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  1. Article ; Online: Vasoconstriction in septic shock.

    De Backer, Daniel / Hajjar, Ludhmila / Monnet, Xavier

    Intensive care medicine

    2024  Volume 50, Issue 3, Page(s) 459–462

    MeSH term(s) Humans ; Vasoconstriction ; Shock, Septic
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07332-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Hemodynamic monitoring using echocardiography in the critically ill

    De Backer, Daniel

    2011  

    Author's details Daniel De Backer ... (ed.)
    Keywords Intensivmedizin ; Ultraschallkardiografie ; Hämodynamik ; Monitoring
    Subject Ultraschallkardiographie ; Echokardiografie ; Echokardiographie ; Ultraschallechokardiographie ; Ultraschallechokardiografie
    Language English
    Size IX, 311 S. : zahlr. Ill., 260 mm x 193 mm
    Publisher Springer
    Publishing place Heidelber u.a.
    Publishing country Germany
    Document type Book
    Accompanying material 1 DVD-ROM (12 cm)
    HBZ-ID HT016785155
    ISBN 978-3-540-87954-1 ; 9783540879565 ; 3-540-87954-4 ; 3540879560
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1531 order for loan Magazin
    2011 MO 185 <<[Begleitmaterial]>> order for loan Magazin

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  3. Article ; Online: Novelties in the evaluation of microcirculation in septic shock.

    De Backer, Daniel

    Journal of intensive medicine

    2022  Volume 3, Issue 2, Page(s) 124–130

    Abstract: Microvascular alterations were first described in critically ill patients about 20 years ago. These alterations are characterized by a decrease in vascular density and presence of non-perfused capillaries close to well-perfused vessels. In addition, ... ...

    Abstract Microvascular alterations were first described in critically ill patients about 20 years ago. These alterations are characterized by a decrease in vascular density and presence of non-perfused capillaries close to well-perfused vessels. In addition, heterogeneity in microvascular perfusion is a key finding in sepsis. In this narrative review, we report our actual understanding of microvascular alterations, their role in the development of organ dysfunction, and the implications for outcome. Herein, we discuss the state of the potential therapeutic interventions and the potential impact of novel therapies. We also discuss how recent technologic development may affect the evaluation of microvascular perfusion.
    Language English
    Publishing date 2022-11-10
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2667-100X
    ISSN (online) 2667-100X
    DOI 10.1016/j.jointm.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The nuts and bolts of fluid de-escalation.

    De Backer, Daniel / Ostermann, Marlies / Monnet, Xavier

    Intensive care medicine

    2023  Volume 49, Issue 9, Page(s) 1120–1122

    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07164-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiac function, cardiac preload and volume status. Author's reply.

    De Backer, Daniel / Monnet, Xavier

    Intensive care medicine

    2022  Volume 48, Issue 12, Page(s) 1825–1826

    MeSH term(s) Humans ; Heart ; Cardiac Output ; Stroke Volume
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06896-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reversal of rocuronium-induced fixed pupillary dilation by sugammadex in ICU patients with COVID-19.

    Winant, Maxime / Engel, Harald / Dubois, Pauline / Halenarova, Katarina / De Backer, Daniel

    British journal of anaesthesia

    2024  Volume 132, Issue 3, Page(s) 627–629

    MeSH term(s) Humans ; Sugammadex/pharmacology ; Rocuronium ; Dilatation ; COVID-19 ; Intensive Care Units ; Neuromuscular Blockade ; Androstanols
    Chemical Substances Sugammadex (361LPM2T56) ; Rocuronium (WRE554RFEZ) ; Androstanols
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.12.011
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  7. Article ; Online: How to assess tissue oxygenation?

    De Backer, Daniel / Ospina-Tascón, Gustavo A

    Current opinion in critical care

    2023  Volume 29, Issue 3, Page(s) 244–251

    Abstract: Purpose of review: To discuss the different techniques used to assess tissue oxygenation in critically ill patients.: Recent findings: While historically the analysis of oxygen consumption (VO2)/oxygen delivery (DO2) relationships has provided ... ...

    Abstract Purpose of review: To discuss the different techniques used to assess tissue oxygenation in critically ill patients.
    Recent findings: While historically the analysis of oxygen consumption (VO2)/oxygen delivery (DO2) relationships has provided important information, methodological limitations prevent its use at bedside. PO2 measurements, while attractive, are unfortunately of limited value in the presence of microvascular blood flow heterogeneity which is observed in many critically ill conditions including sepsis. Surrogates of tissue oxygenation are hence used. Elevated lactate levels may suggest inadequate tissue oxygenation, but other sources than tissue hypoxia can also contribute to hyperlactatemia so that lactate measurements should be used in combination with other measurements of tissue oxygenation. Venous O2 saturation can be used to evaluate the adequacy of DO2 in respect to VO2, but it can be misleading normal or even high in sepsis. Measurements of Pv-aCO2 and computation of Pv-aCO2/CavO2 are very promising as physiologically sound, easy to measure, rapidly respond to therapy, and are associated with outcome. An elevated Pv-aCO2 reflects an impaired tissue perfusion while an increased Pv-aCO2/CavO2 ratio reflects tissue dysoxia.
    Summary: Recent studies have highlighted the interest of surrogate measurements of tissue oxygenation and in particular PCO2 gradients.
    MeSH term(s) Humans ; Oxygen ; Critical Illness ; Hypoxia ; Sepsis/therapy ; Lactates ; Oxygen Consumption
    Chemical Substances Oxygen (S88TT14065) ; Lactates
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001046
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  8. Article ; Online: Hydroxyethyl Starch vs Saline for Volume Expansion After Abdominal Surgery.

    De Backer, Daniel / Michiels, Gregoire

    JAMA

    2020  Volume 324, Issue 2, Page(s) 200

    MeSH term(s) Abdomen ; Humans ; Hydroxyethyl Starch Derivatives ; Postoperative Complications
    Chemical Substances Hydroxyethyl Starch Derivatives
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.6974
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  9. Article ; Online: Evidence for a personalized early start of norepinephrine in septic shock.

    Monnet, Xavier / Lai, Christopher / Ospina-Tascon, Gustavo / De Backer, Daniel

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 322

    Abstract: During septic shock, vasopressor infusion is usually started only after having corrected the hypovolaemic component of circulatory failure, even in the most severe patients. However, earlier administration of norepinephrine, simultaneously with fluid ... ...

    Abstract During septic shock, vasopressor infusion is usually started only after having corrected the hypovolaemic component of circulatory failure, even in the most severe patients. However, earlier administration of norepinephrine, simultaneously with fluid resuscitation, should be considered in some cases. Duration and depth of hypotension strongly worsen outcomes in septic shock patients. However, the response of arterial pressure to volume expansion is inconstant, delayed, and transitory. In the case of profound, life-threatening hypotension, relying only on fluids to restore blood pressure may unduly prolong hypotension and organ hypoperfusion. Conversely, norepinephrine rapidly increases and better stabilizes arterial pressure. By binding venous adrenergic receptors, it transforms part of the unstressed blood volume into stressed blood volume. It increases the mean systemic filling pressure and increases the fluid-induced increase in mean systemic filling pressure, as observed in septic shock patients. This may improve end-organ perfusion, as shown by some animal studies. Two observational studies comparing early vs. later administration of norepinephrine in septic shock patients using a propensity score showed that early administration reduced the administered fluid volume and day-28 mortality. Conversely, in another propensity score-based study, norepinephrine administration within the first hour following shock diagnosis increased day-28 mortality. The only randomized controlled study that compared the early administration of norepinephrine alone to a placebo showed that the early continuous administration of norepinephrine at a fixed dose of 0.05 µg/kg/min, with norepinephrine added in open label, showed that shock control was achieved more often than in the placebo group. The choice of starting norepinephrine administration early should be adapted to the patient's condition. Logically, it should first be addressed to patients with profound hypotension, when the arterial tone is very low, as suggested by a low diastolic blood pressure (e.g. ≤ 40 mmHg), or by a high diastolic shock index (heart rate/diastolic blood pressure) (e.g. ≥ 3). Early administration of norepinephrine should also be considered in patients in whom fluid accumulation is likely to occur or in whom fluid accumulation would be particularly deleterious (in case of acute respiratory distress syndrome or intra-abdominal hypertension for example).
    MeSH term(s) Animals ; Blood Pressure ; Hypotension ; Norepinephrine/pharmacology ; Norepinephrine/therapeutic use ; Shock, Septic/drug therapy ; Vasoconstrictor Agents/pharmacology ; Vasoconstrictor Agents/therapeutic use ; Humans
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Vasoconstrictor Agents
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04593-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV'IT?

    Stoppe, Christian / Preiser, Jean-Charles / de Backer, Daniel / Elke, Gunnar

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 230

    MeSH term(s) Administration, Intravenous ; Adult ; Ascorbic Acid/therapeutic use ; Humans ; Intensive Care Units ; Sepsis/drug therapy ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04106-w
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