) as well as nine broad categories ... of health conditions (n = 24,238). Controlling for sex, age, breed, and other potential confounders ...

Abstract	A variety of diets have been studied for possible anti-aging effects. In particular, studies of intermittent fasting and time-restricted feeding in laboratory rodents have found evidence of beneficial health outcomes. Companion dogs represent a unique opportunity to study diet in a large mammal that shares human environments. The Dog Aging Project has been collecting data on thousands of companion dogs of all different ages, sizes, and breeds since 2019. We leveraged this diverse cross-sectional dataset to investigate associations between feeding frequency and cognitive function (n = 10,474) as well as nine broad categories of health conditions (n = 24,238). Controlling for sex, age, breed, and other potential confounders, we found that dogs fed once daily rather than more frequently had lower mean scores on a cognitive dysfunction scale, and lower odds of having gastrointestinal, dental, orthopedic, kidney/urinary, and liver/pancreas disorders. Therefore, we find that once-daily feeding is associated with better health in multiple domains. Future research with longitudinal data can provide stronger evidence for a possible causal effect of feeding frequency on health in companion dogs.
MeSH term(s)	Aging ; Animals ; Breeding ; Cognition ; Cross-Sectional Studies ; Dogs ; Mammals ; Pets
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-022-00575-7
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

Order via subito